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{{Coexpression_clusters
{{Coexpression_clusters
|full_id=C1444_immature_migratory_CD14_amniotic_Eosinophils_CD19_Neutrophils
|full_id=C1444_immature_migratory_CD14_amniotic_Eosinophils_CD19_Neutrophils
|gostat_on_coexpression_clusters=GO:0019207!kinase regulator activity!0.00913554713606416!10892;27071$GO:0045859!regulation of protein kinase activity!0.00913554713606416!200734;10892$GO:0043549!regulation of kinase activity!0.00913554713606416!200734;10892$GO:0051338!regulation of transferase activity!0.00913554713606416!200734;10892$GO:0004489!methylenetetrahydrofolate reductase (NADPH) activity!0.00913554713606416!4524$GO:0032449!CBM complex!0.00913554713606416!10892$GO:0002711!positive regulation of T cell mediated immunity!0.00913554713606416!10892$GO:0032743!positive regulation of interleukin-2 production!0.00913554713606416!10892$GO:0002726!positive regulation of T cell cytokine production!0.00913554713606416!10892$GO:0002369!T cell cytokine production!0.00913554713606416!10892$GO:0002724!regulation of T cell cytokine production!0.00913554713606416!10892$GO:0002702!positive regulation of production of molecular mediator of immune response!0.00913554713606416!10892$GO:0002720!positive regulation of cytokine production during immune response!0.00913554713606416!10892$GO:0005173!stem cell factor receptor binding!0.00913554713606416!200734$GO:0002709!regulation of T cell mediated immunity!0.00913554713606416!10892$GO:0032663!regulation of interleukin-2 production!0.00913554713606416!10892$GO:0007243!protein kinase cascade!0.00913554713606416!200734;10892$GO:0002824!positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains!0.00937218767921216!10892$GO:0002718!regulation of cytokine production during immune response!0.00937218767921216!10892$GO:0002821!positive regulation of adaptive immune response!0.00937218767921216!10892$GO:0002700!regulation of production of molecular mediator of immune response!0.00937218767921216!10892$GO:0002367!cytokine production during immune response!0.00937218767921216!10892$GO:0035014!phosphoinositide 3-kinase regulator activity!0.00937218767921216!27071$GO:0043621!protein self-association!0.00937218767921216!10892$GO:0002705!positive regulation of leukocyte mediated immunity!0.00937218767921216!10892$GO:0002456!T cell mediated immunity!0.00937218767921216!10892$GO:0002708!positive regulation of lymphocyte mediated immunity!0.00937218767921216!10892$GO:0002699!positive regulation of immune effector process!0.00967412384808736!10892$GO:0007250!activation of NF-kappaB-inducing kinase!0.00967412384808736!10892$GO:0002703!regulation of leukocyte mediated immunity!0.00967412384808736!10892$GO:0002706!regulation of lymphocyte mediated immunity!0.00967412384808736!10892$GO:0009086!methionine biosynthetic process!0.00967412384808736!4524$GO:0002819!regulation of adaptive immune response!0.00967412384808736!10892$GO:0002822!regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.!0.00967412384808736!10892$GO:0002697!regulation of immune effector process!0.0108425657983243!10892$GO:0050790!regulation of catalytic activity!0.0110794343074728!200734;10892$GO:0009067!aspartate family amino acid biosynthetic process!0.0111055472779436!4524$GO:0050852!T cell receptor signaling pathway!0.0111055472779436!10892$GO:0006555!methionine metabolic process!0.0111055472779436!4524$GO:0019209!kinase activator activity!0.0111055472779436!10892$GO:0000188!inactivation of MAPK activity!0.0111055472779436!200734$GO:0065009!regulation of a molecular function!0.0114971521612877!200734;10892$GO:0005942!phosphoinositide 3-kinase complex!0.0114971521612877!27071$GO:0000097!sulfur amino acid biosynthetic process!0.0114971521612877!4524$GO:0032623!interleukin-2 production!0.0118032216391385!10892$GO:0001819!positive regulation of cytokine production!0.0126451920081803!10892$GO:0043407!negative regulation of MAP kinase activity!0.0129136683529758!200734$GO:0002440!production of molecular mediator of immune response!0.0138461843222623!10892$GO:0050851!antigen receptor-mediated signaling pathway!0.0138461843222623!10892$GO:0009966!regulation of signal transduction!0.0138461843222623!200734;10892$GO:0009066!aspartate family amino acid metabolic process!0.0138818511611803!4524$GO:0000096!sulfur amino acid metabolic process!0.0141005159226811!4524$GO:0002429!immune response-activating cell surface receptor signaling pathway!0.0143108870724969!10892$GO:0002768!immune response-regulating cell surface receptor signaling pathway!0.0145134253692679!10892$GO:0002757!immune response-activating signal transduction!0.0147085580619147!10892$GO:0002764!immune response-regulating signal transduction!0.014896681881578!10892$GO:0016646!oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor!0.0150781657186168!4524$GO:0050870!positive regulation of T cell activation!0.0175607085218321!10892$GO:0001817!regulation of cytokine production!0.0175607085218321!10892$GO:0005515!protein binding!0.0176817365756131!4524;200734;10892;27071$GO:0051168!nuclear export!0.0180470171372814!10892$GO:0032501!multicellular organismal process!0.0180470171372814!4524;200734;10892$GO:0044272!sulfur compound biosynthetic process!0.0180470171372814!4524$GO:0030693!caspase activity!0.0197345665058968!10892$GO:0051251!positive regulation of lymphocyte activation!0.0198187015967892!10892$GO:0016645!oxidoreductase activity, acting on the CH-NH group of donors!0.019900253366686!4524$GO:0006469!negative regulation of protein kinase activity!0.0211674835851774!200734$GO:0033673!negative regulation of kinase activity!0.0211674835851774!200734$GO:0051348!negative regulation of transferase activity!0.021282316428579!200734$GO:0050863!regulation of T cell activation!0.021282316428579!10892$GO:0051259!protein oligomerization!0.0220465540844657!10892$GO:0032147!activation of protein kinase activity!0.0245368867182962!10892$GO:0002253!activation of immune response!0.0245454059728686!10892$GO:0002449!lymphocyte mediated immunity!0.0245536648911535!10892$GO:0002250!adaptive immune response!0.0249035740846093!10892$GO:0002460!adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains!0.0249035740846093!10892$GO:0051249!regulation of lymphocyte activation!0.0249035740846093!10892$GO:0002443!leukocyte mediated immunity!0.0252290237302291!10892$GO:0050865!regulation of cell activation!0.0255461214629594!10892$GO:0008652!amino acid biosynthetic process!0.0261196739881982!4524$GO:0050778!positive regulation of immune response!0.0261196739881982!10892$GO:0006790!sulfur metabolic process!0.0261196739881982!4524$GO:0002684!positive regulation of immune system process!0.0261196739881982!10892$GO:0043086!negative regulation of catalytic activity!0.0261196739881982!200734$GO:0043405!regulation of MAP kinase activity!0.027585235601085!200734$GO:0050776!regulation of immune response!0.0283196817116856!10892$GO:0042110!T cell activation!0.0283196817116856!10892$GO:0043123!positive regulation of I-kappaB kinase/NF-kappaB cascade!0.0283196817116856!10892$GO:0002682!regulation of immune system process!0.0283196817116856!10892$GO:0007165!signal transduction!0.0290757114283303!200734;10892;27071$GO:0051240!positive regulation of multicellular organismal process!0.0290757114283303!10892$GO:0043122!regulation of I-kappaB kinase/NF-kappaB cascade!0.0295774556148059!10892$GO:0002252!immune effector process!0.0297986264495236!10892$GO:0001816!cytokine production!0.0302816501657053!10892$GO:0009309!amine biosynthetic process!0.0315454828143631!4524$GO:0007154!cell communication!0.0344384781344397!200734;10892;27071$GO:0007249!I-kappaB kinase/NF-kappaB cascade!0.0360556320903252!10892$GO:0045860!positive regulation of protein kinase activity!0.0360849101192422!10892$GO:0004197!cysteine-type endopeptidase activity!0.0360849101192422!10892$GO:0033674!positive regulation of kinase activity!0.0362240154231583!10892$GO:0044271!nitrogen compound biosynthetic process!0.0362488046806512!4524$GO:0051347!positive regulation of transferase activity!0.0362488046806512!10892$GO:0000165!MAPKKK cascade!0.0365640539599067!200734$GO:0009967!positive regulation of signal transduction!0.0365640539599067!10892$GO:0006913!nucleocytoplasmic transport!0.0365640539599067!10892$GO:0046649!lymphocyte activation!0.0365640539599067!10892$GO:0051169!nuclear transport!0.0365640539599067!10892$GO:0007242!intracellular signaling cascade!0.0365640539599067!200734;10892$GO:0008015!blood circulation!0.0365640539599067!4524$GO:0003013!circulatory system process!0.0365640539599067!4524$GO:0004842!ubiquitin-protein ligase activity!0.0371339497738497!10892$GO:0008639!small protein conjugating enzyme activity!0.037247914142536!10892$GO:0006916!anti-apoptosis!0.0378012012049799!10892$GO:0045321!leukocyte activation!0.0396561771719475!10892$GO:0044445!cytosolic part!0.0414769691378795!27071$GO:0043687!post-translational protein modification!0.0440000489858293!10892;27071$GO:0001775!cell activation!0.0448071134385577!10892$GO:0004725!protein tyrosine phosphatase activity!0.0463221020896512!27071$GO:0043066!negative regulation of apoptosis!0.0478101264284914!10892$GO:0043069!negative regulation of programmed cell death!0.0480319249969728!10892$GO:0019787!small conjugating protein ligase activity!0.049888895594376!10892
|id=C1444
|id=C1444
}}
}}

Revision as of 17:34, 18 May 2012


Full id: C1444_immature_migratory_CD14_amniotic_Eosinophils_CD19_Neutrophils



Phase1 CAGE Peaks

Hg19::chr18:56338727..56338743,+p3@MALT1
Hg19::chr1:11863148..11863162,-p15@MTHFR
Hg19::chr1:11863171..11863195,-p7@MTHFR
Hg19::chr2:65593835..65593877,-p4@SPRED2
Hg19::chr4:100737954..100738014,+p1@DAPP1
Hg19::chr4:100738030..100738037,+p3@DAPP1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0019207kinase regulator activity0.00913554713606416
GO:0045859regulation of protein kinase activity0.00913554713606416
GO:0043549regulation of kinase activity0.00913554713606416
GO:0051338regulation of transferase activity0.00913554713606416
GO:0004489methylenetetrahydrofolate reductase (NADPH) activity0.00913554713606416
GO:0032449CBM complex0.00913554713606416
GO:0002711positive regulation of T cell mediated immunity0.00913554713606416
GO:0032743positive regulation of interleukin-2 production0.00913554713606416
GO:0002726positive regulation of T cell cytokine production0.00913554713606416
GO:0002369T cell cytokine production0.00913554713606416
GO:0002724regulation of T cell cytokine production0.00913554713606416
GO:0002702positive regulation of production of molecular mediator of immune response0.00913554713606416
GO:0002720positive regulation of cytokine production during immune response0.00913554713606416
GO:0005173stem cell factor receptor binding0.00913554713606416
GO:0002709regulation of T cell mediated immunity0.00913554713606416
GO:0032663regulation of interleukin-2 production0.00913554713606416
GO:0007243protein kinase cascade0.00913554713606416
GO:0002824positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.00937218767921216
GO:0002718regulation of cytokine production during immune response0.00937218767921216
GO:0002821positive regulation of adaptive immune response0.00937218767921216
GO:0002700regulation of production of molecular mediator of immune response0.00937218767921216
GO:0002367cytokine production during immune response0.00937218767921216
GO:0035014phosphoinositide 3-kinase regulator activity0.00937218767921216
GO:0043621protein self-association0.00937218767921216
GO:0002705positive regulation of leukocyte mediated immunity0.00937218767921216
GO:0002456T cell mediated immunity0.00937218767921216
GO:0002708positive regulation of lymphocyte mediated immunity0.00937218767921216
GO:0002699positive regulation of immune effector process0.00967412384808736
GO:0007250activation of NF-kappaB-inducing kinase0.00967412384808736
GO:0002703regulation of leukocyte mediated immunity0.00967412384808736
GO:0002706regulation of lymphocyte mediated immunity0.00967412384808736
GO:0009086methionine biosynthetic process0.00967412384808736
GO:0002819regulation of adaptive immune response0.00967412384808736
GO:0002822regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.0.00967412384808736
GO:0002697regulation of immune effector process0.0108425657983243
GO:0050790regulation of catalytic activity0.0110794343074728
GO:0009067aspartate family amino acid biosynthetic process0.0111055472779436
GO:0050852T cell receptor signaling pathway0.0111055472779436
GO:0006555methionine metabolic process0.0111055472779436
GO:0019209kinase activator activity0.0111055472779436
GO:0000188inactivation of MAPK activity0.0111055472779436
GO:0065009regulation of a molecular function0.0114971521612877
GO:0005942phosphoinositide 3-kinase complex0.0114971521612877
GO:0000097sulfur amino acid biosynthetic process0.0114971521612877
GO:0032623interleukin-2 production0.0118032216391385
GO:0001819positive regulation of cytokine production0.0126451920081803
GO:0043407negative regulation of MAP kinase activity0.0129136683529758
GO:0002440production of molecular mediator of immune response0.0138461843222623
GO:0050851antigen receptor-mediated signaling pathway0.0138461843222623
GO:0009966regulation of signal transduction0.0138461843222623
GO:0009066aspartate family amino acid metabolic process0.0138818511611803
GO:0000096sulfur amino acid metabolic process0.0141005159226811
GO:0002429immune response-activating cell surface receptor signaling pathway0.0143108870724969
GO:0002768immune response-regulating cell surface receptor signaling pathway0.0145134253692679
GO:0002757immune response-activating signal transduction0.0147085580619147
GO:0002764immune response-regulating signal transduction0.014896681881578
GO:0016646oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor0.0150781657186168
GO:0050870positive regulation of T cell activation0.0175607085218321
GO:0001817regulation of cytokine production0.0175607085218321
GO:0005515protein binding0.0176817365756131
GO:0051168nuclear export0.0180470171372814
GO:0032501multicellular organismal process0.0180470171372814
GO:0044272sulfur compound biosynthetic process0.0180470171372814
GO:0030693caspase activity0.0197345665058968
GO:0051251positive regulation of lymphocyte activation0.0198187015967892
GO:0016645oxidoreductase activity, acting on the CH-NH group of donors0.019900253366686
GO:0006469negative regulation of protein kinase activity0.0211674835851774
GO:0033673negative regulation of kinase activity0.0211674835851774
GO:0051348negative regulation of transferase activity0.021282316428579
GO:0050863regulation of T cell activation0.021282316428579
GO:0051259protein oligomerization0.0220465540844657
GO:0032147activation of protein kinase activity0.0245368867182962
GO:0002253activation of immune response0.0245454059728686
GO:0002449lymphocyte mediated immunity0.0245536648911535
GO:0002250adaptive immune response0.0249035740846093
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0249035740846093
GO:0051249regulation of lymphocyte activation0.0249035740846093
GO:0002443leukocyte mediated immunity0.0252290237302291
GO:0050865regulation of cell activation0.0255461214629594
GO:0008652amino acid biosynthetic process0.0261196739881982
GO:0050778positive regulation of immune response0.0261196739881982
GO:0006790sulfur metabolic process0.0261196739881982
GO:0002684positive regulation of immune system process0.0261196739881982
GO:0043086negative regulation of catalytic activity0.0261196739881982
GO:0043405regulation of MAP kinase activity0.027585235601085
GO:0050776regulation of immune response0.0283196817116856
GO:0042110T cell activation0.0283196817116856
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade0.0283196817116856
GO:0002682regulation of immune system process0.0283196817116856
GO:0007165signal transduction0.0290757114283303
GO:0051240positive regulation of multicellular organismal process0.0290757114283303
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascade0.0295774556148059
GO:0002252immune effector process0.0297986264495236
GO:0001816cytokine production0.0302816501657053
GO:0009309amine biosynthetic process0.0315454828143631
GO:0007154cell communication0.0344384781344397
GO:0007249I-kappaB kinase/NF-kappaB cascade0.0360556320903252
GO:0045860positive regulation of protein kinase activity0.0360849101192422
GO:0004197cysteine-type endopeptidase activity0.0360849101192422
GO:0033674positive regulation of kinase activity0.0362240154231583
GO:0044271nitrogen compound biosynthetic process0.0362488046806512
GO:0051347positive regulation of transferase activity0.0362488046806512
GO:0000165MAPKKK cascade0.0365640539599067
GO:0009967positive regulation of signal transduction0.0365640539599067
GO:0006913nucleocytoplasmic transport0.0365640539599067
GO:0046649lymphocyte activation0.0365640539599067
GO:0051169nuclear transport0.0365640539599067
GO:0007242intracellular signaling cascade0.0365640539599067
GO:0008015blood circulation0.0365640539599067
GO:0003013circulatory system process0.0365640539599067
GO:0004842ubiquitin-protein ligase activity0.0371339497738497
GO:0008639small protein conjugating enzyme activity0.037247914142536
GO:0006916anti-apoptosis0.0378012012049799
GO:0045321leukocyte activation0.0396561771719475
GO:0044445cytosolic part0.0414769691378795
GO:0043687post-translational protein modification0.0440000489858293
GO:0001775cell activation0.0448071134385577
GO:0004725protein tyrosine phosphatase activity0.0463221020896512
GO:0043066negative regulation of apoptosis0.0478101264284914
GO:0043069negative regulation of programmed cell death0.0480319249969728
GO:0019787small conjugating protein ligase activity0.049888895594376



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.