UBERON:0002410: Difference between revisions
From FANTOM5_SSTAR
No edit summary |
No edit summary |
||
(2 intermediate revisions by the same user not shown) | |||
Line 1: | Line 1: | ||
{{UBERON | {{UBERON | ||
| | |alt_id=UBERON:FMA_9905-MA_0000219-ZFA_0001574 | ||
|comment=This class was created automatically from a combination of ontologies | |comment=This class was created automatically from a combination of ontologies | ||
|created_by= | |created_by= | ||
| | |def="The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." [Wikipedia:Autonomic_nervous_system] | ||
|derives_from= | |derives_from= | ||
|develops_from= | |develops_from= | ||
|disjoint_from= | |||
|has_quality= | |has_quality= | ||
|id=UBERON:0002410 | |||
|is_a=UBERON:0011216 | |||
|is_obsolete= | |||
|located_in= | |located_in= | ||
|part_of= | |name=autonomic nervous system | ||
|namespace=FANTOM | |||
|obo_creation_date= | |||
|part_of=UBERON:0000010 | |||
|preceded_by= | |||
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "Part of the peripheral nervous system which regulates involuntary functions of the body and consists of the sympathetic and parasympathetic system.[AAO]" xsd:string | |property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "Part of the peripheral nervous system which regulates involuntary functions of the body and consists of the sympathetic and parasympathetic system.[AAO]" xsd:string | ||
| | |subset=uberon_slim;;vertebrate_core | ||
| | |synonym="ANS" RELATED [];;"divisio autonomica systematis nervosi peripherici" RELATED LATIN [Wikipedia:Autonomic_nervous_system];;"visceral nervous system" EXACT [] | ||
|union_of= | |||
|xref=AAO:0000033;;BTO:0002507;;EHDA:10095;;EHDAA:3767;;EMAPA:16984;;FMA:9905;;GAID:706;;http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png;;http://upload.wikimedia.org/wikipedia/commons/thumb/f/f7/Gray839.png/200px-Gray839.png;;MA:0000219;;MESH:A.08.800.050;;ncithesaurus:Autonomic_Nervous_System;;NIF_GrossAnatomy:birnlex_1123;;SCTID:362481007;;TAO:0001574;;VHOG:0000396;;ZFA:0001574 | |||
}} | }} |
Latest revision as of 17:31, 12 September 2014
Name: | autonomic nervous system | ||
---|---|---|---|
Namespace: | FANTOM | ||
Definition: | "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." [Wikipedia:Autonomic_nervous_system] | ||
Xrefs: |
| ||
Synonyms: |
"ANS" RELATED [] "divisio autonomica systematis nervosi peripherici" RELATED LATIN [Wikipedia:Autonomic_nervous_system] "visceral nervous system" EXACT [] | ||
Comments: | This class was created automatically from a combination of ontologies | ||
Alt_id: | UBERON:FMA_9905-MA_0000219-ZFA_0001574 | ||
Subset: |
uberon_slim vertebrate_core |
Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data
Parents
is_a: | UBERON:0011216(organ system subdivision) |
---|---|
part_of: | UBERON:0000010(peripheral nervous system) |
Children
is a: | UBERON:0000013 (sympathetic nervous system),UBERON:0002005 (enteric nervous system) |
---|---|
part of: | UBERON:0000011 (parasympathetic nervous system),UBERON:0000013 (sympathetic nervous system),UBERON:0001805 (autonomic ganglion),UBERON:0002005 (enteric nervous system) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology
Human (Homo sapiens)
- 10458-106G8
- 10460-106H1
- 10461-106H2
- 10480-107A3
- 10507-107D3
- 10508-107D4 (neuroblastoma cell line:CHP-134)
- 10538-107G7
- 10539-107G8 (neuroblastoma cell line:NB-1)
- 10554-107I5
- 10555-107I6 (neuroblastoma cell line:NH-12)
... further results Mouse (Mus musculus)
- 10458-106G8
- 10460-106H1
- 10461-106H2
- 10480-107A3
- 10507-107D3
- 10508-107D4 (neuroblastoma cell line:CHP-134)
- 10538-107G7
- 10539-107G8 (neuroblastoma cell line:NB-1)
- 10554-107I5
- 10555-107I6 (neuroblastoma cell line:NH-12)
Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002410 (autonomic nervous system), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
P-value | FFCP | Short description |
---|---|---|
7.76e-118 | FFCP PHASE1:Hg19::chr1:50569575..50569586,+#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p11@ELAVL4 |
7.76e-118 | FFCP PHASE2:Hg19::chr1:50569575..50569586,+#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p11@ELAVL4 |
7.76e-118 | FFCP PHASE1:Hg19::chr11:71952309..71952319,-#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p2@PHOX2A |
7.76e-118 | FFCP PHASE2:Hg19::chr11:71952309..71952319,-#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p2@PHOX2A |
7.76e-118 | FFCP PHASE2:Hg19::chr2:16081024..16081034,+#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p10@MYCN |
7.76e-118 | FFCP PHASE1:Hg19::chr2:16081024..16081034,+#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p10@MYCN |
7.76e-118 | FFCP PHASE1:Hg19::chr4:41884620..41884663,-#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p1@ENST00000504870 |
7.76e-118 | FFCP PHASE2:Hg19::chr4:41884620..41884663,-#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p1@ENST00000504870 |
7.76e-118 | FFCP PHASE1:Hg19::chr4:41859832..41859854,+#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p@chr4:41859832..41859854, + |
7.76e-118 | FFCP PHASE2:Hg19::chr4:41859832..41859854,+#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p@chr4:41859832..41859854, + |
7.76e-118 | FFCP PHASE2:Hg19::chr2:16082384..16082391,+#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p9@MYCN |
7.76e-118 | FFCP PHASE1:Hg19::chr2:16082384..16082391,+#_7de9f8b6bb3b2048f5c4fb9bb7293cd2 | p9@MYCN |
5.18e-105 | FFCP PHASE2:Hg19::chr4:41750860..41750867,-#_6f5009937a4b5a8fceaea7ebd0376621 | p8@PHOX2B |
5.18e-105 | FFCP PHASE1:Hg19::chr4:41750860..41750867,-#_6f5009937a4b5a8fceaea7ebd0376621 | p8@PHOX2B |
6.77e-105 | FFCP PHASE1:Hg19::chr8:142878006..142878015,+#_eb42c68682a7318c06124e789a688c7c | p@chr8:142878006..142878015, + |
6.77e-105 | FFCP PHASE2:Hg19::chr8:142878006..142878015,+#_eb42c68682a7318c06124e789a688c7c | p@chr8:142878006..142878015, + |
6.64e-89 | FFCP PHASE1:Hg19::chr2:16082395..16082415,+#_9d483d40b79a0924263d3745898f19de | p6@MYCN |
6.64e-89 | FFCP PHASE2:Hg19::chr2:16082418..16082429,+#_9d483d40b79a0924263d3745898f19de | p8@MYCN |
6.64e-89 | FFCP PHASE1:Hg19::chr2:16082418..16082429,+#_9d483d40b79a0924263d3745898f19de | p8@MYCN |
6.64e-89 | FFCP PHASE2:Hg19::chr4:174440390..174440400,-#_9d483d40b79a0924263d3745898f19de | p@chr4:174440390..174440400, - |
6.64e-89 | FFCP PHASE2:Hg19::chr5:168271880..168271889,-#_9d483d40b79a0924263d3745898f19de | p15@SLIT3 |
6.64e-89 | FFCP PHASE1:Hg19::chr4:174440390..174440400,-#_9d483d40b79a0924263d3745898f19de | p@chr4:174440390..174440400, - |
6.64e-89 | FFCP PHASE2:Hg19::chr2:74735290..74735299,-#_9d483d40b79a0924263d3745898f19de | p11@PCGF1 |
6.64e-89 | FFCP PHASE1:Hg19::chr5:168271880..168271889,-#_9d483d40b79a0924263d3745898f19de | p15@SLIT3 |
6.64e-89 | FFCP PHASE1:Hg19::chr2:74735290..74735299,-#_9d483d40b79a0924263d3745898f19de | p11@PCGF1 |
6.64e-89 | FFCP PHASE2:Hg19::chr2:16082395..16082415,+#_9d483d40b79a0924263d3745898f19de | p6@MYCN |
8.98e-89 | FFCP PHASE2:Hg19::chr2:74735271..74735288,-#_d1bd1b406d5217e71c362022e71a00de | p10@PCGF1 |
8.98e-89 | FFCP PHASE1:Hg19::chr2:74735271..74735288,-#_d1bd1b406d5217e71c362022e71a00de | p10@PCGF1 |
8.98e-89 | FFCP PHASE1:Hg19::chr11:71952772..71952788,-#_d1bd1b406d5217e71c362022e71a00de | p@chr11:71952772..71952788, - |
8.98e-89 | FFCP PHASE2:Hg19::chr11:71952772..71952788,-#_d1bd1b406d5217e71c362022e71a00de | p@chr11:71952772..71952788, - |
1.21e-88 | FFCP PHASE2:Hg19::chr4:175257438..175257442,+#_99a268189da10d8ceb3dd404e38b5774 | p@chr4:175257438..175257442, + |
1.21e-88 | FFCP PHASE1:Hg19::chr4:175257438..175257442,+#_99a268189da10d8ceb3dd404e38b5774 | p@chr4:175257438..175257442, + |
1.31e-86 | FFCP PHASE2:Mm9::chr7:98820891..98820900,+#_6b2e269dd382efa9499a91aca82a43d0 | p34@Dlg2 |
1.31e-86 | FFCP PHASE2:Mm9::chr11:113795301..113795315,+#_6b2e269dd382efa9499a91aca82a43d0 | p@chr11:113795301..113795315, + |
1.31e-86 | FFCP PHASE1:Mm9::chr15:90848413..90848436,-#_6b2e269dd382efa9499a91aca82a43d0 | p@chr15:90848413..90848436, - |
1.31e-86 | FFCP PHASE1:Mm9::chr7:98820891..98820900,+#_6b2e269dd382efa9499a91aca82a43d0 | p34@Dlg2 |
1.31e-86 | FFCP PHASE2:Mm9::chr9:20777404..20777418,+#_6b2e269dd382efa9499a91aca82a43d0 | p@chr9:20777404..20777418, + |
1.31e-86 | FFCP PHASE1:Mm9::chr11:113795301..113795315,+#_6b2e269dd382efa9499a91aca82a43d0 | p@chr11:113795301..113795315, + |
1.31e-86 | FFCP PHASE1:Mm9::chr9:20777404..20777418,+#_6b2e269dd382efa9499a91aca82a43d0 | p@chr9:20777404..20777418, + |
1.31e-86 | FFCP PHASE2:Mm9::chr15:90848413..90848436,-#_6b2e269dd382efa9499a91aca82a43d0 | p@chr15:90848413..90848436, - |
2.12e-79 | FFCP PHASE1:Hg19::chr4:41750895..41750904,-#_3b79a08c61329cd5335a6bdb092380c0 | p6@PHOX2B |
2.12e-79 | FFCP PHASE2:Hg19::chr4:41750895..41750904,-#_3b79a08c61329cd5335a6bdb092380c0 | p6@PHOX2B |
3.49e-79 | FFCP PHASE2:Hg19::chr5:168310338..168310348,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr5:168310338..168310348, - |
3.49e-79 | FFCP PHASE1:Hg19::chr7:19185044..19185056,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr7:19185044..19185056, + |
3.49e-79 | FFCP PHASE1:Hg19::chr4:174930547..174930558,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:174930547..174930558, - |
3.49e-79 | FFCP PHASE2:Hg19::chr7:19185475..19185487,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p1@FERD3L |
3.49e-79 | FFCP PHASE2:Hg19::chr11:71955016..71955024,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p7@PHOX2A |
3.49e-79 | FFCP PHASE1:Hg19::chr5:168310338..168310348,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr5:168310338..168310348, - |
3.49e-79 | FFCP PHASE1:Hg19::chr17:74540293..74540300,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p15@PRCD |
3.49e-79 | FFCP PHASE2:Hg19::chr4:113870230..113870237,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:113870230..113870237, + |
3.49e-79 | FFCP PHASE2:Hg19::chr18:77044132..77044175,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr18:77044132..77044175, + |
3.49e-79 | FFCP PHASE2:Hg19::chr7:19186529..19186536,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr7:19186529..19186536, + |
3.49e-79 | FFCP PHASE2:Hg19::chr4:175041125..175041137,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:175041125..175041137, - |
3.49e-79 | FFCP PHASE1:Hg19::chr7:19185475..19185487,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p1@FERD3L |
3.49e-79 | FFCP PHASE1:Hg19::chr4:113870230..113870237,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:113870230..113870237, + |
3.49e-79 | FFCP PHASE1:Hg19::chr7:8276508..8276551,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p14@ICA1 |
3.49e-79 | FFCP PHASE1:Hg19::chr11:71952706..71952712,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p4@PHOX2A |
3.49e-79 | FFCP PHASE2:Hg19::chr7:19185493..19185503,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p2@FERD3L |
3.49e-79 | FFCP PHASE2:Hg19::chr4:174954376..174954399,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:174954376..174954399, - |
3.49e-79 | FFCP PHASE1:Hg19::chr7:19186529..19186536,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr7:19186529..19186536, + |
3.49e-79 | FFCP PHASE1:Hg19::chr4:175041125..175041137,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:175041125..175041137, - |
3.49e-79 | FFCP PHASE2:Hg19::chr7:8276508..8276551,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p14@ICA1 |
3.49e-79 | FFCP PHASE2:Hg19::chr17:11389592..11389599,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr17:11389592..11389599, - |
3.49e-79 | FFCP PHASE1:Hg19::chr7:8302002..8302015,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p10@ICA1 |
3.49e-79 | FFCP PHASE1:Hg19::chr18:77044132..77044175,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr18:77044132..77044175, + |
3.49e-79 | FFCP PHASE2:Hg19::chr4:175041762..175041777,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p2@ENST00000503140 |
3.49e-79 | FFCP PHASE2:Hg19::chr7:8302002..8302015,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p10@ICA1 |
3.49e-79 | FFCP PHASE2:Hg19::chr4:174930472..174930480,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:174930472..174930480, - |
3.49e-79 | FFCP PHASE2:Hg19::chr11:71952706..71952712,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p4@PHOX2A |
3.49e-79 | FFCP PHASE1:Hg19::chr17:11389592..11389599,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr17:11389592..11389599, - |
3.49e-79 | FFCP PHASE1:Hg19::chr7:19185493..19185503,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p2@FERD3L |
3.49e-79 | FFCP PHASE1:Hg19::chr4:174954376..174954399,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:174954376..174954399, - |
3.49e-79 | FFCP PHASE1:Hg19::chr2:29728669..29728672,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr2:29728669..29728672, - |
3.49e-79 | FFCP PHASE2:Hg19::chr5:16180927..16180934,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p7@MARCH11 |
3.49e-79 | FFCP PHASE2:Hg19::chr2:16082933..16082942,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr2:16082933..16082942, + |
3.49e-79 | FFCP PHASE1:Hg19::chr7:8276855..8276873,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr7:8276855..8276873, + |
3.49e-79 | FFCP PHASE2:Hg19::chr2:29728669..29728672,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr2:29728669..29728672, - |
3.49e-79 | FFCP PHASE2:Hg19::chr7:19185559..19185569,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr7:19185559..19185569, - |
3.49e-79 | FFCP PHASE2:Hg19::chr18:56886837..56886844,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr18:56886837..56886844, + |
3.49e-79 | FFCP PHASE1:Hg19::chr4:175041762..175041777,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p2@ENST00000503140 |
3.49e-79 | FFCP PHASE2:Hg19::chr7:8276855..8276873,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr7:8276855..8276873, + |
3.49e-79 | FFCP PHASE1:Hg19::chr4:174930472..174930480,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:174930472..174930480, - |
3.49e-79 | FFCP PHASE1:Hg19::chr2:29747945..29747955,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr2:29747945..29747955, - |
3.49e-79 | FFCP PHASE1:Hg19::chr5:16180927..16180934,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p7@MARCH11 |
3.49e-79 | FFCP PHASE2:Hg19::chr2:29747945..29747955,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr2:29747945..29747955, - |
3.49e-79 | FFCP PHASE1:Hg19::chr13:36045103..36045110,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr13:36045103..36045110, + |
3.49e-79 | FFCP PHASE1:Hg19::chr2:16082933..16082942,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr2:16082933..16082942, + |
3.49e-79 | FFCP PHASE2:Hg19::chr2:30142997..30143009,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr2:30142997..30143009, - |
3.49e-79 | FFCP PHASE2:Hg19::chr7:19184929..19184938,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p4@FERD3L |
3.49e-79 | FFCP PHASE2:Hg19::chr4:174930493..174930503,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:174930493..174930503, - |
3.49e-79 | FFCP PHASE1:Hg19::chr7:19185559..19185569,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr7:19185559..19185569, - |
3.49e-79 | FFCP PHASE2:Hg19::chr13:36045103..36045110,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr13:36045103..36045110, + |
3.49e-79 | FFCP PHASE1:Hg19::chr13:37494987..37494992,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p23@SMAD9 |
3.49e-79 | FFCP PHASE1:Hg19::chr2:29894082..29894092,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr2:29894082..29894092, - |
3.49e-79 | FFCP PHASE1:Hg19::chr2:30142997..30143009,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr2:30142997..30143009, - |
3.49e-79 | FFCP PHASE2:Hg19::chr7:19185585..19185590,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr7:19185585..19185590, - |
3.49e-79 | FFCP PHASE2:Hg19::chr4:174968748..174968753,+#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:174968748..174968753, + |
3.49e-79 | FFCP PHASE2:Hg19::chr2:29894082..29894092,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr2:29894082..29894092, - |
3.49e-79 | FFCP PHASE1:Hg19::chr7:19184929..19184938,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p4@FERD3L |
3.49e-79 | FFCP PHASE1:Hg19::chr4:174930493..174930503,-#_2b3ee90e5aa590e2edc7823c5bac8eb6 | p@chr4:174930493..174930503, - |
Property "Property value" (as page type) with input value "UBPROP:0000001 "Part of the peripheral nervous system which regulates involuntary functions of the body and consists of the sympathetic and parasympathetic system.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.