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Revision as of 17:10, 15 June 2012

Name:heart
Definition:"a myogenic muscular organ found in the cardiovascular system. It is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions. The vertebrate heart is composed of cardiac muscle, which is an involuntary striated muscle tissue found only in this organ, and connective tissue. Primitive fish have a four-chambered heart; however, the chambers are arranged sequentially so that this primitive heart is quite unlike the four-chambered hearts of mammals and birds. The first chamber is the sinus venosus, which collects de-oxygenated blood, from the body, through the hepatic and cardinal veins. From here, blood flows into the atrium and then to the powerful muscular ventricle where the main pumping action takes place. The fourth and final chamber is the conus arteriosus which contains several valves and sends blood to the ventral aorta. The ventral aorta delivers blood to the gills where it is oxygenated and flows, through the dorsal aorta, into the rest of the body. (In tetrapods, the ventral aorta has divided in two; one half forms the ascending aorta, while the other forms the pulmonary artery. In the adult fish, the four chambers are not arranged in a straight row but, instead, form an S-shape with the latter two chambers lying above the former two. This relatively simpler pattern is found in cartilaginous fish and in the more primitive ray-finned fish. In teleosts, the conus arteriosus is very small and can more accurately be described as part of the aorta rather than of the heart proper. The conus arteriosus is not present in any amniotes which presumably having been absorbed into the ventricles over the course of evolution. Similarly, while the sinus venosus is present as a vestigial structure in some reptiles and birds, it is otherwise absorbed into the right atrium and is no longer distinguishable[WP]." [Wikipedia:Heart]
Xrefs:
links:

AAO:0010210
BILA:0000020
BTO:0000562
EFO:0000815
EHDAA:420
EHDAA2:0000738
EMAPA:16105
EV:0100018
FMA:7088
GAID:174
galen:Heart
MA:0000072
MAT:0000036
MESH:A.07.541
MIAA:0000036
ncithesaurus:Heart
OpenCyc:Mx4rvVjvDpwpEbGdrcN5Y29ycA
SCTID:302509004
TAO:0000114
VHOG:0000276
XAO:0000064

ZFA:0000114
Synonyms: "chambered heart" EXACT [UBERON:cjm]
"Herz" RELATED [BTO:0000562]
"vertebrate heart" EXACT []
Comments:note that we use the term 'circulatory organ' for the generic class. Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepi- thelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" doi:10.1101/gad.1485706
Alt_id: UBERON:FBbt_00003154-FMA_7088-MA_0000072-MIAA_0000036-XAO_0000064-ZFA_0000114
Subset: major_organ
organ_slim
uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0004120(mesoderm-derived structure),UBERON:0007100(primary circulatory organ)
develops_from:UBERON:0004141(heart tube)
part_of:UBERON:0004535(cardiovascular system)



Children

derives from:FF:0010016 (human heart - adult sample),FF:0010046 (human heart - fetal sample),FF:0011313 (mouse heart- embryo E11 sample),FF:0011318 (mouse heart- embryo E12 sample),FF:0011327 (mouse heart- embryo E13 sample),FF:0011337 (mouse heart- embryo E14 sample),FF:0011347 (mouse heart- embryo E15 sample),FF:0011356 (mouse heart- embryo E16 sample),FF:0011367 (mouse heart- embryo E17 sample),FF:0011393 (mouse heart- neonate N00 sample),FF:0011414 (mouse heart- neonate N10 sample),FF:0011424 (mouse heart- neonate N16 sample),FF:0011427 (mouse heart- neonate N20 sample),FF:0011474 (mouse heart- neonate N03 sample),FF:0011475 (mouse heart- neonate N25 sample),FF:0011476 (mouse heart- neonate N30 sample),FF:0011515 (mouse heart- embryo E18 sample)
part of:CL:0000569 (cardiac mesenchymal cell),UBERON:0000946 (cardial valve),UBERON:0001133 (cardiac muscle tissue),UBERON:0001621 (coronary artery),UBERON:0002062 (endocardial cushion),UBERON:0002165 (endocardium),CL:0002548 (cardiac fibroblast),UBERON:0003498 (heart blood vessel),UBERON:0004145 (outflow tract),UBERON:0004151 (cardiac chamber),UBERON:0005983 (heart layer),UBERON:0005985 (coronary vessel),UBERON:0009751 (cardiac mesenchyme),UBERON:0011820 (atrioventricular region)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0000948 (heart), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.09e-81FFCP PHASE2:Mm9::chr1:137747392..137747402,-#_e7704b1c180ecf49877757dd6b98f67cp@chr1:137747392..137747402, -
1.09e-81FFCP PHASE2:Mm9::chr4:147375434..147375447,+#_e7704b1c180ecf49877757dd6b98f67cp@chr4:147375434..147375447, +
1.09e-81FFCP PHASE1:Mm9::chr1:137747392..137747402,-#_e7704b1c180ecf49877757dd6b98f67cp@chr1:137747392..137747402, -
1.09e-81FFCP PHASE2:Mm9::chr9:24549775..24549776,-#_e7704b1c180ecf49877757dd6b98f67cp@chr9:24549775..24549776, -
1.09e-81FFCP PHASE1:Mm9::chr4:147375434..147375447,+#_e7704b1c180ecf49877757dd6b98f67cp@chr4:147375434..147375447, +
1.09e-81FFCP PHASE1:Mm9::chr9:24549775..24549776,-#_e7704b1c180ecf49877757dd6b98f67cp@chr9:24549775..24549776, -
1.88e-78FFCP PHASE1:Mm9::chr4:140980456..140980463,+#_2a30e0d12cfcbb2debc4d534d4b7517dp@chr4:140980456..140980463, +
1.88e-78FFCP PHASE2:Mm9::chr4:140980456..140980463,+#_2a30e0d12cfcbb2debc4d534d4b7517dp@chr4:140980456..140980463, +
1.92e-77FFCP PHASE1:Mm9::chr1:137737483..137737497,-#_92d72b370eb7756f1cf58dff9b3df06ap@chr1:137737483..137737497, -
1.92e-77FFCP PHASE2:Mm9::chr1:137737483..137737497,-#_92d72b370eb7756f1cf58dff9b3df06ap@chr1:137737483..137737497, -
1.92e-77FFCP PHASE1:Mm9::chr12:113728951..113728965,+#_92d72b370eb7756f1cf58dff9b3df06ap@chr12:113728951..113728965, +
1.92e-77FFCP PHASE2:Mm9::chr12:113728951..113728965,+#_92d72b370eb7756f1cf58dff9b3df06ap@chr12:113728951..113728965, +
2.14e-77FFCP PHASE1:Mm9::chr19:36187511..36187515,-#_9bea4279abc59ad90af5c21c7095ffa2p@chr19:36187511..36187515, -
2.14e-77FFCP PHASE2:Mm9::chr19:36187511..36187515,-#_9bea4279abc59ad90af5c21c7095ffa2p@chr19:36187511..36187515, -
2.14e-77FFCP PHASE1:Mm9::chr4:147375200..147375220,+#_9bea4279abc59ad90af5c21c7095ffa2p@chr4:147375200..147375220, +
2.14e-77FFCP PHASE2:Mm9::chr4:147375200..147375220,+#_9bea4279abc59ad90af5c21c7095ffa2p@chr4:147375200..147375220, +
8.14e-77FFCP PHASE2:Mm9::chr1:137744636..137744654,+#_99026338bf8875ba13890037c2de4537p@chr1:137744636..137744654, +
8.14e-77FFCP PHASE1:Mm9::chr1:137744333..137744352,-#_99026338bf8875ba13890037c2de4537p@chr1:137744333..137744352, -
8.14e-77FFCP PHASE2:Mm9::chr1:137747382..137747385,-#_99026338bf8875ba13890037c2de4537p@chr1:137747382..137747385, -
8.14e-77FFCP PHASE2:Mm9::chr14:55584663..55584731,-#_99026338bf8875ba13890037c2de4537p@chr14:55584663..55584731, -
8.14e-77FFCP PHASE2:Mm9::chr1:137743272..137743307,+#_99026338bf8875ba13890037c2de4537p@chr1:137743272..137743307, +
8.14e-77FFCP PHASE1:Mm9::chr14:55572120..55572173,+#_99026338bf8875ba13890037c2de4537p@chr14:55572120..55572173, +
8.14e-77FFCP PHASE2:Mm9::chr14:55581579..55581620,-#_99026338bf8875ba13890037c2de4537p@chr14:55581579..55581620, -
8.14e-77FFCP PHASE2:Mm9::chr14:55571909..55571953,-#_99026338bf8875ba13890037c2de4537p@chr14:55571909..55571953, -
8.14e-77FFCP PHASE1:Mm9::chr14:55584197..55584239,-#_99026338bf8875ba13890037c2de4537p@chr14:55584197..55584239, -
8.14e-77FFCP PHASE1:Mm9::chr14:55565785..55565833,-#_99026338bf8875ba13890037c2de4537p@chr14:55565785..55565833, -
8.14e-77FFCP PHASE1:Mm9::chr1:137745434..137745445,+#_99026338bf8875ba13890037c2de4537p@chr1:137745434..137745445, +
8.14e-77FFCP PHASE1:Mm9::chr14:55581579..55581620,-#_99026338bf8875ba13890037c2de4537p@chr14:55581579..55581620, -
8.14e-77FFCP PHASE2:Mm9::chr14:55565785..55565833,-#_99026338bf8875ba13890037c2de4537p@chr14:55565785..55565833, -
8.14e-77FFCP PHASE1:Mm9::chr1:137744550..137744565,+#_99026338bf8875ba13890037c2de4537p@chr1:137744550..137744565, +
8.14e-77FFCP PHASE2:Mm9::chr14:55568737..55568746,-#_99026338bf8875ba13890037c2de4537p@chr14:55568737..55568746, -
8.14e-77FFCP PHASE1:Mm9::chr1:137747382..137747385,-#_99026338bf8875ba13890037c2de4537p@chr1:137747382..137747385, -
8.14e-77FFCP PHASE1:Mm9::chr14:55584663..55584731,-#_99026338bf8875ba13890037c2de4537p@chr14:55584663..55584731, -
8.14e-77FFCP PHASE1:Mm9::chr5:120286706..120286736,+#_99026338bf8875ba13890037c2de4537p@chr5:120286706..120286736, +
8.14e-77FFCP PHASE2:Mm9::chr1:137745434..137745445,+#_99026338bf8875ba13890037c2de4537p@chr1:137745434..137745445, +
8.14e-77FFCP PHASE1:Mm9::chr1:137744636..137744654,+#_99026338bf8875ba13890037c2de4537p@chr1:137744636..137744654, +
8.14e-77FFCP PHASE2:Mm9::chr14:55568937..55568988,-#_99026338bf8875ba13890037c2de4537p@chr14:55568937..55568988, -
8.14e-77FFCP PHASE1:Mm9::chr11:65461897..65461929,-#_99026338bf8875ba13890037c2de4537p@chr11:65461897..65461929, -
8.14e-77FFCP PHASE1:Mm9::chr19:36193772..36193793,-#_99026338bf8875ba13890037c2de4537p@chr19:36193772..36193793, -
8.14e-77FFCP PHASE2:Mm9::chr1:137747289..137747313,+#_99026338bf8875ba13890037c2de4537p@chr1:137747289..137747313, +
8.14e-77FFCP PHASE2:Mm9::chr11:58815923..58815951,-#_99026338bf8875ba13890037c2de4537p@chr11:58815923..58815951, -
8.14e-77FFCP PHASE1:Mm9::chr14:55568790..55568803,-#_99026338bf8875ba13890037c2de4537p@chr14:55568790..55568803, -
8.14e-77FFCP PHASE2:Mm9::chr1:137744611..137744621,+#_99026338bf8875ba13890037c2de4537p@chr1:137744611..137744621, +
8.14e-77FFCP PHASE1:Mm9::chr15:88850827..88850850,+#_99026338bf8875ba13890037c2de4537p2@Mov10l1
8.14e-77FFCP PHASE1:Mm9::chr14:55571909..55571953,-#_99026338bf8875ba13890037c2de4537p@chr14:55571909..55571953, -
8.14e-77FFCP PHASE2:Mm9::chr14:55579265..55579297,-#_99026338bf8875ba13890037c2de4537p@chr14:55579265..55579297, -
8.14e-77FFCP PHASE1:Mm9::chr14:55563577..55563611,-#_99026338bf8875ba13890037c2de4537p@chr14:55563577..55563611, -
8.14e-77FFCP PHASE2:Mm9::chr1:137744333..137744352,-#_99026338bf8875ba13890037c2de4537p@chr1:137744333..137744352, -
8.14e-77FFCP PHASE1:Mm9::chr1:137744668..137744681,-#_99026338bf8875ba13890037c2de4537p@chr1:137744668..137744681, -
8.14e-77FFCP PHASE2:Mm9::chr14:55584197..55584239,-#_99026338bf8875ba13890037c2de4537p@chr14:55584197..55584239, -
8.14e-77FFCP PHASE2:Mm9::chr14:55563577..55563611,-#_99026338bf8875ba13890037c2de4537p@chr14:55563577..55563611, -
8.14e-77FFCP PHASE1:Mm9::chr1:137743272..137743307,+#_99026338bf8875ba13890037c2de4537p@chr1:137743272..137743307, +
8.14e-77FFCP PHASE1:Mm9::chr1:137747289..137747313,+#_99026338bf8875ba13890037c2de4537p@chr1:137747289..137747313, +
8.14e-77FFCP PHASE1:Mm9::chr14:55584272..55584298,-#_99026338bf8875ba13890037c2de4537p@chr14:55584272..55584298, -
8.14e-77FFCP PHASE2:Mm9::chr1:137744668..137744681,-#_99026338bf8875ba13890037c2de4537p@chr1:137744668..137744681, -
8.14e-77FFCP PHASE1:Mm9::chr11:58815923..58815951,-#_99026338bf8875ba13890037c2de4537p@chr11:58815923..58815951, -
8.14e-77FFCP PHASE1:Mm9::chr14:55568737..55568746,-#_99026338bf8875ba13890037c2de4537p@chr14:55568737..55568746, -
8.14e-77FFCP PHASE2:Mm9::chr1:137744550..137744565,+#_99026338bf8875ba13890037c2de4537p@chr1:137744550..137744565, +
8.14e-77FFCP PHASE2:Mm9::chr5:120286706..120286736,+#_99026338bf8875ba13890037c2de4537p@chr5:120286706..120286736, +
8.14e-77FFCP PHASE1:Mm9::chr14:55586837..55586880,-#_99026338bf8875ba13890037c2de4537p@chr14:55586837..55586880, -
8.14e-77FFCP PHASE2:Mm9::chr4:147375901..147375913,+#_99026338bf8875ba13890037c2de4537p@chr4:147375901..147375913, +
8.14e-77FFCP PHASE2:Mm9::chr14:55572120..55572173,+#_99026338bf8875ba13890037c2de4537p@chr14:55572120..55572173, +
8.14e-77FFCP PHASE2:Mm9::chr19:36193772..36193793,-#_99026338bf8875ba13890037c2de4537p@chr19:36193772..36193793, -
8.14e-77FFCP PHASE2:Mm9::chr14:55586837..55586880,-#_99026338bf8875ba13890037c2de4537p@chr14:55586837..55586880, -
8.14e-77FFCP PHASE1:Mm9::chr14:55568937..55568988,-#_99026338bf8875ba13890037c2de4537p@chr14:55568937..55568988, -
8.14e-77FFCP PHASE2:Mm9::chr15:88850827..88850850,+#_99026338bf8875ba13890037c2de4537p2@Mov10l1
8.14e-77FFCP PHASE1:Mm9::chr1:137744611..137744621,+#_99026338bf8875ba13890037c2de4537p@chr1:137744611..137744621, +
8.14e-77FFCP PHASE2:Mm9::chr14:55568790..55568803,-#_99026338bf8875ba13890037c2de4537p@chr14:55568790..55568803, -
8.14e-77FFCP PHASE1:Mm9::chr14:55579265..55579297,-#_99026338bf8875ba13890037c2de4537p@chr14:55579265..55579297, -
8.14e-77FFCP PHASE2:Mm9::chr1:137747953..137747967,-#_99026338bf8875ba13890037c2de4537p@chr1:137747953..137747967, -
8.14e-77FFCP PHASE1:Mm9::chr1:137747953..137747967,-#_99026338bf8875ba13890037c2de4537p@chr1:137747953..137747967, -
8.14e-77FFCP PHASE2:Mm9::chr11:65461897..65461929,-#_99026338bf8875ba13890037c2de4537p@chr11:65461897..65461929, -
8.14e-77FFCP PHASE2:Mm9::chr14:55584272..55584298,-#_99026338bf8875ba13890037c2de4537p@chr14:55584272..55584298, -
8.14e-77FFCP PHASE1:Mm9::chr4:147375901..147375913,+#_99026338bf8875ba13890037c2de4537p@chr4:147375901..147375913, +
1.2e-73FFCP PHASE2:Mm9::chr1:137742152..137742184,-#_a6096ee0b3b4f74e8c55ddbbf8ce984ap@chr1:137742152..137742184, -
1.2e-73FFCP PHASE1:Mm9::chr1:137742152..137742184,-#_a6096ee0b3b4f74e8c55ddbbf8ce984ap@chr1:137742152..137742184, -
1.46e-72FFCP PHASE1:Mm9::chr7:4473478..4473505,-#_eac1a86099a21cc231eb4fffcc4da8bdp2@Tnni3
1.46e-72FFCP PHASE1:Mm9::chr1:137742470..137742481,+#_eac1a86099a21cc231eb4fffcc4da8bdp@chr1:137742470..137742481, +
1.46e-72FFCP PHASE1:Mm9::chr14:55577329..55577367,-#_eac1a86099a21cc231eb4fffcc4da8bdp@chr14:55577329..55577367, -
1.46e-72FFCP PHASE1:Mm9::chr16:5431481..5431510,+#_eac1a86099a21cc231eb4fffcc4da8bdp@chr16:5431481..5431510, +
1.46e-72FFCP PHASE2:Mm9::chr7:4473478..4473505,-#_eac1a86099a21cc231eb4fffcc4da8bdp2@Tnni3
1.46e-72FFCP PHASE2:Mm9::chr14:55577329..55577367,-#_eac1a86099a21cc231eb4fffcc4da8bdp@chr14:55577329..55577367, -
1.46e-72FFCP PHASE2:Mm9::chr1:137742470..137742481,+#_eac1a86099a21cc231eb4fffcc4da8bdp@chr1:137742470..137742481, +
1.46e-72FFCP PHASE2:Mm9::chr16:5431481..5431510,+#_eac1a86099a21cc231eb4fffcc4da8bdp@chr16:5431481..5431510, +
1.63e-72FFCP PHASE2:Mm9::chr2:113880065..113880076,+#_21d57e9b687aefedf8f5e294bec64223p1@ENSMUST00000154140
1.63e-72FFCP PHASE1:Mm9::chr19:36193739..36193752,-#_21d57e9b687aefedf8f5e294bec64223p@chr19:36193739..36193752, -
1.63e-72FFCP PHASE2:Mm9::chr19:36193739..36193752,-#_21d57e9b687aefedf8f5e294bec64223p@chr19:36193739..36193752, -
1.63e-72FFCP PHASE1:Mm9::chr16:38713504..38713520,-#_21d57e9b687aefedf8f5e294bec64223p11@Arhgap31
1.63e-72FFCP PHASE1:Mm9::chr10:53062244..53062249,+#_21d57e9b687aefedf8f5e294bec64223p@chr10:53062244..53062249, +
1.63e-72FFCP PHASE2:Mm9::chr5:58108164..58108178,+#_21d57e9b687aefedf8f5e294bec64223p@chr5:58108164..58108178, +
1.63e-72FFCP PHASE2:Mm9::chr10:53062244..53062249,+#_21d57e9b687aefedf8f5e294bec64223p@chr10:53062244..53062249, +
1.63e-72FFCP PHASE1:Mm9::chr2:17382210..17382221,-#_21d57e9b687aefedf8f5e294bec64223p5@Nebl
1.63e-72FFCP PHASE2:Mm9::chr16:38713504..38713520,-#_21d57e9b687aefedf8f5e294bec64223p11@Arhgap31
1.63e-72FFCP PHASE1:Mm9::chr5:58108164..58108178,+#_21d57e9b687aefedf8f5e294bec64223p@chr5:58108164..58108178, +
1.63e-72FFCP PHASE2:Mm9::chr2:17382210..17382221,-#_21d57e9b687aefedf8f5e294bec64223p5@Nebl
1.63e-72FFCP PHASE1:Mm9::chr2:113880065..113880076,+#_21d57e9b687aefedf8f5e294bec64223p1@ENSMUST00000154140
1.82e-72FFCP PHASE2:Mm9::chr9:24529233..24529237,-#_94ef00a191adcb9cbd884141c91fe424p@chr9:24529233..24529237, -
1.82e-72FFCP PHASE1:Mm9::chr9:24529233..24529237,-#_94ef00a191adcb9cbd884141c91fe424p@chr9:24529233..24529237, -
2.03e-72FFCP PHASE2:Mm9::chr2:30851059..30851089,+#_8946f42529de76efe276d359c6304a0fp6@Usp20
2.03e-72FFCP PHASE1:Mm9::chr2:30851059..30851089,+#_8946f42529de76efe276d359c6304a0fp6@Usp20

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