MCL coexpression mm9:516

Phase1 CAGE Peaks

	Short description
Mm9::chr10:69388232..69388250,+	p2@Ank3
Mm9::chr12:85958276..85958369,-	p1@Abcd4
Mm9::chr14:58017323..58017346,-	p1@Cryl1
Mm9::chr15:80019562..80019612,+	p@chr15:80019562..80019612 +
Mm9::chr15:80019614..80019631,+	p@chr15:80019614..80019631 +
Mm9::chr16:21868045..21868054,+	p@chr16:21868045..21868054 +
Mm9::chr17:34999406..34999417,-	p4@Cfb
Mm9::chr17:85427687..85427744,+	p1@Slc3a1
Mm9::chr17:85432956..85432975,+	p@chr17:85432956..85432975 +
Mm9::chr1:166388476..166388494,-	p1@Atp1b1
Mm9::chr3:101408578..101408612,-	p1@Atp1a1
Mm9::chr3:96633992..96634038,+	p1@Pdzk1
Mm9::chr3:96634046..96634062,+	p2@Pdzk1
Mm9::chr7:54051031..54051092,-	p1@Hps5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005391	sodium:potassium-exchanging ATPase activity	0.000649603968083954
GO:0043492	ATPase activity, coupled to movement of substances	0.000649603968083954
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	0.000649603968083954
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.000649603968083954
GO:0015399	primary active transmembrane transporter activity	0.000649603968083954
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	0.000649603968083954
GO:0042623	ATPase activity, coupled	0.00299468280554583
GO:0016887	ATPase activity	0.00406725087011969
GO:0022857	transmembrane transporter activity	0.00489032804989519
GO:0022804	active transmembrane transporter activity	0.00489032804989519
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	0.00489032804989519
GO:0016323	basolateral plasma membrane	0.00489032804989519
GO:0003869	4-nitrophenylphosphatase activity	0.00489032804989519
GO:0031944	negative regulation of glucocorticoid metabolic process	0.00489032804989519
GO:0003812	alternative-complement-pathway C3/C5 convertase activity	0.00489032804989519
GO:0031947	negative regulation of glucocorticoid biosynthetic process	0.00489032804989519
GO:0050104	L-gulonate 3-dehydrogenase activity	0.00489032804989519
GO:0045989	positive regulation of striated muscle contraction	0.00489032804989519
GO:0005890	sodium:potassium-exchanging ATPase complex	0.00489032804989519
GO:0031402	sodium ion binding	0.00540356830941047
GO:0042625	ATPase activity, coupled to transmembrane movement of ions	0.00540356830941047
GO:0016787	hydrolase activity	0.00665296331702059
GO:0017111	nucleoside-triphosphatase activity	0.00665296331702059
GO:0016462	pyrophosphatase activity	0.00665296331702059
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.00665296331702059
GO:0031946	regulation of glucocorticoid biosynthetic process	0.00665296331702059
GO:0006942	regulation of striated muscle contraction	0.00665296331702059
GO:0016817	hydrolase activity, acting on acid anhydrides	0.00665296331702059
GO:0030955	potassium ion binding	0.00719419230784296
GO:0006814	sodium ion transport	0.00720758775445428
GO:0051240	positive regulation of multicellular organismal process	0.00760633875252806
GO:0030641	cellular hydrogen ion homeostasis	0.00844369105956371
GO:0031943	regulation of glucocorticoid metabolic process	0.00844369105956371
GO:0006813	potassium ion transport	0.0117900740447466
GO:0006704	glucocorticoid biosynthetic process	0.0122164455235837
GO:0045823	positive regulation of heart contraction	0.0122164455235837
GO:0004556	alpha-amylase activity	0.0122164455235837
GO:0045933	positive regulation of muscle contraction	0.0122164455235837
GO:0031420	alkali metal ion binding	0.013695949110629
GO:0045822	negative regulation of heart contraction	0.0139240775993345
GO:0019218	regulation of steroid metabolic process	0.014437015586575
GO:0015991	ATP hydrolysis coupled proton transport	0.014437015586575
GO:0030004	cellular monovalent inorganic cation homeostasis	0.014437015586575
GO:0016160	amylase activity	0.014437015586575
GO:0055067	monovalent inorganic cation homeostasis	0.014437015586575
GO:0015988	energy coupled proton transport, against electrochemical gradient	0.0161376681274488
GO:0008211	glucocorticoid metabolic process	0.0177651960227553
GO:0006957	complement activation, alternative pathway	0.0193241698064379
GO:0002026	regulation of the force of heart contraction	0.0245945883898245
GO:0051239	regulation of multicellular organismal process	0.0258274784993673
GO:0015672	monovalent inorganic cation transport	0.0267549287020553
GO:0019216	regulation of lipid metabolic process	0.033833195127419
GO:0030317	sperm motility	0.0366749634372288
GO:0006810	transport	0.0425450358553478
GO:0030001	metal ion transport	0.0449090202084987
GO:0051234	establishment of localization	0.0451118381541869
GO:0042383	sarcolemma	0.0454074163261384
GO:0051241	negative regulation of multicellular organismal process	0.0454261965387048
GO:0006941	striated muscle contraction	0.0454261965387048
GO:0042493	response to drug	0.0462005525431601
GO:0006937	regulation of muscle contraction	0.049958755556072

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
intestinal epithelial cell	1.01e-08	9
epithelial cell of alimentary canal	1.01e-08	9
brush border epithelial cell	2.70e-07	6
gut absorptive cell	2.70e-07	6
absorptive cell	2.70e-07	6
enterocyte	2.70e-07	6
epithelial cell	6.26e-07	25

Uber Anatomy

Ontology term	p-value	n
intestine	3.73e-24	31
gastrointestinal system	4.75e-19	47
mucosa	2.38e-14	15
intestinal mucosa	1.45e-12	13
anatomical wall	1.45e-12	13
wall of intestine	1.45e-12	13
gastrointestinal system mucosa	1.45e-12	13
organ component layer	1.56e-10	24
endoderm-derived structure	4.67e-10	118
endoderm	4.67e-10	118
presumptive endoderm	4.67e-10	118
digestive system	2.91e-09	116
digestive tract	2.91e-09	116
primitive gut	2.91e-09	116
epithelium of mucosa	1.01e-08	9
gastrointestinal system epithelium	1.01e-08	9
intestinal epithelium	1.01e-08	9
subdivision of digestive tract	2.99e-08	114

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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