MCL coexpression mm9:314

Phase1 CAGE Peaks

	Short description
Mm9::chr10:101837063..101837079,+	p1@Mgat4c
Mm9::chr10:98570772..98570840,+	p1@Galnt4
Mm9::chr11:58195782..58195801,+	p@chr11:58195782..58195801 +
Mm9::chr11:58195812..58195827,+	p@chr11:58195812..58195827 +
Mm9::chr11:58195835..58195850,+	p@chr11:58195835..58195850 +
Mm9::chr11:58196339..58196348,+	p@chr11:58196339..58196348 +
Mm9::chr11:58198109..58198122,+	p@chr11:58198109..58198122 +
Mm9::chr11:58198170..58198190,+	p@chr11:58198170..58198190 +
Mm9::chr11:58198242..58198248,+	p@chr11:58198242..58198248 +
Mm9::chr11:58200272..58200306,-	p@chr11:58200272..58200306 -
Mm9::chr11:58200324..58200338,-	p@chr11:58200324..58200338 -
Mm9::chr11:58203653..58203660,-	p@chr11:58203653..58203660 -
Mm9::chr11:58203666..58203680,-	p@chr11:58203666..58203680 -
Mm9::chr11:58203760..58203791,-	p@chr11:58203760..58203791 -
Mm9::chr11:58207426..58207436,+	p@chr11:58207426..58207436 +
Mm9::chr13:101207449..101207462,-	p@chr13:101207449..101207462 -
Mm9::chr5:113918124..113918145,+	p@chr5:113918124..113918145 +
Mm9::chr5:8660059..8660099,+	p1@Abcb1a
Mm9::chr6:4550658..4550676,+	p5@Casd1
Mm9::chr7:26248671..26248685,+	p@chr7:26248671..26248685 +
Mm9::chr7:26251376..26251402,-	p@chr7:26251376..26251402 -
Mm9::chr7:31391945..31391961,-	p@chr7:31391945..31391961 -
Mm9::chr7:52976606..52976614,+	p2@Fam83e
Mm9::chr9:69885861..69885864,-	p5@Gcnt3
Mm9::chrX:136059368..136059390,+	p@chrX:136059368..136059390 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016757	transferase activity, transferring glycosyl groups	0.0011194633290528
GO:0008375	acetylglucosaminyltransferase activity	0.0011194633290528
GO:0008194	UDP-glycosyltransferase activity	0.00565137585170196
GO:0005794	Golgi apparatus	0.00565137585170196
GO:0016758	transferase activity, transferring hexosyl groups	0.00673005426702396
GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	0.00673005426702396
GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	0.00673005426702396
GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	0.00706578264803484
GO:0042910	xenobiotic transporter activity	0.00706578264803484
GO:0008559	xenobiotic-transporting ATPase activity	0.00706578264803484
GO:0015239	multidrug transporter activity	0.0085636465461218
GO:0046581	intercellular canaliculus	0.0137330008805963
GO:0016021	integral to membrane	0.017698505694749
GO:0031224	intrinsic to membrane	0.017698505694749
GO:0015893	drug transport	0.0193728996622652
GO:0006493	protein amino acid O-linked glycosylation	0.0193728996622652
GO:0015238	drug transporter activity	0.0193728996622652
GO:0044425	membrane part	0.0206057324480722
GO:0016740	transferase activity	0.0328944759667272
GO:0042493	response to drug	0.0352245386378794
GO:0016020	membrane	0.0417803696323778

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
intestinal epithelial cell	1.04e-12	9
epithelial cell of alimentary canal	1.04e-12	9
brush border epithelial cell	5.16e-09	6
gut absorptive cell	5.16e-09	6
absorptive cell	5.16e-09	6
enterocyte	5.16e-09	6
columnar/cuboidal epithelial cell	1.32e-07	7
endo-epithelial cell	7.04e-07	15

Uber Anatomy

Ontology term	p-value	n
gastrointestinal system	4.16e-42	47
intestine	2.62e-41	31
mucosa	4.42e-22	15
intestinal mucosa	4.86e-19	13
anatomical wall	4.86e-19	13
wall of intestine	4.86e-19	13
gastrointestinal system mucosa	4.86e-19	13
digestive system	6.55e-13	116
digestive tract	6.55e-13	116
primitive gut	6.55e-13	116
epithelium of mucosa	1.04e-12	9
gastrointestinal system epithelium	1.04e-12	9
intestinal epithelium	1.04e-12	9
endoderm-derived structure	1.63e-12	118
endoderm	1.63e-12	118
presumptive endoderm	1.63e-12	118
organ component layer	3.06e-12	24
subdivision of digestive tract	2.65e-11	114
simple columnar epithelium	4.75e-10	11
small intestine	5.90e-08	4

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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