MCL coexpression mm9:1976

Phase1 CAGE Peaks

	Short description
Mm9::chr11:60023912..60023930,-	p1@Srebf1
Mm9::chr19:4510510..4510532,+	p1@Pcx
Mm9::chr19:4510536..4510552,+	p2@Pcx
Mm9::chr9:110235906..110235939,+	p1@Scap

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006066	alcohol metabolic process	0.000306281834683947
GO:0044255	cellular lipid metabolic process	0.00102675017073312
GO:0006629	lipid metabolic process	0.00102675017073312
GO:0008203	cholesterol metabolic process	0.00102675017073312
GO:0016125	sterol metabolic process	0.00102675017073312
GO:0004736	pyruvate carboxylase activity	0.00250629676560923
GO:0032810	sterol response element binding	0.00250629676560923
GO:0008202	steroid metabolic process	0.00250629676560923
GO:0032787	monocarboxylic acid metabolic process	0.00515569378181183
GO:0009374	biotin binding	0.00755915840589375
GO:0009267	cellular response to starvation	0.00944739489749404
GO:0019217	regulation of fatty acid metabolic process	0.00944739489749404
GO:0016885	ligase activity, forming carbon-carbon bonds	0.00944739489749404
GO:0031669	cellular response to nutrient levels	0.00944739489749404
GO:0015485	cholesterol binding	0.0100020277963888
GO:0042594	response to starvation	0.0100020277963888
GO:0031668	cellular response to extracellular stimulus	0.0100020277963888
GO:0019752	carboxylic acid metabolic process	0.0107367492345269
GO:0006082	organic acid metabolic process	0.0107367492345269
GO:0031667	response to nutrient levels	0.0122775759449278
GO:0032934	sterol binding	0.0123172879608904
GO:0031090	organelle membrane	0.0123172879608904
GO:0009991	response to extracellular stimulus	0.0123172879608904
GO:0033554	cellular response to stress	0.0128414179677663
GO:0006094	gluconeogenesis	0.0128414179677663
GO:0019216	regulation of lipid metabolic process	0.0137986537725932
GO:0051716	cellular response to stimulus	0.0139861729210222
GO:0006090	pyruvate metabolic process	0.0141602239531468
GO:0019319	hexose biosynthetic process	0.0147469997075971
GO:0005783	endoplasmic reticulum	0.0147469997075971
GO:0046165	alcohol biosynthetic process	0.0147469997075971
GO:0046364	monosaccharide biosynthetic process	0.0147469997075971
GO:0044444	cytoplasmic part	0.0163733969640664
GO:0005496	steroid binding	0.0260620613217157
GO:0005789	endoplasmic reticulum membrane	0.0376592756433307
GO:0042175	nuclear envelope-endoplasmic reticulum network	0.0381760376023527
GO:0016051	carbohydrate biosynthetic process	0.0396196000953267
GO:0044432	endoplasmic reticulum part	0.0396196000953267
GO:0006006	glucose metabolic process	0.0467633555420892
GO:0019842	vitamin binding	0.0493329562777339

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
exocrine gland	8.32e-12	25
exocrine system	8.32e-12	25
digestive tract diverticulum	9.38e-11	23
sac	9.38e-11	23
liver	2.36e-10	22
epithelial sac	2.36e-10	22
digestive gland	2.36e-10	22
epithelium of foregut-midgut junction	2.36e-10	22
anatomical boundary	2.36e-10	22
hepatobiliary system	2.36e-10	22
foregut-midgut junction	2.36e-10	22
hepatic diverticulum	2.36e-10	22
liver primordium	2.36e-10	22
septum transversum	2.36e-10	22
liver bud	2.36e-10	22
abdomen element	5.05e-09	49
abdominal segment element	5.05e-09	49
abdominal segment of trunk	5.05e-09	49
abdomen	5.05e-09	49
trunk mesenchyme	1.75e-08	45
trunk region element	9.16e-07	79

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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