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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=-0.0069329150557655,

Latest revision as of 11:46, 17 September 2013


Full id: C1534_gastric_signet_endometrial_pharyngeal_papillotubular_bile_squamous



Phase1 CAGE Peaks

Hg19::chr7:116312178..116312192,+p7@MET
Hg19::chr7:116312193..116312211,+p5@MET
Hg19::chr7:116312213..116312230,+p3@MET
Hg19::chr7:116312243..116312256,+p2@MET
Hg19::chr7:116312277..116312288,+p8@MET
Hg19::chr7:116312308..116312319,+p9@MET


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell9.18e-38253
endo-epithelial cell1.34e-1242
endodermal cell7.58e-1258
embryonic cell1.90e-09250
squamous epithelial cell6.19e-0863
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure2.08e-14160
endoderm2.08e-14160
presumptive endoderm2.08e-14160
digestive system1.81e-11145
digestive tract1.81e-11145
primitive gut1.81e-11145
subdivision of digestive tract1.22e-10118
anatomical system1.96e-10624
anatomical group2.58e-10625
multi-cellular organism1.15e-09656
organ2.77e-09503
respiratory primordium4.16e-0938
endoderm of foregut4.16e-0938
organ part5.13e-09218
trunk region element6.22e-09101
respiratory tract3.00e-0854
renal system3.28e-0848
urinary system structure5.71e-0847
endo-epithelium6.06e-0882
respiratory system8.00e-0874
multi-tissue structure1.18e-07342
anatomical cluster1.36e-07373
foregut4.79e-0787
epithelial bud8.10e-0737
organism subdivision9.27e-07264
Disease
Ontology termp-valuen
carcinoma5.40e-18106
cell type cancer7.11e-17143
adenocarcinoma2.85e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.13.05245
MA0004.13.45359
MA0006.11.79433
MA0007.10.539222
MA0009.11.03681
MA0014.10.108006
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.152639
MA0050.11.34656
MA0051.10.661179
MA0052.10.959373
MA0055.10.0586456
MA0056.10
MA0057.11.41984
MA0058.13.00536
MA0059.10.457555
MA0060.10.267412
MA0061.10.23892
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.11.09642
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.10.00076337
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.11.09824
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.11.80532
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.381434
MA0105.10.134725
MA0106.10.70837
MA0107.10.320267
MA0108.20.868347
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.11.52717
MA0115.11.28169
MA0116.12.36812
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.13.45912
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.11.16614
MA0146.10.0213085
MA0147.14.27395
MA0148.10.584698
MA0149.10.612449
MA0062.20.23336
MA0035.23.73007
MA0039.24.30659
MA0138.20.765223
MA0002.20.255126
MA0137.20.414885
MA0104.23.79531
MA0047.20.695777
MA0112.20.332548
MA0065.21.7308
MA0150.11.21643
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.10.132326
MA0155.10.0961854
MA0156.10.417278
MA0157.10.810597
MA0158.10
MA0159.11.57484
MA0160.10.600559
MA0161.10
MA0162.13.59546
MA0163.10.813808
MA0164.10.738243
MA0080.20.394469
MA0018.20.709805
MA0099.20.629739
MA0079.21.68161
MA0102.21.58513
MA0258.10.289793
MA0259.11.6038
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553644.87181354697741.22070649245094e-101.31161898523748e-08
CTCF#1066465.360256373075034.21437267579784e-050.000756262659600774
E2F1#186964.907389214879327.15746523583771e-050.00112798930400733
E2F6#187665.017155731697396.26776799983417e-050.00102521444343724
EGR1#195864.988179094810146.48943962979974e-050.00105552185873953
EP300#203366.77394172622321.03454107484288e-050.000270048576144752
FOS#235368.99795530889441.88302066097805e-066.94669003221076e-05
JUND#372766.994663941871038.53468650061654e-060.00023242610780649
MAX#414966.452555509007121.3848964723355e-050.000334730855529386
MXI1#460169.96157162875931.02262624227062e-064.3047989567312e-05
MYC#460965.22228187160944.92821127172503e-050.00085469521256674
NR3C1#2908614.9730233311738.86442195171695e-085.24825036403269e-06
POLR2A#543062.147453176558070.01019570676818780.0380744956256576
RAD21#5885610.35503389545638.10515055094479e-073.54626652027701e-05
SMC3#9126615.04493284493288.61317699636729e-085.12857236216421e-06
TAF1#687263.343046285745290.0007162474284635620.00573827594210693
TCF7L2#6934610.77017656313736.40204410218762e-072.91593146091745e-05
TFAP2A#7020616.5186343730454.91595718330683e-083.16143874548881e-06
TFAP2C#7022610.80922860986026.2644941908553e-072.8670355337368e-05
USF1#739166.361499277207961.50818327938273e-050.000357091710531519
USF2#7392612.99219738506962.07721573629339e-071.11423900504748e-05



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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