View source for Swissregulon:NKX2-3 NKX2-5.p1

{{SwissregulonMotif
|associated_transcription_factors=1.000:1482:NKX2-5:NK2 transcription factor related, locus 5 (Drosophila)::NM_004387:CSX1,NKX2.5,NKX4-1;0.930:159296:NKX2-3:NK2 transcription factor related, locus 3 (Drosophila)::NM_145285:NKX2.3,CSX3,NKX4-3	
|datasource=http://www.swissregulon.unibas.ch/
|gostat_on_mara_hg19=GO:0007275!multicellular organismal development!9.47583686329861e-33!22854;6252;7080;8200;7021;2316;4222;2290;10231;3234;3205;3381;5727;6091;9211;2078;6092;474;4661;2313;627;2707;3853;348;2138;5251;9839;1303;4808;93986;7227;4884;5744;3212;3199;81575;8796;1638;1749$GO:0048856!anatomical structure development!2.89783380185462e-28!22854;6252;7080;8200;7021;2316;2290;10231;3381;5727;6091;9211;6092;474;4661;2313;627;2707;3853;348;2138;5251;9839;1303;4808;93986;4884;7227;5744;3199;81575;8796;1638;1749$GO:0032501!multicellular organismal process!1.28325042909517e-25!22854;6252;7080;8200;7021;2316;4222;2290;10231;6337;3234;3205;3381;5727;6091;9211;2078;6092;474;4661;6582;5956;2313;627;786;2570;2707;3853;348;2138;5251;30820;9839;1303;4808;93986;7227;4884;5648;5744;79589;3212;81575;3199;8796;1638;1749$GO:0032502!developmental process!2.86774404661786e-23!22854;6252;7080;8200;7021;2316;4222;2290;10231;3234;3205;3381;5727;6091;9211;2078;6092;474;3315;4661;2313;627;2707;3853;348;2138;5251;9839;1303;4808;93986;7227;22862;4884;55504;5744;3212;81575;3199;8796;1638;1749$GO:0048731!system development!6.32797096315014e-16!22854;6252;7080;7021;2316;2290;10231;3381;5727;6091;9211;6092;474;4661;2313;627;2707;3853;348;5251;1303;9839;4808;93986;4884;7227;5744;3199;81575;8796;1638;1749$GO:0007399!nervous system development!6.70420542553826e-11!22854;474;4661;6252;7080;7021;2316;627;2290;10231;348;9839;4808;93986;4884;6091;9211;6092;1749$GO:0043565!sequence-specific DNA binding!1.75597793886168e-09!57459;7080;7021;2104;6095;2313;4222;2290;159296;3234;9839;3205;93986;7227;3212;3199;2115;2078;1749$GO:0050789!regulation of biological process!1.20611352311929e-08!57459;7080;8200;7021;6095;29995;2316;4222;84253;2290;1993;159296;3234;3205;5727;6091;2078;6092;474;3315;4661;2104;2313;55885;79718;3853;348;2138;389058;6002;9839;57509;4808;7324;93986;7227;55504;5648;5744;79589;3212;3199;2115;1749$GO:0048513!organ development!1.75995115003912e-08!474;7080;7021;2313;2707;3853;2290;5251;1303;93986;3381;7227;5727;5744;81575;3199;8796;6092;1638;1749$GO:0065007!biological regulation!1.38671353983755e-07!57459;7080;8200;7021;6095;29995;2316;4222;84253;2290;1993;159296;3234;3205;5727;6091;2078;6092;474;3315;4661;6582;2104;2313;55885;79718;3853;348;2138;389058;6002;9839;57509;4808;7324;93986;7227;55504;5648;5744;79589;3212;3199;2115;1749$GO:0010468!regulation of gene expression!2.20134404016459e-07!474;4661;3315;57459;7080;7021;2104;6095;55885;29995;2316;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;79589;3212;3199;2115;2078;1749$GO:0050794!regulation of cellular process!2.23472361019223e-07!57459;7080;8200;7021;6095;29995;2316;4222;84253;2290;1993;159296;3234;3205;5727;2078;474;3315;4661;2104;2313;55885;79718;3853;348;2138;389058;6002;9839;57509;4808;93986;7227;55504;5744;79589;3212;3199;2115;1749$GO:0003700!transcription factor activity!2.24356744281147e-07!474;4661;57459;7080;7021;2104;6095;2313;4222;2290;159296;3234;9839;3205;93986;7227;3212;3199;2115;2078;1749$GO:0031323!regulation of cellular metabolic process!4.37671566646268e-07!474;4661;3315;57459;7080;7021;2104;6095;55885;29995;2316;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;79589;3212;3199;2115;2078;1749$GO:0006355!regulation of transcription, DNA-dependent!4.37671566646268e-07!474;4661;57459;7080;7021;2104;6095;55885;29995;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;3212;3199;2115;2078;1749$GO:0019222!regulation of metabolic process!4.66411736620952e-07!474;4661;3315;57459;7080;7021;2104;6095;55885;29995;2316;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;7324;3205;93986;7227;79589;3212;3199;2115;2078;1749$GO:0006351!transcription, DNA-dependent!8.78255306275642e-07!474;4661;57459;7080;7021;2104;6095;55885;29995;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;3212;3199;2115;2078;1749$GO:0032774!RNA biosynthetic process!8.78255306275642e-07!474;4661;57459;7080;7021;2104;6095;55885;29995;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;3212;3199;2115;2078;1749$GO:0045449!regulation of transcription!9.74100061430088e-07!474;4661;57459;7080;7021;2104;6095;55885;29995;2316;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;3212;3199;2115;2078;1749$GO:0019219!regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!1.60103645479517e-06!474;4661;57459;7080;7021;2104;6095;55885;29995;2316;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;3212;3199;2115;2078;1749$GO:0043231!intracellular membrane-bound organelle!2.39848216832547e-06!57459;6252;7080;7021;6095;29995;3013;2316;4222;2290;159296;3234;26040;3205;4717;11227;55145;114789;6196;2078;79071;9472;474;3315;4661;2104;2313;79718;8925;348;2138;389058;6002;2517;9839;54977;57509;4808;6570;93986;7227;22862;5744;79589;3212;3199;2115;1592;1638;1749$GO:0043227!membrane-bound organelle!2.39848216832547e-06!57459;6252;7080;7021;6095;29995;3013;2316;4222;2290;159296;3234;26040;3205;4717;11227;55145;114789;6196;2078;79071;9472;474;3315;4661;2104;2313;79718;8925;348;2138;389058;6002;2517;9839;54977;57509;4808;6570;93986;7227;22862;5744;79589;3212;3199;2115;1592;1638;1749$GO:0006350!transcription!2.98393604373483e-06!474;4661;57459;7080;7021;2104;6095;55885;29995;2316;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;3212;3199;2115;2078;1749$GO:0043229!intracellular organelle!2.98393604373483e-06!57459;6252;7080;7021;83900;6095;29995;3013;2316;4222;2290;159296;3234;26040;3205;4717;11227;55145;288;114789;6196;2078;79071;9472;5144;474;4661;3315;2104;2313;79718;8925;3853;348;2138;389058;6002;2517;9839;54977;4808;57509;6570;93986;7227;4884;22862;5744;79589;3212;3199;8796;2115;1592;1638;1749;337880$GO:0043226!organelle!2.98393604373483e-06!57459;6252;7080;7021;83900;6095;29995;3013;2316;4222;2290;159296;3234;26040;3205;4717;11227;55145;288;114789;6196;2078;79071;9472;5144;474;4661;3315;2104;2313;79718;8925;3853;348;2138;389058;6002;2517;9839;54977;4808;57509;6570;93986;7227;4884;22862;5744;79589;3212;3199;8796;2115;1592;1638;1749;337880$GO:0048869!cellular developmental process!3.38503524619625e-06!22854;474;4661;3315;6252;7080;8200;3853;348;4808;22862;55504;6091;3199;81575;8796;6092;1749$GO:0030154!cell differentiation!3.38503524619625e-06!22854;474;4661;3315;6252;7080;8200;3853;348;4808;22862;55504;6091;3199;81575;8796;6092;1749$GO:0009888!tissue development!1.21680736631211e-05!474;3381;7080;5744;3853;8796;5251;1638;1749$GO:0007417!central nervous system development!1.8447984318236e-05!10231;474;93986;4884;7080;6092;4808;2290$GO:0048699!generation of neurons!2.22462638693533e-05!22854;474;6252;7080;6091;348;6092;1749$GO:0003677!DNA binding!3.12756995980797e-05!474;4661;57459;7080;7021;2104;6095;3013;2313;4222;2290;389058;159296;3234;9839;4808;26040;3205;93986;7227;3212;55145;3199;2115;2078;1749$GO:0007409!axonogenesis!3.66693800387182e-05!6091;22854;474;348;6092;1749$GO:0022008!neurogenesis!3.66693800387182e-05!22854;474;6252;7080;6091;348;6092;1749$GO:0048667!neuron morphogenesis during differentiation!4.58172949577765e-05!6091;22854;474;348;6092;1749$GO:0048812!neurite morphogenesis!4.58172949577765e-05!6091;22854;474;348;6092;1749$GO:0000904!cellular morphogenesis during differentiation!5.91963352199228e-05!6091;22854;474;348;6092;1749$GO:0009653!anatomical structure morphogenesis!7.58704690700991e-05!22854;474;7080;8200;5727;2313;2707;6091;348;81575;3199;2138;6092;1749$GO:0031175!neurite development!8.24236983316959e-05!6091;22854;474;348;6092;1749$GO:0030182!neuron differentiation!8.24236983316959e-05!6091;22854;474;348;6252;6092;1749$GO:0016070!RNA metabolic process!0.000124512435023715!474;4661;57459;7080;7021;2104;6095;55885;29995;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;3212;3199;2115;2078;1749$GO:0005634!nucleus!0.000157869068439604!57459;7080;7021;6095;29995;3013;2316;4222;2290;159296;3234;26040;3205;55145;6196;2078;9472;474;3315;4661;2104;2313;79718;2138;389058;6002;9839;57509;4808;93986;7227;5744;3212;3199;2115;1749$GO:0009790!embryonic development!0.000157869068439604!474;3199;8200;8796;5727;3234;1749$GO:0048666!neuron development!0.000157869068439604!6091;22854;474;348;6092;1749$GO:0048598!embryonic morphogenesis!0.00019413425846441!474;3199;8200;5727;1749$GO:0009887!organ morphogenesis!0.000287837185464962!474;3199;81575;7080;5727;2313;2707;1749$GO:0048518!positive regulation of biological process!0.000360387921900358!474;7080;55504;7021;5648;2104;5744;2316;3853;6091;348;6092;1749$GO:0044424!intracellular part!0.000510608810854604!57459;6252;7080;7021;83900;6095;29995;3013;2316;4222;2290;159296;3234;26040;3205;1849;4717;11227;55145;288;114789;6196;79071;2078;9472;5144;474;4661;3315;2104;2313;79718;8925;3853;348;2138;389058;6002;2517;9839;1303;54977;4808;57509;6570;93986;7227;4884;22862;5744;79589;3212;3199;8796;2115;1592;1638;1749;337880$GO:0008046!axon guidance receptor activity!0.000510608810854604!6091;6092$GO:0044464!cell part!0.000557332268202799!22854;57459;7080;7021;83900;6095;29995;2316;4222;3776;6337;159296;3205;1849;613212;5727;374462;6091;11227;55145;288;114789;2078;79071;9472;6092;5144;3315;5956;2104;79718;79934;786;2707;8925;80333;348;6002;5251;2517;9839;1303;57509;6570;7227;4884;55504;5744;254359;64921;81575;1749;6252;3013;11141;2290;84253;3234;26040;4717;6196;23120;51299;474;4661;6582;2313;2570;3853;2138;389058;30820;54977;4808;93986;22862;79589;3212;3199;8796;2115;1592;92255;1638;337880$GO:0048858!cell projection morphogenesis!0.000640601478844236!6091;22854;474;348;6092;1749$GO:0032990!cell part morphogenesis!0.000640601478844236!6091;22854;474;348;6092;1749$GO:0030030!cell projection organization and biogenesis!0.000640601478844236!6091;22854;474;348;6092;1749$GO:0001501!skeletal development!0.000719369866699155!3381;3199;7227;5251;1303;1749$GO:0051094!positive regulation of developmental process!0.00091385270227187!6091;474;6092;1749$GO:0007420!brain development!0.00106395514794913!474;93986;7080;6092;2290$GO:0050770!regulation of axonogenesis!0.00106395514794913!6091;348;6092$GO:0007398!ectoderm development!0.00131185214567651!474;8796;5744;1638;3853$GO:0005515!protein binding!0.00138044225456068!22854;57459;7080;8200;7021;83900;6095;29995;2316;29951;10231;6337;26040;1849;3205;3381;5727;6091;288;9211;2078;9472;6092;474;3315;4661;2104;627;3853;348;80333;90293;6002;9839;1303;7324;93986;7227;55504;5744;79589;6502;8796;1749$GO:0043283!biopolymer metabolic process!0.00147138822767591!57459;7080;7021;6095;29995;3013;4222;2290;1993;159296;3234;1849;3205;5727;374462;6196;2078;474;4661;4482;2104;5956;2313;55885;79718;8925;2138;389058;90293;5251;9839;4808;7324;93986;7227;79589;6502;3212;3199;2115;1749$GO:0042471!ear morphogenesis!0.00169816350439175!474;3199;1749$GO:0030326!embryonic limb morphogenesis!0.0019796903460635!8200;5727;1749$GO:0035113!embryonic appendage morphogenesis!0.0019796903460635!8200;5727;1749$GO:0010467!gene expression!0.0019796903460635!474;4661;3315;57459;7080;7021;2104;6095;55885;29995;2316;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;79589;3212;3199;2115;2078;1749$GO:0048736!appendage development!0.00259457879473604!8200;5727;1749$GO:0060173!limb development!0.00259457879473604!8200;5727;1749$GO:0035107!appendage morphogenesis!0.00259457879473604!8200;5727;1749$GO:0035108!limb morphogenesis!0.00259457879473604!8200;5727;1749$GO:0050767!regulation of neurogenesis!0.00276950394897317!6091;348;6092$GO:0043583!ear development!0.00368199378318042!474;3199;1749$GO:0048468!cell development!0.00462416300489164!22854;474;3315;6252;7080;8200;22862;55504;6091;348;6092;1749$GO:0042221!response to chemical stimulus!0.00529127462822046!6570;3315;4482;8988;6091;348;30820;6092$GO:0048522!positive regulation of cellular process!0.00767892063678116!474;7080;55504;7021;2104;5744;2316;3853;348;1749$GO:0006139!nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!0.00844403886091855!474;4661;57459;7080;7021;2104;6095;55885;29995;3013;2316;2313;79718;4222;2290;1993;2138;389058;159296;3234;9839;4808;3205;93986;7227;5744;3212;3199;2115;2078;1749$GO:0050772!positive regulation of axonogenesis!0.00844403886091855!6091;6092$GO:0050793!regulation of developmental process!0.00904755910923064!6091;474;348;6092;1749$GO:0008544!epidermis development!0.00904755910923064!474;8796;5744;1638$GO:0050769!positive regulation of neurogenesis!0.0124101244663347!6091;6092$GO:0009986!cell surface!0.0124101244663347!6091;3315;348;6092$GO:0005622!intracellular!0.0191883841088525!57459;6252;7080;7021;83900;6095;29995;3013;2316;4222;84253;2290;159296;3234;26040;3205;1849;4717;11227;55145;288;114789;6196;79071;2078;9472;5144;474;4661;3315;2104;2313;79718;8925;3853;348;2138;389058;6002;2517;9839;1303;54977;4808;57509;6570;93986;7227;4884;22862;5744;79589;3212;3199;8796;2115;1592;1638;337880;1749$GO:0007610!behavior!0.0226085619070175!6091;348;6092;11141;4808$GO:0007423!sensory organ development!0.0254128509761086!474;3199;1749$GO:0003002!regionalization!0.0259432363690102!7080;5727;3234$GO:0031214!biomineral formation!0.0261626793502628!3381;5251;1749$GO:0001503!ossification!0.0261626793502628!3381;5251;1749$GO:0042472!inner ear morphogenesis!0.0289817620703117!474;1749$GO:0005595!collagen type XII!0.0289817620703117!1303$GO:0021757!caudate nucleus development!0.0289817620703117!93986$GO:0050749!apolipoprotein E receptor binding!0.0289817620703117!348$GO:0021758!putamen development!0.0289817620703117!93986$GO:0042667!auditory receptor cell fate specification!0.0289817620703117!474$GO:0030497!fatty acid elongation!0.0289817620703117!79071$GO:0045633!positive regulation of mechanoreceptor differentiation!0.0289817620703117!474$GO:0045609!positive regulation of auditory receptor cell differentiation!0.0289817620703117!474$GO:0043109!regulation of smoothened activity!0.0289817620703117!5727$GO:0008401!retinoic acid 4-hydroxylase activity!0.0289817620703117!1592$GO:0046849!bone remodeling!0.0292951056519846!3381;5251;1749$GO:0009953!dorsal/ventral pattern formation!0.029799579233571!7080;5727$GO:0007267!cell-cell signaling!0.029799579233571!348;4884;8200;5744;5251;30820;2570$GO:0000902!cell morphogenesis!0.029799579233571!6091;22854;474;348;6092;1749$GO:0032989!cellular structure morphogenesis!0.029799579233571!6091;22854;474;348;6092;1749$GO:0001709!cell fate determination!0.0312103389911142!474;3199$GO:0048771!tissue remodeling!0.0354777115438831!3381;5251;1749$GO:0022836!gated channel activity!0.0377827296764992!3776;80333;6337;30820;2570;786$GO:0006605!protein targeting!0.037850251027304!288;7227;2316;9472$GO:0043167!ion binding!0.0378833277323854!4661;57459;2104;6095;55885;29995;2570;786;29951;3776;80333;6337;2138;389058;5251;30820;9839;93986;7227;4884;5648;5744;79589;254359;11227;55145;114789;6196;23120;8796;1592;5144;1638$GO:0031420!alkali metal ion binding!0.0392923134067188!3776;80333;6337;30820$GO:0005624!membrane fraction!0.0392923134067188!6570;6582;6337;22862;1592;1638;786$GO:0045893!positive regulation of transcription, DNA-dependent!0.0394829936286361!474;7080;7021;2104$GO:0012506!vesicle membrane!0.0407556930199674!6570;22862;1638$GO:0022803!passive transmembrane transporter activity!0.0425563440140219!3776;80333;6337;30820;2707;2570;786$GO:0015267!channel activity!0.0425563440140219!3776;80333;6337;30820;2707;2570;786$GO:0001764!neuron migration!0.0426996525751766!474;7080$GO:0001822!kidney development!0.0426996525751766!7021;6092$GO:0031090!organelle membrane!0.0436376903778672!6570;6252;22862;4717;11227;114789;79071;9472;1592;1638;54977$GO:0044237!cellular metabolic process!0.0436376903778672!57459;7080;7021;6095;29995;3013;2316;4222;2290;1993;159296;3234;3205;1849;5727;4717;374462;11227;6196;2078;79071;474;3315;4661;4482;5956;2104;2313;55885;79718;8925;348;2138;389058;5251;90293;2517;9839;4808;7324;93986;7227;5648;5744;79589;6502;3212;81575;3199;2115;1638;1749$GO:0048839!inner ear development!0.0436376903778672!474;1749$GO:0000267!cell fraction!0.0436376903778672!6570;6582;22862;786;6337;1592;1638;5144$GO:0043170!macromolecule metabolic process!0.0436376903778672!57459;7080;7021;6095;29995;3013;4222;2290;1993;159296;3234;3205;1849;5727;374462;11227;6196;2078;474;3315;4661;4482;5956;2104;2313;55885;79718;8925;348;2138;389058;5251;90293;2517;9839;4808;7324;93986;7227;5648;79589;6502;3212;81575;3199;2115;1749$GO:0021756!striatum development!0.0436376903778672!93986$GO:0048156!tau protein binding!0.0436376903778672!348$GO:0021798!forebrain dorsal/ventral pattern formation!0.0436376903778672!7080$GO:0042296!ISG15 conjugating enzyme activity!0.0436376903778672!7324$GO:0030020!extracellular matrix structural constituent conferring tensile strength!0.0436376903778672!1303$GO:0048857!neural nucleus development!0.0436376903778672!93986$GO:0045606!positive regulation of epidermal cell differentiation!0.0436376903778672!474$GO:0045684!positive regulation of epidermis development!0.0436376903778672!474$GO:0007389!pattern specification process!0.0452457817849908!7080;5727;3234$GO:0006512!ubiquitin cycle!0.0452996368461525!7324;90293;79589;79718;6502;8925$GO:0001655!urogenital system development!0.0459496199291496!7021;6092$GO:0046872!metal ion binding!0.0475649282137251!4661;57459;2104;6095;55885;29995;786;29951;3776;80333;6337;2138;389058;5251;30820;9839;93986;7227;4884;5648;5744;79589;254359;11227;55145;114789;6196;23120;8796;1592;5144;1638
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