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Coexpression cluster:C857: Difference between revisions

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|tf_chipseq_enrich=CHD2#1106;4:4.13760913364674:0.0113650969219832:0.0416652400110573!NFYA#4800;4:7.37023227993221:0.00139711276989907:0.00909059003024666!NFYB#4801;4:6.70391730141458:0.00198704723732796:0.0115574307428879!NRF1#4899;4:4.88411177908436:0.0063093473218055:0.0278281145716476!PAX5#5079;5:3.33478276558891:0.00985362449367583:0.0370327355606539!PBX3#5090;4:8.76580507469765:0.00072866783536506:0.005811036962255!SP2#6668;4:10.4614121975379:0.000372484517602528:0.00370353299065979!SUZ12#23512;4:20.0463123644252:3.01865267578508e-05:0.000620600525209287
|tf_chipseq_enrich=CHD2#1106;4:4.13760913364674:0.0113650969219832:0.0416652400110573!NFYA#4800;4:7.37023227993221:0.00139711276989907:0.00909059003024666!NFYB#4801;4:6.70391730141458:0.00198704723732796:0.0115574307428879!NRF1#4899;4:4.88411177908436:0.0063093473218055:0.0278281145716476!PAX5#5079;5:3.33478276558891:0.00985362449367583:0.0370327355606539!PBX3#5090;4:8.76580507469765:0.00072866783536506:0.005811036962255!SP2#6668;4:10.4614121975379:0.000372484517602528:0.00370353299065979!SUZ12#23512;4:20.0463123644252:3.01865267578508e-05:0.000620600525209287
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|tfbs_overrepresentation_for_novel_motifs=0.280498,0.0347211,0.273994,0.404877,0.668883,0.403356,0.474413,0.140612,0.847231,0.437939,0.375531,0.515448,0.348369,0.46359,1.23932,0.256724,1.64332,0.559826,0.371758,0.708167,0.274046,0.111654,0.396189,0.233338,0.314616,0.537051,0.310025,0.39419,0.240354,0.590419,0.355553,0.722879,0.958783,0.715457,0.20845,0.200804,1.12112,0.404426,0.186493,0.125439,0.207288,0.340749,0.127662,0.235234,0.413441,0.814459,0.47544,0.365597,0.116302,0.240465,0.550604,0.486559,0.0591862,0.797754,0.947672,1.17737,0.244111,0.435652,0.59006,0.434711,0.762758,0.477672,0.139078,0.660336,0.494624,0.627106,1.0348,1.4,0.712787,1.2388,0.328852,0.144996,0.0579262,0.945703,1.14624,0.0955465,0.292851,0.644006,1.68999,0.309107,0.11972,0.659298,0.49429,0.864635,0.89511,3.81901,1.53064,0.0795497,0.575506,1.4989,1.12715,0.868602,0.739223,0.509773,0.238337,0.53563,0.368981,0.780743,0.579925,2.45119,0.187593,0.733724,0.775299,0.690713,0.616014,0.37138,0.675372,1.16447,1.52535,0.637089,0.283874,0.772599,0.269151,0.384185,1.07963,0.204477,1.19911,0.933543,0.624851,0.173291,0.937551,0.57318,0.400807,0.504966,1.18924,0.644741,0.468435,0.744085,0.979528,1.02842,0.869279,0.358161,0.993705,2.16696,1.13991,0.260985,0.350108,0.394712,1.09788,1.95265,1.55112,2.41,0.470062,0.777301,0.617705,0.42776,0.601672,1.79367,0.337738,1.54649,1.15174,0.119096,0.869654,0.132719,0.477214,1.26919,0.560015,0.225815,0.314669,0.786832,1.05976,0.851493,0.708865,0.291837,0.633206,0.493542,0.158769,0.473159,0.248237
}}
}}

Revision as of 14:31, 26 November 2012


Full id: C857_non_lymphoma_CD19_acute_diffuse_Burkitt_B



Phase1 CAGE Peaks

Hg19::chr2:209185693..209185720,+p@chr2:209185693..209185720
+
Hg19::chr5:158526709..158526741,-p7@EBF1
Hg19::chr5:158526756..158526797,-p3@EBF1
Hg19::chr7:138793082..138793121,+p@chr7:138793082..138793121
+
Hg19::chr9:36834591..36834598,-p@chr9:36834591..36834598
-
Hg19::chr9:37024936..37024940,+p@chr9:37024936..37024940
+
Hg19::chr9:37027587..37027596,-p@chr9:37027587..37027596
-
Hg19::chr9:37027617..37027635,-p@chr9:37027617..37027635
-
Hg19::chr9:37027645..37027660,-p@chr9:37027645..37027660
-
Hg19::chr9:37027670..37027709,-p@chr9:37027670..37027709
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
blood4.97e-1115
haemolymphatic fluid4.97e-1115
organism substance4.97e-1115
hemopoietic organ2.87e-107
immune organ2.87e-107
spleen5.36e-103
gastrointestinal system mesentery5.36e-103
stomach region5.36e-103
mesentery5.36e-103
gastrointestinal system serosa5.36e-103
mesentery of stomach5.36e-103
gut mesentery5.36e-103
dorsal mesentery5.36e-103
dorsal mesogastrium5.36e-103
peritoneal cavity5.36e-103
spleen primordium5.36e-103
Disease
Ontology termp-valuen
lymphoma6.07e-1110


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CHD2#110644.137609133646740.01136509692198320.0416652400110573
NFYA#480047.370232279932210.001397112769899070.00909059003024666
NFYB#480146.703917301414580.001987047237327960.0115574307428879
NRF1#489944.884111779084360.00630934732180550.0278281145716476
PAX5#507953.334782765588910.009853624493675830.0370327355606539
PBX3#509048.765805074697650.000728667835365060.005811036962255
SP2#6668410.46141219753790.0003724845176025280.00370353299065979
SUZ12#23512420.04631236442523.01865267578508e-050.000620600525209287



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.