Coexpression cluster:C1169

Full id: C1169_Urothelial_meningioma_medulloblastoma_Prostate_fibrosarcoma_Anulus_Nucleus

Phase1 CAGE Peaks

Hg19::chr12:47472578..47472594,-	p14@AMIGO2
Hg19::chr12:47472684..47472703,-	p12@AMIGO2
Hg19::chr18:26736753..26736764,+	p@chr18:26736753..26736764 +
Hg19::chr18:43307294..43307345,+	p@chr18:43307294..43307345 +
Hg19::chr1:183212642..183212654,+	p@chr1:183212642..183212654 +
Hg19::chr21:39628993..39628998,+	p25@KCNJ15
Hg19::chr8:141728731..141728740,-	p38@PTK2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007157	heterophilic cell adhesion	0.0478276194456524
GO:0007172	signal complex assembly	0.0478276194456524
GO:0005886	plasma membrane	0.0478276194456524
GO:0042169	SH2 domain binding	0.0478276194456524
GO:0005242	inward rectifier potassium channel activity	0.0478276194456524
GO:0005925	focal adhesion	0.0478276194456524
GO:0005924	cell-substrate adherens junction	0.0478276194456524
GO:0004715	non-membrane spanning protein tyrosine kinase activity	0.0478276194456524
GO:0030055	cell-matrix junction	0.0478276194456524

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
transitional epithelial cell	1.50e-25	4
urothelial cell	1.50e-25	4
gingival epithelial cell	7.60e-19	3
endo-epithelial cell	3.80e-18	42
respiratory epithelial cell	3.89e-16	13
epithelial cell	4.19e-13	253
endodermal cell	1.70e-12	58
general ecto-epithelial cell	1.39e-10	14
stratified squamous epithelial cell	2.92e-09	6
keratin accumulating cell	2.92e-09	6
stratified epithelial cell	2.92e-09	6
keratinizing barrier epithelial cell	2.92e-09	6
epithelial fate stem cell	2.92e-09	6
stratified epithelial stem cell	2.92e-09	6
surface ectodermal cell	2.92e-09	6
epithelial cell of Malassez	3.34e-09	3
bronchial epithelial cell	6.33e-09	3
epithelial cell of alimentary canal	3.14e-07	20
buccal mucosa cell	4.08e-07	1
endothelial cell of viscerocranial mucosa	4.08e-07	1
keratinized cell of the oral mucosa	4.08e-07	1
bladder cell	4.34e-07	1
lower urinary tract cell	4.34e-07	1

Uber Anatomy

Ontology term	p-value	n
urothelium	6.71e-31	5
transitional epithelium	9.95e-26	6
gingival epithelium	7.60e-19	3
urinary bladder	1.29e-12	2
lower urinary tract	1.29e-12	2
epithelium of mucosa	3.39e-12	8
mouth mucosa	2.98e-11	13
urinary system structure	6.22e-11	47
renal system	1.14e-10	48
mucosa	4.11e-10	20
endoderm-derived structure	1.99e-09	160
endoderm	1.99e-09	160
presumptive endoderm	1.99e-09	160
orifice	2.43e-09	36
lower respiratory tract epithelium	6.33e-09	3
epithelium of bronchus	6.33e-09	3
surface structure	7.08e-09	99
endo-epithelium	2.66e-08	82
gingiva	2.29e-07	8
mammalian vulva	3.62e-07	1
external female genitalia	3.62e-07	1
jaw skeleton	4.22e-07	4
splanchnocranium	4.22e-07	4
urinary bladder urothelium	4.34e-07	1
wall of urinary bladder	4.34e-07	1
mucosa of urinary bladder	4.34e-07	1
uterus or analog	4.89e-07	1
cloaca	7.18e-07	14
anal region	7.18e-07	14
embryonic cloaca	7.18e-07	14
terminal part of digestive tract	7.18e-07	14
primitive urogenital sinus	7.18e-07	14
proctodeum	7.18e-07	14

Disease

Ontology term	p-value	n
squamous cell carcinoma	6.43e-07	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.