MCL coexpression mm9:259

Phase1 CAGE Peaks

	Short description
Mm9::chr10:127188729..127188740,-	p3@Gpr182
Mm9::chr10:127188763..127188793,-	p1@Gpr182
Mm9::chr10:127188795..127188807,-	p2@Gpr182
Mm9::chr10:58904456..58904461,-	p6@Oit3
Mm9::chr10:58904496..58904530,-	p1@Oit3
Mm9::chr10:58904532..58904548,-	p3@Oit3
Mm9::chr10:86470760..86470776,-	p1@Stab2
Mm9::chr11:101108238..101108249,+	p7@Ramp2
Mm9::chr11:101108274..101108295,+	p4@Ramp2
Mm9::chr14:73637960..73637972,+	p3@Lpar6
Mm9::chr14:8800226..8800241,-	p@chr14:8800226..8800241 -
Mm9::chr14:8826519..8826534,-	p1@Dnase1l3
Mm9::chr14:8826705..8826731,-	p2@Dnase1l3
Mm9::chr14:8826736..8826741,-	p7@Dnase1l3
Mm9::chr17:26145823..26145867,-	p@chr17:26145823..26145867 -
Mm9::chr17:74154223..74154241,+	p1@Ehd3
Mm9::chr19:57349285..57349290,-	p@chr19:57349285..57349290 -
Mm9::chr1:172906175..172906237,-	p1@Fcgr2b
Mm9::chr1:172906243..172906251,-	p4@Fcgr2b
Mm9::chr1:45984844..45984854,-	p@chr1:45984844..45984854 -
Mm9::chr2:14151017..14151031,+	p1@Mrc1
Mm9::chr3:129236571..129236575,+	p@chr3:129236571..129236575 +
Mm9::chr4:129255756..129255761,-	p3@Fam167b
Mm9::chr4:86490683..86490694,+	p12@Dennd4c
Mm9::chr6:129347496..129347516,+	p1@Clec1b
Mm9::chr6:23048067..23048077,-	p@chr6:23048067..23048077 -
Mm9::chr6:23048089..23048097,-	p@chr6:23048089..23048097 -
Mm9::chr6:23048103..23048116,-	p@chr6:23048103..23048116 -
Mm9::chr7:105233983..105234029,-	p@chr7:105233983..105234029 -
Mm9::chr8:3720640..3720682,-	p1@Clec4g
Mm9::chr8:40721510..40721528,+	p@chr8:40721510..40721528 +
Mm9::chr8:40721546..40721559,+	p@chr8:40721546..40721559 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030246	carbohydrate binding	0.00191584833239487
GO:0010324	membrane invagination	0.00657334377428434
GO:0006897	endocytosis	0.00657334377428434
GO:0005529	sugar binding	0.00666741606348981
GO:0016044	membrane organization and biogenesis	0.010377638772252
GO:0002713	negative regulation of B cell mediated immunity	0.0141299554327411
GO:0001811	negative regulation of type I hypersensitivity	0.0141299554327411
GO:0002890	negative regulation of immunoglobulin mediated immune response	0.0141299554327411
GO:0005509	calcium ion binding	0.0141299554327411
GO:0002704	negative regulation of leukocyte mediated immunity	0.0158313286891551
GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus	0.0158313286891551
GO:0002862	negative regulation of inflammatory response to antigenic stimulus	0.0158313286891551
GO:0002884	negative regulation of hypersensitivity	0.0158313286891551
GO:0002674	negative regulation of acute inflammatory response	0.0158313286891551
GO:0002707	negative regulation of lymphocyte mediated immunity	0.0158313286891551
GO:0016192	vesicle-mediated transport	0.0158313286891551
GO:0004872	receptor activity	0.0195047244678391
GO:0002698	negative regulation of immune effector process	0.0205344390387834
GO:0004871	signal transducer activity	0.0234621448798781
GO:0060089	molecular transducer activity	0.0234621448798781
GO:0015027	coreceptor, soluble ligand activity	0.0234621448798781
GO:0002820	negative regulation of adaptive immune response	0.0256553949754007
GO:0019864	IgG binding	0.0256553949754007
GO:0002823	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.0256553949754007
GO:0050777	negative regulation of immune response	0.0284112784656538
GO:0002683	negative regulation of immune system process	0.0284112784656538
GO:0006309	DNA fragmentation during apoptosis	0.0298314799756331
GO:0015026	coreceptor activity	0.0298314799756331
GO:0009986	cell surface	0.0298314799756331
GO:0001810	regulation of type I hypersensitivity	0.0298314799756331
GO:0006921	cell structure disassembly during apoptosis	0.0298314799756331
GO:0030889	negative regulation of B cell proliferation	0.0298314799756331
GO:0016068	type I hypersensitivity	0.0298314799756331
GO:0016043	cellular component organization and biogenesis	0.0307561314100322
GO:0030262	apoptotic nuclear changes	0.0307561314100322
GO:0019865	immunoglobulin binding	0.0307561314100322
GO:0050869	negative regulation of B cell activation	0.0313872998376249
GO:0031348	negative regulation of defense response	0.0313872998376249
GO:0050728	negative regulation of inflammatory response	0.0313872998376249
GO:0002889	regulation of immunoglobulin mediated immune response	0.0313872998376249
GO:0002883	regulation of hypersensitivity	0.0313872998376249
GO:0002673	regulation of acute inflammatory response	0.0313872998376249
GO:0002712	regulation of B cell mediated immunity	0.0313872998376249
GO:0002438	acute inflammatory response to antigenic stimulus	0.0313872998376249
GO:0002864	regulation of acute inflammatory response to antigenic stimulus	0.0313872998376249
GO:0002524	hypersensitivity	0.0313872998376249
GO:0005537	mannose binding	0.0313872998376249
GO:0006308	DNA catabolic process	0.0326069972186087
GO:0030139	endocytic vesicle	0.0326069972186087
GO:0002861	regulation of inflammatory response to antigenic stimulus	0.0330811956029298
GO:0002437	inflammatory response to antigenic stimulus	0.0330811956029298
GO:0006911	phagocytosis, engulfment	0.0330811956029298
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	0.0344736754666101
GO:0050766	positive regulation of phagocytosis	0.0344736754666101
GO:0050764	regulation of phagocytosis	0.0344736754666101
GO:0005540	hyaluronic acid binding	0.0344736754666101
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	0.0344736754666101
GO:0002703	regulation of leukocyte mediated immunity	0.0353289800284238
GO:0002706	regulation of lymphocyte mediated immunity	0.0353289800284238
GO:0002478	antigen processing and presentation of exogenous peptide antigen	0.0353289800284238
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	0.0353289800284238
GO:0004536	deoxyribonuclease activity	0.0353289800284238
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	0.0353289800284238
GO:0002697	regulation of immune effector process	0.0353289800284238
GO:0050672	negative regulation of lymphocyte proliferation	0.0353289800284238
GO:0032945	negative regulation of mononuclear cell proliferation	0.0353289800284238
GO:0045807	positive regulation of endocytosis	0.0373316893855504
GO:0048029	monosaccharide binding	0.0373316893855504
GO:0030888	regulation of B cell proliferation	0.0373316893855504
GO:0022411	cellular component disassembly	0.0374705988820493
GO:0002819	regulation of adaptive immune response	0.0374705988820493
GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.	0.0374705988820493
GO:0019884	antigen processing and presentation of exogenous antigen	0.0386276636442263
GO:0016021	integral to membrane	0.038785723061121
GO:0031224	intrinsic to membrane	0.0388722406608826
GO:0051250	negative regulation of lymphocyte activation	0.0403093622187683
GO:0006997	nuclear organization and biogenesis	0.0413671082796243
GO:0042100	B cell proliferation	0.0423969618808694
GO:0031347	regulation of defense response	0.0438293105113802
GO:0051241	negative regulation of multicellular organismal process	0.0438293105113802
GO:0050727	regulation of inflammatory response	0.0438293105113802
GO:0051050	positive regulation of transport	0.0492180015186909
GO:0048002	antigen processing and presentation of peptide antigen	0.0494899013562665
GO:0030100	regulation of endocytosis	0.0494899013562665

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
abdomen element	1.41e-26	49
abdominal segment element	1.41e-26	49
abdominal segment of trunk	1.41e-26	49
abdomen	1.41e-26	49
subdivision of trunk	1.63e-26	66
trunk region element	1.66e-21	79
liver	5.08e-20	22
epithelial sac	5.08e-20	22
digestive gland	5.08e-20	22
epithelium of foregut-midgut junction	5.08e-20	22
anatomical boundary	5.08e-20	22
hepatobiliary system	5.08e-20	22
foregut-midgut junction	5.08e-20	22
hepatic diverticulum	5.08e-20	22
liver primordium	5.08e-20	22
septum transversum	5.08e-20	22
liver bud	5.08e-20	22
digestive tract diverticulum	9.55e-19	23
sac	9.55e-19	23
trunk	1.49e-16	90
exocrine gland	1.62e-16	25
exocrine system	1.62e-16	25
mesenchyme	1.23e-12	61
entire embryonic mesenchyme	1.23e-12	61
trunk mesenchyme	1.74e-12	45
immaterial anatomical entity	8.84e-11	79
foregut	1.75e-09	80
endocrine gland	1.11e-07	60
epithelial tube	7.93e-07	47

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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