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MCL coexpression mm9:70: Difference between revisions

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|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000473!2.14e-47!14;UBERON:0003135!3.71e-44!15;UBERON:0000991!2.06e-43!18;UBERON:0005564!2.06e-43!18;UBERON:0003101!2.54e-41!16;UBERON:0000079!2.54e-41!16;UBERON:0004176!8.10e-39!17;UBERON:0009196!8.10e-39!17;UBERON:0009117!8.10e-39!17;UBERON:0003133!3.24e-32!24;UBERON:0005156!1.25e-29!26;UBERON:0000990!1.25e-29!26;UBERON:0002323!2.20e-20!37;UBERON:0004458!2.20e-20!37;UBERON:0003886!8.29e-20!38;UBERON:0002553!2.92e-19!39;UBERON:0000464!1.10e-12!57;UBERON:0000466!1.08e-08!79
|ontology_enrichment_uberon=UBERON:0000473!2.14e-47!14;UBERON:0003135!3.71e-44!15;UBERON:0000991!2.06e-43!18;UBERON:0005564!2.06e-43!18;UBERON:0003101!2.54e-41!16;UBERON:0000079!2.54e-41!16;UBERON:0004176!8.10e-39!17;UBERON:0009196!8.10e-39!17;UBERON:0009117!8.10e-39!17;UBERON:0003133!3.24e-32!24;UBERON:0005156!1.25e-29!26;UBERON:0000990!1.25e-29!26;UBERON:0002323!2.20e-20!37;UBERON:0004458!2.20e-20!37;UBERON:0003886!8.29e-20!38;UBERON:0002553!2.92e-19!39;UBERON:0000464!1.10e-12!57;UBERON:0000466!1.08e-08!79
|tfbs_overrepresentation_for_novel_motifs=1.0272,0.000834825,0.812848,0.471201,1.03488,0.403176,0.336944,0.159885,0.935411,0.00334529,0.219933,0.197384,0.407522,1.42708,0.627764,0,0.267776,0.351712,1.09994,0.37628,0.55113,0.49687,0.916593,1.36083,0.037175,1.09278,0.239266,1.03471,0.0664247,1.34697,0.931755,0.737563,0.338858,0.177898,0.0859168,0.0522948,0.56611,0.421197,0.188315,0.0289813,0.116408,0.601697,0.459951,0.644196,0.324903,1.30879,1.69611,0.737195,0.336126,0.618633,0.124771,0.769473,0.396513,0.126765,0.139261,0.557206,0.686807,0.267464,0.237952,0.390813,0.672783,0.169179,0.834446,0.2189,0.434455,0.96614,0.0745516,0.255919,0.423361,0.96481,0.16017,0.548102,0.00279401,0.669844,0.0462849,0.579998,0.778483,1.01299,0.224002,1.04901,1.18176,0.29992,0.166954,0.176756,0.217837,2.82132e-05,0.409623,0.0434215,1.73351,0.371247,1.13115,0.0201579,0.512478,0.0997542,0.0256142,0.610027,0.0575367,0.305831,1.3713,0.602524,1.46491,0.73664,0.276943,0.596622,0.593107,1.18307,1.44737,0.282913,0.483266,0.0488003,0.631348,0.279332,2.17532,0.639856,0.342152,0.0764928,0.121599,0.488761,0.270119,0.43466,0.384161,0.318689,0.207349,1.00808,0.407,0.403637,0.361703,0.757547,0.257349,0.278038,0.478158,0.320848,0.0638654,0.443056,0.114621,0.0114362,0.159532,0.459129,0.311022,0.677785,0.347397,0.947132,0.357737,0.297277,0.377119,0.97227,0.602733,0.642649,0.164824,0.627735,0.117735,0.00223883,0.302919,0.924241,0.611186,0.0516976,0.0831393,0.217637,0.516987,0.0606548,0.0973335,0.416096,0.229934,0.12313,0.369191,0.176333,0.160013,0.297693,0.00249814
}}
}}

Revision as of 17:44, 26 November 2012


Phase1 CAGE Peaks

 Short description
Mm9::chr10:19868263..19868284,+p8@Mtap7
Mm9::chr10:6486766..6486804,-p@chr10:6486766..6486804
-
Mm9::chr10:6486850..6486860,-p@chr10:6486850..6486860
-
Mm9::chr10:80809447..80809515,-p5@Hmg20b
Mm9::chr10:86371461..86371471,+p2@ENSMUST00000162458
Mm9::chr11:107180560..107180583,-p@chr11:107180560..107180583
-
Mm9::chr11:116586509..116586516,-p@chr11:116586509..116586516
-
Mm9::chr11:120764932..120764940,-p@chr11:120764932..120764940
-
Mm9::chr11:3892492..3892527,+p@chr11:3892492..3892527
+
Mm9::chr11:58775267..58775282,+p1@ENSMUST00000122447
Mm9::chr11:58775412..58775435,+p2@ENSMUST00000122447
Mm9::chr11:61156296..61156305,-p2@Slc47a2
Mm9::chr11:61156311..61156316,-p3@Slc47a2
Mm9::chr11:61156323..61156370,-p1@Slc47a2
Mm9::chr11:69430476..69430487,-p4@Shbg
Mm9::chr11:87218551..87218615,+p1@Tex14
Mm9::chr12:113957448..113957467,+p@chr12:113957448..113957467
+
Mm9::chr12:74018837..74018852,-p2@4930447C04Rik
Mm9::chr12:77084678..77084683,+p@chr12:77084678..77084683
+
Mm9::chr13:112477972..112477982,+p@chr13:112477972..112477982
+
Mm9::chr13:12292672..12292684,-p6@Mtr
Mm9::chr13:23585688..23585699,+p@chr13:23585688..23585699
+
Mm9::chr13:24026303..24026308,+p1@Hist1h2aa
Mm9::chr13:58377008..58377012,-p@chr13:58377008..58377012
-
Mm9::chr14:24655068..24655077,-p@chr14:24655068..24655077
-
Mm9::chr14:55432981..55432993,+p@chr14:55432981..55432993
+
Mm9::chr14:57021542..57021549,+p@chr14:57021542..57021549
+
Mm9::chr14:70829178..70829221,-p1@Piwil2
Mm9::chr15:102275818..102275834,+p1@Amhr2
Mm9::chr15:102277099..102277126,+p@chr15:102277099..102277126
+
Mm9::chr15:35984869..35984883,-p@chr15:35984869..35984883
-
Mm9::chr15:64402726..64402730,-p@chr15:64402726..64402730
-
Mm9::chr15:79435516..79435544,-p1@Dmc1
Mm9::chr15:81602763..81602776,+p@chr15:81602763..81602776
+
Mm9::chr15:91029884..91029893,+p@chr15:91029884..91029893
+
Mm9::chr15:99463233..99463245,-p2@Racgap1
Mm9::chr16:33179212..33179229,+p@chr16:33179212..33179229
+
Mm9::chr17:13102778..13102820,-p1@Pnldc1
Mm9::chr17:26158861..26158880,-p6@Rab11fip3
Mm9::chr17:26158886..26158904,-p8@Rab11fip3
Mm9::chr17:43705239..43705252,+p10@Pla2g7
Mm9::chr17:49649179..49649202,-p@chr17:49649179..49649202
-
Mm9::chr17:49649205..49649222,-p@chr17:49649205..49649222
-
Mm9::chr17:49649263..49649268,-p@chr17:49649263..49649268
-
Mm9::chr17:49668428..49668449,-p@chr17:49668428..49668449
-
Mm9::chr17:49689353..49689360,-p@chr17:49689353..49689360
-
Mm9::chr17:49689426..49689442,-p@chr17:49689426..49689442
-
Mm9::chr17:50432917..50432931,-p1@Dazl
Mm9::chr17:68663935..68663949,+p3@L3mbtl4
Mm9::chr17:84256276..84256289,+p@chr17:84256276..84256289
+
Mm9::chr18:14887856..14887867,-p@chr18:14887856..14887867
-
Mm9::chr18:31858304..31858313,+p@chr18:31858304..31858313
+
Mm9::chr18:35395153..35395171,+p@chr18:35395153..35395171
+
Mm9::chr18:74029632..74029644,+p@chr18:74029632..74029644
+
Mm9::chr19:10166685..10166694,-p@chr19:10166685..10166694
-
Mm9::chr19:10166695..10166707,-p@chr19:10166695..10166707
-
Mm9::chr19:20566755..20566762,+p9@E030003E18Rik
Mm9::chr19:24217365..24217376,-p@chr19:24217365..24217376
-
Mm9::chr19:24217397..24217404,-p@chr19:24217397..24217404
-
Mm9::chr19:25580353..25580364,+p4@Dmrt1
Mm9::chr19:40968642..40968653,+p@chr19:40968642..40968653
+
Mm9::chr1:13216009..13216028,-p@chr1:13216009..13216028
-
Mm9::chr1:13216038..13216051,-p@chr1:13216038..13216051
-
Mm9::chr2:104967357..104967379,+p9@Wt1
Mm9::chr2:104971121..104971138,+p14@Wt1
Mm9::chr2:119838899..119838947,+p@chr2:119838899..119838947
+
Mm9::chr2:148660930..148660931,+p4@Cst9
Mm9::chr2:148660933..148660963,+p2@Cst9
Mm9::chr2:151470928..151470931,-p@chr2:151470928..151470931
-
Mm9::chr2:151496314..151496349,-p@chr2:151496314..151496349
-
Mm9::chr2:152430060..152430086,+p3@Defb36
Mm9::chr2:152430094..152430135,+p1@Defb36
Mm9::chr2:152430137..152430146,+p4@Defb36
Mm9::chr2:152430154..152430175,+p2@Defb36
Mm9::chr2:152695188..152695197,+p10@Tpx2
Mm9::chr2:152695278..152695289,+p4@Tpx2
Mm9::chr2:160409132..160409136,+p1@ENSMUST00000128681
Mm9::chr2:172944903..172944916,-p1@Ctcfl
Mm9::chr2:181313067..181313079,+p4@Gm16119
Mm9::chr2:32985741..32985771,-p@chr2:32985741..32985771
-
Mm9::chr2:32987165..32987178,-p5@Garnl3
Mm9::chr2:84499222..84499239,+p1@Gm13718
Mm9::chr2:84518722..84518777,+p@chr2:84518722..84518777
+
Mm9::chr3:40512838..40512859,+p2@Slc25a31
Mm9::chr3:54985946..54985981,+p1@Sohlh2
Mm9::chr3:82680305..82680345,-p1@Rbm46
Mm9::chr4:107356833..107356836,-p7@Dmrtb1
Mm9::chr4:131476934..131476937,-p@chr4:131476934..131476937
-
Mm9::chr4:142984313..142984319,+p1@Pramel1
Mm9::chr4:59130705..59130715,-p@chr4:59130705..59130715
-
Mm9::chr4:89354729..89354776,+p1@Dmrta1
Mm9::chr4:89354785..89354801,+p2@Dmrta1
Mm9::chr4:89354887..89354888,+p5@Dmrta1
Mm9::chr5:109204040..109204051,-p@chr5:109204040..109204051
-
Mm9::chr5:130210839..130210864,-p@chr5:130210839..130210864
-
Mm9::chr5:135825867..135825910,-p1@Fkbp6
Mm9::chr5:135827139..135827150,-p@chr5:135827139..135827150
-
Mm9::chr5:135827158..135827172,-p@chr5:135827158..135827172
-
Mm9::chr5:135827306..135827308,-p@chr5:135827306..135827308
-
Mm9::chr5:138229081..138229099,+p3@Zcwpw1
Mm9::chr5:92821739..92821750,+p12@Art3
Mm9::chr5:92821756..92821769,+p8@Art3
Mm9::chr6:120726529..120726551,+p@chr6:120726529..120726551
+
Mm9::chr6:129335493..129335504,-p2@Clec12b
Mm9::chr6:129335515..129335528,-p1@Clec12b
Mm9::chr6:129336070..129336080,-p3@Clec12b
Mm9::chr6:18059063..18059084,-p2@Asz1
Mm9::chr6:34870941..34870954,+p1@Stra8
Mm9::chr6:34870971..34870973,+p2@Stra8
Mm9::chr6:49345558..49345593,+p2@Stk31
Mm9::chr6:82896892..82896918,+p1@D6Mm5e
Mm9::chr6:82948823..82948824,+p@chr6:82948823..82948824
+
Mm9::chr6:89046097..89046109,+p1@4933427D06Rik
Mm9::chr6:89046148..89046157,+p2@4933427D06Rik
Mm9::chr7:105261128..105261146,-p@chr7:105261128..105261146
-
Mm9::chr7:106461903..106461933,+p@chr7:106461903..106461933
+
Mm9::chr7:146212586..146212600,-p@chr7:146212586..146212600
-
Mm9::chr7:19703681..19703702,-p1@ENSMUST00000127433
p1@uc009fks.1
Mm9::chr7:19703706..19703753,-p1@ENSMUST00000141380
Mm9::chr7:27959571..27959595,-p4@Rab4b
Mm9::chr7:28403100..28403119,+p@chr7:28403100..28403119
+
Mm9::chr7:29416605..29416613,-p6@C330005M16Rik
Mm9::chr7:29680031..29680053,-p3@Actn4
Mm9::chr7:52741708..52741709,+p8@Tulp2
Mm9::chr7:52741730..52741769,+p2@Tulp2
Mm9::chr8:34627202..34627216,+p1@Tex15
Mm9::chr9:100543944..100543961,+p5@Stag1
Mm9::chr9:100543970..100543983,+p4@Stag1
Mm9::chr9:108334141..108334176,-p@chr9:108334141..108334176
-
Mm9::chr9:110760432..110760442,+p2@Prss50
Mm9::chr9:110760462..110760491,+p1@Prss50
Mm9::chr9:110782015..110782028,-p@chr9:110782015..110782028
-
Mm9::chr9:117949431..117949451,-p@chr9:117949431..117949451
-
Mm9::chr9:26668234..26668282,-p2@Glb1l3
Mm9::chr9:50369366..50369373,-p4@Tex12
Mm9::chr9:50369425..50369436,-p3@Tex12
Mm9::chr9:71567156..71567166,-p@chr9:71567156..71567166
-
Mm9::chr9:75316366..75316392,+p@chr9:75316366..75316392
+
Mm9::chr9:75316396..75316404,+p@chr9:75316396..75316404
+
Mm9::chrX:103416484..103416508,-p4@Taf9b
Mm9::chrX:104863295..104863324,+p1@Tbx22
Mm9::chrX:109008560..109008571,+p@chrX:109008560..109008571
+
Mm9::chrX:111398212..111398223,+p@chrX:111398212..111398223
+
Mm9::chrX:111398256..111398267,+p@chrX:111398256..111398267
+
Mm9::chrX:131011018..131011034,-p2@Taf7l
Mm9::chrX:131797846..131797855,+p@chrX:131797846..131797855
+
Mm9::chrX:132619925..132619942,-p2@Nxf3
Mm9::chrX:133461859..133461868,+p1@1700014N06Rik
Mm9::chrX:135744570..135744585,+p1@Mum1l1
Mm9::chrX:137348001..137348006,-p1@Tex13
Mm9::chrX:146870025..146870033,-p9@Tmem29
Mm9::chrX:146870053..146870084,-p4@Tmem29
Mm9::chrX:147604019..147604030,+p7@ENSMUST00000151778
Mm9::chrX:147604042..147604061,+p2@ENSMUST00000151778
Mm9::chrX:154006915..154006923,-p1@Yy2
Mm9::chrX:154136917..154136945,+p5@Smpx
Mm9::chrX:157520436..157520469,+p@chrX:157520436..157520469
+
Mm9::chrX:157735699..157735710,+p@chrX:157735699..157735710
+
Mm9::chrX:157735725..157735738,+p@chrX:157735725..157735738
+
Mm9::chrX:160944159..160944196,+p2@Asb9
Mm9::chrX:16195689..16195702,+p@chrX:16195689..16195702
+
Mm9::chrX:33565836..33565855,-p@chrX:33565836..33565855
-
Mm9::chrX:33997121..33997125,-p@chrX:33997121..33997125
-
Mm9::chrX:34032615..34032632,-p@chrX:34032615..34032632
-
Mm9::chrX:35474351..35474366,+p1@Rhox13
Mm9::chrX:45255952..45255969,+p@chrX:45255952..45255969
+
Mm9::chrX:49154255..49154260,-p1@Usp26
Mm9::chrX:50788129..50788149,+p2@Etd
Mm9::chrX:50788166..50788192,+p1@Etd
Mm9::chrX:54662324..54662337,+p1@Gm364
Mm9::chrX:55173231..55173238,+p@chrX:55173231..55173238
+
Mm9::chrX:56164649..56164665,+p1@4930550L24Rik
Mm9::chrX:56164680..56164690,+p2@4930550L24Rik
Mm9::chrX:64129336..64129342,-p@chrX:64129336..64129342
-
Mm9::chrX:65298026..65298036,-p@chrX:65298026..65298036
-
Mm9::chrX:6618776..6618784,-p1@Ccnb3
Mm9::chrX:69177772..69177783,+p1@Gm1141
Mm9::chrX:71422591..71422607,+p1@Tktl1
Mm9::chrX:7553670..7553688,-p4@Gata1
Mm9::chrX:7553714..7553733,-p6@Gata1
Mm9::chrX:83437105..83437121,+p1@Nr0b1
Mm9::chrX:83646393..83646403,-p@chrX:83646393..83646403
-
Mm9::chrX:89925362..89925393,-p@chrX:89925362..89925393
-
Mm9::chrX:91168346..91168351,-p@chrX:91168346..91168351
-
Mm9::chrX:92194346..92194357,-p1@ENSMUST00000142240
Mm9::chrX:93160368..93160377,-p@chrX:93160368..93160377
-
Mm9::chrX:93160385..93160398,-p@chrX:93160385..93160398
-
Mm9::chrX:97624245..97624251,+p1@Otud6a
Mm9::chrX:98254953..98254981,-p1@Tex11
Mm9::chrX:98254982..98254993,-p2@Tex11
Mm9::chrX:98891172..98891180,+p@chrX:98891172..98891180
+
Mm9::chrX:98989714..98989726,-p@chrX:98989714..98989726
-
Mm9::chrX:98989983..98990019,+p1@8030474K03Rik
Mm9::chrY:155026..155076,+p1@Ube1y1
Mm9::chrY:155089..155099,+p2@Ube1y1
Mm9::chrY:796214..796225,-p1@Usp9y


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0007548sex differentiation2.03578009326924e-06
GO:0000003reproduction2.16497557013415e-06
GO:0003006reproductive developmental process2.16497557013415e-06
GO:0007276gamete generation1.51226305277813e-05
GO:0019953sexual reproduction4.49438179970822e-05
GO:0007530sex determination7.60584778234405e-05
GO:0007281germ cell development0.000127945363868857
GO:0007283spermatogenesis0.000187032866444009
GO:0048232male gamete generation0.000187032866444009
GO:0051327M phase of meiotic cell cycle0.000187032866444009
GO:0007126meiosis0.000187032866444009
GO:0051321meiotic cell cycle0.000187032866444009
GO:0022414reproductive process0.000192994690355212
GO:0008406gonad development0.000858847084355522
GO:0048608reproductive structure development0.000934685543343138
GO:0045137development of primary sexual characteristics0.00125415041341918
GO:0007127meiosis I0.00300326324239682
GO:0005844polysome0.00300326324239682
GO:0007131meiotic recombination0.00565216074923919
GO:0016591DNA-directed RNA polymerase II, holoenzyme0.0137993686951777
GO:0000279M phase0.019738458753447
GO:0008584male gonad development0.026546625307394
GO:0005669transcription factor TFIID complex0.026546625307394
GO:0001541ovarian follicle development0.028737541994697
GO:0022403cell cycle phase0.0328105114990602
GO:0007049cell cycle0.0328105114990602
GO:0048477oogenesis0.0354014626951595
GO:0046546development of primary male sexual characteristics0.0365871959106186
GO:0045836positive regulation of meiosis0.0365871959106186
GO:0031143pseudopodium0.0365871959106186
GO:0006311meiotic gene conversion0.0365871959106186
GO:0033313meiotic cell cycle checkpoint0.0365871959106186
GO:0042138meiotic DNA double-strand break formation0.0365871959106186
GO:0048549positive regulation of pinocytosis0.0365871959106186
GO:0010032meiotic chromosome condensation0.0365871959106186
GO:0000400four-way junction DNA binding0.0365871959106186
GO:0048548regulation of pinocytosis0.0365871959106186
GO:0033315meiotic cell cycle DNA replication checkpoint0.0365871959106186
GO:0005026transforming growth factor beta receptor activity, type II0.0365871959106186
GO:0000332template for synthesis of G-rich strand of telomere DNA activity0.0365871959106186
GO:0002111BRCA2-BRAF35 complex0.0365871959106186
GO:0005697telomerase holoenzyme complex0.0365871959106186
GO:0046661male sex differentiation0.0385365912660113
GO:0022601menstrual cycle phase0.0434627625269996
GO:0043283biopolymer metabolic process0.043735709260655
GO:0022602menstrual cycle process0.043735709260655
GO:0003729mRNA binding0.043735709260655
GO:0003700transcription factor activity0.0453837195440103
GO:0003677DNA binding0.0487040819257248
GO:0008585female gonad development0.0487040819257248
GO:0046660female sex differentiation0.0487040819257248
GO:0007292female gamete generation0.0487040819257248
GO:0046545development of primary female sexual characteristics0.0487040819257248
GO:0008494translation activator activity0.0487040819257248
GO:0045948positive regulation of translational initiation0.0487040819257248
GO:0003720telomerase activity0.0487040819257248
GO:0003730mRNA 3'-UTR binding0.0487040819257248
GO:0001823mesonephros development0.0487040819257248
GO:0060008Sertoli cell differentiation0.0487040819257248
GO:0000737DNA catabolic process, endonucleolytic0.0487040819257248
GO:0009341beta-galactosidase complex0.0487040819257248
GO:00082472-acetyl-1-alkylglycerophosphocholine esterase complex0.0487040819257248
GO:0000217DNA secondary structure binding0.0487040819257248
GO:0033327Leydig cell differentiation0.0487040819257248
GO:0042788polysomal ribosome0.0487040819257248
GO:0031323regulation of cellular metabolic process0.0498492540149218



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
testis2.14e-4714
male reproductive organ3.71e-4415
gonad2.06e-4318
gonad primordium2.06e-4318
male organism2.54e-4116
male reproductive system2.54e-4116
external genitalia8.10e-3917
indifferent external genitalia8.10e-3917
indifferent gonad8.10e-3917
reproductive organ3.24e-3224
reproductive structure1.25e-2926
reproductive system1.25e-2926
body cavity2.20e-2037
body cavity or lining2.20e-2037
body cavity precursor8.29e-2038
anatomical cavity2.92e-1939
anatomical space1.10e-1257
immaterial anatomical entity1.08e-0879


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}

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