MCL coexpression mm9:1532

Phase1 CAGE Peaks

	Short description
Mm9::chr10:79605024..79605035,+	p5@Atp5d
Mm9::chr10:79605040..79605056,+	p4@Atp5d
Mm9::chr10:79605079..79605098,+	p2@Atp5d
Mm9::chr11:54679876..54679894,+	p2@Hint1
Mm9::chr19:47165168..47165173,-	p2@Gm14539 p2@LOC100504912 p2@Usmg5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0005743	mitochondrial inner membrane	0.0143950233737972
GO:0019866	organelle inner membrane	0.0143950233737972
GO:0031966	mitochondrial membrane	0.0143950233737972
GO:0005740	mitochondrial envelope	0.0143950233737972
GO:0044429	mitochondrial part	0.0143950233737972
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	0.0143950233737972
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	0.0143950233737972
GO:0031975	envelope	0.0143950233737972
GO:0031967	organelle envelope	0.0143950233737972
GO:0031090	organelle membrane	0.0249855892454239
GO:0045259	proton-transporting ATP synthase complex	0.0279444512698392
GO:0015985	energy coupled proton transport, down electrochemical gradient	0.0290678163773041
GO:0015986	ATP synthesis coupled proton transport	0.0290678163773041
GO:0006754	ATP biosynthetic process	0.0290678163773041
GO:0006753	nucleoside phosphate metabolic process	0.0290678163773041
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	0.0290678163773041
GO:0016469	proton-transporting two-sector ATPase complex	0.0290678163773041
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	0.0290678163773041
GO:0046034	ATP metabolic process	0.0290678163773041
GO:0005739	mitochondrion	0.0290678163773041
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	0.0290678163773041
GO:0009201	ribonucleoside triphosphate biosynthetic process	0.0290678163773041
GO:0009145	purine nucleoside triphosphate biosynthetic process	0.0290678163773041
GO:0019829	cation-transporting ATPase activity	0.0290678163773041
GO:0009142	nucleoside triphosphate biosynthetic process	0.0290678163773041
GO:0009205	purine ribonucleoside triphosphate metabolic process	0.0290678163773041
GO:0009199	ribonucleoside triphosphate metabolic process	0.0290678163773041
GO:0009144	purine nucleoside triphosphate metabolic process	0.0290678163773041
GO:0006119	oxidative phosphorylation	0.0290678163773041
GO:0015992	proton transport	0.0290678163773041
GO:0006752	group transfer coenzyme metabolic process	0.0290678163773041
GO:0009141	nucleoside triphosphate metabolic process	0.0290678163773041
GO:0009152	purine ribonucleotide biosynthetic process	0.0290678163773041
GO:0006818	hydrogen transport	0.0290678163773041
GO:0009260	ribonucleotide biosynthetic process	0.0296929715106224
GO:0009150	purine ribonucleotide metabolic process	0.0299232124906377
GO:0006164	purine nucleotide biosynthetic process	0.0299232124906377
GO:0009259	ribonucleotide metabolic process	0.0313683668974196
GO:0006163	purine nucleotide metabolic process	0.032303477403647
GO:0042625	ATPase activity, coupled to transmembrane movement of ions	0.03444783581511
GO:0009108	coenzyme biosynthetic process	0.03444783581511
GO:0015078	hydrogen ion transmembrane transporter activity	0.0368526864043736
GO:0015077	monovalent inorganic cation transmembrane transporter activity	0.0371002154178416
GO:0051188	cofactor biosynthetic process	0.0371002154178416
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	0.041921923177726
GO:0043492	ATPase activity, coupled to movement of substances	0.041921923177726
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.041921923177726
GO:0009165	nucleotide biosynthetic process	0.0431575302318435
GO:0015399	primary active transmembrane transporter activity	0.0434545106322518
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	0.0434545106322518
GO:0022890	inorganic cation transmembrane transporter activity	0.0435937737411297
GO:0005737	cytoplasm	0.0493307875638466

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}