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{{Coexpression_clusters
{
|full_id=C1633_uterus_kidney_ovary_Hepatic_Mesothelial_Renal_spleen
 

Latest revision as of 11:48, 17 September 2013


Full id: C1633_uterus_kidney_ovary_Hepatic_Mesothelial_Renal_spleen



Phase1 CAGE Peaks

Hg19::chr11:32456954..32456965,-p4@WT1
Hg19::chr11:32457075..32457095,-p1@WT1
Hg19::chr11:32457185..32457193,-p7@WT1
Hg19::chr11:32457307..32457323,+p4@WT1-AS
Hg19::chr11:32457350..32457361,+p5@WT1-AS


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
kidney tubule cell4.51e-0910
nephron tubule epithelial cell4.51e-0910
mesothelial cell1.51e-0819
Uber Anatomy
Ontology termp-valuen
reproductive organ2.64e-1048
nephron tubule epithelium4.51e-0910
female reproductive organ1.28e-0837
female reproductive system1.28e-0837
compound organ1.95e-0868
reproductive structure2.40e-0859
reproductive system2.40e-0859
abdomen element1.25e-0754
abdominal segment element1.25e-0754
female organism2.03e-0741
excretory tube9.98e-0716
kidney epithelium9.98e-0716
Disease
Ontology termp-valuen
myeloid leukemia3.59e-1631
leukemia2.10e-1339
organ system cancer9.51e-11137
hematologic cancer3.86e-1051
immune system cancer3.86e-1051
disease of cellular proliferation6.61e-10239
chronic leukemia1.01e-088
benign neoplasm3.18e-084
cancer5.29e-08235
ovarian cancer7.60e-0814
cell type benign neoplasm7.15e-073
leiomyoma7.15e-073


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.04569
MA0004.10.626788
MA0006.11.14863
MA0007.10.606704
MA0009.11.11255
MA0014.10.0418333
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.14.94778
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.603517
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.12.2047
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.692739
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.13.39561
MA0074.14.19986
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.818263
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.11.58771
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.11.76306
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.143698
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.527987
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.409315
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.469165
MA0163.10.168633
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.21.27276
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90556.336201576962639.78880505817628e-050.00138866206393762
CTCF#1066455.360256373075030.0002259278299937090.00249425757259122
CTCFL#140690519.74647435897443.32745051287657e-071.65562460273614e-05
E2F6#187655.017155731697390.0003144978599297790.00322460651808425
EGR1#195854.988179094810140.0003237398000590710.00330412009951816
ELF1#199754.258097958807540.0007142416939776840.00572572062306842
HEY1#2346254.040111043105710.0009288852205177990.00673599802427846
HMGN3#932458.178547723350592.73180911341838e-050.000581429411037909
MAX#414956.452555509007128.93743970843928e-050.00130547869330026
SUZ12#23512550.11578091106293.15480790456198e-092.61081602808676e-07
TAF1#687253.343046285745290.002394600090870310.0135139759478226
TBP#690853.706770687096390.001428755106721120.00917698367717388
YY1#752854.911170749853860.00034993140821360.00352459121828721
ZBTB7A#5134157.35190930787594.65425347594289e-050.000815169509934595
ZNF263#1012758.221841637010682.6606316672286e-050.000570582568159524



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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