MCL coexpression mm9:1435

Phase1 CAGE Peaks

	Short description
Mm9::chr2:127188905..127188929,+	p2@Adra2b
Mm9::chr2:127188933..127188953,+	p1@Adra2b
Mm9::chr2:127188960..127188978,+	p3@Adra2b
Mm9::chr2:127188996..127189007,+	p4@Adra2b
Mm9::chr2:127191098..127191102,+	p@chr2:127191098..127191102 +
Mm9::chr4:118781400..118781417,+	p1@Slc2a1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004938	alpha2-adrenergic receptor activity	0.0118486862664497
GO:0004936	alpha-adrenergic receptor activity	0.0118486862664497
GO:0005355	glucose transmembrane transporter activity	0.0118486862664497
GO:0015149	hexose transmembrane transporter activity	0.0118486862664497
GO:0004935	adrenoceptor activity	0.0118486862664497
GO:0015145	monosaccharide transmembrane transporter activity	0.0118486862664497
GO:0005351	sugar:hydrogen ion symporter activity	0.0277661867333112
GO:0051119	sugar transmembrane transporter activity	0.0277661867333112
GO:0015144	carbohydrate transmembrane transporter activity	0.0277661867333112
GO:0008227	amine receptor activity	0.0277661867333112
GO:0008643	carbohydrate transport	0.0363764591625976
GO:0016323	basolateral plasma membrane	0.0376394150573527

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
abdomen element	8.59e-15	49
abdominal segment element	8.59e-15	49
abdominal segment of trunk	8.59e-15	49
abdomen	8.59e-15	49
liver	3.28e-09	22
epithelial sac	3.28e-09	22
digestive gland	3.28e-09	22
epithelium of foregut-midgut junction	3.28e-09	22
anatomical boundary	3.28e-09	22
hepatobiliary system	3.28e-09	22
foregut-midgut junction	3.28e-09	22
hepatic diverticulum	3.28e-09	22
liver primordium	3.28e-09	22
septum transversum	3.28e-09	22
liver bud	3.28e-09	22
digestive tract diverticulum	1.90e-08	23
sac	1.90e-08	23
subdivision of trunk	2.41e-08	66
exocrine gland	8.16e-08	25
exocrine system	8.16e-08	25
trunk region element	1.21e-07	79
mesenchyme	3.55e-07	61
entire embryonic mesenchyme	3.55e-07	61
epithelial tube	3.66e-07	47

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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