MCL coexpression mm9:667

Phase1 CAGE Peaks

	Short description
Mm9::chr13:29041020..29041041,-	p@chr13:29041020..29041041 -
Mm9::chr13:29041931..29041947,-	p@chr13:29041931..29041947 -
Mm9::chr13:29042107..29042118,-	p@chr13:29042107..29042118 -
Mm9::chr13:29042426..29042441,-	p@chr13:29042426..29042441 -
Mm9::chr13:29042631..29042655,-	p@chr13:29042631..29042655 -
Mm9::chr13:29043308..29043321,-	p1@ENSMUST00000099654
Mm9::chr13:29043389..29043410,+	p@chr13:29043389..29043410 +
Mm9::chr13:29043435..29043446,+	p@chr13:29043435..29043446 +
Mm9::chr13:29043513..29043517,+	p@chr13:29043513..29043517 +
Mm9::chr13:29045559..29045574,-	p1@Sox4
Mm9::chr5:138612220..138612261,-	p2@Mcm7

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0031017	exocrine pancreas development	0.00964225058894429
GO:0032392	DNA geometric change	0.0192776334780389
GO:0006268	DNA unwinding during replication	0.0192776334780389
GO:0032508	DNA duplex unwinding	0.0192776334780389
GO:0031016	pancreas development	0.0192776334780389
GO:0035272	exocrine system development	0.0192776334780389
GO:0006270	DNA replication initiation	0.0192776334780389
GO:0003678	DNA helicase activity	0.0214160708560177
GO:0003697	single-stranded DNA binding	0.0214160708560177
GO:0008483	transaminase activity	0.0260155338005554
GO:0008094	DNA-dependent ATPase activity	0.0280263626984292
GO:0016769	transferase activity, transferring nitrogenous groups	0.0280970367728147
GO:0006261	DNA-dependent DNA replication	0.0330165802311582
GO:0043566	structure-specific DNA binding	0.0330165802311582
GO:0006355	regulation of transcription, DNA-dependent	0.047119967891685
GO:0006351	transcription, DNA-dependent	0.047119967891685
GO:0032774	RNA biosynthetic process	0.047119967891685
GO:0003677	DNA binding	0.047119967891685
GO:0045449	regulation of transcription	0.047119967891685
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.047119967891685
GO:0006350	transcription	0.047119967891685
GO:0010468	regulation of gene expression	0.0480498860111905
GO:0031323	regulation of cellular metabolic process	0.0480628636693369
GO:0004386	helicase activity	0.0480628636693369
GO:0019222	regulation of metabolic process	0.0480628636693369
GO:0006260	DNA replication	0.0480628636693369
GO:0016070	RNA metabolic process	0.0480628636693369

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br><br>

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Cell Type

Ontology term	p-value	n
electrically responsive cell	8.92e-09	39
electrically active cell	8.92e-09	39
neuron	3.74e-08	33
neuronal stem cell	3.74e-08	33
neuroblast	3.74e-08	33
electrically signaling cell	3.74e-08	33
non-terminally differentiated cell	8.10e-08	49
ectodermal cell	3.28e-07	44
neurectodermal cell	3.28e-07	44
neural cell	4.13e-07	43

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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