MCL coexpression mm9:1381

Phase1 CAGE Peaks

	Short description
Mm9::chr16:43363152..43363186,+	p3@Zbtb20
Mm9::chr16:43363190..43363242,+	p2@Zbtb20
Mm9::chr17:47147360..47147379,-	p3@Ubr2
Mm9::chr18:64648600..64648630,-	p2@Fech
Mm9::chr18:64648631..64648636,-	p4@Fech
Mm9::chr9:106378703..106378715,-	p5@Parp3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004325	ferrochelatase activity	0.0118336711773407
GO:0009589	detection of UV	0.0118336711773407
GO:0007141	male meiosis I	0.0236634524010587
GO:0007140	male meiosis	0.0386743023199266
GO:0006783	heme biosynthetic process	0.0386743023199266
GO:0033014	tetrapyrrole biosynthetic process	0.0386743023199266
GO:0006779	porphyrin biosynthetic process	0.0386743023199266
GO:0051537	2 iron, 2 sulfur cluster binding	0.0386743023199266
GO:0042168	heme metabolic process	0.0386743023199266
GO:0033013	tetrapyrrole metabolic process	0.0386743023199266
GO:0006778	porphyrin metabolic process	0.0386743023199266
GO:0009411	response to UV	0.0438634091509944
GO:0009583	detection of light stimulus	0.0438634091509944
GO:0046148	pigment biosynthetic process	0.0438634091509944
GO:0042440	pigment metabolic process	0.0474009416398943
GO:0046914	transition metal ion binding	0.0474009416398943
GO:0000151	ubiquitin ligase complex	0.0494137464595127
GO:0051536	iron-sulfur cluster binding	0.0494137464595127
GO:0019748	secondary metabolic process	0.0494137464595127
GO:0051540	metal cluster binding	0.0494137464595127
GO:0009582	detection of abiotic stimulus	0.0494137464595127

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
epithelial tube	1.64e-10	47
cardiovascular system	4.88e-08	23
circulatory system	4.88e-08	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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