MCL coexpression mm9:693

Phase1 CAGE Peaks

	Short description
Mm9::chr10:79723648..79723690,-	p1@Gamt
Mm9::chr10:79723704..79723720,-	p2@Gamt
Mm9::chr10:79723749..79723758,-	p4@Gamt
Mm9::chr10:79723760..79723771,-	p3@Gamt
Mm9::chr10:87324040..87324051,+	p14@Igf1
Mm9::chr15:98558459..98558464,-	p@chr15:98558459..98558464 -
Mm9::chr4:144483114..144483127,+	p9@Dhrs3
Mm9::chr7:72947916..72947934,+	p@chr7:72947916..72947934 +
Mm9::chr8:74067075..74067113,+	p@chr8:74067075..74067113 +
Mm9::chr8:96910386..96910409,+	p1@Herpud1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0035264	multicellular organism growth	0.0176644566200871
GO:0030731	guanidinoacetate N-methyltransferase activity	0.0176644566200871
GO:0005159	insulin-like growth factor receptor binding	0.0176644566200871
GO:0006601	creatine biosynthetic process	0.0176644566200871
GO:0018445	prothoracicotrophic hormone activity	0.0176644566200871
GO:0033143	regulation of steroid hormone receptor signaling pathway	0.0176644566200871
GO:0006600	creatine metabolic process	0.0176644566200871
GO:0042396	phosphagen biosynthetic process	0.0176644566200871
GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	0.021406770417925
GO:0050654	chondroitin sulfate proteoglycan metabolic process	0.021406770417925
GO:0006599	phosphagen metabolic process	0.021406770417925
GO:0030104	water homeostasis	0.0247732094639659
GO:0018987	osmoregulation	0.0247732094639659
GO:0021940	positive regulation of granule cell precursor proliferation	0.0247732094639659
GO:0021936	regulation of granule cell precursor proliferation	0.0247732094639659
GO:0048009	insulin-like growth factor receptor signaling pathway	0.0247732094639659
GO:0021534	cell proliferation in hindbrain	0.0247732094639659
GO:0021924	cell proliferation in the external granule layer	0.0247732094639659
GO:0021930	granule cell precursor proliferation	0.0247732094639659
GO:0030518	steroid hormone receptor signaling pathway	0.0305848572924333
GO:0030166	proteoglycan biosynthetic process	0.0358385983338119
GO:0030522	intracellular receptor-mediated signaling pathway	0.037226303460844
GO:0005184	neuropeptide hormone activity	0.037226303460844
GO:0006029	proteoglycan metabolic process	0.037226303460844
GO:0030879	mammary gland development	0.0413663738297994
GO:0009887	organ morphogenesis	0.0465295563906256
GO:0042398	amino acid derivative biosynthetic process	0.0485262686279161
GO:0044272	sulfur compound biosynthetic process	0.0485262686279161
GO:0051789	response to protein stimulus	0.0485262686279161
GO:0006986	response to unfolded protein	0.0485262686279161

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
liver	1.23e-10	22
epithelial sac	1.23e-10	22
digestive gland	1.23e-10	22
epithelium of foregut-midgut junction	1.23e-10	22
anatomical boundary	1.23e-10	22
hepatobiliary system	1.23e-10	22
foregut-midgut junction	1.23e-10	22
hepatic diverticulum	1.23e-10	22
liver primordium	1.23e-10	22
septum transversum	1.23e-10	22
liver bud	1.23e-10	22
digestive tract diverticulum	1.34e-09	23
sac	1.34e-09	23
pancreas	1.58e-08	12
exocrine gland	2.99e-08	25
exocrine system	2.99e-08	25
trunk mesenchyme	3.44e-07	45

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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