MCL coexpression mm9:1304

Phase1 CAGE Peaks

	Short description
Mm9::chr11:73012488..73012510,-	p2@Ctns
Mm9::chr13:106084899..106084909,-	p10@Rnf180
Mm9::chr14:56983841..56983853,+	p1@Atp12a
Mm9::chr2:113245260..113245269,+	p17@Fmn1
Mm9::chr2:113245271..113245284,+	p11@Fmn1
Mm9::chr2:113245288..113245314,+	p6@Fmn1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015184	L-cystine transmembrane transporter activity	0.00467503058857905
GO:0000101	sulfur amino acid transport	0.00467503058857905
GO:0051125	regulation of actin nucleation	0.00467503058857905
GO:0000099	sulfur amino acid transmembrane transporter activity	0.00467503058857905
GO:0015811	L-cystine transport	0.00467503058857905
GO:0051127	positive regulation of actin nucleation	0.00467503058857905
GO:0008900	hydrogen:potassium-exchanging ATPase activity	0.00801367951130475
GO:0030838	positive regulation of actin filament polymerization	0.00934852440535652
GO:0045010	actin nucleation	0.00934852440535652
GO:0051130	positive regulation of cellular component organization and biogenesis	0.016823195403582
GO:0015807	L-amino acid transport	0.023357868680412
GO:0030833	regulation of actin filament polymerization	0.023357868680412
GO:0030041	actin filament polymerization	0.0366328029020975
GO:0015179	L-amino acid transmembrane transporter activity	0.0459991902383788
GO:0008064	regulation of actin polymerization and/or depolymerization	0.0460173561850889
GO:0032535	regulation of cellular component size	0.0460173561850889
GO:0032956	regulation of actin cytoskeleton organization and biogenesis	0.0460173561850889
GO:0030832	regulation of actin filament length	0.0460173561850889
GO:0051493	regulation of cytoskeleton organization and biogenesis	0.0460173561850889
GO:0033043	regulation of organelle organization and biogenesis	0.0460173561850889
GO:0015171	amino acid transmembrane transporter activity	0.0460173561850889
GO:0051258	protein polymerization	0.0460173561850889
GO:0022891	substrate-specific transmembrane transporter activity	0.0460173561850889
GO:0008154	actin polymerization and/or depolymerization	0.0460173561850889
GO:0006865	amino acid transport	0.0460173561850889
GO:0015837	amine transport	0.0460173561850889
GO:0015992	proton transport	0.0460173561850889
GO:0022857	transmembrane transporter activity	0.0460173561850889
GO:0051128	regulation of cellular component organization and biogenesis	0.0460173561850889
GO:0046943	carboxylic acid transmembrane transporter activity	0.0460173561850889
GO:0006818	hydrogen transport	0.0460173561850889
GO:0005342	organic acid transmembrane transporter activity	0.0460173561850889
GO:0044425	membrane part	0.0460173561850889
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	0.0460173561850889
GO:0046942	carboxylic acid transport	0.0460173561850889
GO:0015849	organic acid transport	0.0460173561850889
GO:0005912	adherens junction	0.0460173561850889
GO:0022892	substrate-specific transporter activity	0.0465164382921448

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
surface structure	2.64e-12	22
zone of skin	1.49e-09	5
skin epidermis	1.49e-09	5
skin of body	1.49e-09	5
integument	1.49e-09	5
surface	1.49e-09	5
outer epithelium	1.49e-09	5
integumental system	1.49e-09	5
enveloping layer of ectoderm	1.49e-09	5

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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