Template:MCL coexpression mm9: Difference between revisions
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{{Loading|loadingimage=sprites.gif}}<html> | {{Loading|loadingimage=sprites.gif}}<html> | ||
<script type="text/javascript" language="javascript" src="/ | <script type="text/javascript" language="javascript" src="/5/sstar/rb_js/jquery-1.7.1.min.js"></script> | ||
<script type="text/javascript" language="javascript" src="/ | <script type="text/javascript" language="javascript" src="/5/sstar/rb_js/html5button/datatables.min.js"></script> | ||
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rexp_median_data.push([rexp_sample[i1], rexp_median_values[i1]]); | rexp_median_data.push([rexp_sample[i1], rexp_median_values[i1]]); | ||
} | } | ||
var coexpression_dpi_cluster_scores_table = $('#coexpression_dpi_cluster_scores_median_table').DataTable({ | |||
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data: rexp_median_data, | |||
var id = | columns: [{ title: "FF samples", orderable: false, render: function ( data, type, row, meta ) { | ||
var elems = id.split('.'); | var id = data; | ||
return | var elems = id.split('.'); | ||
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// ontology enrichment table | // ontology enrichment table | ||
$('.enrichment_list'). | |||
$('.enrichment_list').DataTable({ | |||
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}); | }); | ||
// ffcp list | // ffcp list | ||
$('.ffcp_list'). | var ffcp_list_table=$('.ffcp_list').DataTable({ | ||
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} ); | } ); | ||
</script> | </script> | ||
</html> | </html> | ||
<br> | |||
== Phase1 CAGE Peaks == | == Phase1 CAGE Peaks == | ||
{{#ask:[[Category:FFCP]][[FFCP_PHASE2:+]][[Species::Mouse (Mus musculus)]][[MCL_coexpression_id::{{PAGENAME}}]]|?Short_description|format=ttable|class=ffcp_list stripe cell-border order-column compact|limit=20000}} | |||
<br> | |||
{{ | {{Fontsize|3|Enriched pathways on this co-expression cluster}}{{#info:<b>Summary:</b> | ||
<br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont | |||
<br> | |||
<br>link to source dataset | |||
{{#info:The | <br>[//fantom.gsc.riken.jp/5/datafiles/phase1.1/extra/Co-expression_clusters/mm9_co-expression_modules.tar.gz data] | ||
}} | |||
<br> | |||
---- | |||
{{#if:{{{gostat_on_MCL_coexpression}}}| | {{#if:{{{gostat_on_MCL_coexpression}}}| | ||
<html> | <html> | ||
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// GOstat results table start | // GOstat results table start | ||
var oTable = $('#gostat_table'). | var oTable = $('#gostat_table').DataTable({ | ||
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columnDefs: [ { type: "html-num", targets: [2],render: function ( data, type, row, meta ) { | |||
var num =data; | |||
return exp_converter(num,2,"e"); | |||
} }], | |||
order: [[2,'asc']] | |||
}); | }); | ||
// GOstat results table end | // GOstat results table end | ||
}); | }); | ||
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</html> | </html> | ||
<table id="gostat_table" class="stripe cell-border order-column compact"><html><thead></html><tr><th>GO ID</th><th>GO name</th><th>FDR corrected p-value</th></tr><html></thead><tbody></html> | |||
< | |||
<tr> | <tr> | ||
{{#arraymap:{{{gostat_on_MCL_coexpression}}}|!|$ | {{#arraymap:{{{gostat_on_MCL_coexpression}}}|!|$ | ||
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|no results for this coexpression | |no results for this coexpression | ||
}} | }} | ||
<br><br> | |||
{{Fontsize|3|Relative expression of the co-expression cluster over median }}{{#info: <br>Analyst: }} | |||
---- | |||
<div id="relative_exp_of_coexp_table_button"></div><br> | |||
{{#info: <br>Analyst: }} | <table id="coexpression_dpi_cluster_scores_median_table" class="stripe cell-border order-column compact"></table> | ||
<table id="coexpression_dpi_cluster_scores_median_table"></table> | |||
{{#array_recordprops:coexpression_dpi_cluster_scores_median | {{#array_recordprops:coexpression_dpi_cluster_scores_median | ||
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| ||
|{{{coexpression_dpi_cluster_scores_median}}} | |{{{coexpression_dpi_cluster_scores_median}}} | ||
}} | }} | ||
<br><br> | |||
{{Fontsize|3|Enriched sample ontology terms on this co-expression cluster}}{{#info:<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji | |||
<br><br>links to source dataset<br><br> | |||
{{# | {{#if:{{{ontology_enrichment_celltype}}}|[//fantom.gsc.riken.jp/5/datafiles/phase1.1/extra/Sample_ontology_enrichment_of_coexpression_clusters/mcl_mm9_clusters_relative_exp_enrichment_cell_type.txt.gz cell_data]|}}<br> | ||
{{#if:{{{ontology_enrichment_uberon}}}|[//fantom.gsc.riken.jp/5/datafiles/phase1.1/extra/Sample_ontology_enrichment_of_coexpression_clusters/mcl_mm9_clusters_relative_exp_enrichment_uberon.txt.gz uberon_data]|}}<br> | |||
{{#if:{{{ontology_enrichment_disease}}}|[//fantom.gsc.riken.jp/5/datafiles/phase1.1/extra/Sample_ontology_enrichment_of_coexpression_clusters/mcl_mm9_clusters_relative_exp_enrichment_disease.txt.gz disease_data]|}}<br> | |||
}} | |||
---- | |||
{{#if:{{{ontology_enrichment_celltype}}}| | {{#if:{{{ontology_enrichment_celltype}}}| | ||
<div style="float:left;width:33%;"> | <div style="float:left;width:33%;"> | ||
<table class="enrichment_list"><caption class="table_title">Cell Type</caption><html><thead></html> | <table class="enrichment_list stripe cell-border order-column compact" id="enrichment_list_cell_type_table"><caption class="table_title">Cell Type</caption><html><thead></html> | ||
<tr><th>Ontology term</th><th>p-value</th><th>n</th></tr> | <tr><th>Ontology term</th><th>p-value</th><th>n</th></tr> | ||
<html></thead><tbody></html | <html></thead><tbody></html> | ||
{{#arraymap:{{{ontology_enrichment_celltype}}}|;|$ | {{#arraymap:{{{ontology_enrichment_celltype}}}|;|$ | ||
|{{# | |{{#ifexist:{{#explode:$|!|0}}|<tr><td>[[{{#explode:$|!|0}}|{{#show:{{#explode:$|!|0}}|?name}}]]</td><td>{{#explode:$|!|1}}</td><td>{{#explode:$|!|2}}</td></tr>| }} | ||
| | |||
}} | |||
<html></tbody></html></table> | <html></tbody></html></table> | ||
</div> | </div> | ||
}}{{#if:{{{ontology_enrichment_uberon}}}| | }}{{#if:{{{ontology_enrichment_uberon}}}| | ||
<div style="float:left;width:33%;"> | <div style="float:left;width:33%;"> | ||
<table class="enrichment_list"><caption class="table_title">Uber Anatomy</caption><html><thead></html> | <table class="enrichment_list stripe cell-border order-column compact" id="enrichment_list_uberon_table"><caption class="table_title">Uber Anatomy</caption><html><thead></html> | ||
<tr><th>Ontology term</th><th>p-value</th><th>n</th></tr> | <tr><th>Ontology term</th><th>p-value</th><th>n</th></tr> | ||
<html></thead><tbody></html | <html></thead><tbody></html> | ||
{{#arraymap:{{{ontology_enrichment_uberon}}}|;|$ | {{#arraymap:{{{ontology_enrichment_uberon}}}|;|$ | ||
|{{# | |{{#ifexist:{{#explode:$|!|0}}|<tr><td>[[{{#explode:$|!|0}}|{{#show:{{#explode:$|!|0}}|?name}}]]</td><td>{{#explode:$|!|1}}</td><td>{{#explode:$|!|2}}</td></tr>| }} | ||
|}} | |||
<html></tbody></html></table> | <html></tbody></html></table> | ||
</div> | </div> | ||
}}{{#if:{{{ontology_enrichment_disease}}}| | }}{{#if:{{{ontology_enrichment_disease}}}| | ||
<div style="float:left;width:33%;"> | <div style="float:left;width:33%;"> | ||
<table class="enrichment_list"><caption class="table_title">Disease</caption><html><thead></html> | <table class="enrichment_list stripe cell-border order-column compact" id="enrichment_list_disease_table"><caption class="table_title">Disease</caption><html><thead></html> | ||
<tr><th>Ontology term</th><th>p-value</th><th>n</th></tr> | <tr><th>Ontology term</th><th>p-value</th><th>n</th></tr> | ||
<html></thead><tbody></html | <html></thead><tbody></html> | ||
{{#arraymap:{{{ontology_enrichment_disease}}}|;|$ | {{#arraymap:{{{ontology_enrichment_disease}}}|;|$ | ||
|{{# | |{{#ifexist:{{#explode:$|!|0}}|<tr><td>[[{{#explode:$|!|0}}|{{#show:{{#explode:$|!|0}}|?name}}]]</td><td>{{#explode:$|!|1}}</td><td>{{#explode:$|!|2}}</td></tr>| }} | ||
|}} | |||
<html></tbody></html></table> | <html></tbody></html></table> | ||
</div> | </div> | ||
}} | }} | ||
<div style="clear:both;"></div> | <div style="clear:both;"></div> | ||
<br> | |||
{{Fontsize|3|TFBS overrepresentation}}{{#info:<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br> | |||
link to source data <br> Novel motifs <br> | |||
{{#info:The values shown are the p-values for | [//fantom.gsc.riken.jp/5/datafiles/phase1.1/extra/Co-expression_clusters/mm9.novel_motif.coexpression_clusters_overrepresentation.txt.gz data] <br> | ||
<br> Jaspar motifs <br> | |||
[//fantom.gsc.riken.jp/5/datafiles/phase1.1/extra/Co-expression_clusters/mm9.KNOWN_JASPAR_130.coexpression_clusters_overrepresentation.txt.gz data] | |||
}} | |||
---- | |||
<html> | <html> | ||
<script type="text/javascript"> | <script type="text/javascript"> | ||
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columns: [{ title: "Motifs", width: "300pt", orderable: true, render: function ( data, type, row, meta ) { | |||
var id = data; | |||
var elems = id.split('_')[0]; | |||
var motif_id=elems.substr(5,elems.length); | |||
return "<a href=\"/5/sstar/Novel_motif:"+motif_id+"\">"+decodeURIComponent(id)+"</a>"; | |||
} }, | |||
{ title: "-log10(p-value)",type: "html-num",render: function ( data, type, row, meta ) { | |||
var num =data; | |||
var num_as_number=Number(num); | |||
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var num =data; | |||
var num_as_number=Number(num); | |||
return num_as_number.toFixed(2) ; | |||
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{{Fontsize|3|Novel motifs}} | |||
<table id="tfbs_overexpression_table"></table> | <div id="tfbs_overexpression_novel_table_button"></div><br> | ||
<table id="tfbs_overexpression_table" class="stripe cell-border order-column compact"></table><br><br> | |||
<table id="tfbs_overexpression_jaspar"><html><thead></html> | {{Fontsize|3|JASPAR motifs}} | ||
<div id="tfbs_overexpression_jaspar_table_button"></div><br> | |||
<table id="tfbs_overexpression_jaspar" class="stripe cell-border order-column compact"><html><thead></html> | |||
<tr><th>Motifs</th><th>-log10(p-value)</th></tr><html></thead><tbody></html> | <tr><th>Motifs</th><th>-log10(p-value)</th></tr><html></thead><tbody></html> | ||
<tr><td> | <tr><td> | ||
Line 202: | Line 239: | ||
<html></tbody></html> | <html></tbody></html> | ||
</table> | </table> | ||
{{#set:cp_member_count={{#ask:[[Category:FFCP]][[Species::Mouse (Mus musculus)]][[MCL_coexpression_id::{{PAGENAME}}]]|format=count}}}} | {{#set:cp_member_count={{#ask:[[Category:FFCP]][[Species::Mouse (Mus musculus)]][[MCL_coexpression_id::{{PAGENAME}}]]|format=count}}}} | ||
[[Category:MCL_coexpression_mm9]] | [[Category:MCL_coexpression_mm9]] |
Latest revision as of 20:14, 4 July 2023
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
{{{gostat_on_MCL_coexpression}}} |
Relative expression of the co-expression cluster over median <br>Analyst:
"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
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Ontology term | p-value | n |
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Ontology term | p-value | n |
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TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
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{{{tfbs_overrepresentation_jaspar}}} |