Coexpression cluster:C378

Full id: C378_Smooth_mesenchymal_placenta_clear_leiomyoma_renal_Preadipocyte

Phase1 CAGE Peaks

Hg19::chr3:119012895..119012908,+	p6@ARHGAP31
Hg19::chr7:93515840..93515856,-	p@chr7:93515840..93515856 -
Hg19::chr7:93515914..93515935,-	p@chr7:93515914..93515935 -
Hg19::chr7:93515962..93515978,-	p@chr7:93515962..93515978 -
Hg19::chr7:93516018..93516037,-	p@chr7:93516018..93516037 -
Hg19::chr7:93516035..93516056,+	p1@CU675118
Hg19::chr7:93516064..93516108,-	p@chr7:93516064..93516108 -
Hg19::chr7:93516178..93516195,-	p@chr7:93516178..93516195 -
Hg19::chr7:93516564..93516575,+	p@chr7:93516564..93516575 +
Hg19::chr7:93516582..93516600,+	p@chr7:93516582..93516600 +
Hg19::chr7:93516601..93516634,+	p@chr7:93516601..93516634 +
Hg19::chr7:93516618..93516631,-	p@chr7:93516618..93516631 -
Hg19::chr7:93516635..93516656,-	p@chr7:93516635..93516656 -
Hg19::chr7:93516672..93516693,+	p@chr7:93516672..93516693 +
Hg19::chr7:93516698..93516745,-	p@chr7:93516698..93516745 -
Hg19::chr7:93518340..93518370,+	p@chr7:93518340..93518370 +
Hg19::chr7:93518374..93518429,-	p@chr7:93518374..93518429 -
Hg19::chr7:93518433..93518444,-	p@chr7:93518433..93518444 -
Hg19::chr7:93518473..93518503,+	p@chr7:93518473..93518503 +
Hg19::chr7:93518492..93518540,-	p@chr7:93518492..93518540 -
Hg19::chr7:93519471..93519485,-	p5@TFPI2
Hg19::chr7:93519497..93519525,-	p2@TFPI2
Hg19::chr7:93519528..93519538,-	p7@TFPI2
Hg19::chr7:93519532..93519563,+	p@chr7:93519532..93519563 +
Hg19::chr7:93519562..93519586,-	p4@TFPI2
Hg19::chr7:93519576..93519598,+	p@chr7:93519576..93519598 +
Hg19::chr7:93519591..93519595,-	p9@TFPI2
Hg19::chr7:93519597..93519625,-	p3@TFPI2
Hg19::chr7:93520056..93520072,-	p1@TFPI2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007596	blood coagulation	0.0115683504062169
GO:0050817	coagulation	0.0115683504062169
GO:0007599	hemostasis	0.0115683504062169
GO:0005201	extracellular matrix structural constituent	0.0115683504062169
GO:0050878	regulation of body fluid levels	0.0115683504062169
GO:0042060	wound healing	0.0115683504062169
GO:0004867	serine-type endopeptidase inhibitor activity	0.0127163546450018
GO:0004866	endopeptidase inhibitor activity	0.0156599552572707
GO:0030414	protease inhibitor activity	0.0156599552572707
GO:0004857	enzyme inhibitor activity	0.0186771458848463
GO:0005578	proteinaceous extracellular matrix	0.0186771458848463
GO:0009611	response to wounding	0.0186771458848463
GO:0009605	response to external stimulus	0.0257995272124555
GO:0044421	extracellular region part	0.0336630166019074
GO:0065008	regulation of biological quality	0.0336630166019074
GO:0006950	response to stress	0.0404671494171671

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.