Novel motif:22

name:	motif22_GGMCTG

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0010624	regulation of Schwann cell proliferation	1.168538e-15
GO:0042506	tyrosine phosphorylation of Stat5 protein	1.640923e-12
GO:0010625	positive regulation of Schwann cell proliferation	1.848607e-11
GO:0010288	response to lead ion	3.914670e-11
GO:0008078	mesodermal cell migration	5.937741e-11
GO:0042503	tyrosine phosphorylation of Stat3 protein	8.227879e-11
GO:0031440	regulation of mRNA 3'-end processing	8.826510e-11
GO:0010506	regulation of autophagy	2.336041e-10
GO:0061014	positive regulation of mRNA catabolic process	2.792945e-10
GO:0015879	carnitine transport	3.152432e-10
GO:0031442	positive regulation of mRNA 3'-end processing	4.578571e-10
GO:0007296	vitellogenesis	3.319176e-9
GO:0060337	type I interferon-mediated signaling pathway	3.371575e-9
GO:0035814	negative regulation of renal sodium excretion	4.640483e-9
GO:0032863	activation of Rac GTPase activity	5.403364e-9
GO:0000413	protein peptidyl-prolyl isomerization	6.192350e-9
GO:0034340	response to type I interferon	7.039940e-9
GO:0043503	skeletal muscle fiber adaptation	7.652424e-9
GO:0071732	cellular response to nitric oxide	7.827064e-9
GO:0030037	actin filament reorganization involved in cell cycle	8.283362e-9
GO:0035966	response to topologically incorrect protein	8.869105e-9
GO:0006544	glycine metabolic process	1.562699e-8
GO:0035313	wound healing, spreading of epidermal cells	1.663216e-8
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	3.060716e-8
GO:0045112	integrin biosynthetic process	3.466641e-8
GO:0061383	trabecula morphogenesis	4.328632e-8
GO:0006457	protein folding	4.737104e-8
GO:0015936	coenzyme A metabolic process	7.084570e-8
GO:0090241	negative regulation of histone H4 acetylation	8.242388e-8
GO:0060343	trabecula formation	1.000078e-7
GO:0034505	tooth mineralization	1.021895e-7
GO:0022009	central nervous system vasculogenesis	1.455284e-7
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	1.586690e-7
GO:0043206	fibril organization	1.627445e-7
GO:0048242	epinephrine secretion	1.702808e-7
GO:0015939	pantothenate metabolic process	1.789727e-7
GO:0043585	nose morphogenesis	1.792528e-7
GO:0006853	carnitine shuttle	2.032253e-7
GO:0002528	regulation of vascular permeability involved in acute inflammatory response	2.118505e-7
GO:0035854	eosinophil fate commitment	2.159974e-7
GO:0030222	eosinophil differentiation	2.159974e-7
GO:0042891	antibiotic transport	2.221395e-7
GO:0031330	negative regulation of cellular catabolic process	2.413613e-7
GO:0043088	regulation of Cdc42 GTPase activity	2.435893e-7
GO:0044319	wound healing, spreading of cells	2.613213e-7
GO:0070483	detection of hypoxia	2.715774e-7
GO:0042508	tyrosine phosphorylation of Stat1 protein	2.896212e-7
GO:0072321	chaperone-mediated protein transport	3.480324e-7
GO:0050779	RNA destabilization	4.340953e-7
GO:0006986	response to unfolded protein	4.588974e-7
GO:0031329	regulation of cellular catabolic process	4.991576e-7
GO:0031282	regulation of guanylate cyclase activity	6.393152e-7
GO:0055026	negative regulation of cardiac muscle tissue development	7.087665e-7
GO:0043462	regulation of ATPase activity	7.381566e-7
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	7.639251e-7
GO:0018208	peptidyl-proline modification	7.978315e-7
GO:0050685	positive regulation of mRNA processing	8.220144e-7
GO:0007006	mitochondrial membrane organization	9.212261e-7
GO:0071731	response to nitric oxide	9.657666e-7
GO:0090084	negative regulation of inclusion body assembly	1.305575e-6
GO:0010626	negative regulation of Schwann cell proliferation	1.336166e-6
GO:0032956	regulation of actin cytoskeleton organization	1.351129e-6
GO:0019221	cytokine-mediated signaling pathway	1.513655e-6
GO:0070715	sodium-dependent organic cation transport	1.530507e-6
GO:0060731	positive regulation of intestinal epithelial structure maintenance	1.530507e-6
GO:0052106	quorum sensing involved in interaction with host	1.530507e-6
GO:0051029	rRNA transport	1.602987e-6
GO:0007028	cytoplasm organization	1.646372e-6
GO:0010896	regulation of triglyceride catabolic process	1.667964e-6
GO:0060346	bone trabecula formation	1.675805e-6
GO:0031064	negative regulation of histone deacetylation	1.680799e-6
GO:0043089	positive regulation of Cdc42 GTPase activity	1.740082e-6
GO:0032862	activation of Rho GTPase activity	1.885477e-6
GO:0032970	regulation of actin filament-based process	1.939425e-6
GO:0007509	mesoderm migration involved in gastrulation	2.024079e-6
GO:0045039	protein import into mitochondrial inner membrane	2.071387e-6
GO:0032312	regulation of ARF GTPase activity	2.096380e-6
GO:0060251	regulation of glial cell proliferation	2.372717e-6
GO:0060730	regulation of intestinal epithelial structure maintenance	2.566361e-6
GO:0060491	regulation of cell projection assembly	2.639300e-6
GO:0032926	negative regulation of activin receptor signaling pathway	2.845236e-6
GO:0061028	establishment of endothelial barrier	3.168811e-6
GO:0010310	regulation of hydrogen peroxide metabolic process	3.218148e-6
GO:0043314	negative regulation of neutrophil degranulation	3.272169e-6
GO:0014044	Schwann cell development	3.291736e-6
GO:0071276	cellular response to cadmium ion	3.456199e-6
GO:0048708	astrocyte differentiation	3.815132e-6
GO:0007021	tubulin complex assembly	3.992095e-6
GO:0060351	cartilage development involved in endochondral bone morphogenesis	4.234144e-6
GO:0006545	glycine biosynthetic process	4.413051e-6
GO:0006984	ER-nucleus signaling pathway	5.205506e-6
GO:0002886	regulation of myeloid leukocyte mediated immunity	5.733114e-6
GO:0008624	induction of apoptosis by extracellular signals	6.283515e-6
GO:0002098	tRNA wobble uridine modification	6.486772e-6
GO:0072488	ammonium transmembrane transport	6.486772e-6
GO:0034227	tRNA thio-modification	6.486772e-6
GO:0044342	type B pancreatic cell proliferation	6.518774e-6
GO:0010918	positive regulation of mitochondrial membrane potential	6.518774e-6
GO:0001892	embryonic placenta development	6.981705e-6
GO:0070345	negative regulation of fat cell proliferation	7.095139e-6
GO:0043249	erythrocyte maturation	7.193554e-6
GO:0033209	tumor necrosis factor-mediated signaling pathway	7.318818e-6
GO:0007007	inner mitochondrial membrane organization	7.445866e-6
GO:0032231	regulation of actin filament bundle assembly	7.626617e-6
GO:0046320	regulation of fatty acid oxidation	8.399849e-6
GO:0071260	cellular response to mechanical stimulus	9.878524e-6
GO:2000249	regulation of actin cytoskeleton reorganization	9.907314e-6
GO:0046655	folic acid metabolic process	1.030253e-5
GO:0090130	tissue migration	1.035144e-5
GO:0051016	barbed-end actin filament capping	1.098475e-5
GO:0060020	Bergmann glial cell differentiation	1.220371e-5
GO:0006646	phosphatidylethanolamine biosynthetic process	1.228074e-5
GO:0032374	regulation of cholesterol transport	1.313781e-5
GO:0043300	regulation of leukocyte degranulation	1.323698e-5
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate	1.368694e-5
GO:0046724	oxalic acid secretion	1.368694e-5
GO:0031284	positive regulation of guanylate cyclase activity	1.392541e-5
GO:0015937	coenzyme A biosynthetic process	1.435073e-5
GO:0032720	negative regulation of tumor necrosis factor production	1.476549e-5
GO:0070498	interleukin-1-mediated signaling pathway	1.564316e-5
GO:0045415	negative regulation of interleukin-8 biosynthetic process	1.577719e-5
GO:0045085	negative regulation of interleukin-2 biosynthetic process	1.578959e-5
GO:0022011	myelination in peripheral nervous system	1.631483e-5
GO:0043313	regulation of neutrophil degranulation	1.916785e-5
GO:0045351	type I interferon biosynthetic process	1.945979e-5
GO:0046626	regulation of insulin receptor signaling pathway	2.014761e-5
GO:0033505	floor plate morphogenesis	2.051758e-5
GO:0014002	astrocyte development	2.106509e-5
GO:0043467	regulation of generation of precursor metabolites and energy	2.160594e-5
GO:0032232	negative regulation of actin filament bundle assembly	2.287693e-5
GO:0046325	negative regulation of glucose import	2.392421e-5
GO:0006914	autophagy	2.531855e-5
GO:0022617	extracellular matrix disassembly	2.623461e-5
GO:0090083	regulation of inclusion body assembly	3.289205e-5
GO:0014037	Schwann cell differentiation	3.322127e-5
GO:0035928	rRNA import into mitochondrion	3.392223e-5
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	3.443420e-5
GO:0061013	regulation of mRNA catabolic process	3.670788e-5
GO:0019264	glycine biosynthetic process from serine	3.727769e-5
GO:0007141	male meiosis I	3.775672e-5
GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process	3.789506e-5
GO:0002017	regulation of blood volume by renal aldosterone	3.794845e-5
GO:0048261	negative regulation of receptor-mediated endocytosis	4.201725e-5
GO:0090239	regulation of histone H4 acetylation	4.326096e-5
GO:0032964	collagen biosynthetic process	4.486250e-5
GO:0060338	regulation of type I interferon-mediated signaling pathway	4.691658e-5
GO:0010874	regulation of cholesterol efflux	4.812787e-5
GO:0060620	regulation of cholesterol import	4.839586e-5
GO:0042117	monocyte activation	4.862268e-5
GO:0051580	regulation of neurotransmitter uptake	4.993997e-5
GO:0009650	UV protection	5.284441e-5
GO:0060311	negative regulation of elastin catabolic process	5.377340e-5
GO:0060313	negative regulation of blood vessel remodeling	5.377340e-5
GO:0010711	negative regulation of collagen catabolic process	5.377340e-5
GO:0010703	negative regulation of histolysis	5.377340e-5
GO:0051492	regulation of stress fiber assembly	5.393424e-5
GO:0032474	otolith morphogenesis	5.463539e-5
GO:0048382	mesendoderm development	5.581481e-5
GO:0048144	fibroblast proliferation	6.083634e-5
GO:0033159	negative regulation of protein import into nucleus, translocation	6.083634e-5
GO:0001880	Mullerian duct regression	6.083634e-5
GO:0030433	ER-associated protein catabolic process	6.114759e-5
GO:0032855	positive regulation of Rac GTPase activity	6.651104e-5
GO:0033239	negative regulation of cellular amine metabolic process	6.760143e-5
GO:0032929	negative regulation of superoxide anion generation	6.760143e-5
GO:0018879	biphenyl metabolic process	6.905407e-5
GO:0045806	negative regulation of endocytosis	7.093415e-5
GO:0009070	serine family amino acid biosynthetic process	7.205976e-5
GO:0045940	positive regulation of steroid metabolic process	7.221106e-5
GO:0048241	epinephrine transport	7.420523e-5
GO:0016236	macroautophagy	7.471402e-5
GO:0006956	complement activation	7.604627e-5
GO:0010987	negative regulation of high-density lipoprotein particle clearance	8.299403e-5
GO:0010897	negative regulation of triglyceride catabolic process	8.299403e-5
GO:0006526	arginine biosynthetic process	8.299403e-5
GO:0033197	response to vitamin E	8.726121e-5
GO:0072364	regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter	8.839650e-5
GO:0072061	inner medullary collecting duct development	9.624193e-5
GO:0016332	establishment or maintenance of polarity of embryonic epithelium	9.624193e-5
GO:0072060	outer medullary collecting duct development	9.624193e-5
GO:0007635	chemosensory behavior	1.014044e-4
GO:0051005	negative regulation of lipoprotein lipase activity	1.027498e-4
GO:2000465	regulation of glycogen (starch) synthase activity	1.050613e-4
GO:0044062	regulation of excretion	1.109771e-4
GO:0007260	tyrosine phosphorylation of STAT protein	1.115814e-4
GO:0009894	regulation of catabolic process	1.219951e-4
GO:0015695	organic cation transport	1.230866e-4
GO:0046069	cGMP catabolic process	1.327546e-4
GO:0046687	response to chromate	1.336239e-4
GO:0033986	response to methanol	1.336239e-4
GO:2001037	positive regulation of tongue muscle cell differentiation	1.412643e-4
GO:0097152	mesenchymal cell apoptosis	1.412643e-4
GO:0002438	acute inflammatory response to antigenic stimulus	1.412643e-4
GO:0060982	coronary artery morphogenesis	1.412643e-4
GO:2000467	positive regulation of glycogen (starch) synthase activity	1.418272e-4
GO:0000115	regulation of transcription involved in S phase of mitotic cell cycle	1.433527e-4
GO:0046474	glycerophospholipid biosynthetic process	1.437476e-4
GO:0009895	negative regulation of catabolic process	1.448440e-4
GO:0044240	multicellular organismal lipid catabolic process	1.470500e-4
GO:0048320	axial mesoderm formation	1.514788e-4
GO:0042074	cell migration involved in gastrulation	1.535283e-4
GO:0060872	semicircular canal development	1.599074e-4
GO:0000720	pyrimidine dimer repair by nucleotide-excision repair	1.620442e-4
GO:0006702	androgen biosynthetic process	1.624467e-4
GO:0090207	regulation of triglyceride metabolic process	1.649695e-4
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	1.743757e-4
GO:0006085	acetyl-CoA biosynthetic process	1.743757e-4
GO:0033601	positive regulation of mammary gland epithelial cell proliferation	1.767303e-4
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	1.767303e-4
GO:0046039	GTP metabolic process	1.778001e-4
GO:0002019	regulation of renal output by angiotensin	1.825493e-4
GO:0006767	water-soluble vitamin metabolic process	1.858253e-4
GO:0051693	actin filament capping	1.862963e-4
GO:0021526	medial motor column neuron differentiation	1.915755e-4
GO:0033133	positive regulation of glucokinase activity	1.915788e-4
GO:0060621	negative regulation of cholesterol import	1.915788e-4
GO:0016241	regulation of macroautophagy	1.917962e-4
GO:0045453	bone resorption	1.963410e-4
GO:0008033	tRNA processing	1.989253e-4
GO:0003084	positive regulation of systemic arterial blood pressure	2.080709e-4
GO:0097107	postsynaptic density assembly	2.162148e-4
GO:0050668	positive regulation of homocysteine metabolic process	2.162148e-4
GO:2000969	positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	2.162148e-4
GO:0045963	negative regulation of dopamine metabolic process	2.162148e-4
GO:0015878	biotin transport	2.162148e-4
GO:0015887	pantothenate transmembrane transport	2.162148e-4
GO:0051956	negative regulation of amino acid transport	2.179338e-4
GO:0010591	regulation of lamellipodium assembly	2.185504e-4
GO:0070634	transepithelial ammonium transport	2.228202e-4
GO:0006184	GTP catabolic process	2.276994e-4
GO:0031017	exocrine pancreas development	2.304856e-4
GO:0010507	negative regulation of autophagy	2.319569e-4
GO:0035967	cellular response to topologically incorrect protein	2.323100e-4
GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	2.372643e-4
GO:0010713	negative regulation of collagen metabolic process	2.401319e-4
GO:0060707	trophoblast giant cell differentiation	2.441554e-4
GO:0046686	response to cadmium ion	2.442416e-4
GO:0052697	xenobiotic glucuronidation	2.473298e-4
GO:0060286	flagellar cell motility	2.473298e-4
GO:0070980	biphenyl catabolic process	2.473298e-4
GO:0052696	flavonoid glucuronidation	2.473298e-4
GO:0002077	acrosome matrix dispersal	2.473298e-4
GO:0006789	bilirubin conjugation	2.473298e-4
GO:0051552	flavone metabolic process	2.473298e-4
GO:0021528	commissural neuron differentiation in spinal cord	2.473298e-4
GO:0051315	attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation	2.473298e-4
GO:0051497	negative regulation of stress fiber assembly	2.493756e-4
GO:0032526	response to retinoic acid	2.521025e-4
GO:0055010	ventricular cardiac muscle tissue morphogenesis	2.558632e-4
GO:0003136	negative regulation of heart induction by canonical Wnt receptor signaling pathway	2.646438e-4
GO:0042512	negative regulation of tyrosine phosphorylation of Stat1 protein	2.646438e-4
GO:0050666	regulation of homocysteine metabolic process	2.704732e-4
GO:0070286	axonemal dynein complex assembly	2.763859e-4
GO:0051489	regulation of filopodium assembly	2.794780e-4
GO:0032796	uropod organization	2.795782e-4
GO:0060253	negative regulation of glial cell proliferation	2.830262e-4
GO:0003105	negative regulation of glomerular filtration	2.860548e-4
GO:0090031	positive regulation of steroid hormone biosynthetic process	2.867462e-4
GO:2000251	positive regulation of actin cytoskeleton reorganization	3.047440e-4
GO:0060167	regulation of adenosine receptor signaling pathway	3.047440e-4
GO:0031125	rRNA 3'-end processing	3.047440e-4
GO:0060456	positive regulation of digestive system process	3.050932e-4
GO:0045814	negative regulation of gene expression, epigenetic	3.155565e-4
GO:0045217	cell-cell junction maintenance	3.158542e-4
GO:0002432	granuloma formation	3.248196e-4
GO:0046902	regulation of mitochondrial membrane permeability	3.321836e-4
GO:0043574	peroxisomal transport	3.482788e-4
GO:0042274	ribosomal small subunit biogenesis	3.514584e-4
GO:0009069	serine family amino acid metabolic process	3.555211e-4
GO:0071356	cellular response to tumor necrosis factor	3.577041e-4
GO:0051567	histone H3-K9 methylation	3.605766e-4
GO:0006659	phosphatidylserine biosynthetic process	3.609730e-4
GO:0003009	skeletal muscle contraction	3.614542e-4
GO:0071318	cellular response to ATP	3.665935e-4
GO:0006839	mitochondrial transport	3.696960e-4
GO:0045746	negative regulation of Notch signaling pathway	3.743120e-4
GO:0048627	myoblast development	3.797723e-4
GO:0045835	negative regulation of meiosis	3.881417e-4
GO:0007195	inhibition of adenylate cyclase activity by dopamine receptor signaling pathway	3.912265e-4
GO:0045084	positive regulation of interleukin-12 biosynthetic process	4.087539e-4
GO:0007140	male meiosis	4.306092e-4
GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process	4.310755e-4
GO:0061302	smooth muscle cell-matrix adhesion	4.310755e-4
GO:0010875	positive regulation of cholesterol efflux	4.547436e-4
GO:0006657	CDP-choline pathway	4.782904e-4
GO:0005979	regulation of glycogen biosynthetic process	4.911030e-4
GO:0032376	positive regulation of cholesterol transport	5.045695e-4
GO:0006625	protein targeting to peroxisome	5.127809e-4
GO:0060319	primitive erythrocyte differentiation	5.130403e-4
GO:0002575	basophil chemotaxis	5.130403e-4
GO:0060706	cell differentiation involved in embryonic placenta development	5.147682e-4
GO:0070625	zymogen granule exocytosis	5.262277e-4
GO:0014895	smooth muscle hypertrophy	5.262277e-4
GO:0003106	negative regulation of glomerular filtration by angiotensin	5.262277e-4
GO:0048484	enteric nervous system development	5.329684e-4
GO:0072053	renal inner medulla development	5.342737e-4
GO:0072054	renal outer medulla development	5.342737e-4
GO:0071072	negative regulation of phospholipid biosynthetic process	5.342737e-4
GO:0051764	actin crosslink formation	5.446611e-4
GO:0060179	male mating behavior	5.459426e-4
GO:0032375	negative regulation of cholesterol transport	5.705207e-4
GO:0030968	endoplasmic reticulum unfolded protein response	5.720123e-4
GO:0032793	positive regulation of CREB transcription factor activity	5.807390e-4
GO:0072376	protein activation cascade	5.881335e-4
GO:0010891	negative regulation of sequestering of triglyceride	5.890036e-4
GO:0035813	regulation of renal sodium excretion	5.942105e-4
GO:0015804	neutral amino acid transport	5.977165e-4
GO:0060014	granulosa cell differentiation	6.094904e-4
GO:0070914	UV-damage excision repair	6.539055e-4
GO:0060160	negative regulation of dopamine receptor signaling pathway	6.539055e-4
GO:0015840	urea transport	6.687215e-4
GO:0032509	endosome transport via multivesicular body sorting pathway	6.820227e-4
GO:0050975	sensory perception of touch	6.892288e-4
GO:0021508	floor plate formation	7.405179e-4
GO:0015862	uridine transport	7.405179e-4
GO:0070417	cellular response to cold	7.411331e-4
GO:0031643	positive regulation of myelination	7.545856e-4
GO:0045541	negative regulation of cholesterol biosynthetic process	7.683870e-4
GO:0030421	defecation	7.683870e-4
GO:0019370	leukotriene biosynthetic process	7.705394e-4
GO:0035357	peroxisome proliferator activated receptor signaling pathway	7.706094e-4
GO:0045017	glycerolipid biosynthetic process	7.790137e-4
GO:0007217	tachykinin receptor signaling pathway	8.018003e-4
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	8.193215e-4
GO:0006506	GPI anchor biosynthetic process	8.382653e-4
GO:0090209	negative regulation of triglyceride metabolic process	8.408792e-4
GO:0042407	cristae formation	8.555683e-4
GO:0010637	negative regulation of mitochondrial fusion	8.555683e-4
GO:0071279	cellular response to cobalt ion	8.555683e-4
GO:0010046	response to mycotoxin	8.555683e-4
GO:0000053	argininosuccinate metabolic process	8.555683e-4
GO:0071071	regulation of phospholipid biosynthetic process	8.626473e-4
GO:0070194	synaptonemal complex disassembly	8.777997e-4
GO:0031662	positive regulation of cyclin-dependent protein kinase activity involved in G2/M	8.777997e-4
GO:0006703	estrogen biosynthetic process	8.835354e-4
GO:0046931	pore complex assembly	8.902211e-4
GO:0043301	negative regulation of leukocyte degranulation	9.276569e-4
GO:0070873	regulation of glycogen metabolic process	9.374030e-4
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade	9.480406e-4
GO:0006636	unsaturated fatty acid biosynthetic process	9.530312e-4
GO:0010724	regulation of definitive erythrocyte differentiation	9.595876e-4
GO:0071733	transcriptional activation by promoter-enhancer looping	9.595876e-4
GO:0001560	regulation of cell growth by extracellular stimulus	9.606484e-4
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9.772242e-4
GO:0071345	cellular response to cytokine stimulus	9.920141e-4
GO:0044154	histone H3-K14 acetylation	9.938445e-4
GO:0033189	response to vitamin A	1.032956e-3
GO:0051588	regulation of neurotransmitter transport	1.046015e-3
GO:0071392	cellular response to estradiol stimulus	1.079235e-3
GO:0046456	icosanoid biosynthetic process	1.111925e-3
GO:0050432	catecholamine secretion	1.113664e-3
GO:0032298	positive regulation of DNA-dependent DNA replication initiation	1.119614e-3
GO:0002636	positive regulation of germinal center formation	1.152938e-3
GO:0072500	negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	1.173750e-3
GO:0060708	spongiotrophoblast differentiation	1.189560e-3
GO:0032606	type I interferon production	1.190058e-3
GO:0009443	pyridoxal 5'-phosphate salvage	1.209311e-3
GO:0042424	catecholamine catabolic process	1.212388e-3
GO:0030100	regulation of endocytosis	1.220539e-3
GO:0010982	regulation of high-density lipoprotein particle clearance	1.220987e-3
GO:0006768	biotin metabolic process	1.220987e-3
GO:0051006	positive regulation of lipoprotein lipase activity	1.232996e-3
GO:0002037	negative regulation of L-glutamate transport	1.232996e-3
GO:0045994	positive regulation of translational initiation by iron	1.232996e-3
GO:0006691	leukotriene metabolic process	1.235581e-3
GO:0015858	nucleoside transport	1.256772e-3
GO:0032536	regulation of cell projection size	1.256866e-3
GO:0003229	ventricular cardiac muscle tissue development	1.263952e-3
GO:0044027	hypermethylation of CpG island	1.268030e-3
GO:0010898	positive regulation of triglyceride catabolic process	1.314366e-3
GO:0070947	neutrophil mediated killing of fungus	1.323214e-3
GO:0003420	regulation of growth plate cartilage chondrocyte proliferation	1.323214e-3
GO:0006423	cysteinyl-tRNA aminoacylation	1.323214e-3
GO:0006706	steroid catabolic process	1.340196e-3
GO:0010906	regulation of glucose metabolic process	1.372586e-3
GO:0032012	regulation of ARF protein signal transduction	1.382089e-3
GO:0051788	response to misfolded protein	1.384933e-3
GO:0032088	negative regulation of NF-kappaB transcription factor activity	1.399491e-3
GO:0019217	regulation of fatty acid metabolic process	1.410665e-3
GO:0015697	quaternary ammonium group transport	1.422147e-3
GO:0030032	lamellipodium assembly	1.468339e-3
GO:0045820	negative regulation of glycolysis	1.472025e-3
GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway	1.474031e-3
GO:0010985	negative regulation of lipoprotein particle clearance	1.485195e-3
GO:0060564	negative regulation of mitotic anaphase-promoting complex activity	1.503317e-3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.504363e-3
GO:0045078	positive regulation of interferon-gamma biosynthetic process	1.518496e-3
GO:0046628	positive regulation of insulin receptor signaling pathway	1.528005e-3
GO:0072272	proximal/distal pattern formation involved in metanephric nephron development	1.545099e-3
GO:0046777	protein autophosphorylation	1.545105e-3
GO:0046627	negative regulation of insulin receptor signaling pathway	1.579956e-3
GO:0050764	regulation of phagocytosis	1.594950e-3
GO:0046128	purine ribonucleoside metabolic process	1.615369e-3
GO:0001885	endothelial cell development	1.616107e-3
GO:0072365	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter	1.617385e-3
GO:0060683	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	1.656522e-3
GO:0003329	pancreatic PP cell fate commitment	1.656522e-3
GO:0003326	pancreatic A cell fate commitment	1.656522e-3
GO:0002554	serotonin secretion by platelet	1.689256e-3
GO:0042989	sequestering of actin monomers	1.702033e-3
GO:0006505	GPI anchor metabolic process	1.710844e-3
GO:0019883	antigen processing and presentation of endogenous antigen	1.777721e-3
GO:0051055	negative regulation of lipid biosynthetic process	1.788333e-3
GO:0072070	loop of Henle development	1.819604e-3
GO:0060252	positive regulation of glial cell proliferation	1.819604e-3
GO:0002418	immune response to tumor cell	1.827671e-3
GO:0051586	positive regulation of dopamine uptake	1.854911e-3
GO:0060580	ventral spinal cord interneuron fate determination	1.854911e-3
GO:0046416	D-amino acid metabolic process	1.854911e-3
GO:0048210	Golgi vesicle fusion to target membrane	1.854911e-3
GO:0003327	type B pancreatic cell fate commitment	1.854911e-3
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	1.923171e-3
GO:0060711	labyrinthine layer development	1.929122e-3
GO:0048352	paraxial mesoderm structural organization	1.957400e-3
GO:0021998	neural plate mediolateral regionalization	1.957400e-3
GO:0009440	cyanate catabolic process	1.957400e-3
GO:0035020	regulation of Rac protein signal transduction	1.977667e-3
GO:0030835	negative regulation of actin filament depolymerization	1.991683e-3
GO:0030490	maturation of SSU-rRNA	2.020020e-3
GO:0071496	cellular response to external stimulus	2.041220e-3
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	2.057746e-3
GO:0033131	regulation of glucokinase activity	2.060383e-3
GO:0071956	cellular component maintenance at cellular level	2.067759e-3
GO:0042886	amide transport	2.067759e-3
GO:0021843	substrate-independent telencephalic tangential interneuron migration	2.082492e-3
GO:0002268	follicular dendritic cell differentiation	2.082492e-3
GO:0010893	positive regulation of steroid biosynthetic process	2.092918e-3
GO:0032321	positive regulation of Rho GTPase activity	2.153930e-3
GO:0045218	zonula adherens maintenance	2.179072e-3
GO:0016056	rhodopsin mediated signaling pathway	2.204570e-3
GO:0010912	positive regulation of isomerase activity	2.260832e-3
GO:0090205	positive regulation of cholesterol metabolic process	2.287208e-3
GO:0034097	response to cytokine stimulus	2.305056e-3
GO:0032984	macromolecular complex disassembly	2.320385e-3
GO:0006525	arginine metabolic process	2.377335e-3
GO:0006695	cholesterol biosynthetic process	2.377779e-3
GO:0008594	photoreceptor cell morphogenesis	2.382101e-3
GO:0045922	negative regulation of fatty acid metabolic process	2.389510e-3
GO:0051004	regulation of lipoprotein lipase activity	2.405062e-3
GO:0032365	intracellular lipid transport	2.405062e-3
GO:0060112	generation of ovulation cycle rhythm	2.459427e-3
GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway	2.463422e-3
GO:0061370	testosterone biosynthetic process	2.463422e-3
GO:0033595	response to genistein	2.463422e-3
GO:0050756	fractalkine metabolic process	2.463422e-3
GO:0070842	aggresome assembly	2.469455e-3
GO:0060448	dichotomous subdivision of terminal units involved in lung branching	2.469455e-3
GO:0043304	regulation of mast cell degranulation	2.488057e-3
GO:0010745	negative regulation of macrophage derived foam cell differentiation	2.488057e-3
GO:0006097	glyoxylate cycle	2.491646e-3
GO:0040030	regulation of molecular function, epigenetic	2.491646e-3
GO:0065002	intracellular protein transmembrane transport	2.499155e-3
GO:0043628	ncRNA 3'-end processing	2.499155e-3
GO:0010984	regulation of lipoprotein particle clearance	2.559913e-3
GO:0015844	monoamine transport	2.612030e-3
GO:0032856	activation of Ras GTPase activity	2.632585e-3
GO:0000212	meiotic spindle organization	2.687408e-3
GO:0002357	defense response to tumor cell	2.694447e-3
GO:0008203	cholesterol metabolic process	2.726530e-3
GO:0000185	activation of MAPKKK activity	2.784772e-3
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	2.867028e-3
GO:0030031	cell projection assembly	2.915435e-3
GO:0030224	monocyte differentiation	2.921382e-3
GO:0034612	response to tumor necrosis factor	3.022764e-3
GO:0090136	epithelial cell-cell adhesion	3.085743e-3
GO:0010872	regulation of cholesterol esterification	3.095456e-3
GO:0048570	notochord morphogenesis	3.122230e-3
GO:0048790	maintenance of presynaptic active zone structure	3.138339e-3
GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane	3.138339e-3
GO:0045948	positive regulation of translational initiation	3.175366e-3
GO:0002115	store-operated calcium entry	3.231913e-3
GO:0008064	regulation of actin polymerization or depolymerization	3.234795e-3
GO:0060349	bone morphogenesis	3.243315e-3
GO:0051882	mitochondrial depolarization	3.315206e-3
GO:0060263	regulation of respiratory burst	3.326487e-3
GO:0015696	ammonium transport	3.350337e-3
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	3.350337e-3
GO:0070602	regulation of centromeric sister chromatid cohesion	3.399331e-3
GO:0016242	negative regulation of macroautophagy	3.402525e-3
GO:0006669	sphinganine-1-phosphate biosynthetic process	3.402525e-3
GO:0006400	tRNA modification	3.432264e-3
GO:0003416	endochondral bone growth	3.437155e-3
GO:0016125	sterol metabolic process	3.457251e-3
GO:0045075	regulation of interleukin-12 biosynthetic process	3.495482e-3
GO:0046847	filopodium assembly	3.529137e-3
GO:0031331	positive regulation of cellular catabolic process	3.569926e-3
GO:0060236	regulation of mitotic spindle organization	3.585533e-3
GO:0034470	ncRNA processing	3.586368e-3
GO:0001916	positive regulation of T cell mediated cytotoxicity	3.703000e-3
GO:0048143	astrocyte activation	3.734210e-3
GO:0035722	interleukin-12-mediated signaling pathway	3.734210e-3
GO:0016557	peroxisome membrane biogenesis	3.779592e-3
GO:0008625	induction of apoptosis via death domain receptors	3.789107e-3
GO:0042278	purine nucleoside metabolic process	3.821300e-3
GO:0060290	transdifferentiation	3.869845e-3
GO:0032319	regulation of Rho GTPase activity	3.906763e-3
GO:0002455	humoral immune response mediated by circulating immunoglobulin	3.942263e-3
GO:0046502	uroporphyrinogen III metabolic process	3.993845e-3
GO:0034770	histone H4-K20 methylation	3.993845e-3
GO:0032049	cardiolipin biosynthetic process	3.993845e-3

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0033239	negative regulation of cellular amine metabolic process	5.171475e-10
GO:0010900	negative regulation of phosphatidylcholine catabolic process	1.892120e-8
GO:0046580	negative regulation of Ras protein signal transduction	7.198656e-8
GO:0060696	regulation of phospholipid catabolic process	1.061468e-7
GO:0051058	negative regulation of small GTPase mediated signal transduction	2.724263e-7
GO:0046339	diacylglycerol metabolic process	3.251865e-7
GO:0042267	natural killer cell mediated cytotoxicity	5.194940e-7
GO:0032375	negative regulation of cholesterol transport	1.287886e-6
GO:0045723	positive regulation of fatty acid biosynthetic process	1.419402e-6
GO:0014819	regulation of skeletal muscle contraction	1.759433e-6
GO:0051135	positive regulation of NK T cell activation	1.799103e-6
GO:0018022	peptidyl-lysine methylation	1.805883e-6
GO:0006654	phosphatidic acid biosynthetic process	2.697620e-6
GO:2000465	regulation of glycogen (starch) synthase activity	5.595609e-6
GO:0090208	positive regulation of triglyceride metabolic process	5.796344e-6
GO:0015884	folic acid transport	6.207697e-6
GO:0010898	positive regulation of triglyceride catabolic process	7.814284e-6
GO:0032374	regulation of cholesterol transport	7.862152e-6
GO:0046015	regulation of transcription by glucose	8.913295e-6
GO:0050728	negative regulation of inflammatory response	9.145031e-6
GO:0030421	defecation	9.357682e-6
GO:0032049	cardiolipin biosynthetic process	9.457748e-6
GO:0001909	leukocyte mediated cytotoxicity	9.688516e-6
GO:0010565	regulation of cellular ketone metabolic process	1.141560e-5
GO:0034447	very-low-density lipoprotein particle clearance	1.395667e-5
GO:0061014	positive regulation of mRNA catabolic process	1.508030e-5
GO:0051181	cofactor transport	1.662969e-5
GO:0015718	monocarboxylic acid transport	1.946385e-5
GO:0015908	fatty acid transport	2.039113e-5
GO:0034261	negative regulation of Ras GTPase activity	2.145713e-5
GO:2000467	positive regulation of glycogen (starch) synthase activity	2.158168e-5
GO:0048240	sperm capacitation	2.675085e-5
GO:0001829	trophectodermal cell differentiation	2.924906e-5
GO:0035966	response to topologically incorrect protein	3.224511e-5
GO:0018023	peptidyl-lysine trimethylation	3.231556e-5
GO:0010614	negative regulation of cardiac muscle hypertrophy	3.780494e-5
GO:0072012	glomerulus vasculature development	3.845256e-5
GO:0070509	calcium ion import	3.882682e-5
GO:0015891	siderophore transport	4.153959e-5
GO:0010906	regulation of glucose metabolic process	4.250439e-5
GO:0014741	negative regulation of muscle hypertrophy	4.452728e-5
GO:0033700	phospholipid efflux	4.981803e-5
GO:0032012	regulation of ARF protein signal transduction	5.044059e-5
GO:0042304	regulation of fatty acid biosynthetic process	5.125711e-5
GO:2000251	positive regulation of actin cytoskeleton reorganization	5.554454e-5
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	5.963492e-5
GO:0016575	histone deacetylation	7.539617e-5
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade	7.936980e-5
GO:0046628	positive regulation of insulin receptor signaling pathway	8.872900e-5
GO:0033344	cholesterol efflux	8.949723e-5
GO:0051693	actin filament capping	9.005849e-5
GO:0043320	natural killer cell degranulation	9.139780e-5
GO:0006474	N-terminal protein amino acid acetylation	9.621157e-5
GO:0090207	regulation of triglyceride metabolic process	9.802691e-5
GO:0015909	long-chain fatty acid transport	9.802691e-5
GO:0071715	icosanoid transport	9.868526e-5
GO:0000305	response to oxygen radical	1.019873e-4
GO:0072126	positive regulation of glomerular mesangial cell proliferation	1.038293e-4
GO:0071506	cellular response to mycophenolic acid	1.038293e-4
GO:0060457	negative regulation of digestive system process	1.087265e-4
GO:0061370	testosterone biosynthetic process	1.165562e-4
GO:0006415	translational termination	1.269368e-4
GO:0090130	tissue migration	1.330470e-4
GO:0018026	peptidyl-lysine monomethylation	1.387698e-4
GO:0046889	positive regulation of lipid biosynthetic process	1.456970e-4
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	1.461322e-4
GO:0034260	negative regulation of GTPase activity	1.488235e-4
GO:0045026	plasma membrane fusion	1.520419e-4
GO:0045014	negative regulation of transcription by glucose	1.615308e-4
GO:0010870	positive regulation of receptor biosynthetic process	1.615308e-4
GO:0017156	calcium ion-dependent exocytosis	1.659795e-4
GO:0010452	histone H3-K36 methylation	1.665925e-4
GO:0045834	positive regulation of lipid metabolic process	1.913926e-4
GO:0061034	olfactory bulb mitral cell layer development	2.046562e-4
GO:0018230	peptidyl-L-cysteine S-palmitoylation	2.052513e-4
GO:0045351	type I interferon biosynthetic process	2.052985e-4
GO:0043154	negative regulation of caspase activity	2.220852e-4
GO:0060014	granulosa cell differentiation	2.337021e-4
GO:0045835	negative regulation of meiosis	2.386792e-4
GO:0051006	positive regulation of lipoprotein lipase activity	2.443448e-4
GO:0015914	phospholipid transport	2.819905e-4
GO:0035601	protein deacylation	2.869831e-4
GO:0051788	response to misfolded protein	3.184060e-4
GO:0010224	response to UV-B	3.205383e-4
GO:0010948	negative regulation of cell cycle process	3.216462e-4
GO:0031444	slow-twitch skeletal muscle fiber contraction	3.224768e-4
GO:0060290	transdifferentiation	3.313278e-4
GO:0032369	negative regulation of lipid transport	3.631737e-4
GO:0031331	positive regulation of cellular catabolic process	3.673309e-4
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	3.778519e-4
GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	3.778519e-4
GO:0002886	regulation of myeloid leukocyte mediated immunity	3.797845e-4
GO:0007342	fusion of sperm to egg plasma membrane	4.042167e-4
GO:0046168	glycerol-3-phosphate catabolic process	4.100911e-4
GO:0042506	tyrosine phosphorylation of Stat5 protein	4.100911e-4
GO:0016338	calcium-independent cell-cell adhesion	4.113599e-4
GO:0006651	diacylglycerol biosynthetic process	4.271727e-4
GO:0072668	tubulin complex biogenesis	4.557492e-4
GO:0001885	endothelial cell development	4.735518e-4
GO:0006476	protein deacetylation	5.004866e-4
GO:0046686	response to cadmium ion	5.080162e-4
GO:0030913	paranodal junction assembly	5.088249e-4
GO:0071072	negative regulation of phospholipid biosynthetic process	5.112275e-4
GO:0031365	N-terminal protein amino acid modification	5.324635e-4
GO:0032048	cardiolipin metabolic process	5.399105e-4
GO:0046655	folic acid metabolic process	5.399105e-4
GO:0030834	regulation of actin filament depolymerization	5.416636e-4
GO:0035307	positive regulation of protein dephosphorylation	5.531146e-4
GO:0050482	arachidonic acid secretion	5.729584e-4
GO:0032007	negative regulation of TOR signaling cascade	5.740235e-4
GO:0016188	synaptic vesicle maturation	5.759335e-4
GO:0000096	sulfur amino acid metabolic process	5.988658e-4
GO:0002385	mucosal immune response	6.117846e-4
GO:0042593	glucose homeostasis	6.248491e-4
GO:0009082	branched chain family amino acid biosynthetic process	6.358155e-4
GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction	6.424478e-4
GO:0030336	negative regulation of cell migration	6.538390e-4
GO:0032312	regulation of ARF GTPase activity	6.726159e-4
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	6.769654e-4
GO:0072110	glomerular mesangial cell proliferation	6.822107e-4
GO:0010985	negative regulation of lipoprotein particle clearance	6.997428e-4
GO:0032429	regulation of phospholipase A2 activity	7.020216e-4
GO:0034551	mitochondrial respiratory chain complex III assembly	7.070642e-4
GO:0034382	chylomicron remnant clearance	7.435029e-4
GO:0042946	glucoside transport	7.609189e-4
GO:0002432	granuloma formation	7.609189e-4
GO:0006420	arginyl-tRNA aminoacylation	7.609189e-4
GO:0033238	regulation of cellular amine metabolic process	7.707948e-4
GO:0090177	establishment of planar polarity involved in neural tube closure	7.880546e-4
GO:0010312	detoxification of zinc ion	7.880546e-4
GO:0035306	positive regulation of dephosphorylation	7.887490e-4
GO:2000227	negative regulation of pancreatic A cell differentiation	8.394337e-4
GO:2000978	negative regulation of forebrain neuron differentiation	8.394337e-4
GO:0061106	negative regulation of stomach neuroendocrine cell differentiation	8.394337e-4
GO:0046331	lateral inhibition	8.394337e-4
GO:0032863	activation of Rac GTPase activity	8.452407e-4
GO:0072109	glomerular mesangium development	8.647117e-4
GO:0042420	dopamine catabolic process	8.843617e-4
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	8.843617e-4
GO:0018342	protein prenylation	8.964016e-4
GO:0044062	regulation of excretion	9.012399e-4
GO:0014067	negative regulation of phosphatidylinositol 3-kinase cascade	9.403415e-4
GO:0015724	formate transport	9.612107e-4
GO:0010918	positive regulation of mitochondrial membrane potential	9.612107e-4
GO:0000059	protein import into nucleus, docking	9.612107e-4
GO:0003219	cardiac right ventricle formation	9.660202e-4
GO:0042107	cytokine metabolic process	9.777673e-4
GO:0046717	acid secretion	1.008335e-3
GO:0006700	C21-steroid hormone biosynthetic process	1.014859e-3
GO:0043314	negative regulation of neutrophil degranulation	1.021818e-3
GO:0018198	peptidyl-cysteine modification	1.024667e-3
GO:0043301	negative regulation of leukocyte degranulation	1.107480e-3
GO:0006837	serotonin transport	1.107480e-3
GO:0000303	response to superoxide	1.136167e-3
GO:0006546	glycine catabolic process	1.165184e-3
GO:0043300	regulation of leukocyte degranulation	1.188895e-3
GO:0050994	regulation of lipid catabolic process	1.218595e-3
GO:0032272	negative regulation of protein polymerization	1.227810e-3
GO:0019318	hexose metabolic process	1.229869e-3
GO:0002251	organ or tissue specific immune response	1.250515e-3
GO:0010984	regulation of lipoprotein particle clearance	1.251608e-3
GO:2000210	positive regulation of anoikis	1.303052e-3
GO:0032020	ISG15-protein conjugation	1.416629e-3
GO:2000491	positive regulation of hepatic stellate cell activation	1.419724e-3
GO:0055014	atrial cardiac muscle cell development	1.475032e-3
GO:0021558	trochlear nerve development	1.475032e-3
GO:0019430	removal of superoxide radicals	1.484561e-3
GO:0032862	activation of Rho GTPase activity	1.496304e-3
GO:0048664	neuron fate determination	1.497273e-3
GO:0060160	negative regulation of dopamine receptor signaling pathway	1.504306e-3
GO:0045796	negative regulation of intestinal cholesterol absorption	1.504306e-3
GO:0071877	regulation of adrenergic receptor signaling pathway	1.504306e-3
GO:0035419	activation of MAPK activity involved in innate immune response	1.504306e-3
GO:0010949	negative regulation of intestinal phytosterol absorption	1.504306e-3
GO:0034635	glutathione transport	1.504306e-3
GO:0090031	positive regulation of steroid hormone biosynthetic process	1.521104e-3
GO:0005978	glycogen biosynthetic process	1.528880e-3
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	1.535744e-3
GO:0051488	activation of anaphase-promoting complex activity	1.540953e-3
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	1.541273e-3
GO:0006620	posttranslational protein targeting to membrane	1.560282e-3
GO:0046890	regulation of lipid biosynthetic process	1.586552e-3
GO:0090076	relaxation of skeletal muscle	1.636254e-3
GO:0032470	elevation of endoplasmic reticulum calcium ion concentration	1.636254e-3
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway	1.647168e-3
GO:0019217	regulation of fatty acid metabolic process	1.675985e-3
GO:0060191	regulation of lipase activity	1.684270e-3
GO:0001825	blastocyst formation	1.700588e-3
GO:0035094	response to nicotine	1.745804e-3
GO:0046341	CDP-diacylglycerol metabolic process	1.777120e-3
GO:0010735	positive regulation of transcription via serum response element binding	1.777120e-3
GO:0006109	regulation of carbohydrate metabolic process	1.791611e-3
GO:0033085	negative regulation of T cell differentiation in thymus	1.830640e-3
GO:0021679	cerebellar molecular layer development	1.847045e-3
GO:0021750	vestibular nucleus development	1.847045e-3
GO:0021590	cerebellum maturation	1.847045e-3
GO:0017004	cytochrome complex assembly	1.847045e-3
GO:0000072	M phase specific microtubule process	1.847045e-3
GO:0043278	response to morphine	1.917475e-3
GO:0060561	apoptosis involved in morphogenesis	1.924348e-3
GO:0032321	positive regulation of Rho GTPase activity	1.983369e-3
GO:0010631	epithelial cell migration	2.005486e-3
GO:0010675	regulation of cellular carbohydrate metabolic process	2.023682e-3
GO:0007290	spermatid nucleus elongation	2.038492e-3
GO:0042228	interleukin-8 biosynthetic process	2.080072e-3
GO:0032782	bile acid secretion	2.080072e-3
GO:0051447	negative regulation of meiotic cell cycle	2.080072e-3
GO:0003096	renal sodium ion transport	2.080072e-3
GO:0017196	N-terminal peptidyl-methionine acetylation	2.080072e-3
GO:0006986	response to unfolded protein	2.084962e-3
GO:0007339	binding of sperm to zona pellucida	2.103817e-3
GO:0031440	regulation of mRNA 3'-end processing	2.118323e-3
GO:0021555	midbrain-hindbrain boundary morphogenesis	2.118323e-3
GO:0032368	regulation of lipid transport	2.135527e-3
GO:0007021	tubulin complex assembly	2.145721e-3
GO:0060490	lateral sprouting involved in lung morphogenesis	2.164230e-3
GO:0060489	planar dichotomous subdivision of terminal units involved in lung branching morphogenesis	2.164230e-3
GO:0048105	establishment of body hair planar orientation	2.164230e-3
GO:0060488	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis	2.164230e-3
GO:0031329	regulation of cellular catabolic process	2.188430e-3
GO:0009081	branched chain family amino acid metabolic process	2.203635e-3
GO:0045792	negative regulation of cell size	2.304953e-3
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway	2.313770e-3
GO:0030835	negative regulation of actin filament depolymerization	2.325211e-3
GO:0006646	phosphatidylethanolamine biosynthetic process	2.325361e-3
GO:0061196	fungiform papilla development	2.356370e-3
GO:0071071	regulation of phospholipid biosynthetic process	2.379709e-3
GO:0046340	diacylglycerol catabolic process	2.404116e-3
GO:0090234	regulation of kinetochore assembly	2.415655e-3
GO:0061088	regulation of sequestering of zinc ion	2.415655e-3
GO:0090169	regulation of spindle assembly	2.415655e-3
GO:0051781	positive regulation of cell division	2.432478e-3
GO:0045923	positive regulation of fatty acid metabolic process	2.445719e-3
GO:0072303	positive regulation of glomerular metanephric mesangial cell proliferation	2.553254e-3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.553254e-3
GO:0018101	peptidyl-citrulline biosynthetic process from peptidyl-arginine	2.553254e-3
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.553254e-3
GO:0051323	metaphase	2.579221e-3
GO:0030002	cellular anion homeostasis	2.783383e-3
GO:0009912	auditory receptor cell fate commitment	2.792445e-3
GO:0006006	glucose metabolic process	2.823735e-3
GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	2.833416e-3
GO:2000273	positive regulation of receptor activity	2.835310e-3
GO:0046755	non-lytic virus budding	2.847638e-3
GO:0055026	negative regulation of cardiac muscle tissue development	2.847638e-3
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	2.847638e-3
GO:0070831	basement membrane assembly	2.847638e-3
GO:0006391	transcription initiation from mitochondrial promoter	2.847638e-3
GO:0018364	peptidyl-glutamine methylation	2.847638e-3
GO:0032971	regulation of muscle filament sliding	2.847638e-3
GO:0061308	cardiac neural crest cell development involved in heart development	2.893529e-3
GO:0045608	negative regulation of auditory receptor cell differentiation	2.953755e-3
GO:0033211	adiponectin-mediated signaling pathway	3.034815e-3
GO:0019388	galactose catabolic process	3.051919e-3
GO:0032606	type I interferon production	3.052549e-3
GO:0043353	enucleate erythrocyte differentiation	3.052549e-3
GO:0007217	tachykinin receptor signaling pathway	3.052549e-3
GO:0060193	positive regulation of lipase activity	3.098597e-3
GO:0035441	cell migration involved in vasculogenesis	3.121000e-3
GO:0010868	negative regulation of triglyceride biosynthetic process	3.145072e-3
GO:0031442	positive regulation of mRNA 3'-end processing	3.216174e-3
GO:0010896	regulation of triglyceride catabolic process	3.272629e-3
GO:0045017	glycerolipid biosynthetic process	3.306427e-3
GO:0045721	negative regulation of gluconeogenesis	3.395494e-3
GO:0006998	nuclear envelope organization	3.501155e-3
GO:0097150	neuronal stem cell maintenance	3.582646e-3
GO:0090002	establishment of protein localization in plasma membrane	3.582646e-3
GO:0061198	fungiform papilla formation	3.582646e-3
GO:0032328	alanine transport	3.582646e-3
GO:0043313	regulation of neutrophil degranulation	3.725007e-3
GO:0035907	dorsal aorta development	3.788014e-3
GO:0007094	mitotic cell cycle spindle assembly checkpoint	3.788014e-3
GO:0034498	early endosome to Golgi transport	3.797810e-3
GO:2000146	negative regulation of cell motility	3.817781e-3
GO:0051156	glucose 6-phosphate metabolic process	3.878596e-3
GO:0010874	regulation of cholesterol efflux	3.922311e-3
GO:0009083	branched chain family amino acid catabolic process	3.992056e-3
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	4.017318e-3
GO:0006116	NADH oxidation	4.056238e-3
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	4.056238e-3
GO:0043467	regulation of generation of precursor metabolites and energy	4.083934e-3
GO:0031117	positive regulation of microtubule depolymerization	4.139349e-3
GO:0060158	activation of phospholipase C activity by dopamine receptor signaling pathway	4.139349e-3
GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	4.139349e-3
GO:0035814	negative regulation of renal sodium excretion	4.161737e-3
GO:0032984	macromolecular complex disassembly	4.226824e-3
GO:0071173	spindle assembly checkpoint	4.309846e-3
GO:0033131	regulation of glucokinase activity	4.309846e-3
GO:0010907	positive regulation of glucose metabolic process	4.354087e-3
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.388580e-3
GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	4.418035e-3
GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process	4.501257e-3
GO:0055107	Golgi to secretory granule transport	4.501257e-3
GO:0045358	negative regulation of interferon-beta biosynthetic process	4.501257e-3
GO:0060385	axonogenesis involved in innervation	4.501257e-3
GO:0015878	biotin transport	4.501257e-3
GO:0015887	pantothenate transmembrane transport	4.501257e-3
GO:0032972	regulation of muscle filament sliding speed	4.501257e-3
GO:0034651	cortisol biosynthetic process	4.501257e-3
GO:0035865	cellular response to potassium ion	4.501257e-3
GO:0043547	positive regulation of GTPase activity	4.505285e-3
GO:0061099	negative regulation of protein tyrosine kinase activity	4.513365e-3
GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis	4.608061e-3
GO:0060695	negative regulation of cholesterol transporter activity	4.608061e-3
GO:0050756	fractalkine metabolic process	4.608061e-3
GO:0033595	response to genistein	4.608061e-3
GO:0006701	progesterone biosynthetic process	4.608061e-3
GO:0015759	beta-glucoside transport	4.608061e-3
GO:0051497	negative regulation of stress fiber assembly	4.641474e-3
GO:0018094	protein polyglycylation	4.675208e-3
GO:0050996	positive regulation of lipid catabolic process	4.739643e-3
GO:0072333	signal transduction by p53 class mediator resulting in induction of anoikis	4.761419e-3
GO:0070375	BMK cascade	4.761419e-3
GO:0032318	regulation of Ras GTPase activity	4.791943e-3
GO:0042668	auditory receptor cell fate determination	5.025146e-3
GO:0046498	S-adenosylhomocysteine metabolic process	5.081056e-3
GO:0060448	dichotomous subdivision of terminal units involved in lung branching	5.088422e-3
GO:0019405	alditol catabolic process	5.088422e-3
GO:0061028	establishment of endothelial barrier	5.111692e-3
GO:0031577	spindle checkpoint	5.180414e-3
GO:0035583	negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	5.183687e-3
GO:0019532	oxalate transport	5.183687e-3
GO:0021681	cerebellar granular layer development	5.296586e-3
GO:0072337	modified amino acid transport	5.308747e-3
GO:0072011	glomerular endothelium development	5.339353e-3
GO:2000188	regulation of cholesterol homeostasis	5.339353e-3
GO:0046333	octopamine metabolic process	5.339353e-3
GO:0042309	homoiothermy	5.339353e-3
GO:0007168	receptor guanylyl cyclase signaling pathway	5.395041e-3
GO:0021578	hindbrain maturation	5.395041e-3
GO:0001835	blastocyst hatching	5.395041e-3
GO:2000974	negative regulation of pro-B cell differentiation	5.465941e-3
GO:0030644	cellular chloride ion homeostasis	5.465941e-3
GO:0071218	cellular response to misfolded protein	5.499189e-3
GO:0030718	germ-line stem cell maintenance	5.499189e-3
GO:0008078	mesodermal cell migration	5.514617e-3
GO:0071879	positive regulation of adrenergic receptor signaling pathway	5.614529e-3
GO:0070267	oncosis	5.614529e-3
GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	5.614529e-3
GO:0048243	norepinephrine secretion	5.614529e-3
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.665852e-3
GO:0002674	negative regulation of acute inflammatory response	5.717867e-3
GO:0048635	negative regulation of muscle organ development	5.720689e-3
GO:0046688	response to copper ion	5.732293e-3
GO:0022038	corpus callosum development	5.923208e-3
GO:0071174	mitotic cell cycle spindle checkpoint	6.004133e-3
GO:0060347	heart trabecula formation	6.004215e-3
GO:0006354	transcription elongation, DNA-dependent	6.026648e-3
GO:0007340	acrosome reaction	6.143639e-3
GO:0070972	protein localization in endoplasmic reticulum	6.151919e-3
GO:0009166	nucleotide catabolic process	6.188023e-3
GO:0097039	protein linear polyubiquitination	6.189269e-3
GO:0045047	protein targeting to ER	6.279868e-3
GO:0015698	inorganic anion transport	6.302107e-3
GO:0046499	S-adenosylmethioninamine metabolic process	6.340508e-3
GO:0045345	positive regulation of MHC class I biosynthetic process	6.588717e-3
GO:0045875	negative regulation of sister chromatid cohesion	6.588717e-3
GO:0033278	cell proliferation in midbrain	6.588717e-3
GO:0006669	sphinganine-1-phosphate biosynthetic process	6.588717e-3
GO:0046886	positive regulation of hormone biosynthetic process	6.606481e-3
GO:0071333	cellular response to glucose stimulus	6.657928e-3
GO:0000089	mitotic metaphase	6.663848e-3
GO:0072365	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter	6.677581e-3
GO:0072078	nephron tubule morphogenesis	6.698269e-3
GO:0032320	positive regulation of Ras GTPase activity	6.744679e-3
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	6.768494e-3
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	6.768494e-3
GO:0051387	negative regulation of nerve growth factor receptor signaling pathway	6.768494e-3
GO:0044275	cellular carbohydrate catabolic process	6.834114e-3
GO:0032700	negative regulation of interleukin-17 production	6.835693e-3
GO:0007143	female meiosis	6.835693e-3
GO:0051051	negative regulation of transport	6.886817e-3
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	6.975315e-3
GO:0002426	immunoglobulin production in mucosal tissue	6.975315e-3
GO:0051186	cofactor metabolic process	7.044149e-3
GO:0010866	regulation of triglyceride biosynthetic process	7.072275e-3
GO:0006997	nucleus organization	7.073187e-3
GO:0051983	regulation of chromosome segregation	7.094821e-3
GO:0072141	renal interstitial cell development	7.190671e-3
GO:0045332	phospholipid translocation	7.190671e-3
GO:0033108	mitochondrial respiratory chain complex assembly	7.249140e-3
GO:0006111	regulation of gluconeogenesis	7.256543e-3
GO:0071322	cellular response to carbohydrate stimulus	7.291280e-3
GO:2000981	negative regulation of inner ear receptor cell differentiation	7.318512e-3
GO:0071321	cellular response to cGMP	7.319049e-3
GO:0030046	parallel actin filament bundle assembly	7.319049e-3
GO:0060978	angiogenesis involved in coronary vascular morphogenesis	7.319049e-3
GO:0035095	behavioral response to nicotine	7.319049e-3
GO:0032418	lysosome localization	7.319049e-3
GO:0032874	positive regulation of stress-activated MAPK cascade	7.350179e-3
GO:0045988	negative regulation of striated muscle contraction	7.465791e-3
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	7.478102e-3
GO:0016601	Rac protein signal transduction	7.567056e-3
GO:0010875	positive regulation of cholesterol efflux	7.589902e-3
GO:0007063	regulation of sister chromatid cohesion	7.599317e-3
GO:0051055	negative regulation of lipid biosynthetic process	7.771945e-3
GO:0005979	regulation of glycogen biosynthetic process	7.775926e-3
GO:0006337	nucleosome disassembly	7.925446e-3
GO:0022616	DNA strand elongation	8.199788e-3
GO:0050668	positive regulation of homocysteine metabolic process	8.220967e-3
GO:0070845	polyubiquitinated misfolded protein transport	8.220967e-3
GO:0045963	negative regulation of dopamine metabolic process	8.220967e-3
GO:0043255	regulation of carbohydrate biosynthetic process	8.240951e-3
GO:0007214	gamma-aminobutyric acid signaling pathway	8.346069e-3
GO:0006821	chloride transport	8.360567e-3
GO:0072239	metanephric glomerulus vasculature development	8.389517e-3
GO:0001820	serotonin secretion	8.389517e-3
GO:0048733	sebaceous gland development	8.462406e-3
GO:0033159	negative regulation of protein import into nucleus, translocation	8.462406e-3
GO:0019853	L-ascorbic acid biosynthetic process	8.493189e-3
GO:0017144	drug metabolic process	8.646446e-3
GO:0072539	T-helper 17 cell differentiation	8.698550e-3
GO:0046942	carboxylic acid transport	8.772036e-3
GO:0001678	cellular glucose homeostasis	8.811087e-3
GO:0051403	stress-activated MAPK cascade	8.844998e-3
GO:0006659	phosphatidylserine biosynthetic process	8.844998e-3
GO:0061072	iris morphogenesis	8.890375e-3
GO:0046022	positive regulation of transcription from RNA polymerase II promoter during mitosis	8.890375e-3
GO:0015874	norepinephrine transport	8.890375e-3
GO:0001893	maternal placenta development	8.908791e-3
GO:0014045	establishment of endothelial blood-brain barrier	9.132947e-3
GO:0030837	negative regulation of actin filament polymerization	9.176719e-3
GO:0016045	detection of bacterium	9.291149e-3
GO:0016052	carbohydrate catabolic process	9.422448e-3
GO:0042398	cellular modified amino acid biosynthetic process	9.447810e-3
GO:0006071	glycerol metabolic process	9.533169e-3
GO:0032856	activation of Ras GTPase activity	9.600111e-3
GO:0060192	negative regulation of lipase activity	9.605368e-3
GO:0019320	hexose catabolic process	9.714836e-3
GO:0045607	regulation of auditory receptor cell differentiation	9.729263e-3
GO:0042424	catecholamine catabolic process	9.729263e-3
GO:0000052	citrulline metabolic process	9.729263e-3
GO:0045872	positive regulation of rhodopsin gene expression	9.740582e-3
GO:0061144	alveolar secondary septum development	9.740582e-3
GO:0051041	positive regulation of calcium-independent cell-cell adhesion	9.740582e-3
GO:0032065	cortical protein anchoring	9.740582e-3
GO:0021528	commissural neuron differentiation in spinal cord	9.740582e-3
GO:0019086	late viral mRNA transcription	9.740582e-3
GO:0001886	endothelial cell morphogenesis	9.741157e-3
GO:0003015	heart process	9.782525e-3
GO:0072086	specification of loop of Henle identity	9.812979e-3
GO:0008654	phospholipid biosynthetic process	9.864293e-3
GO:0072385	minus-end-directed organelle transport along microtubule	9.901874e-3
GO:0023035	CD40 signaling pathway	9.901874e-3
GO:0070873	regulation of glycogen metabolic process	1.011071e-2
GO:0034393	positive regulation of smooth muscle cell apoptosis	1.015318e-2
GO:0006801	superoxide metabolic process	1.015786e-2
GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process	1.055538e-2
GO:0051302	regulation of cell division	1.057820e-2
GO:0045833	negative regulation of lipid metabolic process	1.070122e-2
GO:0050883	musculoskeletal movement, spinal reflex action	1.074283e-2
GO:0033504	floor plate development	1.074283e-2
GO:0071593	lymphocyte aggregation	1.086840e-2
GO:0015886	heme transport	1.086840e-2
GO:0070869	heterochromatin formation involved in chromatin silencing	1.086840e-2
GO:0003050	regulation of systemic arterial blood pressure by atrial natriuretic peptide	1.086840e-2
GO:0009299	mRNA transcription	1.086840e-2
GO:0006668	sphinganine-1-phosphate metabolic process	1.086840e-2
GO:0071584	negative regulation of zinc ion import	1.103096e-2
GO:0071594	thymocyte aggregation	1.103096e-2
GO:0090281	negative regulation of calcium ion import	1.103096e-2
GO:0046967	cytosol to ER transport	1.103096e-2
GO:0019060	intracellular transport of viral proteins in host cell	1.103096e-2
GO:0006196	AMP catabolic process	1.103096e-2
GO:0046108	uridine metabolic process	1.103096e-2
GO:0034259	negative regulation of Rho GTPase activity	1.103096e-2
GO:0046086	adenosine biosynthetic process	1.103096e-2
GO:0018193	peptidyl-amino acid modification	1.115376e-2
GO:0051494	negative regulation of cytoskeleton organization	1.120487e-2
GO:2000142	regulation of transcription initiation, DNA-dependent	1.124714e-2
GO:0070914	UV-damage excision repair	1.128618e-2
GO:0090292	nuclear matrix anchoring at nuclear membrane	1.128618e-2
GO:0044342	type B pancreatic cell proliferation	1.128618e-2
GO:0042996	regulation of Golgi to plasma membrane protein transport	1.128618e-2
GO:0001830	trophectodermal cell fate commitment	1.128618e-2
GO:0018343	protein farnesylation	1.128618e-2
GO:0035562	negative regulation of chromatin binding	1.128618e-2
GO:0034227	tRNA thio-modification	1.132410e-2
GO:0006177	GMP biosynthetic process	1.132410e-2
GO:0015864	pyrimidine nucleoside transport	1.132410e-2
GO:0033591	response to L-ascorbic acid	1.137066e-2
GO:0050685	positive regulation of mRNA processing	1.150301e-2
GO:0007184	SMAD protein import into nucleus	1.162908e-2
GO:0015849	organic acid transport	1.177559e-2
GO:0006544	glycine metabolic process	1.184915e-2
GO:0010724	regulation of definitive erythrocyte differentiation	1.186231e-2
GO:0006705	mineralocorticoid biosynthetic process	1.186231e-2
GO:0090150	establishment of protein localization in membrane	1.215759e-2
GO:0002758	innate immune response-activating signal transduction	1.218909e-2
GO:0060047	heart contraction	1.223879e-2
GO:0035036	sperm-egg recognition	1.238209e-2
GO:0035813	regulation of renal sodium excretion	1.250830e-2
GO:0032872	regulation of stress-activated MAPK cascade	1.264077e-2
GO:0019511	peptidyl-proline hydroxylation	1.265086e-2
GO:0008633	activation of pro-apoptotic gene products	1.271285e-2
GO:0010824	regulation of centrosome duplication	1.282132e-2
GO:0045930	negative regulation of mitotic cell cycle	1.286673e-2
GO:0046174	polyol catabolic process	1.287111e-2
GO:0045541	negative regulation of cholesterol biosynthetic process	1.287111e-2
GO:0034329	cell junction assembly	1.291829e-2