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{{MCL_coexpression_mm9|gostat_on_MCL_coexpression=GO:0045659;negative regulation of neutrophil differentiation;0.0121075987508903;16331!GO:0045658;regulation of neutrophil differentiation;0.0121075987508903;16331!GO:0030852;regulation of granulocyte differentiation;0.0121075987508903;16331!GO:0045656;negative regulation of monocyte differentiation;0.0121075987508903;16331!GO:0045655;regulation of monocyte differentiation;0.0121075987508903;16331!GO:0030853;negative regulation of granulocyte differentiation;0.0121075987508903;16331!GO:0045409;negative regulation of interleukin-6 biosynthetic process;0.0121075987508903;16331!GO:0030223;neutrophil differentiation;0.0211848151878558;16331!GO:0030224;monocyte differentiation;0.0282417775969532;16331!GO:0045779;negative regulation of bone resorption;0.0302242529538034;16331!GO:0004115;3',5'-cyclic-AMP phosphodiesterase activity;0.0302242529538034;18578!GO:0045579;positive regulation of B cell differentiation;0.0302242529538034;16331!GO:0045648;positive regulation of erythrocyte differentiation;0.0302242529538034;16331!GO:0050777;negative regulation of immune response;0.0302242529538034;16331!GO:0002683;negative regulation of immune system process;0.0302242529538034;16331!GO:0045124;regulation of bone resorption;0.0302242529538034;16331!GO:0030851;granulocyte differentiation;0.0302242529538034;16331!GO:0008340;determination of adult life span;0.0302242529538034;16331!GO:0008270;zinc ion binding;0.0302242529538034;12785,76073,52521!GO:0030889;negative regulation of B cell proliferation;0.0302242529538034;16331!GO:0045671;negative regulation of osteoclast differentiation;0.0302242529538034;16331!GO:0002762;negative regulation of myeloid leukocyte differentiation;0.0302242529538034;16331!GO:0045408;regulation of interleukin-6 biosynthetic process;0.0302242529538034;16331!GO:0045577;regulation of B cell differentiation;0.0302242529538034;16331!GO:0045646;regulation of erythrocyte differentiation;0.0302242529538034;16331!GO:0010259;multicellular organismal aging;0.0302242529538034;16331!GO:0042036;negative regulation of cytokine biosynthetic process;0.0302242529538034;16331!GO:0042226;interleukin-6 biosynthetic process;0.0302242529538034;16331!GO:0050869;negative regulation of B cell activation;0.032094965763412;16331!GO:0042578;phosphoric ester hydrolase activity;0.0343631409171035;18578,16331!GO:0045639;positive regulation of myeloid cell differentiation;0.0343631409171035;16331!GO:0046851;negative regulation of bone remodeling;0.0343631409171035;16331!GO:0045621;positive regulation of lymphocyte differentiation;0.0358917949791537;16331!GO:0045453;bone resorption;0.0358917949791537;16331!GO:0045670;regulation of osteoclast differentiation;0.0358917949791537;16331!GO:0042127;regulation of cell proliferation;0.0358917949791537;12785,16331!GO:0032635;interleukin-6 production;0.0358917949791537;16331!GO:0046914;transition metal ion binding;0.0358917949791537;12785,76073,52521!GO:0002761;regulation of myeloid leukocyte differentiation;0.0382274712110252;16331!GO:0050672;negative regulation of lymphocyte proliferation;0.0382274712110252;16331!GO:0032945;negative regulation of mononuclear cell proliferation;0.0382274712110252;16331!GO:0045638;negative regulation of myeloid cell differentiation;0.0382274712110252;16331!GO:0030316;osteoclast differentiation;0.0392971843375408;16331!GO:0030888;regulation of B cell proliferation;0.0403176442248182;16331!GO:0006695;cholesterol biosynthetic process;0.0406397771232482;12785!GO:0045619;regulation of lymphocyte differentiation;0.0406397771232482;16331!GO:0004114;3',5'-cyclic-nucleotide phosphodiesterase activity;0.0406397771232482;18578!GO:0017148;negative regulation of translation;0.0406397771232482;16331!GO:0051250;negative regulation of lymphocyte activation;0.0406397771232482;16331!GO:0001894;tissue homeostasis;0.0406397771232482;16331!GO:0031327;negative regulation of cellular biosynthetic process;0.0406397771232482;16331!GO:0048871;multicellular organismal homeostasis;0.0406397771232482;16331!GO:0004112;cyclic-nucleotide phosphodiesterase activity;0.0406397771232482;18578!GO:0050871;positive regulation of B cell activation;0.0406397771232482;16331!GO:0042100;B cell proliferation;0.0414287135628179;16331!GO:0007568;aging;0.0414670987599829;16331!GO:0051241;negative regulation of multicellular organismal process;0.0414670987599829;16331!GO:0046850;regulation of bone remodeling;0.0414670987599829;16331!GO:0016126;sterol biosynthetic process;0.0414670987599829;12785!GO:0004437;inositol or phosphatidylinositol phosphatase activity;0.0421751190266734;16331!GO:0009890;negative regulation of biosynthetic process;0.0439822517988457;16331!GO:0008283;cell proliferation;0.0439822517988457;12785,16331!GO:0045637;regulation of myeloid cell differentiation;0.0460911603436185;16331!GO:0030183;B cell differentiation;0.0460911603436185;16331!GO:0030218;erythrocyte differentiation;0.0472329066675493;16331!GO:0050864;regulation of B cell activation;0.0472329066675493;16331!}}
{{MCL_coexpression_mm9
|coexpression_dpi_cluster_scores_mean=0.0287781952372142,-0.0346621525704144,-0.0326958150641656,-0.0740780901639147,-0.140703115401241,-0.083779344455414,-0.0496788546947454,0.40234462718467,0.859789119347795,0.906646008517136,0.29875904847135,0.268956253693993,0.377324001155336,0.382625042554537,0.101607864372225,0.152755961176129,-0.00501551588502964,0.441623523361117,0.459326870439635,0.460693395308585,0.0916590436608294,0.269594889792394,0.264220422700634,0.0839914516032434,0.099325478819893,-0.0643158211385621,-0.0747434113019076,-0.0841601209400993,-0.11744178129474,-0.134820867457348,-0.0706786698173002,-0.0632290384844081,-0.113283312631591,-0.291890500235516,-0.111011072810615,-0.129381114989617,-0.0984122160467283,0.452804957057403,0.39892906946945,0.290912013889395,0.515262391649951,0.555767895006422,0.434503559255426,0.0823093535016036,0.0729059758188185,0.0687989797177727,-0.063279081638024,-0.128851464682141,-0.139666578505915,-0.103562489772703,-0.146832524162383,-0.227024983971797,0.821835512339838,0.671268990931685,0.709890989328253,0.0275898574602949,0.0561714595264345,0.00635134248232412,-0.114064178678001,-0.121745349307543,-0.12040747770813,-0.175433371041241,-0.156958924555452,-0.0499003531813261,-0.0408113984110696,-0.0393588696317477,-0.0592021040050848,-0.0461861501782375,-0.0815744542995137,-0.126312456662902,-0.132974508259768,-0.0404690905417566,-0.054642785490792,-0.125735301700934,-0.10781241231532,-0.123928361952476,0.0161530754446356,0.030355666346306,0.0633405313146211,-0.123753382058603,-0.0930027378709915,-0.107664434402766,-0.0147518433332193,-0.00557903997186939,0.05836979682017,-0.0377539618023476,-0.0185800322176154,-0.079195991275952,-0.0182548377024281,-0.067100203508381,0.370331947483014,0.0887419906090653,0.162381284911606,0.0399869109546977,0.00764986213512006,0.061711144937188,0.0424722890606033,-0.00808739197380153,-0.0518577637824842,-0.0768938081468668,0.0177993772409357,0.109880137472561,0.0981948261678077,-0.109942346827106,-0.107245088028388,-0.096459747098923,-0.0995944583063482,0.085163752036845,0.459383055259601,0.036410199561208,-0.0856500491744653,-0.0279772975432286,-0.035189267783876,-0.0581573617728452,0.0729607057382407,-0.0557167074670451,0.177559070685753,0.103967533299829,0.166281013359326,0.0826288856427995,0.176838136457173,0.147623220832378,-0.090469391270408,0.00732755292938171,0.0151427568120226,0.0137377648646805,0.897912745847599,0.734426741093449,0.785620036368501,0.0352334798080827,0.0668615509354552,-0.0195596016452256,0.110693010684213,0.12014188746639,0.0696706238784311,0.0888809251045526,0.0361827268254381,0.145802651808052,-0.0188126418489531,-0.0191069318644553,-0.0564184281692876,-0.0472799064469539,-0.0462941581730391,0.0457298359042323,0.133431893548845,0.108179140897792,0.0888044606152753,0.0644026462534831,-0.102400774712408,-0.0862574167938206,-0.0741352872477213,-0.0650613149907614,-0.0473161384474596,-0.00502411204610797,0.0541456642541094,-0.110585495861665,0.538006463460856,0.516631195245191,0.52235378328149,-0.0232702198523036,-0.0156947859398084,0.00655135407235777,-0.0118435842563742,-0.0217186978905661,-0.0164414563908233,0.0399412374040126,0.0529419262890331,0.0543712263817245,0.0490921135301759,0.0778527621047913,0.0764382399072133,0.0746626282388577,0.0747749865602954,0.099941945145038,0.0780386578562344,-0.0170735303377242,0.00947984022007737,-0.110409824979626,-0.0995548144773977,-0.0682671040074853,-0.0928299555575262,-0.077834483877181,-0.0757417446328869,-0.06655163327677,0.00314060482724151,-0.041044060019446,-0.0471130923420914,-0.00269974574659364,-0.0127159661314967,-0.0862125561704125,-0.0408568350503413,-0.00229452170360487,-0.1534194681391,-0.0934538186987873,-0.145134369626158,-0.0675823723265866,-0.0737925457256993,-0.040716906716212,-0.0413623854900422,-0.0247650221452329,-0.0602167679454151,0.00167451864313055,0.0499498133158513,0.0213771035912311,0.0488225825588348,0.0319240416913437,0.0811074944362697,0.0575081467478509,0.0523720175161077,0.0921411210521815,0.167152232317169,0.0470897746650353,0.124833791198556,0.126212066422964,0.0878769311361491,0.0517772462791706,0.0516665090833467,0.117467664959682,0.222538592188088,-0.0651434088555212,0.00174248038459844,-0.0384663300343074,-0.0257540222433467,0.033603338123341,0.0776374173440544,0.154333216865739,0.168483064195934,0.163736840446357,0.102885879119045,0.21268640344365,0.165941122379701,0.234165515783377,0.0249562403427134,0.0699011264812962,0.0635225447517528,0.0432534702215866,0.0256610554443831,0.0747273629310056,0.062386081050951,0.109186495472647,-0.0251191473053939,-0.0312340591688278,-0.0129376684392041,-0.0201516799496502,-0.0146756005392024,0.00287043767121376,0.00731583765761572,-0.0439131741124725,-0.00362167166861376,0.0860520128580868,-0.0131952731688437,-0.0594979549963075,-0.0132129259577854,0.0342846770285664,-0.0636610953337914,-0.0978167949205714,-0.107293168128347,-0.0471010088490614,-0.103452848489047,-0.0606723681239439,0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|gostat_on_MCL_coexpression=GO:0045659;negative regulation of neutrophil differentiation;0.0121075987508903;16331!GO:0045658;regulation of neutrophil differentiation;0.0121075987508903;16331!GO:0030852;regulation of granulocyte differentiation;0.0121075987508903;16331!GO:0045656;negative regulation of monocyte differentiation;0.0121075987508903;16331!GO:0045655;regulation of monocyte differentiation;0.0121075987508903;16331!GO:0030853;negative regulation of granulocyte differentiation;0.0121075987508903;16331!GO:0045409;negative regulation of interleukin-6 biosynthetic process;0.0121075987508903;16331!GO:0030223;neutrophil differentiation;0.0211848151878558;16331!GO:0030224;monocyte differentiation;0.0282417775969532;16331!GO:0045779;negative regulation of bone resorption;0.0302242529538034;16331!GO:0004115;3',5'-cyclic-AMP phosphodiesterase activity;0.0302242529538034;18578!GO:0045579;positive regulation of B cell differentiation;0.0302242529538034;16331!GO:0045648;positive regulation of erythrocyte differentiation;0.0302242529538034;16331!GO:0050777;negative regulation of immune response;0.0302242529538034;16331!GO:0002683;negative regulation of immune system process;0.0302242529538034;16331!GO:0045124;regulation of bone resorption;0.0302242529538034;16331!GO:0030851;granulocyte differentiation;0.0302242529538034;16331!GO:0008340;determination of adult life span;0.0302242529538034;16331!GO:0008270;zinc ion binding;0.0302242529538034;12785,76073,52521!GO:0030889;negative regulation of B cell proliferation;0.0302242529538034;16331!GO:0045671;negative regulation of osteoclast differentiation;0.0302242529538034;16331!GO:0002762;negative regulation of myeloid leukocyte differentiation;0.0302242529538034;16331!GO:0045408;regulation of interleukin-6 biosynthetic process;0.0302242529538034;16331!GO:0045577;regulation of B cell differentiation;0.0302242529538034;16331!GO:0045646;regulation of erythrocyte differentiation;0.0302242529538034;16331!GO:0010259;multicellular organismal aging;0.0302242529538034;16331!GO:0042036;negative regulation of cytokine biosynthetic process;0.0302242529538034;16331!GO:0042226;interleukin-6 biosynthetic process;0.0302242529538034;16331!GO:0050869;negative regulation of B cell activation;0.032094965763412;16331!GO:0042578;phosphoric ester hydrolase activity;0.0343631409171035;18578,16331!GO:0045639;positive regulation of myeloid cell differentiation;0.0343631409171035;16331!GO:0046851;negative regulation of bone remodeling;0.0343631409171035;16331!GO:0045621;positive regulation of lymphocyte differentiation;0.0358917949791537;16331!GO:0045453;bone resorption;0.0358917949791537;16331!GO:0045670;regulation of osteoclast differentiation;0.0358917949791537;16331!GO:0042127;regulation of cell proliferation;0.0358917949791537;12785,16331!GO:0032635;interleukin-6 production;0.0358917949791537;16331!GO:0046914;transition metal ion binding;0.0358917949791537;12785,76073,52521!GO:0002761;regulation of myeloid leukocyte differentiation;0.0382274712110252;16331!GO:0050672;negative regulation of lymphocyte proliferation;0.0382274712110252;16331!GO:0032945;negative regulation of mononuclear cell proliferation;0.0382274712110252;16331!GO:0045638;negative regulation of myeloid cell differentiation;0.0382274712110252;16331!GO:0030316;osteoclast differentiation;0.0392971843375408;16331!GO:0030888;regulation of B cell proliferation;0.0403176442248182;16331!GO:0006695;cholesterol biosynthetic process;0.0406397771232482;12785!GO:0045619;regulation of lymphocyte differentiation;0.0406397771232482;16331!GO:0004114;3',5'-cyclic-nucleotide phosphodiesterase activity;0.0406397771232482;18578!GO:0017148;negative regulation of translation;0.0406397771232482;16331!GO:0051250;negative regulation of lymphocyte activation;0.0406397771232482;16331!GO:0001894;tissue homeostasis;0.0406397771232482;16331!GO:0031327;negative regulation of cellular biosynthetic process;0.0406397771232482;16331!GO:0048871;multicellular organismal homeostasis;0.0406397771232482;16331!GO:0004112;cyclic-nucleotide phosphodiesterase activity;0.0406397771232482;18578!GO:0050871;positive regulation of B cell activation;0.0406397771232482;16331!GO:0042100;B cell proliferation;0.0414287135628179;16331!GO:0007568;aging;0.0414670987599829;16331!GO:0051241;negative regulation of multicellular organismal process;0.0414670987599829;16331!GO:0046850;regulation of bone remodeling;0.0414670987599829;16331!GO:0016126;sterol biosynthetic process;0.0414670987599829;12785!GO:0004437;inositol or phosphatidylinositol phosphatase activity;0.0421751190266734;16331!GO:0009890;negative regulation of biosynthetic process;0.0439822517988457;16331!GO:0008283;cell proliferation;0.0439822517988457;12785,16331!GO:0045637;regulation of myeloid cell differentiation;0.0460911603436185;16331!GO:0030183;B cell differentiation;0.0460911603436185;16331!GO:0030218;erythrocyte differentiation;0.0472329066675493;16331!GO:0050864;regulation of B cell activation;0.0472329066675493;16331!
}}

Revision as of 11:07, 11 October 2012


Phase1 CAGE Peaks

 Short description
Mm9::chr15:25914217..25914232,+p3@Zfp622
Mm9::chr17:36005563..36005592,+p@chr17:36005563..36005592
+
Mm9::chr19:36422775..36422803,+p5@Pcgf5
Mm9::chr19:36422807..36422843,+p2@Pcgf5
Mm9::chr19:36424066..36424074,+p@chr19:36424066..36424074
+
Mm9::chr1:89516881..89516898,+p2@Inpp5d
Mm9::chr4:102243160..102243173,+p7@Pde4b
Mm9::chr4:102243191..102243223,+p1@Pde4b
Mm9::chr4:102258666..102258669,+p@chr4:102258666..102258669
+
Mm9::chr4:120689752..120689804,-p2@Smap2
Mm9::chr4:140255901..140255913,+p@chr4:140255901..140255913
+
Mm9::chr6:124679957..124679972,-p@chr6:124679957..124679972
-
Mm9::chr6:128789641..128789666,-p@chr6:128789641..128789666
-
Mm9::chr6:87800966..87800977,-p2@Cnbp
Mm9::chr8:26311787..26311816,-p4@Tacc1
Mm9::chr8:86773565..86773580,-p2@D8Ertd738e
Mm9::chr9:64659258..64659283,+p1@Dennd4a
Mm9::chr9:64659291..64659310,+p2@Dennd4a
Mm9::chr9:64659311..64659314,+p6@Dennd4a
Mm9::chr9:64659338..64659345,+p5@Dennd4a
Mm9::chrX:12649180..12649195,+p@chrX:12649180..12649195
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0045659negative regulation of neutrophil differentiation0.0121075987508903
GO:0045658regulation of neutrophil differentiation0.0121075987508903
GO:0030852regulation of granulocyte differentiation0.0121075987508903
GO:0045656negative regulation of monocyte differentiation0.0121075987508903
GO:0045655regulation of monocyte differentiation0.0121075987508903
GO:0030853negative regulation of granulocyte differentiation0.0121075987508903
GO:0045409negative regulation of interleukin-6 biosynthetic process0.0121075987508903
GO:0030223neutrophil differentiation0.0211848151878558
GO:0030224monocyte differentiation0.0282417775969532
GO:0045779negative regulation of bone resorption0.0302242529538034
GO:00041153',5'-cyclic-AMP phosphodiesterase activity0.0302242529538034
GO:0045579positive regulation of B cell differentiation0.0302242529538034
GO:0045648positive regulation of erythrocyte differentiation0.0302242529538034
GO:0050777negative regulation of immune response0.0302242529538034
GO:0002683negative regulation of immune system process0.0302242529538034
GO:0045124regulation of bone resorption0.0302242529538034
GO:0030851granulocyte differentiation0.0302242529538034
GO:0008340determination of adult life span0.0302242529538034
GO:0008270zinc ion binding0.0302242529538034
GO:0030889negative regulation of B cell proliferation0.0302242529538034
GO:0045671negative regulation of osteoclast differentiation0.0302242529538034
GO:0002762negative regulation of myeloid leukocyte differentiation0.0302242529538034
GO:0045408regulation of interleukin-6 biosynthetic process0.0302242529538034
GO:0045577regulation of B cell differentiation0.0302242529538034
GO:0045646regulation of erythrocyte differentiation0.0302242529538034
GO:0010259multicellular organismal aging0.0302242529538034
GO:0042036negative regulation of cytokine biosynthetic process0.0302242529538034
GO:0042226interleukin-6 biosynthetic process0.0302242529538034
GO:0050869negative regulation of B cell activation0.032094965763412
GO:0042578phosphoric ester hydrolase activity0.0343631409171035
GO:0045639positive regulation of myeloid cell differentiation0.0343631409171035
GO:0046851negative regulation of bone remodeling0.0343631409171035
GO:0045621positive regulation of lymphocyte differentiation0.0358917949791537
GO:0045453bone resorption0.0358917949791537
GO:0045670regulation of osteoclast differentiation0.0358917949791537
GO:0042127regulation of cell proliferation0.0358917949791537
GO:0032635interleukin-6 production0.0358917949791537
GO:0046914transition metal ion binding0.0358917949791537
GO:0002761regulation of myeloid leukocyte differentiation0.0382274712110252
GO:0050672negative regulation of lymphocyte proliferation0.0382274712110252
GO:0032945negative regulation of mononuclear cell proliferation0.0382274712110252
GO:0045638negative regulation of myeloid cell differentiation0.0382274712110252
GO:0030316osteoclast differentiation0.0392971843375408
GO:0030888regulation of B cell proliferation0.0403176442248182
GO:0006695cholesterol biosynthetic process0.0406397771232482
GO:0045619regulation of lymphocyte differentiation0.0406397771232482
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity0.0406397771232482
GO:0017148negative regulation of translation0.0406397771232482
GO:0051250negative regulation of lymphocyte activation0.0406397771232482
GO:0001894tissue homeostasis0.0406397771232482
GO:0031327negative regulation of cellular biosynthetic process0.0406397771232482
GO:0048871multicellular organismal homeostasis0.0406397771232482
GO:0004112cyclic-nucleotide phosphodiesterase activity0.0406397771232482
GO:0050871positive regulation of B cell activation0.0406397771232482
GO:0042100B cell proliferation0.0414287135628179
GO:0007568aging0.0414670987599829
GO:0051241negative regulation of multicellular organismal process0.0414670987599829
GO:0046850regulation of bone remodeling0.0414670987599829
GO:0016126sterol biosynthetic process0.0414670987599829
GO:0004437inositol or phosphatidylinositol phosphatase activity0.0421751190266734
GO:0009890negative regulation of biosynthetic process0.0439822517988457
GO:0008283cell proliferation0.0439822517988457
GO:0045637regulation of myeloid cell differentiation0.0460911603436185
GO:0030183B cell differentiation0.0460911603436185
GO:0030218erythrocyte differentiation0.0472329066675493
GO:0050864regulation of B cell activation0.0472329066675493



Relative expression of the co-expression cluster over median <br>Analyst:



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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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