MCL coexpression mm9:381

Phase1 CAGE Peaks

	Short description
Mm9::chr11:102742578..102742592,+	p2@Ccdc103
Mm9::chr11:3102879..3102907,+	p4@Eif4enif1
Mm9::chr11:60231109..60231127,+	p4@4933439F18Rik
Mm9::chr11:6315652..6315694,-	p@chr11:6315652..6315694 -
Mm9::chr11:84693382..84693424,+	p2@Myo19
Mm9::chr11:86358484..86358501,+	p3@Tubd1
Mm9::chr12:114067697..114067715,-	p3@Cdca4
Mm9::chr15:72921277..72921316,+	p@chr15:72921277..72921316 +
Mm9::chr17:24607766..24607780,+	p7@Pgp
Mm9::chr17:25410199..25410210,-	p10@Gm14176 p10@LOC100044900 p10@LOC100505174 p11@Ube2i
Mm9::chr17:56812744..56812751,+	p3@Ranbp3
Mm9::chr18:35091647..35091658,-	p3@Etf1
Mm9::chr19:6061267..6061288,+	p@chr19:6061267..6061288 +
Mm9::chr2:166731949..166731986,+	p@chr2:166731949..166731986 +
Mm9::chr4:116229726..116229746,+	p@chr4:116229726..116229746 +
Mm9::chr4:124743967..124743976,+	p2@Snip1
Mm9::chr4:133229131..133229157,-	p@chr4:133229131..133229157 -
Mm9::chr6:125142114..125142135,-	p@chr6:125142114..125142135 -
Mm9::chr7:19722877..19722881,+	p@chr7:19722877..19722881 +
Mm9::chr8:127421746..127421769,+	p2@Gm505

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0051301	cell division	0.0249238319822111
GO:0007059	chromosome segregation	0.0249238319822111
GO:0005634	nucleus	0.0249238319822111
GO:0043398	HLH domain binding	0.0278721306086671
GO:0016149	translation release factor activity, codon specific	0.0371323093972729
GO:0042910	xenobiotic transporter activity	0.0371323093972729
GO:0008559	xenobiotic-transporting ATPase activity	0.0371323093972729
GO:0008135	translation factor activity, nucleic acid binding	0.0371323093972729
GO:0003747	translation release factor activity	0.0371323093972729
GO:0015239	multidrug transporter activity	0.0371323093972729
GO:0008079	translation termination factor activity	0.0371323093972729
GO:0006415	translational termination	0.0371323093972729
GO:0046581	intercellular canaliculus	0.0456002105207138
GO:0005814	centriole	0.0456002105207138
GO:0043229	intracellular organelle	0.0456002105207138
GO:0007067	mitosis	0.0456002105207138
GO:0043226	organelle	0.0456002105207138
GO:0000087	M phase of mitotic cell cycle	0.0456002105207138

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
nucleate cell	7.72e-10	16
hematopoietic lineage restricted progenitor cell	6.71e-08	25
lymphocyte	7.28e-08	13
common lymphoid progenitor	7.28e-08	13
lymphoid lineage restricted progenitor cell	2.26e-07	12
hematopoietic cell	2.42e-07	32
hematopoietic oligopotent progenitor cell	2.42e-07	32
hematopoietic stem cell	2.42e-07	32
angioblastic mesenchymal cell	2.42e-07	32
hematopoietic multipotent progenitor cell	2.42e-07	32
T cell	8.35e-07	11
pro-T cell	8.35e-07	11

Uber Anatomy

Ontology term	p-value	n
hemopoietic organ	5.63e-09	29
immune organ	5.63e-09	29
mixed endoderm/mesoderm-derived structure	6.38e-08	35
hematopoietic system	1.91e-07	45
blood island	1.91e-07	45
hemolymphoid system	2.09e-07	48
immune system	2.09e-07	48
male reproductive organ	2.40e-07	15
thymus	5.04e-07	23
neck	5.04e-07	23
respiratory system epithelium	5.04e-07	23
hemolymphoid system gland	5.04e-07	23
pharyngeal epithelium	5.04e-07	23
thymic region	5.04e-07	23
pharyngeal gland	5.04e-07	23
entire pharyngeal arch endoderm	5.04e-07	23
thymus primordium	5.04e-07	23
early pharyngeal endoderm	5.04e-07	23
testis	5.86e-07	14
gland of gut	6.16e-07	24

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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