Novel motif:83

name:	motif83_TTWTAAA

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0009888	tissue development	3.551588e-25
GO:0050896	response to stimulus	4.653115e-24
GO:0048513	organ development	8.758533e-24
GO:0050794	regulation of cellular process	6.544777e-22
GO:0051716	cellular response to stimulus	2.006815e-21
GO:0048856	anatomical structure development	2.537354e-21
GO:0009611	response to wounding	1.228801e-20
GO:0048731	system development	4.463085e-20
GO:0032501	multicellular organismal process	1.201389e-19
GO:0032502	developmental process	1.425628e-18
GO:0042060	wound healing	7.758746e-18
GO:0042221	response to chemical stimulus	1.749544e-17
GO:0023052	signaling	5.373977e-17
GO:0065007	biological regulation	9.537781e-17
GO:0050789	regulation of biological process	3.424274e-16
GO:0007154	cell communication	3.748412e-16
GO:0006950	response to stress	5.903522e-16
GO:0072358	cardiovascular system development	1.409016e-15
GO:0007275	multicellular organismal development	1.730396e-15
GO:0030240	skeletal muscle thin filament assembly	2.551806e-15
GO:0007165	signal transduction	4.129891e-15
GO:0048468	cell development	4.304755e-15
GO:0048869	cellular developmental process	1.349486e-14
GO:0065008	regulation of biological quality	1.357532e-14
GO:0030154	cell differentiation	3.255434e-14
GO:0048769	sarcomerogenesis	5.630784e-14
GO:0051179	localization	2.346855e-13
GO:0007186	G-protein coupled receptor protein signaling pathway	2.403131e-13
GO:0055003	cardiac myofibril assembly	6.863913e-13
GO:0048646	anatomical structure formation involved in morphogenesis	6.994608e-13
GO:0007517	muscle organ development	7.088931e-13
GO:0014706	striated muscle tissue development	2.164649e-12
GO:0035051	cardiac cell differentiation	4.199618e-12
GO:0007596	blood coagulation	6.658973e-12
GO:0008152	metabolic process	6.945779e-12
GO:0019220	regulation of phosphate metabolic process	7.829675e-12
GO:0060537	muscle tissue development	9.104777e-12
GO:0007599	hemostasis	1.063189e-11
GO:0007076	mitotic chromosome condensation	1.305065e-11
GO:0002576	platelet degranulation	1.446914e-11
GO:0044237	cellular metabolic process	2.073130e-11
GO:0007166	cell surface receptor linked signaling pathway	2.107537e-11
GO:0006810	transport	2.913534e-11
GO:0001775	cell activation	3.276813e-11
GO:0003008	system process	3.661491e-11
GO:0014866	skeletal myofibril assembly	3.664658e-11
GO:0009987	cellular process	4.101427e-11
GO:0032989	cellular component morphogenesis	4.469110e-11
GO:0061061	muscle structure development	4.999407e-11
GO:0050878	regulation of body fluid levels	5.750633e-11
GO:0042325	regulation of phosphorylation	6.322178e-11
GO:0044260	cellular macromolecule metabolic process	7.035468e-11
GO:0050793	regulation of developmental process	1.004258e-10
GO:0051234	establishment of localization	1.039396e-10
GO:0018149	peptide cross-linking	1.450698e-10
GO:0048583	regulation of response to stimulus	1.604051e-10
GO:0030241	skeletal muscle myosin thick filament assembly	1.616671e-10
GO:0007507	heart development	1.619039e-10
GO:0045663	positive regulation of myoblast differentiation	1.810223e-10
GO:0048729	tissue morphogenesis	2.092042e-10
GO:0055007	cardiac muscle cell differentiation	2.443734e-10
GO:0001932	regulation of protein phosphorylation	2.917453e-10
GO:0009653	anatomical structure morphogenesis	3.352689e-10
GO:0045666	positive regulation of neuron differentiation	5.636125e-10
GO:0003007	heart morphogenesis	9.630628e-10
GO:0044238	primary metabolic process	1.225777e-9
GO:0001944	vasculature development	1.304923e-9
GO:0071559	response to transforming growth factor beta stimulus	1.327890e-9
GO:0070887	cellular response to chemical stimulus	1.467830e-9
GO:0055013	cardiac muscle cell development	1.806459e-9
GO:0010033	response to organic substance	1.847040e-9
GO:0001568	blood vessel development	3.140864e-9
GO:0007399	nervous system development	3.170511e-9
GO:0043170	macromolecule metabolic process	3.177740e-9
GO:0007417	central nervous system development	3.191571e-9
GO:0051592	response to calcium ion	3.365786e-9
GO:0043438	acetoacetic acid metabolic process	3.405098e-9
GO:0019605	butyrate metabolic process	3.421044e-9
GO:2000026	regulation of multicellular organismal development	3.494765e-9
GO:0000070	mitotic sister chromatid segregation	3.972937e-9
GO:0045137	development of primary sexual characteristics	4.046719e-9
GO:0000819	sister chromatid segregation	4.836334e-9
GO:0048608	reproductive structure development	5.766682e-9
GO:0045597	positive regulation of cell differentiation	5.932771e-9
GO:0010863	positive regulation of phospholipase C activity	7.394416e-9
GO:0016202	regulation of striated muscle tissue development	7.466101e-9
GO:0010038	response to metal ion	7.754398e-9
GO:0060736	prostate gland growth	8.375847e-9
GO:0071842	cellular component organization at cellular level	8.414952e-9
GO:0030168	platelet activation	8.628212e-9
GO:0006629	lipid metabolic process	1.210012e-8
GO:0007420	brain development	1.253262e-8
GO:2000741	positive regulation of mesenchymal stem cell differentiation	1.325264e-8
GO:0007160	cell-matrix adhesion	1.493106e-8
GO:0010517	regulation of phospholipase activity	1.670355e-8
GO:0007202	activation of phospholipase C activity	1.802726e-8
GO:0016043	cellular component organization	1.851868e-8
GO:0001655	urogenital system development	2.150698e-8
GO:0032268	regulation of cellular protein metabolic process	2.217667e-8
GO:0033036	macromolecule localization	2.287681e-8
GO:0015721	bile acid and bile salt transport	2.307198e-8
GO:0051094	positive regulation of developmental process	2.332536e-8
GO:0042438	melanin biosynthetic process	2.402922e-8
GO:0008285	negative regulation of cell proliferation	2.416423e-8
GO:0048634	regulation of muscle organ development	2.679116e-8
GO:0009719	response to endogenous stimulus	2.792187e-8
GO:0071495	cellular response to endogenous stimulus	3.629845e-8
GO:0007267	cell-cell signaling	4.048298e-8
GO:0071841	cellular component organization or biogenesis at cellular level	4.095888e-8
GO:0031399	regulation of protein modification process	4.332299e-8
GO:0030850	prostate gland development	4.732176e-8
GO:0071840	cellular component organization or biogenesis	5.191651e-8
GO:0045214	sarcomere organization	5.740038e-8
GO:0006068	ethanol catabolic process	5.872439e-8
GO:0045595	regulation of cell differentiation	6.168795e-8
GO:0030199	collagen fibril organization	7.425860e-8
GO:0046459	short-chain fatty acid metabolic process	8.564473e-8
GO:0008104	protein localization	9.205904e-8
GO:0000902	cell morphogenesis	9.546088e-8
GO:0060740	prostate gland epithelium morphogenesis	9.592316e-8
GO:0006582	melanin metabolic process	9.966122e-8
GO:0048522	positive regulation of cellular process	1.092869e-7
GO:0010518	positive regulation of phospholipase activity	1.232675e-7
GO:0008406	gonad development	1.236503e-7
GO:0048565	digestive tract development	1.295833e-7
GO:0060068	vagina development	1.440072e-7
GO:0046546	development of primary male sexual characteristics	1.477159e-7
GO:0031323	regulation of cellular metabolic process	1.657193e-7
GO:0060512	prostate gland morphogenesis	1.746795e-7
GO:0060429	epithelium development	1.761862e-7
GO:0060011	Sertoli cell proliferation	1.762158e-7
GO:0044255	cellular lipid metabolic process	2.029984e-7
GO:0033382	maintenance of granzyme B location in T cell secretory granule	2.089969e-7
GO:0033373	maintenance of protease location in mast cell secretory granule	2.089969e-7
GO:0048747	muscle fiber development	2.147056e-7
GO:0051970	negative regulation of transmission of nerve impulse	2.234675e-7
GO:0072507	divalent inorganic cation homeostasis	2.372249e-7
GO:0045661	regulation of myoblast differentiation	2.502020e-7
GO:0019748	secondary metabolic process	2.506535e-7
GO:2000739	regulation of mesenchymal stem cell differentiation	2.530189e-7
GO:0060191	regulation of lipase activity	2.539008e-7
GO:0048519	negative regulation of biological process	2.663678e-7
GO:0006805	xenobiotic metabolic process	2.764375e-7
GO:0019222	regulation of metabolic process	2.824935e-7
GO:0006366	transcription from RNA polymerase II promoter	2.843130e-7
GO:0022008	neurogenesis	2.912170e-7
GO:0048699	generation of neurons	2.967507e-7
GO:0051153	regulation of striated muscle cell differentiation	2.975380e-7
GO:0050907	detection of chemical stimulus involved in sensory perception	3.017372e-7
GO:0030182	neuron differentiation	3.240960e-7
GO:0043408	regulation of MAPKKK cascade	3.486031e-7
GO:0007548	sex differentiation	3.572238e-7
GO:0045785	positive regulation of cell adhesion	3.633868e-7
GO:0048589	developmental growth	3.807540e-7
GO:0007519	skeletal muscle tissue development	3.924351e-7
GO:0032514	positive regulation of protein phosphatase type 2B activity	4.071368e-7
GO:0048742	regulation of skeletal muscle fiber development	4.327328e-7
GO:0006029	proteoglycan metabolic process	4.520583e-7
GO:0051239	regulation of multicellular organismal process	4.559020e-7
GO:0031032	actomyosin structure organization	4.622593e-7
GO:0010811	positive regulation of cell-substrate adhesion	4.632626e-7
GO:0048523	negative regulation of cellular process	4.680169e-7
GO:0009966	regulation of signal transduction	4.805516e-7
GO:0014031	mesenchymal cell development	4.811027e-7
GO:0071103	DNA conformation change	5.069608e-7
GO:0043473	pigmentation	5.656090e-7
GO:0006887	exocytosis	5.784980e-7
GO:0030098	lymphocyte differentiation	5.804211e-7
GO:0006464	protein modification process	5.957899e-7
GO:0055074	calcium ion homeostasis	6.123228e-7
GO:0060193	positive regulation of lipase activity	6.189771e-7
GO:0009410	response to xenobiotic stimulus	6.408296e-7
GO:0042692	muscle cell differentiation	6.543053e-7
GO:0048518	positive regulation of biological process	6.610914e-7
GO:0023051	regulation of signaling	6.862624e-7
GO:0050805	negative regulation of synaptic transmission	7.182017e-7
GO:0048066	developmental pigmentation	7.424854e-7
GO:0071466	cellular response to xenobiotic stimulus	7.558034e-7
GO:0048514	blood vessel morphogenesis	7.785418e-7
GO:0090286	cytoskeletal anchoring at nuclear membrane	7.943550e-7
GO:0048739	cardiac muscle fiber development	8.672025e-7
GO:0071560	cellular response to transforming growth factor beta stimulus	9.505773e-7
GO:0048641	regulation of skeletal muscle tissue development	1.151339e-6
GO:0009617	response to bacterium	1.259509e-6
GO:0031645	negative regulation of neurological system process	1.302479e-6
GO:0002520	immune system development	1.420160e-6
GO:0000186	activation of MAPKK activity	1.474268e-6
GO:0010927	cellular component assembly involved in morphogenesis	1.518261e-6
GO:0051641	cellular localization	1.564813e-6
GO:0016567	protein ubiquitination	1.575370e-6
GO:0042246	tissue regeneration	1.685325e-6
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	1.687894e-6
GO:0072503	cellular divalent inorganic cation homeostasis	1.718222e-6
GO:0042113	B cell activation	1.740664e-6
GO:0031589	cell-substrate adhesion	1.761183e-6
GO:0055002	striated muscle cell development	1.821822e-6
GO:0046826	negative regulation of protein export from nucleus	1.829829e-6
GO:0048304	positive regulation of isotype switching to IgG isotypes	1.877538e-6
GO:0007059	chromosome segregation	2.037636e-6
GO:0008584	male gonad development	2.137507e-6
GO:0030183	B cell differentiation	2.281777e-6
GO:0090270	regulation of fibroblast growth factor production	2.368011e-6
GO:0016331	morphogenesis of embryonic epithelium	2.420619e-6
GO:0001841	neural tube formation	2.487272e-6
GO:0070493	thrombin receptor signaling pathway	2.605488e-6
GO:0043412	macromolecule modification	2.633659e-6
GO:0055123	digestive system development	2.701017e-6
GO:0044267	cellular protein metabolic process	2.715892e-6
GO:0008038	neuron recognition	2.743701e-6
GO:0046661	male sex differentiation	2.765999e-6
GO:0060255	regulation of macromolecule metabolic process	2.782481e-6
GO:0032940	secretion by cell	2.894254e-6
GO:0002009	morphogenesis of an epithelium	2.944917e-6
GO:0055114	oxidation-reduction process	2.987745e-6
GO:0019932	second-messenger-mediated signaling	3.020724e-6
GO:0042127	regulation of cell proliferation	3.122131e-6
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway	3.209391e-6
GO:0007368	determination of left/right symmetry	3.217967e-6
GO:0048386	positive regulation of retinoic acid receptor signaling pathway	3.522422e-6
GO:0060538	skeletal muscle organ development	3.586822e-6
GO:0008202	steroid metabolic process	3.677006e-6
GO:0060317	cardiac epithelial to mesenchymal transition	3.721343e-6
GO:0051338	regulation of transferase activity	3.970158e-6
GO:0006874	cellular calcium ion homeostasis	3.998712e-6
GO:0035115	embryonic forelimb morphogenesis	4.177442e-6
GO:0032147	activation of protein kinase activity	4.245376e-6
GO:0048762	mesenchymal cell differentiation	4.260871e-6
GO:0040011	locomotion	4.419944e-6
GO:0055008	cardiac muscle tissue morphogenesis	4.439565e-6
GO:0001654	eye development	4.503487e-6
GO:0090292	nuclear matrix anchoring at nuclear membrane	4.541866e-6
GO:0070252	actin-mediated cell contraction	4.553161e-6
GO:0032879	regulation of localization	4.648341e-6
GO:0048534	hemopoietic or lymphoid organ development	4.658971e-6
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	5.016365e-6
GO:0030097	hemopoiesis	5.138619e-6
GO:0080090	regulation of primary metabolic process	5.575887e-6
GO:0048738	cardiac muscle tissue development	5.653792e-6
GO:0000904	cell morphogenesis involved in differentiation	5.677554e-6
GO:0048385	regulation of retinoic acid receptor signaling pathway	5.879934e-6
GO:0045664	regulation of neuron differentiation	5.913462e-6
GO:0060442	branching involved in prostate gland morphogenesis	6.025975e-6
GO:0032870	cellular response to hormone stimulus	6.144985e-6
GO:0042180	cellular ketone metabolic process	6.174293e-6
GO:0045165	cell fate commitment	6.432427e-6
GO:0032990	cell part morphogenesis	6.515618e-6
GO:0060525	prostate glandular acinus development	6.516101e-6
GO:0060284	regulation of cell development	7.144269e-6
GO:0006796	phosphate-containing compound metabolic process	7.215931e-6
GO:0003401	axis elongation	7.241794e-6
GO:0007229	integrin-mediated signaling pathway	7.973585e-6
GO:0014910	regulation of smooth muscle cell migration	8.004591e-6
GO:0006928	cellular component movement	8.080288e-6
GO:0061008	hepaticobiliary system development	8.128346e-6
GO:0055080	cation homeostasis	8.462439e-6
GO:0046836	glycolipid transport	8.844050e-6
GO:0090304	nucleic acid metabolic process	8.881122e-6
GO:0065009	regulation of molecular function	8.974800e-6
GO:0009799	specification of symmetry	9.123827e-6
GO:0060737	prostate gland morphogenetic growth	9.140365e-6
GO:0032446	protein modification by small protein conjugation	9.141884e-6
GO:0048858	cell projection morphogenesis	9.226558e-6
GO:0009855	determination of bilateral symmetry	9.530115e-6
GO:0007040	lysosome organization	9.551555e-6
GO:0030261	chromosome condensation	9.793592e-6
GO:0050654	chondroitin sulfate proteoglycan metabolic process	9.847942e-6
GO:0080135	regulation of cellular response to stress	9.939643e-6
GO:0009887	organ morphogenesis	1.009613e-5
GO:0009725	response to hormone stimulus	1.041536e-5
GO:0002376	immune system process	1.048775e-5
GO:0003006	developmental process involved in reproduction	1.071390e-5
GO:0051480	cytosolic calcium ion homeostasis	1.103587e-5
GO:0061036	positive regulation of cartilage development	1.113581e-5
GO:0040012	regulation of locomotion	1.138834e-5
GO:0043549	regulation of kinase activity	1.248514e-5
GO:0007033	vacuole organization	1.262600e-5
GO:0050877	neurological system process	1.268006e-5
GO:0007204	elevation of cytosolic calcium ion concentration	1.304751e-5
GO:0030049	muscle filament sliding	1.340107e-5
GO:0009593	detection of chemical stimulus	1.431681e-5
GO:0021915	neural tube development	1.436045e-5
GO:0051146	striated muscle cell differentiation	1.437014e-5
GO:0006954	inflammatory response	1.438801e-5
GO:0008543	fibroblast growth factor receptor signaling pathway	1.510851e-5
GO:0033059	cellular pigmentation	1.521623e-5
GO:0048709	oligodendrocyte differentiation	1.546073e-5
GO:0009893	positive regulation of metabolic process	1.552840e-5
GO:0002683	negative regulation of immune system process	1.563328e-5
GO:0016198	axon choice point recognition	1.676140e-5
GO:0030239	myofibril assembly	1.693387e-5
GO:0050931	pigment cell differentiation	1.697919e-5
GO:0019752	carboxylic acid metabolic process	1.721326e-5
GO:0001889	liver development	1.745415e-5
GO:0001525	angiogenesis	1.751561e-5
GO:0060383	positive regulation of DNA strand elongation	1.810811e-5
GO:0032332	positive regulation of chondrocyte differentiation	1.906757e-5
GO:0060415	muscle tissue morphogenesis	1.945945e-5
GO:0010627	regulation of intracellular protein kinase cascade	2.003770e-5
GO:0006935	chemotaxis	2.167698e-5
GO:0060602	branch elongation of an epithelium	2.179386e-5
GO:0001838	embryonic epithelial tube formation	2.227898e-5
GO:0050790	regulation of catalytic activity	2.264303e-5
GO:0006082	organic acid metabolic process	2.298842e-5
GO:2000145	regulation of cell motility	2.314707e-5
GO:0050911	detection of chemical stimulus involved in sensory perception of smell	2.322915e-5
GO:0006323	DNA packaging	2.324792e-5
GO:0014033	neural crest cell differentiation	2.324822e-5
GO:0048584	positive regulation of response to stimulus	2.352731e-5
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	2.361000e-5
GO:0002430	complement receptor mediated signaling pathway	2.401372e-5
GO:0006952	defense response	2.462095e-5
GO:0010646	regulation of cell communication	2.463835e-5
GO:0048015	phosphatidylinositol-mediated signaling	2.487111e-5
GO:0055001	muscle cell development	2.513688e-5
GO:0070848	response to growth factor stimulus	2.546190e-5
GO:0047496	vesicle transport along microtubule	2.579558e-5
GO:0030728	ovulation	2.586747e-5
GO:0008206	bile acid metabolic process	2.671461e-5
GO:0008228	opsonization	2.696530e-5
GO:0044344	cellular response to fibroblast growth factor stimulus	2.727688e-5
GO:0060523	prostate epithelial cord elongation	2.781204e-5
GO:0090336	positive regulation of brown fat cell differentiation	2.797078e-5
GO:0090362	positive regulation of platelet-derived growth factor production	2.797078e-5
GO:0090271	positive regulation of fibroblast growth factor production	2.797078e-5
GO:0055065	metal ion homeostasis	2.802318e-5
GO:0045070	positive regulation of viral genome replication	2.859954e-5
GO:0046587	positive regulation of calcium-dependent cell-cell adhesion	2.864805e-5
GO:0007155	cell adhesion	2.870882e-5
GO:0010810	regulation of cell-substrate adhesion	2.922887e-5
GO:0006720	isoprenoid metabolic process	2.975333e-5
GO:0071671	regulation of smooth muscle cell chemotaxis	2.982121e-5
GO:0006833	water transport	3.018403e-5
GO:0032438	melanosome organization	3.131792e-5
GO:0051345	positive regulation of hydrolase activity	3.157173e-5
GO:0009072	aromatic amino acid family metabolic process	3.300016e-5
GO:0015722	canalicular bile acid transport	3.334912e-5
GO:0048812	neuron projection morphogenesis	3.373184e-5
GO:0031394	positive regulation of prostaglandin biosynthetic process	3.407772e-5
GO:0001764	neuron migration	3.423227e-5
GO:0006069	ethanol oxidation	3.608178e-5
GO:0022602	ovulation cycle process	3.622450e-5
GO:0048592	eye morphogenesis	3.662490e-5
GO:0046903	secretion	3.688261e-5
GO:0060174	limb bud formation	3.798287e-5
GO:0040017	positive regulation of locomotion	3.824584e-5
GO:0048878	chemical homeostasis	3.894917e-5
GO:0072175	epithelial tube formation	4.051711e-5
GO:0071310	cellular response to organic substance	4.080926e-5
GO:0002070	epithelial cell maturation	4.112256e-5
GO:0060485	mesenchyme development	4.216604e-5
GO:0042044	fluid transport	4.233251e-5
GO:0007525	somatic muscle development	4.446122e-5
GO:0097070	ductus arteriosus closure	4.542649e-5
GO:0051149	positive regulation of muscle cell differentiation	4.657718e-5
GO:0061033	secretion by lung epithelial cell involved in lung growth	4.700756e-5
GO:0010838	positive regulation of keratinocyte proliferation	4.700756e-5
GO:0032512	regulation of protein phosphatase type 2B activity	4.700756e-5
GO:0030155	regulation of cell adhesion	4.708154e-5
GO:0010604	positive regulation of macromolecule metabolic process	4.718211e-5
GO:0030900	forebrain development	5.029743e-5
GO:0001708	cell fate specification	5.063695e-5
GO:0035058	nonmotile primary cilium assembly	5.192886e-5
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	5.266235e-5
GO:0030204	chondroitin sulfate metabolic process	5.269023e-5
GO:0048753	pigment granule organization	5.342957e-5
GO:0045185	maintenance of protein location	5.480016e-5
GO:0009820	alkaloid metabolic process	5.563771e-5
GO:0060548	negative regulation of cell death	5.652480e-5
GO:0035556	intracellular signal transduction	5.674565e-5
GO:0006721	terpenoid metabolic process	5.774330e-5
GO:0008037	cell recognition	5.838946e-5
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	5.841438e-5
GO:0051046	regulation of secretion	5.916874e-5
GO:0042698	ovulation cycle	5.932312e-5
GO:0050906	detection of stimulus involved in sensory perception	5.983487e-5
GO:0070168	negative regulation of biomineral tissue development	6.408830e-5
GO:0035136	forelimb morphogenesis	6.421871e-5
GO:0035148	tube formation	6.454541e-5
GO:0060638	mesenchymal-epithelial cell signaling	6.519538e-5
GO:0030003	cellular cation homeostasis	6.558063e-5
GO:0031325	positive regulation of cellular metabolic process	6.764966e-5
GO:0045923	positive regulation of fatty acid metabolic process	7.000653e-5
GO:0002521	leukocyte differentiation	7.156442e-5
GO:0001947	heart looping	7.181175e-5
GO:0071305	cellular response to vitamin D	7.501416e-5
GO:0051602	response to electrical stimulus	7.559681e-5
GO:0006875	cellular metal ion homeostasis	7.819105e-5
GO:0030335	positive regulation of cell migration	7.893920e-5
GO:0051649	establishment of localization in cell	8.193971e-5
GO:0032787	monocarboxylic acid metabolic process	8.383226e-5
GO:0090049	regulation of cell migration involved in sprouting angiogenesis	8.475708e-5
GO:0051246	regulation of protein metabolic process	8.549443e-5
GO:0006775	fat-soluble vitamin metabolic process	8.608472e-5
GO:0055082	cellular chemical homeostasis	8.649194e-5
GO:0016477	cell migration	8.701670e-5
GO:0030334	regulation of cell migration	8.831311e-5
GO:0048667	cell morphogenesis involved in neuron differentiation	9.011489e-5
GO:0072383	plus-end-directed vesicle transport along microtubule	9.082390e-5
GO:0006072	glycerol-3-phosphate metabolic process	9.135022e-5
GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	9.246467e-5
GO:0045859	regulation of protein kinase activity	9.247019e-5
GO:0051336	regulation of hydrolase activity	9.363468e-5
GO:0072001	renal system development	9.440137e-5
GO:0016310	phosphorylation	9.465372e-5
GO:0010648	negative regulation of cell communication	9.778437e-5
GO:0007389	pattern specification process	1.020983e-4
GO:0060606	tube closure	1.038070e-4
GO:0070647	protein modification by small protein conjugation or removal	1.047743e-4
GO:0030522	intracellular receptor mediated signaling pathway	1.048071e-4
GO:0014032	neural crest cell development	1.080511e-4
GO:0032252	secretory granule localization	1.094796e-4
GO:0006583	melanin biosynthetic process from tyrosine	1.101486e-4
GO:0051270	regulation of cellular component movement	1.107758e-4
GO:2000027	regulation of organ morphogenesis	1.126159e-4
GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching	1.149557e-4
GO:0046649	lymphocyte activation	1.176389e-4
GO:0010001	glial cell differentiation	1.176410e-4
GO:0023057	negative regulation of signaling	1.178095e-4
GO:0030048	actin filament-based movement	1.180601e-4
GO:0007618	mating	1.190859e-4
GO:0023056	positive regulation of signaling	1.230843e-4
GO:0051235	maintenance of location	1.232225e-4
GO:0030203	glycosaminoglycan metabolic process	1.239935e-4
GO:0006468	protein phosphorylation	1.243525e-4
GO:0048806	genitalia development	1.258903e-4
GO:0001843	neural tube closure	1.365500e-4
GO:2000147	positive regulation of cell motility	1.372290e-4
GO:0051272	positive regulation of cellular component movement	1.377696e-4
GO:0030502	negative regulation of bone mineralization	1.393001e-4
GO:0007567	parturition	1.406797e-4
GO:0003014	renal system process	1.412343e-4
GO:0043069	negative regulation of programmed cell death	1.422757e-4
GO:0070302	regulation of stress-activated protein kinase signaling cascade	1.430217e-4
GO:0048870	cell motility	1.432750e-4
GO:0032330	regulation of chondrocyte differentiation	1.473830e-4
GO:0021953	central nervous system neuron differentiation	1.486465e-4
GO:0060008	Sertoli cell differentiation	1.493107e-4
GO:0046292	formaldehyde metabolic process	1.500579e-4
GO:0007409	axonogenesis	1.501090e-4
GO:0046328	regulation of JNK cascade	1.531606e-4
GO:0048662	negative regulation of smooth muscle cell proliferation	1.541700e-4
GO:0021778	oligodendrocyte cell fate specification	1.550726e-4
GO:0043066	negative regulation of apoptosis	1.581863e-4
GO:0009082	branched chain family amino acid biosynthetic process	1.613776e-4
GO:0010232	vascular transport	1.644742e-4
GO:0006426	glycyl-tRNA aminoacylation	1.644742e-4
GO:0003408	optic cup formation involved in camera-type eye development	1.676050e-4
GO:0014912	negative regulation of smooth muscle cell migration	1.719169e-4
GO:0042063	gliogenesis	1.722112e-4
GO:0048683	regulation of collateral sprouting of intact axon in response to injury	1.779646e-4
GO:0032227	negative regulation of synaptic transmission, dopaminergic	1.779646e-4
GO:0033144	negative regulation of steroid hormone receptor signaling pathway	1.781153e-4
GO:0051704	multi-organism process	1.837508e-4
GO:0052697	xenobiotic glucuronidation	1.837693e-4
GO:0070980	biphenyl catabolic process	1.837693e-4
GO:0051552	flavone metabolic process	1.837693e-4
GO:0052696	flavonoid glucuronidation	1.837693e-4
GO:0006789	bilirubin conjugation	1.837693e-4
GO:0051276	chromosome organization	1.838648e-4
GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway	1.892235e-4
GO:0050869	negative regulation of B cell activation	1.893842e-4
GO:0007600	sensory perception	1.922960e-4
GO:0010647	positive regulation of cell communication	1.950825e-4
GO:0021517	ventral spinal cord development	1.977494e-4
GO:0014020	primary neural tube formation	2.007932e-4
GO:0009083	branched chain family amino acid catabolic process	2.054851e-4
GO:0046854	phosphatidylinositol phosphorylation	2.069914e-4
GO:0015701	bicarbonate transport	2.080958e-4
GO:0051705	behavioral interaction between organisms	2.121376e-4
GO:0017144	drug metabolic process	2.177293e-4
GO:0042572	retinol metabolic process	2.226333e-4
GO:0009063	cellular amino acid catabolic process	2.248904e-4
GO:0050801	ion homeostasis	2.253785e-4
GO:0006916	anti-apoptosis	2.297629e-4
GO:0007030	Golgi organization	2.305892e-4
GO:0006807	nitrogen compound metabolic process	2.342604e-4
GO:0060900	embryonic camera-type eye formation	2.389179e-4
GO:0019359	nicotinamide nucleotide biosynthetic process	2.403357e-4
GO:0014911	positive regulation of smooth muscle cell migration	2.496165e-4
GO:0045767	regulation of anti-apoptosis	2.497129e-4
GO:0030318	melanocyte differentiation	2.557519e-4
GO:0051147	regulation of muscle cell differentiation	2.602976e-4
GO:0060562	epithelial tube morphogenesis	2.607300e-4
GO:0019441	tryptophan catabolic process to kynurenine	2.653683e-4
GO:0035588	G-protein coupled purinergic receptor signaling pathway	2.681907e-4
GO:0001822	kidney development	2.715645e-4
GO:0015031	protein transport	2.762266e-4
GO:0045884	regulation of survival gene product expression	2.858345e-4
GO:0060629	regulation of homologous chromosome segregation	2.876728e-4
GO:0051598	meiotic recombination checkpoint	2.876728e-4
GO:0006357	regulation of transcription from RNA polymerase II promoter	2.938873e-4
GO:0009081	branched chain family amino acid metabolic process	2.958390e-4
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	3.046129e-4
GO:0010834	telomere maintenance via telomere shortening	3.068912e-4
GO:0009435	NAD biosynthetic process	3.149828e-4
GO:0019538	protein metabolic process	3.175918e-4
GO:0019935	cyclic-nucleotide-mediated signaling	3.197546e-4
GO:0007157	heterophilic cell-cell adhesion	3.240413e-4
GO:0007156	homophilic cell adhesion	3.251453e-4
GO:0046329	negative regulation of JNK cascade	3.266290e-4

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0048513	organ development	1.808976e-13
GO:0048731	system development	4.299585e-10
GO:0048034	heme O biosynthetic process	4.638166e-10
GO:0002376	immune system process	1.118989e-9
GO:0048856	anatomical structure development	1.250776e-9
GO:0032817	regulation of natural killer cell proliferation	1.907130e-9
GO:0045321	leukocyte activation	2.899822e-9
GO:0006955	immune response	3.784219e-9
GO:0006014	D-ribose metabolic process	4.641627e-9
GO:0009052	pentose-phosphate shunt, non-oxidative branch	4.877888e-9
GO:0007275	multicellular organismal development	5.639174e-9
GO:0045445	myoblast differentiation	6.396210e-9
GO:0019693	ribose phosphate metabolic process	8.007014e-9
GO:0032502	developmental process	9.833989e-9
GO:0048584	positive regulation of response to stimulus	4.486255e-8
GO:0035295	tube development	4.637171e-8
GO:0043129	surfactant homeostasis	6.277334e-8
GO:0046649	lymphocyte activation	1.241560e-7
GO:0032501	multicellular organismal process	1.597222e-7
GO:0017004	cytochrome complex assembly	1.700353e-7
GO:0001775	cell activation	2.130608e-7
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway	2.348842e-7
GO:0043620	regulation of DNA-dependent transcription in response to stress	2.707415e-7
GO:0048520	positive regulation of behavior	4.152300e-7
GO:0050793	regulation of developmental process	5.337070e-7
GO:0032814	regulation of natural killer cell activation	6.289594e-7
GO:0045671	negative regulation of osteoclast differentiation	7.261108e-7
GO:0050930	induction of positive chemotaxis	7.543516e-7
GO:0006704	glucocorticoid biosynthetic process	8.932113e-7
GO:0050801	ion homeostasis	9.430192e-7
GO:0097091	synaptic vesicle clustering	9.572910e-7
GO:0097105	presynaptic membrane assembly	9.928011e-7
GO:0048534	hemopoietic or lymphoid organ development	1.026295e-6
GO:0051648	vesicle localization	1.072293e-6
GO:0009653	anatomical structure morphogenesis	1.179444e-6
GO:0002520	immune system development	1.211131e-6
GO:0007157	heterophilic cell-cell adhesion	1.373737e-6
GO:0010960	magnesium ion homeostasis	1.592705e-6
GO:0042110	T cell activation	1.651602e-6
GO:0030097	hemopoiesis	1.740987e-6
GO:0007158	neuron cell-cell adhesion	2.186516e-6
GO:0048869	cellular developmental process	2.254392e-6
GO:0042098	T cell proliferation	2.256846e-6
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	2.352002e-6
GO:0030098	lymphocyte differentiation	2.389761e-6
GO:0060412	ventricular septum morphogenesis	2.720274e-6
GO:0097090	presynaptic membrane organization	2.728061e-6
GO:0046651	lymphocyte proliferation	3.083682e-6
GO:0070661	leukocyte proliferation	3.155823e-6
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	3.667395e-6
GO:0002683	negative regulation of immune system process	3.789359e-6
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	4.111429e-6
GO:0035644	phosphoanandamide dephosphorylation	4.164330e-6
GO:0061053	somite development	4.794790e-6
GO:0051239	regulation of multicellular organismal process	4.910373e-6
GO:0016339	calcium-dependent cell-cell adhesion	4.998816e-6
GO:0043482	cellular pigment accumulation	5.270366e-6
GO:0006784	heme a biosynthetic process	5.843295e-6
GO:0097120	receptor localization to synapse	6.130990e-6
GO:0072578	neurotransmitter-gated ion channel clustering	6.130990e-6
GO:0016080	synaptic vesicle targeting	6.226505e-6
GO:0048878	chemical homeostasis	6.296007e-6
GO:0032943	mononuclear cell proliferation	6.598070e-6
GO:0030154	cell differentiation	6.801223e-6
GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	8.913038e-6
GO:2001051	positive regulation of tendon cell differentiation	8.946924e-6
GO:0021509	roof plate formation	8.946924e-6
GO:0002541	activation of plasma proteins involved in acute inflammatory response	9.943506e-6
GO:0043496	regulation of protein homodimerization activity	1.084445e-5
GO:0065008	regulation of biological quality	1.115212e-5
GO:0008207	C21-steroid hormone metabolic process	1.123388e-5
GO:0055080	cation homeostasis	1.152593e-5
GO:0003091	renal water homeostasis	1.164546e-5
GO:0055065	metal ion homeostasis	1.259901e-5
GO:0030217	T cell differentiation	1.263591e-5
GO:0007417	central nervous system development	1.287648e-5
GO:0048583	regulation of response to stimulus	1.289104e-5
GO:0006873	cellular ion homeostasis	1.331209e-5
GO:0051093	negative regulation of developmental process	1.488976e-5
GO:0002521	leukocyte differentiation	1.633281e-5
GO:0046620	regulation of organ growth	1.754438e-5
GO:0043476	pigment accumulation	1.792796e-5
GO:0050852	T cell receptor signaling pathway	1.836945e-5
GO:0097104	postsynaptic membrane assembly	1.887519e-5
GO:0097119	postsynaptic density protein 95 clustering	1.887519e-5
GO:0034754	cellular hormone metabolic process	1.991338e-5
GO:0050795	regulation of behavior	2.079218e-5
GO:0097115	neurexin clustering	2.110737e-5
GO:0007062	sister chromatid cohesion	2.114975e-5
GO:0002252	immune effector process	2.304594e-5
GO:0022602	ovulation cycle process	2.459914e-5
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	2.462782e-5
GO:0030514	negative regulation of BMP signaling pathway	2.648954e-5
GO:0032879	regulation of localization	2.938275e-5
GO:0048646	anatomical structure formation involved in morphogenesis	2.977150e-5
GO:0002768	immune response-regulating cell surface receptor signaling pathway	3.001987e-5
GO:0008284	positive regulation of cell proliferation	3.029390e-5
GO:0055082	cellular chemical homeostasis	3.367194e-5
GO:0032819	positive regulation of natural killer cell proliferation	3.543670e-5
GO:0042753	positive regulation of circadian rhythm	3.712764e-5
GO:0035590	purinergic nucleotide receptor signaling pathway	3.806755e-5
GO:2000463	positive regulation of excitatory postsynaptic membrane potential	4.320464e-5
GO:0046884	follicle-stimulating hormone secretion	4.694974e-5
GO:0032275	luteinizing hormone secretion	4.694974e-5
GO:0030278	regulation of ossification	4.737531e-5
GO:0090403	oxidative stress-induced premature senescence	4.884700e-5
GO:0003281	ventricular septum development	5.042824e-5
GO:0007399	nervous system development	5.150153e-5
GO:0001756	somitogenesis	5.171188e-5
GO:0046660	female sex differentiation	5.463360e-5
GO:0046545	development of primary female sexual characteristics	5.536810e-5
GO:0051240	positive regulation of multicellular organismal process	5.593222e-5
GO:0001944	vasculature development	5.757016e-5
GO:0002429	immune response-activating cell surface receptor signaling pathway	5.806345e-5
GO:0009888	tissue development	6.026934e-5
GO:0045176	apical protein localization	6.105322e-5
GO:0072395	signal transduction involved in cell cycle checkpoint	6.271750e-5
GO:2000026	regulation of multicellular organismal development	6.324755e-5
GO:0030071	regulation of mitotic metaphase/anaphase transition	6.358748e-5
GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	6.399689e-5
GO:0002366	leukocyte activation involved in immune response	6.420163e-5
GO:0030888	regulation of B cell proliferation	6.467017e-5
GO:0055081	anion homeostasis	6.686304e-5
GO:0019321	pentose metabolic process	6.953898e-5
GO:0045666	positive regulation of neuron differentiation	7.131775e-5
GO:0042698	ovulation cycle	7.154355e-5
GO:0042445	hormone metabolic process	7.224949e-5
GO:0050851	antigen receptor-mediated signaling pathway	7.250660e-5
GO:0072404	signal transduction involved in G1/S transition checkpoint	7.819565e-5
GO:0045838	positive regulation of membrane potential	7.931437e-5
GO:0002051	osteoblast fate commitment	8.112694e-5
GO:0050670	regulation of lymphocyte proliferation	8.115435e-5
GO:0035418	protein localization to synapse	8.791605e-5
GO:0032655	regulation of interleukin-12 production	8.991471e-5
GO:2000466	negative regulation of glycogen (starch) synthase activity	9.065068e-5
GO:0021891	olfactory bulb interneuron development	9.752259e-5
GO:0001953	negative regulation of cell-matrix adhesion	9.845029e-5
GO:0034261	negative regulation of Ras GTPase activity	1.035201e-4
GO:0032944	regulation of mononuclear cell proliferation	1.054879e-4
GO:0002285	lymphocyte activation involved in immune response	1.060277e-4
GO:0045165	cell fate commitment	1.091890e-4
GO:0048598	embryonic morphogenesis	1.129284e-4
GO:0035588	G-protein coupled purinergic receptor signaling pathway	1.155611e-4
GO:0061302	smooth muscle cell-matrix adhesion	1.178672e-4
GO:0035623	renal glucose absorption	1.178672e-4
GO:0045668	negative regulation of osteoblast differentiation	1.194605e-4
GO:0032695	negative regulation of interleukin-12 production	1.210902e-4
GO:0048304	positive regulation of isotype switching to IgG isotypes	1.210902e-4
GO:0030003	cellular cation homeostasis	1.228709e-4
GO:0048625	myoblast cell fate commitment	1.231369e-4
GO:0042127	regulation of cell proliferation	1.260400e-4
GO:0050926	regulation of positive chemotaxis	1.268401e-4
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	1.280526e-4
GO:0006875	cellular metal ion homeostasis	1.284996e-4
GO:0048762	mesenchymal cell differentiation	1.341646e-4
GO:0051640	organelle localization	1.349787e-4
GO:0050927	positive regulation of positive chemotaxis	1.353471e-4
GO:0072358	cardiovascular system development	1.365287e-4
GO:0050871	positive regulation of B cell activation	1.388284e-4
GO:0035690	cellular response to drug	1.427377e-4
GO:0018298	protein-chromophore linkage	1.440842e-4
GO:0070663	regulation of leukocyte proliferation	1.527269e-4
GO:0043374	CD8-positive, alpha-beta T cell differentiation	1.532825e-4
GO:0001568	blood vessel development	1.586211e-4
GO:0002684	positive regulation of immune system process	1.595348e-4
GO:0001887	selenium compound metabolic process	1.599643e-4
GO:0050776	regulation of immune response	1.630043e-4
GO:0055078	sodium ion homeostasis	1.645308e-4
GO:0045596	negative regulation of cell differentiation	1.671848e-4
GO:0006098	pentose-phosphate shunt	1.704897e-4
GO:0060411	cardiac septum morphogenesis	1.721596e-4
GO:0014033	neural crest cell differentiation	1.735260e-4
GO:0001501	skeletal system development	1.770684e-4
GO:0008057	eye pigment granule organization	1.807403e-4
GO:0021889	olfactory bulb interneuron differentiation	1.850067e-4
GO:0006739	NADP metabolic process	1.866412e-4
GO:0030510	regulation of BMP signaling pathway	1.868152e-4
GO:0008354	germ cell migration	1.873779e-4
GO:0051250	negative regulation of lymphocyte activation	1.877530e-4
GO:0008585	female gonad development	1.877530e-4
GO:0048857	neural nucleus development	1.895497e-4
GO:0007420	brain development	1.931026e-4
GO:0042448	progesterone metabolic process	1.952847e-4
GO:0051586	positive regulation of dopamine uptake	1.975236e-4
GO:0060173	limb development	2.001985e-4
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	2.056558e-4
GO:0051971	positive regulation of transmission of nerve impulse	2.069943e-4
GO:0001525	angiogenesis	2.127792e-4
GO:0014031	mesenchymal cell development	2.225906e-4
GO:0045667	regulation of osteoblast differentiation	2.255247e-4
GO:0035810	positive regulation of urine volume	2.276007e-4
GO:0046851	negative regulation of bone remodeling	2.292332e-4
GO:0051650	establishment of vesicle localization	2.340834e-4
GO:0035108	limb morphogenesis	2.374935e-4
GO:0002682	regulation of immune system process	2.459638e-4
GO:0048854	brain morphogenesis	2.505573e-4
GO:0031290	retinal ganglion cell axon guidance	2.535815e-4
GO:0097070	ductus arteriosus closure	2.541260e-4
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	2.541260e-4
GO:0061039	ovum-producing ovary development	2.570691e-4
GO:0051898	negative regulation of protein kinase B signaling cascade	2.586209e-4
GO:2000794	regulation of epithelial cell proliferation involved in lung morphogenesis	2.666105e-4
GO:0019725	cellular homeostasis	2.677635e-4
GO:0055013	cardiac muscle cell development	2.715112e-4
GO:0071380	cellular response to prostaglandin E stimulus	2.847468e-4
GO:0045595	regulation of cell differentiation	2.867849e-4
GO:0010754	negative regulation of cGMP-mediated signaling	2.888061e-4
GO:0010751	negative regulation of nitric oxide mediated signal transduction	2.888061e-4
GO:0002605	negative regulation of dendritic cell antigen processing and presentation	2.888061e-4
GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	2.888061e-4
GO:0018149	peptide cross-linking	3.034246e-4
GO:0001941	postsynaptic membrane organization	3.079572e-4
GO:0001763	morphogenesis of a branching structure	3.083192e-4
GO:0003151	outflow tract morphogenesis	3.135145e-4
GO:0001952	regulation of cell-matrix adhesion	3.204247e-4
GO:0050921	positive regulation of chemotaxis	3.230277e-4
GO:0048514	blood vessel morphogenesis	3.248696e-4
GO:0003006	developmental process involved in reproduction	3.251114e-4
GO:0060134	prepulse inhibition	3.312365e-4
GO:0042113	B cell activation	3.376597e-4
GO:0051966	regulation of synaptic transmission, glutamatergic	3.565837e-4
GO:0045938	positive regulation of circadian sleep/wake cycle, sleep	3.763753e-4
GO:0071560	cellular response to transforming growth factor beta stimulus	3.772010e-4
GO:0000245	spliceosome assembly	3.795057e-4
GO:0000733	DNA strand renaturation	3.824231e-4
GO:0009162	deoxyribonucleoside monophosphate metabolic process	4.079185e-4
GO:0090074	negative regulation of protein homodimerization activity	4.079185e-4
GO:0033688	regulation of osteoblast proliferation	4.130509e-4
GO:0050778	positive regulation of immune response	4.132490e-4
GO:0010817	regulation of hormone levels	4.287881e-4
GO:0002764	immune response-regulating signaling pathway	4.542777e-4
GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering	4.564869e-4
GO:0009219	pyrimidine deoxyribonucleotide metabolic process	4.564869e-4
GO:0034104	negative regulation of tissue remodeling	4.577120e-4
GO:0006952	defense response	4.622698e-4
GO:0010749	regulation of nitric oxide mediated signal transduction	4.646540e-4
GO:0050806	positive regulation of synaptic transmission	4.658072e-4
GO:0030323	respiratory tube development	4.813491e-4
GO:0051607	defense response to virus	4.850990e-4
GO:0050891	multicellular organismal water homeostasis	4.884936e-4
GO:0001911	negative regulation of leukocyte mediated cytotoxicity	5.030486e-4
GO:0019320	hexose catabolic process	5.098351e-4
GO:0043032	positive regulation of macrophage activation	5.141473e-4
GO:0071305	cellular response to vitamin D	5.195060e-4
GO:0030324	lung development	5.201405e-4
GO:0042592	homeostatic process	5.307625e-4
GO:0031646	positive regulation of neurological system process	5.444800e-4
GO:0031342	negative regulation of cell killing	5.456346e-4
GO:0071559	response to transforming growth factor beta stimulus	5.461433e-4
GO:0043009	chordate embryonic development	5.507898e-4
GO:0002757	immune response-activating signal transduction	5.528570e-4
GO:0040017	positive regulation of locomotion	5.572941e-4
GO:0045659	negative regulation of neutrophil differentiation	5.665523e-4
GO:0006925	inflammatory cell apoptosis	5.665523e-4
GO:0046621	negative regulation of organ growth	5.668766e-4
GO:0009264	deoxyribonucleotide catabolic process	5.816484e-4
GO:0002009	morphogenesis of an epithelium	5.816940e-4
GO:0030183	B cell differentiation	5.835488e-4
GO:0060174	limb bud formation	5.854825e-4
GO:0033373	maintenance of protease location in mast cell secretory granule	6.186984e-4
GO:0033382	maintenance of granzyme B location in T cell secretory granule	6.186984e-4
GO:0033363	secretory granule organization	6.284954e-4
GO:0000375	RNA splicing, via transesterification reactions	6.362825e-4
GO:0055006	cardiac cell development	6.481305e-4
GO:0007548	sex differentiation	6.483190e-4
GO:0032825	positive regulation of natural killer cell differentiation	6.562360e-4
GO:0051968	positive regulation of synaptic transmission, glutamatergic	6.619196e-4
GO:0072507	divalent inorganic cation homeostasis	6.678083e-4
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	6.703183e-4
GO:0046601	positive regulation of centriole replication	6.740060e-4
GO:0000398	nuclear mRNA splicing, via spliceosome	6.757374e-4
GO:0045638	negative regulation of myeloid cell differentiation	6.784058e-4
GO:0065007	biological regulation	6.903524e-4
GO:0035909	aorta morphogenesis	6.931260e-4
GO:0050864	regulation of B cell activation	6.964585e-4
GO:0043603	cellular amide metabolic process	7.016262e-4
GO:0006007	glucose catabolic process	7.065815e-4
GO:0055074	calcium ion homeostasis	7.121679e-4
GO:0010627	regulation of intracellular protein kinase cascade	7.138931e-4
GO:0051272	positive regulation of cellular component movement	7.208491e-4
GO:0060563	neuroepithelial cell differentiation	7.268526e-4
GO:0001841	neural tube formation	7.312399e-4
GO:0002011	morphogenesis of an epithelial sheet	7.355984e-4
GO:0032816	positive regulation of natural killer cell activation	7.593452e-4
GO:0002253	activation of immune response	7.938749e-4
GO:0071377	cellular response to glucagon stimulus	8.058168e-4
GO:0045348	positive regulation of MHC class II biosynthetic process	8.058168e-4
GO:0002066	columnar/cuboidal epithelial cell development	8.099970e-4
GO:0060485	mesenchyme development	8.113649e-4
GO:0031424	keratinization	8.428539e-4
GO:0009792	embryo development ending in birth or egg hatching	8.476739e-4
GO:0050679	positive regulation of epithelial cell proliferation	8.628320e-4
GO:0006953	acute-phase response	8.631239e-4
GO:0050678	regulation of epithelial cell proliferation	8.721166e-4
GO:0046365	monosaccharide catabolic process	8.882295e-4
GO:0043652	engulfment of apoptotic cell	8.898030e-4
GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	9.037366e-4
GO:0019836	hemolysis by symbiont of host erythrocytes	9.135911e-4
GO:0035809	regulation of urine volume	9.281942e-4
GO:0015871	choline transport	9.454983e-4
GO:0044275	cellular carbohydrate catabolic process	9.458535e-4
GO:0072422	signal transduction involved in DNA damage checkpoint	9.460145e-4
GO:0023056	positive regulation of signaling	9.548398e-4
GO:0030335	positive regulation of cell migration	9.864941e-4
GO:0002637	regulation of immunoglobulin production	9.929170e-4
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	9.981988e-4
GO:0032252	secretory granule localization	1.014921e-3
GO:0001822	kidney development	1.066484e-3
GO:0050701	interleukin-1 secretion	1.088331e-3
GO:0045062	extrathymic T cell selection	1.088331e-3
GO:0071675	regulation of mononuclear cell migration	1.102414e-3
GO:0009265	2'-deoxyribonucleotide biosynthetic process	1.103331e-3
GO:0051387	negative regulation of nerve growth factor receptor signaling pathway	1.110229e-3
GO:0008535	respiratory chain complex IV assembly	1.110229e-3
GO:0051918	negative regulation of fibrinolysis	1.123381e-3
GO:0071773	cellular response to BMP stimulus	1.135334e-3
GO:0060429	epithelium development	1.150316e-3
GO:0002312	B cell activation involved in immune response	1.158477e-3
GO:0045663	positive regulation of myoblast differentiation	1.171131e-3
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.186152e-3
GO:0003300	cardiac muscle hypertrophy	1.209050e-3
GO:0045058	T cell selection	1.250901e-3
GO:0044344	cellular response to fibroblast growth factor stimulus	1.267248e-3
GO:0010955	negative regulation of protein processing	1.269766e-3
GO:0035904	aorta development	1.273228e-3
GO:0060079	regulation of excitatory postsynaptic membrane potential	1.277084e-3
GO:0002762	negative regulation of myeloid leukocyte differentiation	1.317551e-3
GO:0003207	cardiac chamber formation	1.317551e-3
GO:0032612	interleukin-1 production	1.321950e-3
GO:0003279	cardiac septum development	1.326543e-3
GO:2000147	positive regulation of cell motility	1.326563e-3
GO:0003014	renal system process	1.334301e-3
GO:0035282	segmentation	1.341574e-3
GO:0032755	positive regulation of interleukin-6 production	1.355842e-3
GO:0070848	response to growth factor stimulus	1.358775e-3
GO:0006367	transcription initiation from RNA polymerase II promoter	1.360244e-3
GO:0050767	regulation of neurogenesis	1.366831e-3
GO:0006779	porphyrin-containing compound biosynthetic process	1.369102e-3
GO:0045577	regulation of B cell differentiation	1.398643e-3
GO:0006879	cellular iron ion homeostasis	1.398643e-3
GO:2000270	negative regulation of fibroblast apoptosis	1.407714e-3
GO:2000271	positive regulation of fibroblast apoptosis	1.407714e-3
GO:2000080	negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation	1.407714e-3
GO:0044345	stromal-epithelial cell signaling involved in prostate gland development	1.407714e-3
GO:0021570	rhombomere 4 development	1.407714e-3
GO:0006915	apoptosis	1.410997e-3
GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process	1.415827e-3
GO:0015939	pantothenate metabolic process	1.466671e-3
GO:0006911	phagocytosis, engulfment	1.509500e-3
GO:0051094	positive regulation of developmental process	1.525601e-3
GO:0016052	carbohydrate catabolic process	1.544205e-3
GO:0060044	negative regulation of cardiac muscle cell proliferation	1.589184e-3
GO:0015867	ATP transport	1.595165e-3
GO:0060043	regulation of cardiac muscle cell proliferation	1.596681e-3
GO:0015721	bile acid and bile salt transport	1.627653e-3
GO:0001932	regulation of protein phosphorylation	1.634259e-3
GO:0032103	positive regulation of response to external stimulus	1.639128e-3
GO:0010810	regulation of cell-substrate adhesion	1.656093e-3
GO:0043030	regulation of macrophage activation	1.673625e-3
GO:0048699	generation of neurons	1.678368e-3
GO:0046078	dUMP metabolic process	1.709829e-3
GO:0009223	pyrimidine deoxyribonucleotide catabolic process	1.709829e-3
GO:0051960	regulation of nervous system development	1.721818e-3
GO:0040011	locomotion	1.730089e-3
GO:0001757	somite specification	1.761615e-3
GO:0042147	retrograde transport, endosome to Golgi	1.764099e-3
GO:0009605	response to external stimulus	1.783331e-3
GO:0055024	regulation of cardiac muscle tissue development	1.813115e-3
GO:0021915	neural tube development	1.817821e-3
GO:0070293	renal absorption	1.839915e-3
GO:0002695	negative regulation of leukocyte activation	1.842778e-3
GO:0051883	killing of cells in other organism involved in symbiotic interaction	1.868783e-3
GO:0003357	noradrenergic neuron differentiation	1.868783e-3
GO:0030901	midbrain development	1.873212e-3
GO:0046640	regulation of alpha-beta T cell proliferation	1.880528e-3
GO:0046631	alpha-beta T cell activation	1.886801e-3
GO:0042136	neurotransmitter biosynthetic process	1.902748e-3
GO:2000648	positive regulation of stem cell proliferation	1.923738e-3
GO:0016202	regulation of striated muscle tissue development	1.927005e-3
GO:0030001	metal ion transport	1.941903e-3
GO:0046164	alcohol catabolic process	1.945060e-3
GO:0034695	response to prostaglandin E stimulus	1.945430e-3
GO:0090287	regulation of cellular response to growth factor stimulus	1.955496e-3
GO:0048608	reproductive structure development	1.979691e-3
GO:0015908	fatty acid transport	1.983391e-3
GO:0030889	negative regulation of B cell proliferation	1.986910e-3
GO:0070365	hepatocyte differentiation	1.989952e-3
GO:2000079	regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation	2.020242e-3
GO:0048634	regulation of muscle organ development	2.051460e-3
GO:0031640	killing of cells of other organism	2.059864e-3
GO:0060554	induction of necroptosis of activated-T cells	2.085925e-3
GO:0071842	cellular component organization at cellular level	2.088302e-3
GO:0050854	regulation of antigen receptor-mediated signaling pathway	2.110539e-3
GO:0006700	C21-steroid hormone biosynthetic process	2.127170e-3
GO:0044271	cellular nitrogen compound biosynthetic process	2.146925e-3
GO:0051186	cofactor metabolic process	2.153838e-3
GO:0002326	B cell lineage commitment	2.204957e-3
GO:0050777	negative regulation of immune response	2.215215e-3
GO:0031399	regulation of protein modification process	2.219095e-3
GO:0051893	regulation of focal adhesion assembly	2.238041e-3
GO:0072001	renal system development	2.239810e-3
GO:0048518	positive regulation of biological process	2.242759e-3
GO:0012501	programmed cell death	2.258539e-3
GO:0010758	regulation of macrophage chemotaxis	2.267261e-3
GO:0051584	regulation of dopamine uptake	2.280044e-3
GO:0002309	T cell proliferation involved in immune response	2.280044e-3
GO:0006302	double-strand break repair	2.365783e-3
GO:0060078	regulation of postsynaptic membrane potential	2.382920e-3
GO:0051917	regulation of fibrinolysis	2.387917e-3
GO:0001542	ovulation from ovarian follicle	2.395290e-3
GO:0070373	negative regulation of ERK1 and ERK2 cascade	2.413233e-3
GO:0061337	cardiac conduction	2.418585e-3
GO:0048468	cell development	2.426998e-3
GO:0006477	protein sulfation	2.427724e-3
GO:0034453	microtubule anchoring	2.433525e-3
GO:0010812	negative regulation of cell-substrate adhesion	2.451788e-3
GO:0003211	cardiac ventricle formation	2.466352e-3
GO:0051656	establishment of organelle localization	2.499111e-3
GO:0055062	phosphate ion homeostasis	2.508166e-3
GO:0045670	regulation of osteoclast differentiation	2.509975e-3
GO:0030890	positive regulation of B cell proliferation	2.526291e-3
GO:0001890	placenta development	2.534698e-3
GO:0060402	calcium ion transport into cytosol	2.553494e-3
GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	2.562526e-3
GO:0035239	tube morphogenesis	2.564625e-3
GO:0022008	neurogenesis	2.597732e-3
GO:0044087	regulation of cellular component biogenesis	2.617390e-3
GO:2000791	negative regulation of mesenchymal cell proliferation involved in lung development	2.618628e-3
GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis	2.618628e-3
GO:0061141	lung ciliated cell differentiation	2.618628e-3
GO:0021740	principal sensory nucleus of trigeminal nerve development	2.618628e-3
GO:0010757	negative regulation of plasminogen activation	2.618628e-3
GO:0001910	regulation of leukocyte mediated cytotoxicity	2.657561e-3
GO:0043113	receptor clustering	2.695434e-3
GO:0048302	regulation of isotype switching to IgG isotypes	2.695736e-3
GO:0055075	potassium ion homeostasis	2.702338e-3
GO:0045992	negative regulation of embryonic development	2.736236e-3
GO:0035587	purinergic receptor signaling pathway	2.739945e-3
GO:0002360	T cell lineage commitment	2.746180e-3
GO:2000058	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	2.800484e-3
GO:0045329	carnitine biosynthetic process	2.814433e-3
GO:0055117	regulation of cardiac muscle contraction	2.830544e-3
GO:0008105	asymmetric protein localization	2.858939e-3
GO:0010755	regulation of plasminogen activation	2.864601e-3
GO:0034260	negative regulation of GTPase activity	2.864601e-3
GO:0006529	asparagine biosynthetic process	2.984711e-3
GO:0010647	positive regulation of cell communication	2.996751e-3
GO:0048385	regulation of retinoic acid receptor signaling pathway	2.998407e-3
GO:0015868	purine ribonucleotide transport	3.050952e-3
GO:0071363	cellular response to growth factor stimulus	3.076644e-3
GO:0051149	positive regulation of muscle cell differentiation	3.121174e-3
GO:0035136	forelimb morphogenesis	3.129750e-3
GO:0050860	negative regulation of T cell receptor signaling pathway	3.153913e-3
GO:0070861	regulation of protein exit from endoplasmic reticulum	3.153981e-3
GO:0071955	recycling endosome to Golgi transport	3.153981e-3
GO:0045356	positive regulation of interferon-alpha biosynthetic process	3.153981e-3
GO:0034499	late endosome to Golgi transport	3.153981e-3
GO:0007208	activation of phospholipase C activity by serotonin receptor signaling pathway	3.153981e-3
GO:0001964	startle response	3.169556e-3
GO:0015718	monocarboxylic acid transport	3.176448e-3
GO:0042573	retinoic acid metabolic process	3.223381e-3
GO:0097114	N-methyl-D-aspartate receptor clustering	3.232242e-3
GO:0097117	guanylate kinase-associated protein clustering	3.232242e-3
GO:0097112	gamma-aminobutyric acid receptor clustering	3.232242e-3
GO:0001915	negative regulation of T cell mediated cytotoxicity	3.256882e-3
GO:0031065	positive regulation of histone deacetylation	3.282362e-3
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	3.294919e-3
GO:0014009	glial cell proliferation	3.303199e-3
GO:0050671	positive regulation of lymphocyte proliferation	3.312176e-3
GO:0008340	determination of adult lifespan	3.363691e-3
GO:0006903	vesicle targeting	3.406681e-3
GO:0002526	acute inflammatory response	3.407095e-3
GO:0006376	mRNA splice site selection	3.447094e-3
GO:0008211	glucocorticoid metabolic process	3.447094e-3
GO:0035117	embryonic arm morphogenesis	3.457993e-3
GO:0051896	regulation of protein kinase B signaling cascade	3.475309e-3
GO:0001654	eye development	3.486956e-3
GO:0001655	urogenital system development	3.516776e-3
GO:0046826	negative regulation of protein export from nucleus	3.521320e-3
GO:0055021	regulation of cardiac muscle tissue growth	3.522777e-3
GO:0043576	regulation of respiratory gaseous exchange	3.527430e-3
GO:0060040	retinal bipolar neuron differentiation	3.555943e-3
GO:0070409	carbamoyl phosphate biosynthetic process	3.555943e-3
GO:0033625	positive regulation of integrin activation	3.555943e-3
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	3.555943e-3
GO:0060420	regulation of heart growth	3.682873e-3
GO:0071481	cellular response to X-ray	3.735505e-3
GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	3.820867e-3
GO:0008406	gonad development	3.830394e-3
GO:0045590	negative regulation of regulatory T cell differentiation	3.845394e-3
GO:0044065	regulation of respiratory system process	3.942572e-3
GO:0014888	striated muscle adaptation	3.963798e-3
GO:0007220	Notch receptor processing	3.975524e-3
GO:0060706	cell differentiation involved in embryonic placenta development	3.979703e-3
GO:0002087	regulation of respiratory gaseous exchange by neurological system process	3.979703e-3
GO:0050866	negative regulation of cell activation	4.026450e-3
GO:0048806	genitalia development	4.035879e-3
GO:2000045	regulation of G1/S transition of mitotic cell cycle	4.037009e-3
GO:0045137	development of primary sexual characteristics	4.100514e-3
GO:0032946	positive regulation of mononuclear cell proliferation	4.167281e-3