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{{MCL_coexpression_mm9|gostat_on_MCL_coexpression=GO:0008104;protein localization;0.0320997394001498;69162,69608,66913,21405!GO:0033036;macromolecule localization;0.0320997394001498;69162,69608,66913,21405!GO:0046483;heterocycle metabolic process;0.0320997394001498;18453,21405!GO:0043691;reverse cholesterol transport;0.0320997394001498;21405!GO:0005046;KDEL sequence binding;0.0320997394001498;66913!GO:0015721;bile acid and bile salt transport;0.0320997394001498;21405!GO:0004656;procollagen-proline 4-dioxygenase activity;0.0320997394001498;18453!GO:0018401;peptidyl-proline hydroxylation to 4-hydroxy-L-proline;0.0320997394001498;18453!GO:0019511;peptidyl-proline hydroxylation;0.0320997394001498;18453!GO:0031545;peptidyl-proline 4-dioxygenase activity;0.0320997394001498;18453!GO:0046923;ER retention sequence binding;0.0320997394001498;66913!GO:0006621;protein retention in ER;0.0320997394001498;66913!GO:0019471;4-hydroxyproline metabolic process;0.0320997394001498;18453!GO:0009743;response to carbohydrate stimulus;0.0320997394001498;21405!GO:0006699;bile acid biosynthetic process;0.0320997394001498;21405!GO:0009746;response to hexose stimulus;0.0320997394001498;21405!GO:0009749;response to glucose stimulus;0.0320997394001498;21405!GO:0018208;peptidyl-proline modification;0.0320997394001498;18453!GO:0006810;transport;0.0320997394001498;69162,69608,20535,66913,21405!GO:0015908;fatty acid transport;0.0320997394001498;21405!GO:0051234;establishment of localization;0.0320997394001498;69162,69608,20535,66913,21405!GO:0015031;protein transport;0.0320997394001498;69162,69608,66913!GO:0048341;paraxial mesoderm formation;0.0320997394001498;21405!GO:0031543;peptidyl-proline dioxygenase activity;0.0320997394001498;18453!GO:0019798;procollagen-proline dioxygenase activity;0.0320997394001498;18453!GO:0015718;monocarboxylic acid transport;0.0320997394001498;21405!GO:0032507;maintenance of cellular protein localization;0.0320997394001498;66913!GO:0042802;identical protein binding;0.0320997394001498;73137,21405!GO:0045184;establishment of protein localization;0.0320997394001498;69162,69608,66913!GO:0016864;intramolecular oxidoreductase activity, transposing S-S bonds;0.0320997394001498;18453!GO:0003756;protein disulfide isomerase activity;0.0320997394001498;18453!GO:0031018;endocrine pancreas development;0.0320997394001498;21405!GO:0005783;endoplasmic reticulum;0.0326021141895586;69162,18453,66913!GO:0051651;maintenance of cellular localization;0.0326021141895586;66913!GO:0016862;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;0.0326021141895586;18453!GO:0005452;inorganic anion exchanger activity;0.0326021141895586;20535!GO:0005048;signal sequence binding;0.0338486238688349;66913!GO:0048340;paraxial mesoderm morphogenesis;0.0338486238688349;21405!GO:0045185;maintenance of protein localization;0.0338486238688349;66913!GO:0051179;localization;0.0343283832004196;69162,69608,20535,66913,21405!GO:0015380;anion exchanger activity;0.0350596560803832;20535!GO:0008206;bile acid metabolic process;0.0350596560803832;21405!GO:0015106;bicarbonate transmembrane transporter activity;0.0350596560803832;20535!GO:0050796;regulation of insulin secretion;0.0350596560803832;21405!GO:0015301;anion:anion antiporter activity;0.0350596560803832;20535!GO:0006783;heme biosynthetic process;0.0350596560803832;21405!GO:0015108;chloride transmembrane transporter activity;0.0373555961627596;20535!GO:0006779;porphyrin biosynthetic process;0.0373555961627596;21405!GO:0048339;paraxial mesoderm development;0.0373555961627596;21405!GO:0033014;tetrapyrrole biosynthetic process;0.0373555961627596;21405!GO:0031016;pancreas development;0.0373555961627596;21405!GO:0045120;pronucleus;0.0385486000284395;21405!GO:0030301;cholesterol transport;0.0385486000284395;21405!GO:0015918;sterol transport;0.0385486000284395;21405!GO:0051235;maintenance of localization;0.0385486000284395;66913!GO:0045453;bone resorption;0.0385486000284395;21405!GO:0001750;photoreceptor outer segment;0.0385486000284395;21405!GO:0042168;heme metabolic process;0.0404007155440419;21405!GO:0031513;nonmotile primary cilium;0.0421889621772222;21405!GO:0033013;tetrapyrrole metabolic process;0.0431965906050089;21405!GO:0006778;porphyrin metabolic process;0.0431965906050089;21405!GO:0046883;regulation of hormone secretion;0.0472013970439534;21405!GO:0001889;liver development;0.0484875740425892;21405!GO:0042592;homeostatic process;0.0484875740425892;18453,21405!GO:0030111;regulation of Wnt receptor signaling pathway;0.049503468730572;21405!}}
{{MCL_coexpression_mm9
|coexpression_dpi_cluster_scores_mean=-0.0207116916800058,0.733197101480648,0.687087086075529,0.766422418551891,0.775126893111973,0.3719396801164,0.418758557532078,-0.32816288573284,-0.211918723203028,-0.233766138620426,-0.251225933776869,-0.258422179766117,-0.323732145224908,-0.338727936537395,-0.112971300296006,-0.20024223418871,-0.164563521907533,-0.285474532572689,-0.246203459802081,-0.286763155109108,0.00569471345511119,-0.252318492761894,-0.290085021007363,0.490938392195646,0.473525421475795,0.59650003734451,0.469309062771565,0.516704465717422,0.534958993131849,0.444154675753332,0.407953857627315,-0.143992041841178,-0.155264369691296,-0.389586929374729,-0.016328514097066,0.0499652054233021,0.0100902416629549,-0.251667856514718,-0.220628518003679,-0.239515604719485,-0.333794065857911,-0.328279974708357,-0.258361392412319,0.0723880586834344,0.0702580751817396,0.0594691671189428,0.113201932970484,0.0307162402556675,0.111999800285691,0.152961697845762,0.103369981236584,0.0229173775554239,-0.309913826097747,-0.278707493299111,-0.257769450637644,0.196943724094196,0.167874539947998,0.122299060473356,-0.180728998282696,-0.179335702919797,-0.148007892449341,0.190428588861232,0.18263824289796,0.0361101949160712,0.0497742182251869,0.0415009523009996,0.0242267638000552,0.0119295961581787,-0.161449141568121,-0.177712043279838,-0.161976927356724,-0.139046950462489,-0.132114079260397,-0.196848123107599,-0.205469235136059,-0.192865809571489,-0.221779770327706,-0.155226323931881,-0.165851660934047,-0.187040292357755,-0.176556628600367,-0.196154285327871,-0.165860739102506,-0.197437326253194,-0.150991142633012,-0.137195012263851,-0.146590353212582,-0.160592300780403,-0.0747769312250853,-0.0725801741462594,0.047366202528015,0.32655215742683,0.480251420738596,0.58918467853428,0.600032207434855,0.573234515940447,0.257458338646459,0.0360301816800333,-0.0143704285897779,0.000379906990430751,-0.0164754088506843,0.0503417952336496,0.0451654274233003,0.120021340726353,-0.0593996843458325,-0.060412133055463,-0.0394042407814869,0.390609462775675,-0.0567382034395455,0.0143265492279663,0.0157093319407015,0.0231495158994677,0.00870596052660011,-0.012411746100229,0.00160210834704809,-0.0118621590214666,0.289980881276714,-0.0480398340150288,-0.0650513652378368,0.0872536092613612,0.0179021905839748,0.0571034746313845,0.30345805345681,-0.286988528748965,-0.238977502457603,0.586650844602379,-0.2034254497482,-0.136373229684579,-0.156259015012454,-0.252142858572064,-0.258427305112626,-0.263624137327088,-0.280962958429385,-0.273082438734034,-0.225281424022261,-0.256658674416458,0.0901171108762221,0.0811872346676225,0.217141665830747,-0.0336779607727293,-0.107947974186651,-0.0699153491224014,-0.0400937422647026,-0.0294901355089579,-0.0741533182094182,-0.0672918398518521,-0.0834505440697374,-0.108247254805345,-0.0343160370089657,-0.0205565853150302,0.00509199275557968,0.0447605578000328,0.0257144518768399,0.114739918190722,0.0660089673228613,-0.0378768931724122,-0.09099475391414,-0.0349463052979836,-0.0663252933739492,-0.00740122941253793,0.0320599761799528,-0.00451889958157083,-0.0130630771535556,-0.0382040657410177,-0.0468637031875472,-0.0476305009402584,-0.0227594829110704,-0.0414383066162582,-0.0318385500954074,-0.0378047116030771,-0.0734053355752152,-0.0585740410319389,-0.0743964134599464,-0.0703423084208723,-0.213715823621389,-0.192809226670439,0.750275514276091,0.797617787939237,-0.0148388457323336,-0.0135618949241657,0.160932172527741,0.354662488082654,0.425591563919064,0.456927049489462,0.585462225012066,0.547166498340759,0.437266704887568,0.466325508381771,0.486585527867735,0.581184880862277,0.534252249782851,0.5339495778139,0.0103096341817735,0.00122766683602461,0.015905510565377,0.0484311701894484,0.0380129965012317,0.0880693256308161,0.0779864731116422,0.126106706555436,0.104409316703713,0.123976166281547,0.57380201832261,0.0115096635384928,0.0688649778128151,0.075067942322235,0.146215805764611,0.231117739865788,0.24353622609873,0.337740342426574,0.27599019274937,0.323724173910747,0.437048226865874,0.450897862324626,0.449139974793684,0.496864593968275,0.555673311035195,0.445686866210359,0.0912895733785224,-0.00941385081529658,0.0313042000959528,-0.0229817747072465,-0.0433463199505443,0.00353881469684074,0.0206902103468086,0.0265878898842133,0.0567460100716574,0.0479693679586833,0.0246567297065074,0.0328791481263514,0.0673676736923899,0.0309622892036195,-0.161815548728784,-0.0953207136398115,0.264979068431072,0.161906212096983,-0.190970467216217,-0.161767344625386,0.0759792483083082,-0.0635328278125192,-0.0718786378815489,-0.0783085608187481,-0.103005282814843,-0.0694358570927527,-0.0899565587041414,-0.0765174714892828,-0.0803678733543732,-0.0651059394935537,-0.0836050127981353,-0.271985716114237,0.0268637774774366,0.0625418102188186,0.0676370433228487,0.0538440313963517,0.774822014196909,0.125501314383552,0.253062844232626,0.459864943922003,0.588482793197376,0.493521449274969,0.364453356532907,0.346243916822055,0.401698250439648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|gostat_on_MCL_coexpression=GO:0008104;protein localization;0.0320997394001498;69162,69608,66913,21405!GO:0033036;macromolecule localization;0.0320997394001498;69162,69608,66913,21405!GO:0046483;heterocycle metabolic process;0.0320997394001498;18453,21405!GO:0043691;reverse cholesterol transport;0.0320997394001498;21405!GO:0005046;KDEL sequence binding;0.0320997394001498;66913!GO:0015721;bile acid and bile salt transport;0.0320997394001498;21405!GO:0004656;procollagen-proline 4-dioxygenase activity;0.0320997394001498;18453!GO:0018401;peptidyl-proline hydroxylation to 4-hydroxy-L-proline;0.0320997394001498;18453!GO:0019511;peptidyl-proline hydroxylation;0.0320997394001498;18453!GO:0031545;peptidyl-proline 4-dioxygenase activity;0.0320997394001498;18453!GO:0046923;ER retention sequence binding;0.0320997394001498;66913!GO:0006621;protein retention in ER;0.0320997394001498;66913!GO:0019471;4-hydroxyproline metabolic process;0.0320997394001498;18453!GO:0009743;response to carbohydrate stimulus;0.0320997394001498;21405!GO:0006699;bile acid biosynthetic process;0.0320997394001498;21405!GO:0009746;response to hexose stimulus;0.0320997394001498;21405!GO:0009749;response to glucose stimulus;0.0320997394001498;21405!GO:0018208;peptidyl-proline modification;0.0320997394001498;18453!GO:0006810;transport;0.0320997394001498;69162,69608,20535,66913,21405!GO:0015908;fatty acid transport;0.0320997394001498;21405!GO:0051234;establishment of localization;0.0320997394001498;69162,69608,20535,66913,21405!GO:0015031;protein transport;0.0320997394001498;69162,69608,66913!GO:0048341;paraxial mesoderm formation;0.0320997394001498;21405!GO:0031543;peptidyl-proline dioxygenase activity;0.0320997394001498;18453!GO:0019798;procollagen-proline dioxygenase activity;0.0320997394001498;18453!GO:0015718;monocarboxylic acid transport;0.0320997394001498;21405!GO:0032507;maintenance of cellular protein localization;0.0320997394001498;66913!GO:0042802;identical protein binding;0.0320997394001498;73137,21405!GO:0045184;establishment of protein localization;0.0320997394001498;69162,69608,66913!GO:0016864;intramolecular oxidoreductase activity, transposing S-S bonds;0.0320997394001498;18453!GO:0003756;protein disulfide isomerase activity;0.0320997394001498;18453!GO:0031018;endocrine pancreas development;0.0320997394001498;21405!GO:0005783;endoplasmic reticulum;0.0326021141895586;69162,18453,66913!GO:0051651;maintenance of cellular localization;0.0326021141895586;66913!GO:0016862;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;0.0326021141895586;18453!GO:0005452;inorganic anion exchanger activity;0.0326021141895586;20535!GO:0005048;signal sequence binding;0.0338486238688349;66913!GO:0048340;paraxial mesoderm morphogenesis;0.0338486238688349;21405!GO:0045185;maintenance of protein localization;0.0338486238688349;66913!GO:0051179;localization;0.0343283832004196;69162,69608,20535,66913,21405!GO:0015380;anion exchanger activity;0.0350596560803832;20535!GO:0008206;bile acid metabolic process;0.0350596560803832;21405!GO:0015106;bicarbonate transmembrane transporter activity;0.0350596560803832;20535!GO:0050796;regulation of insulin secretion;0.0350596560803832;21405!GO:0015301;anion:anion antiporter activity;0.0350596560803832;20535!GO:0006783;heme biosynthetic process;0.0350596560803832;21405!GO:0015108;chloride transmembrane transporter activity;0.0373555961627596;20535!GO:0006779;porphyrin biosynthetic process;0.0373555961627596;21405!GO:0048339;paraxial mesoderm development;0.0373555961627596;21405!GO:0033014;tetrapyrrole biosynthetic process;0.0373555961627596;21405!GO:0031016;pancreas development;0.0373555961627596;21405!GO:0045120;pronucleus;0.0385486000284395;21405!GO:0030301;cholesterol transport;0.0385486000284395;21405!GO:0015918;sterol transport;0.0385486000284395;21405!GO:0051235;maintenance of localization;0.0385486000284395;66913!GO:0045453;bone resorption;0.0385486000284395;21405!GO:0001750;photoreceptor outer segment;0.0385486000284395;21405!GO:0042168;heme metabolic process;0.0404007155440419;21405!GO:0031513;nonmotile primary cilium;0.0421889621772222;21405!GO:0033013;tetrapyrrole metabolic process;0.0431965906050089;21405!GO:0006778;porphyrin metabolic process;0.0431965906050089;21405!GO:0046883;regulation of hormone secretion;0.0472013970439534;21405!GO:0001889;liver development;0.0484875740425892;21405!GO:0042592;homeostatic process;0.0484875740425892;18453,21405!GO:0030111;regulation of Wnt receptor signaling pathway;0.049503468730572;21405!
}}

Revision as of 11:11, 11 October 2012


Phase1 CAGE Peaks

 Short description
Mm9::chr11:113612097..113612161,-p3@Cdc42ep4
Mm9::chr11:120434178..120434195,-p1@P4hb
Mm9::chr13:115879674..115879694,+p@chr13:115879674..115879694
+
Mm9::chr13:115879700..115879724,+p@chr13:115879700..115879724
+
Mm9::chr18:57514387..57514451,+p1@Prrc1
Mm9::chr3:122970363..122970418,+p1@Sec24d
Mm9::chr3:40886914..40886946,-p1@Pgrmc2
Mm9::chr4:118217520..118217535,-p@chr4:118217520..118217535
-
Mm9::chr5:100845134..100845301,-p1@Sec31a
Mm9::chr5:115420882..115420896,-p3@Hnf1a
Mm9::chr5:144165498..144165561,+p1@Kdelr2
Mm9::chr5:23934029..23934061,+p3@Slc4a2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0008104protein localization0.0320997394001498
GO:0033036macromolecule localization0.0320997394001498
GO:0046483heterocycle metabolic process0.0320997394001498
GO:0043691reverse cholesterol transport0.0320997394001498
GO:0005046KDEL sequence binding0.0320997394001498
GO:0015721bile acid and bile salt transport0.0320997394001498
GO:0004656procollagen-proline 4-dioxygenase activity0.0320997394001498
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline0.0320997394001498
GO:0019511peptidyl-proline hydroxylation0.0320997394001498
GO:0031545peptidyl-proline 4-dioxygenase activity0.0320997394001498
GO:0046923ER retention sequence binding0.0320997394001498
GO:0006621protein retention in ER0.0320997394001498
GO:00194714-hydroxyproline metabolic process0.0320997394001498
GO:0009743response to carbohydrate stimulus0.0320997394001498
GO:0006699bile acid biosynthetic process0.0320997394001498
GO:0009746response to hexose stimulus0.0320997394001498
GO:0009749response to glucose stimulus0.0320997394001498
GO:0018208peptidyl-proline modification0.0320997394001498
GO:0006810transport0.0320997394001498
GO:0015908fatty acid transport0.0320997394001498
GO:0051234establishment of localization0.0320997394001498
GO:0015031protein transport0.0320997394001498
GO:0048341paraxial mesoderm formation0.0320997394001498
GO:0031543peptidyl-proline dioxygenase activity0.0320997394001498
GO:0019798procollagen-proline dioxygenase activity0.0320997394001498
GO:0015718monocarboxylic acid transport0.0320997394001498
GO:0032507maintenance of cellular protein localization0.0320997394001498
GO:0042802identical protein binding0.0320997394001498
GO:0045184establishment of protein localization0.0320997394001498
GO:0016864intramolecular oxidoreductase activity, transposing S-S bonds0.0320997394001498
GO:0003756protein disulfide isomerase activity0.0320997394001498
GO:0031018endocrine pancreas development0.0320997394001498
GO:0005783endoplasmic reticulum0.0326021141895586
GO:0051651maintenance of cellular localization0.0326021141895586
GO:0016862intramolecular oxidoreductase activity, interconverting keto- and enol-groups0.0326021141895586
GO:0005452inorganic anion exchanger activity0.0326021141895586
GO:0005048signal sequence binding0.0338486238688349
GO:0048340paraxial mesoderm morphogenesis0.0338486238688349
GO:0045185maintenance of protein localization0.0338486238688349
GO:0051179localization0.0343283832004196
GO:0015380anion exchanger activity0.0350596560803832
GO:0008206bile acid metabolic process0.0350596560803832
GO:0015106bicarbonate transmembrane transporter activity0.0350596560803832
GO:0050796regulation of insulin secretion0.0350596560803832
GO:0015301anion:anion antiporter activity0.0350596560803832
GO:0006783heme biosynthetic process0.0350596560803832
GO:0015108chloride transmembrane transporter activity0.0373555961627596
GO:0006779porphyrin biosynthetic process0.0373555961627596
GO:0048339paraxial mesoderm development0.0373555961627596
GO:0033014tetrapyrrole biosynthetic process0.0373555961627596
GO:0031016pancreas development0.0373555961627596
GO:0045120pronucleus0.0385486000284395
GO:0030301cholesterol transport0.0385486000284395
GO:0015918sterol transport0.0385486000284395
GO:0051235maintenance of localization0.0385486000284395
GO:0045453bone resorption0.0385486000284395
GO:0001750photoreceptor outer segment0.0385486000284395
GO:0042168heme metabolic process0.0404007155440419
GO:0031513nonmotile primary cilium0.0421889621772222
GO:0033013tetrapyrrole metabolic process0.0431965906050089
GO:0006778porphyrin metabolic process0.0431965906050089
GO:0046883regulation of hormone secretion0.0472013970439534
GO:0001889liver development0.0484875740425892
GO:0042592homeostatic process0.0484875740425892
GO:0030111regulation of Wnt receptor signaling pathway0.049503468730572



Relative expression of the co-expression cluster over median <br>Analyst:


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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}

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