Coexpression cluster:C3033

Full id: C3033_non_colon_hepatoblastoma_astrocytoma_prostate_rhabdomyosarcoma_acute

Phase1 CAGE Peaks

Hg19::chr10:64028377..64028388,-	p5@RTKN2
Hg19::chr10:64028400..64028433,-	p1@RTKN2
Hg19::chr10:64028466..64028509,-	p2@RTKN2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>

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Cell Type

Ontology term	p-value	n
neurectodermal cell	6.72e-10	59
neural cell	4.05e-09	25
epithelial cell	9.55e-09	254

Disease

Ontology term	p-value	n
cancer	1.58e-36	235
disease of cellular proliferation	8.95e-35	239
cell type cancer	2.05e-27	143
carcinoma	4.04e-22	106
organ system cancer	3.32e-14	137
germ cell and embryonal cancer	3.60e-09	22
germ cell cancer	3.60e-09	22

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0323423193280263
E2F4#1874	3	12.6680603152844	0.000491798700629898	0.00435131857803168
E2F6#1876	3	5.01715573169739	0.0079176980688633	0.0320261994041059
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0459858204898278
EP300#2033	3	6.7739417262232	0.00321688050010379	0.0166774774162492
GABPB1#2553	3	7.06768383618217	0.00283221282541742	0.015361904714296
JUND#3727	3	6.99466394187103	0.00292184504273499	0.0156105266225803
NRF1#4899	3	12.2102794477109	0.000549217240102001	0.00469199994593153
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0275298711004279
SP1#6667	3	5.6983813781409	0.00540396270171217	0.0245352545582801
TAF7#6879	3	11.4330694049239	0.000669018198194583	0.00540299965985494
TCF7L2#6934	3	10.7701765631373	0.000800318129839838	0.00611578438299136
ZEB1#6935	3	16.8884320175439	0.000207548691732758	0.0024181367487592
ZNF263#10127	3	8.22184163701068	0.00179904392556587	0.0108903001531429

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.