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|gostat_on_coexpression_clusters=GO:0033782!24-hydroxycholesterol 7alpha-hydroxylase activity!0.00300247262451431!51302$GO:0008387!steroid 7-alpha-hydroxylase activity!0.00300247262451431!51302$GO:0008396!oxysterol 7-alpha-hydroxylase activity!0.00360286108933212!51302$GO:0003883!CTP synthase activity!0.00360286108933212!1503$GO:0030573!bile acid catabolic process!0.00360286108933212!51302$GO:0006699!bile acid biosynthetic process!0.00500345816532559!51302$GO:0006707!cholesterol catabolic process!0.00500345816532559!51302$GO:0016127!sterol catabolic process!0.00500345816532559!51302$GO:0019752!carboxylic acid metabolic process!0.00500345816532559!51302;1503$GO:0006082!organic acid metabolic process!0.00500345816532559!51302;1503$GO:0046395!carboxylic acid catabolic process!0.00500345816532559!51302$GO:0016054!organic acid catabolic process!0.00500345816532559!51302$GO:0008206!bile acid metabolic process!0.00643254415861032!51302$GO:0008395!steroid hydroxylase activity!0.00643254415861032!51302$GO:0006706!steroid catabolic process!0.00680400192983605!51302$GO:0006541!glutamine metabolic process!0.00937941257394925!1503$GO:0016709!oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen!0.0102888888512249!51302$GO:0046036!CTP metabolic process!0.0102888888512249!1503$GO:0009209!pyrimidine ribonucleoside triphosphate biosynthetic process!0.0102888888512249!1503$GO:0009208!pyrimidine ribonucleoside triphosphate metabolic process!0.0102888888512249!1503$GO:0006241!CTP biosynthetic process!0.0102888888512249!1503$GO:0009220!pyrimidine ribonucleotide biosynthetic process!0.0106981654968376!1503$GO:0009218!pyrimidine ribonucleotide metabolic process!0.0106981654968376!1503$GO:0044242!cellular lipid catabolic process!0.0120012289244444!51302$GO:0009147!pyrimidine nucleoside triphosphate metabolic process!0.0120012289244444!1503$GO:0006221!pyrimidine nucleotide biosynthetic process!0.0122314812898656!1503$GO:0044249!cellular biosynthetic process!0.0122882589398147!51302;1503$GO:0042493!response to drug!0.0134987973254267!1503$GO:0006220!pyrimidine nucleotide metabolic process!0.0142733285258762!1503$GO:0008203!cholesterol metabolic process!0.0150851187339486!51302$GO:0009064!glutamine family amino acid metabolic process!0.0150851187339486!1503$GO:0016053!organic acid biosynthetic process!0.0150851187339486!51302$GO:0046394!carboxylic acid biosynthetic process!0.0150851187339486!51302$GO:0009058!biosynthetic process!0.0152499402383358!51302;1503$GO:0006694!steroid biosynthetic process!0.0152499402383358!51302$GO:0016125!sterol metabolic process!0.015396771212381!51302$GO:0007586!digestion!0.015396771212381!51302$GO:0009201!ribonucleoside triphosphate biosynthetic process!0.0190872381079814!1503$GO:0009142!nucleoside triphosphate biosynthetic process!0.0193648990451604!1503$GO:0009199!ribonucleoside triphosphate metabolic process!0.0197781111761532!1503$GO:0016042!lipid catabolic process!0.0209721444520474!51302$GO:0009141!nucleoside triphosphate metabolic process!0.0209721444520474!1503$GO:0009260!ribonucleotide biosynthetic process!0.0218746911107329!1503$GO:0005792!microsome!0.0220070949015963!51302$GO:0042598!vesicular fraction!0.0220070949015963!51302$GO:0009259!ribonucleotide metabolic process!0.0220070949015963!1503$GO:0016705!oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen!0.0225557870057453!51302$GO:0008202!steroid metabolic process!0.0278068183692588!51302$GO:0004497!monooxygenase activity!0.028456624280113!51302$GO:0009165!nucleotide biosynthetic process!0.0305107289082287!1503$GO:0032787!monocarboxylic acid metabolic process!0.0328298187167133!51302$GO:0020037!heme binding!0.0328298187167133!51302$GO:0046906!tetrapyrrole binding!0.0328298187167133!51302$GO:0008610!lipid biosynthetic process!0.0368495454127848!51302$GO:0009117!nucleotide metabolic process!0.0369362602454575!1503$GO:0055086!nucleobase, nucleoside and nucleotide metabolic process!0.0388719701314618!1503$GO:0016879!ligase activity, forming carbon-nitrogen bonds!0.0388719701314618!1503$GO:0006066!alcohol metabolic process!0.0457713421174718!51302$GO:0005789!endoplasmic reticulum membrane!0.0463011143602194!51302$GO:0042175!nuclear envelope-endoplasmic reticulum network!0.0463365297057089!51302$GO:0006520!amino acid metabolic process!0.0463365297057089!1503$GO:0005506!iron ion binding!0.0483575825870521!51302$GO:0044432!endoplasmic reticulum part!0.0491860097835861!51302
|gostat_on_coexpression_clusters=GO:0033782!24-hydroxycholesterol 7alpha-hydroxylase activity!0.00300247262451431!51302$GO:0008387!steroid 7-alpha-hydroxylase activity!0.00300247262451431!51302$GO:0008396!oxysterol 7-alpha-hydroxylase activity!0.00360286108933212!51302$GO:0003883!CTP synthase activity!0.00360286108933212!1503$GO:0030573!bile acid catabolic process!0.00360286108933212!51302$GO:0006699!bile acid biosynthetic process!0.00500345816532559!51302$GO:0006707!cholesterol catabolic process!0.00500345816532559!51302$GO:0016127!sterol catabolic process!0.00500345816532559!51302$GO:0019752!carboxylic acid metabolic process!0.00500345816532559!51302;1503$GO:0006082!organic acid metabolic process!0.00500345816532559!51302;1503$GO:0046395!carboxylic acid catabolic process!0.00500345816532559!51302$GO:0016054!organic acid catabolic process!0.00500345816532559!51302$GO:0008206!bile acid metabolic process!0.00643254415861032!51302$GO:0008395!steroid hydroxylase activity!0.00643254415861032!51302$GO:0006706!steroid catabolic process!0.00680400192983605!51302$GO:0006541!glutamine metabolic process!0.00937941257394925!1503$GO:0016709!oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen!0.0102888888512249!51302$GO:0046036!CTP metabolic process!0.0102888888512249!1503$GO:0009209!pyrimidine ribonucleoside triphosphate biosynthetic process!0.0102888888512249!1503$GO:0009208!pyrimidine ribonucleoside triphosphate metabolic process!0.0102888888512249!1503$GO:0006241!CTP biosynthetic process!0.0102888888512249!1503$GO:0009220!pyrimidine ribonucleotide biosynthetic process!0.0106981654968376!1503$GO:0009218!pyrimidine ribonucleotide metabolic process!0.0106981654968376!1503$GO:0044242!cellular lipid catabolic process!0.0120012289244444!51302$GO:0009147!pyrimidine nucleoside triphosphate metabolic process!0.0120012289244444!1503$GO:0006221!pyrimidine nucleotide biosynthetic process!0.0122314812898656!1503$GO:0044249!cellular biosynthetic process!0.0122882589398147!51302;1503$GO:0042493!response to drug!0.0134987973254267!1503$GO:0006220!pyrimidine nucleotide metabolic process!0.0142733285258762!1503$GO:0008203!cholesterol metabolic process!0.0150851187339486!51302$GO:0009064!glutamine family amino acid metabolic process!0.0150851187339486!1503$GO:0016053!organic acid biosynthetic process!0.0150851187339486!51302$GO:0046394!carboxylic acid biosynthetic process!0.0150851187339486!51302$GO:0009058!biosynthetic process!0.0152499402383358!51302;1503$GO:0006694!steroid biosynthetic process!0.0152499402383358!51302$GO:0016125!sterol metabolic process!0.015396771212381!51302$GO:0007586!digestion!0.015396771212381!51302$GO:0009201!ribonucleoside triphosphate biosynthetic process!0.0190872381079814!1503$GO:0009142!nucleoside triphosphate biosynthetic process!0.0193648990451604!1503$GO:0009199!ribonucleoside triphosphate metabolic process!0.0197781111761532!1503$GO:0016042!lipid catabolic process!0.0209721444520474!51302$GO:0009141!nucleoside triphosphate metabolic process!0.0209721444520474!1503$GO:0009260!ribonucleotide biosynthetic process!0.0218746911107329!1503$GO:0005792!microsome!0.0220070949015963!51302$GO:0042598!vesicular fraction!0.0220070949015963!51302$GO:0009259!ribonucleotide metabolic process!0.0220070949015963!1503$GO:0016705!oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen!0.0225557870057453!51302$GO:0008202!steroid metabolic process!0.0278068183692588!51302$GO:0004497!monooxygenase activity!0.028456624280113!51302$GO:0009165!nucleotide biosynthetic process!0.0305107289082287!1503$GO:0032787!monocarboxylic acid metabolic process!0.0328298187167133!51302$GO:0020037!heme binding!0.0328298187167133!51302$GO:0046906!tetrapyrrole binding!0.0328298187167133!51302$GO:0008610!lipid biosynthetic process!0.0368495454127848!51302$GO:0009117!nucleotide metabolic process!0.0369362602454575!1503$GO:0055086!nucleobase, nucleoside and nucleotide metabolic process!0.0388719701314618!1503$GO:0016879!ligase activity, forming carbon-nitrogen bonds!0.0388719701314618!1503$GO:0006066!alcohol metabolic process!0.0457713421174718!51302$GO:0005789!endoplasmic reticulum membrane!0.0463011143602194!51302$GO:0042175!nuclear envelope-endoplasmic reticulum network!0.0463365297057089!51302$GO:0006520!amino acid metabolic process!0.0463365297057089!1503$GO:0005506!iron ion binding!0.0483575825870521!51302$GO:0044432!endoplasmic reticulum part!0.0491860097835861!51302
|id=C1858
|id=C1858
|ontology_enrichment_celltype=CL:0000223!7.22e-09!59;CL:0000066!3.92e-07!254
|ontology_enrichment_disease=DOID:305!3.69e-13!106;DOID:0050687!1.44e-08!143
|ontology_enrichment_uberon=UBERON:0001007!8.98e-27!155;UBERON:0001555!8.98e-27!155;UBERON:0007026!8.98e-27!155;UBERON:0004119!1.70e-25!169;UBERON:0000925!1.70e-25!169;UBERON:0006595!1.70e-25!169;UBERON:0004921!4.93e-24!129;UBERON:0004185!4.93e-24!129;UBERON:0007023!1.12e-20!115;UBERON:0000077!1.13e-17!130;UBERON:0000481!2.54e-17!347;UBERON:0000062!2.44e-15!511;UBERON:0002530!2.40e-14!59;UBERON:0001041!9.70e-14!98;UBERON:0001048!3.29e-11!168;UBERON:0001004!9.66e-11!72;UBERON:0005911!1.10e-10!82;UBERON:0000477!4.37e-10!286;UBERON:0000161!1.42e-09!35;UBERON:0002365!1.49e-09!31;UBERON:0002330!1.49e-09!31;UBERON:0000466!3.36e-09!126;UBERON:0003929!3.57e-09!54;UBERON:0000475!6.53e-09!365;UBERON:0003104!8.68e-09!238;UBERON:0009142!8.68e-09!238;UBERON:0000467!1.36e-08!625;UBERON:0000063!1.44e-08!97;UBERON:0000480!1.78e-08!626;UBERON:0000468!2.70e-08!659;UBERON:0000064!8.81e-08!219;UBERON:0000153!9.89e-08!129;UBERON:0007811!9.89e-08!129;UBERON:0000922!1.14e-07!612;UBERON:0005409!2.28e-07!35;UBERON:0002368!4.52e-07!35;UBERON:0000033!4.59e-07!123;UBERON:0000923!5.97e-07!604;UBERON:0005291!5.97e-07!604;UBERON:0006598!5.97e-07!604;UBERON:0002532!5.97e-07!604;UBERON:0000065!7.41e-07!53;UBERON:0002050!7.57e-07!605;UBERON:0005423!7.57e-07!605
}}
}}

Revision as of 14:16, 21 May 2012


Full id: C1858_Hepatocyte_parotid_salivary_submaxillary_liver_small_cerebellum



Phase1 CAGE Peaks

Hg19::chr1:41454160..41454176,+p6@CTPS
Hg19::chr1:41454185..41454224,+p5@CTPS
Hg19::chr1:41454251..41454260,+p21@CTPS
Hg19::chr6:46620445..46620463,-p1@CYP39A1
Hg19::chr6:46620465..46620476,-p3@CYP39A1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:003378224-hydroxycholesterol 7alpha-hydroxylase activity0.00300247262451431
GO:0008387steroid 7-alpha-hydroxylase activity0.00300247262451431
GO:0008396oxysterol 7-alpha-hydroxylase activity0.00360286108933212
GO:0003883CTP synthase activity0.00360286108933212
GO:0030573bile acid catabolic process0.00360286108933212
GO:0006699bile acid biosynthetic process0.00500345816532559
GO:0006707cholesterol catabolic process0.00500345816532559
GO:0016127sterol catabolic process0.00500345816532559
GO:0019752carboxylic acid metabolic process0.00500345816532559
GO:0006082organic acid metabolic process0.00500345816532559
GO:0046395carboxylic acid catabolic process0.00500345816532559
GO:0016054organic acid catabolic process0.00500345816532559
GO:0008206bile acid metabolic process0.00643254415861032
GO:0008395steroid hydroxylase activity0.00643254415861032
GO:0006706steroid catabolic process0.00680400192983605
GO:0006541glutamine metabolic process0.00937941257394925
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0102888888512249
GO:0046036CTP metabolic process0.0102888888512249
GO:0009209pyrimidine ribonucleoside triphosphate biosynthetic process0.0102888888512249
GO:0009208pyrimidine ribonucleoside triphosphate metabolic process0.0102888888512249
GO:0006241CTP biosynthetic process0.0102888888512249
GO:0009220pyrimidine ribonucleotide biosynthetic process0.0106981654968376
GO:0009218pyrimidine ribonucleotide metabolic process0.0106981654968376
GO:0044242cellular lipid catabolic process0.0120012289244444
GO:0009147pyrimidine nucleoside triphosphate metabolic process0.0120012289244444
GO:0006221pyrimidine nucleotide biosynthetic process0.0122314812898656
GO:0044249cellular biosynthetic process0.0122882589398147
GO:0042493response to drug0.0134987973254267
GO:0006220pyrimidine nucleotide metabolic process0.0142733285258762
GO:0008203cholesterol metabolic process0.0150851187339486
GO:0009064glutamine family amino acid metabolic process0.0150851187339486
GO:0016053organic acid biosynthetic process0.0150851187339486
GO:0046394carboxylic acid biosynthetic process0.0150851187339486
GO:0009058biosynthetic process0.0152499402383358
GO:0006694steroid biosynthetic process0.0152499402383358
GO:0016125sterol metabolic process0.015396771212381
GO:0007586digestion0.015396771212381
GO:0009201ribonucleoside triphosphate biosynthetic process0.0190872381079814
GO:0009142nucleoside triphosphate biosynthetic process0.0193648990451604
GO:0009199ribonucleoside triphosphate metabolic process0.0197781111761532
GO:0016042lipid catabolic process0.0209721444520474
GO:0009141nucleoside triphosphate metabolic process0.0209721444520474
GO:0009260ribonucleotide biosynthetic process0.0218746911107329
GO:0005792microsome0.0220070949015963
GO:0042598vesicular fraction0.0220070949015963
GO:0009259ribonucleotide metabolic process0.0220070949015963
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen0.0225557870057453
GO:0008202steroid metabolic process0.0278068183692588
GO:0004497monooxygenase activity0.028456624280113
GO:0009165nucleotide biosynthetic process0.0305107289082287
GO:0032787monocarboxylic acid metabolic process0.0328298187167133
GO:0020037heme binding0.0328298187167133
GO:0046906tetrapyrrole binding0.0328298187167133
GO:0008610lipid biosynthetic process0.0368495454127848
GO:0009117nucleotide metabolic process0.0369362602454575
GO:0055086nucleobase, nucleoside and nucleotide metabolic process0.0388719701314618
GO:0016879ligase activity, forming carbon-nitrogen bonds0.0388719701314618
GO:0006066alcohol metabolic process0.0457713421174718
GO:0005789endoplasmic reticulum membrane0.0463011143602194
GO:0042175nuclear envelope-endoplasmic reticulum network0.0463365297057089
GO:0006520amino acid metabolic process0.0463365297057089
GO:0005506iron ion binding0.0483575825870521
GO:0044432endoplasmic reticulum part0.0491860097835861



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
endodermal cell7.22e-0959
epithelial cell3.92e-07254
Uber Anatomy
Ontology termp-valuen
digestive system8.98e-27155
digestive tract8.98e-27155
primitive gut8.98e-27155
endoderm-derived structure1.70e-25169
endoderm1.70e-25169
presumptive endoderm1.70e-25169
subdivision of digestive tract4.93e-24129
endodermal part of digestive tract4.93e-24129
adult organism1.12e-20115
mixed endoderm/mesoderm-derived structure1.13e-17130
multi-tissue structure2.54e-17347
organ2.44e-15511
gland2.40e-1459
foregut9.70e-1498
primordium3.29e-11168
respiratory system9.66e-1172
endo-epithelium1.10e-1082
anatomical cluster4.37e-10286
orifice1.42e-0935
exocrine gland1.49e-0931
exocrine system1.49e-0931
immaterial anatomical entity3.36e-09126
gut epithelium3.57e-0954
organism subdivision6.53e-09365
mesenchyme8.68e-09238
entire embryonic mesenchyme8.68e-09238
anatomical system1.36e-08625
organ segment1.44e-0897
anatomical group1.78e-08626
multi-cellular organism2.70e-08659
organ part8.81e-08219
anterior region of body9.89e-08129
craniocervical region9.89e-08129
embryo1.14e-07612
gastrointestinal system2.28e-0735
endocrine gland4.52e-0735
head4.59e-07123
germ layer5.97e-07604
embryonic tissue5.97e-07604
presumptive structure5.97e-07604
epiblast (generic)5.97e-07604
respiratory tract7.41e-0753
embryonic structure7.57e-07605
developing anatomical structure7.57e-07605
Disease
Ontology termp-valuen
carcinoma3.69e-13106
cell type cancer1.44e-08143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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