Coexpression cluster:C427

Full id: C427_Eosinophils_CD4_Peripheral_Neutrophils_Basophils_mature_Mast

Phase1 CAGE Peaks

Hg19::chr10:105880871..105880889,+	p5@SFR1
Hg19::chr11:58346375..58346390,-	p@chr11:58346375..58346390 -
Hg19::chr14:35342116..35342120,-	p@chr14:35342116..35342120 -
Hg19::chr15:72612817..72612837,+	p@chr15:72612817..72612837 +
Hg19::chr15:73075463..73075507,+	p1@LOC100287559
Hg19::chr15:93426078..93426080,+	p2@LOC100507217
Hg19::chr19:12902289..12902307,+	p1@JUNB
Hg19::chr19:39897943..39897995,+	p@chr19:39897943..39897995 +
Hg19::chr1:45273015..45273052,-	p1@TCTEX1D4
Hg19::chr22:41347007..41347050,-	p@chr22:41347007..41347050 -
Hg19::chr2:100106078..100106095,+	p@chr2:100106078..100106095 +
Hg19::chr2:208394817..208394834,+	p3@CREB1
Hg19::chr3:196229754..196229771,+	p@chr3:196229754..196229771 +
Hg19::chr3:53164571..53164592,+	p@chr3:53164571..53164592 +
Hg19::chr5:172199488..172199515,-	p@chr5:172199488..172199515 -
Hg19::chr6:30294186..30294251,+	p1@TRIM39
Hg19::chr6:36650894..36650908,+	p@chr6:36650894..36650908 +
Hg19::chr7:104654038..104654052,-	p1@LOC100216545
Hg19::chr7:130792940..130792965,+	p@chr7:130792940..130792965 +
Hg19::chr7:140624878..140624906,+	p@chr7:140624878..140624906 +
Hg19::chr9:74980291..74980312,+	p@chr9:74980291..74980312 +
Hg19::chrX:15353629..15353684,-	p1@PIGA
Hg19::chrX:15693462..15693479,-	p@chrX:15693462..15693479 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003712	transcription cofactor activity	0.018187435853225
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	0.018187435853225
GO:0046983	protein dimerization activity	0.018187435853225
GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	0.018187435853225
GO:0008134	transcription factor binding	0.0196061772370119
GO:0006506	GPI anchor biosynthetic process	0.045457632223145
GO:0006505	GPI anchor metabolic process	0.045457632223145
GO:0043565	sequence-specific DNA binding	0.045457632223145
GO:0046489	phosphoinositide biosynthetic process	0.045457632223145
GO:0005515	protein binding	0.045457632223145
GO:0008375	acetylglucosaminyltransferase activity	0.045457632223145
GO:0046474	glycerophospholipid biosynthetic process	0.045457632223145
GO:0006497	protein amino acid lipidation	0.045457632223145
GO:0042158	lipoprotein biosynthetic process	0.045457632223145
GO:0019222	regulation of metabolic process	0.045457632223145

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.