Coexpression cluster:C3840

Full id: C3840_optic_cerebellum_Neutrophils_Eosinophils_occipital_skeletal_substantia

Phase1 CAGE Peaks

Hg19::chr1:10270620..10270637,+	p1@KIF1B
Hg19::chr1:10270675..10270686,+	p5@KIF1B
Hg19::chr5:147763388..147763474,-	p1@ENST00000501695 p1@uc003lpb.1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008089	anterograde axon cargo transport	0.00476863299187566
GO:0008088	axon cargo transport	0.00476863299187566
GO:0019894	kinesin binding	0.00476863299187566
GO:0007274	neuromuscular synaptic transmission	0.00476863299187566
GO:0007270	nerve-nerve synaptic transmission	0.00805369127516778
GO:0030659	cytoplasmic vesicle membrane	0.029936418226775
GO:0044433	cytoplasmic vesicle part	0.029936418226775
GO:0012506	vesicle membrane	0.029936418226775
GO:0003777	microtubule motor activity	0.0332038149063935
GO:0007018	microtubule-based movement	0.0346167432002826
GO:0005875	microtubule associated complex	0.0346167432002826
GO:0030705	cytoskeleton-dependent intracellular transport	0.0346167432002826
GO:0007268	synaptic transmission	0.0414458966207465
GO:0005874	microtubule	0.0414458966207465
GO:0007017	microtubule-based process	0.0414458966207465
GO:0019226	transmission of nerve impulse	0.0414458966207465
GO:0016023	cytoplasmic membrane-bound vesicle	0.0414458966207465
GO:0031988	membrane-bound vesicle	0.0414458966207465
GO:0031410	cytoplasmic vesicle	0.0457788767220064
GO:0031982	vesicle	0.0457788767220064

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.