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{{Coexpression_clusters
{{Coexpression_clusters
|full_id=C580_chronic_thymus_Hodgkin_acute_iPS_vein_Burkitt
|full_id=C580_chronic_thymus_Hodgkin_acute_iPS_vein_Burkitt
|gostat_on_coexpression_clusters=GO:0030217!T cell differentiation!0.00187293756729479!3932;399$GO:0030098!lymphocyte differentiation!0.00230026342169233!3932;399$GO:0002521!leukocyte differentiation!0.0027079740611187!3932;399$GO:0042110!T cell activation!0.0027079740611187!3932;399$GO:0042610!CD8 receptor binding!0.00374128978289831!3932$GO:0046649!lymphocyte activation!0.00374128978289831!3932;399$GO:0030097!hemopoiesis!0.00374128978289831!3932;399$GO:0048534!hemopoietic or lymphoid organ development!0.00374128978289831!3932;399$GO:0045321!leukocyte activation!0.00374128978289831!3932;399$GO:0002520!immune system development!0.00374128978289831!3932;399$GO:0001775!cell activation!0.00398500640042086!3932;399$GO:0050862!positive regulation of T cell receptor signaling pathway!0.00398500640042086!3932$GO:0042609!CD4 receptor binding!0.00398500640042086!3932$GO:0051117!ATPase binding!0.00517959338214823!3932$GO:0006882!cellular zinc ion homeostasis!0.00517959338214823!3932$GO:0009249!protein lipoylation!0.00517959338214823!9397$GO:0055069!zinc ion homeostasis!0.00517959338214823!3932$GO:0019899!enzyme binding!0.00517959338214823!3932;399$GO:0043548!phosphoinositide 3-kinase binding!0.00517959338214823!3932$GO:0018065!protein-cofactor linkage!0.00517959338214823!9397$GO:0006499!N-terminal protein myristoylation!0.00517959338214823!9397$GO:0004379!glycylpeptide N-tetradecanoyltransferase activity!0.00517959338214823!9397$GO:0018319!protein amino acid myristoylation!0.00517959338214823!9397$GO:0018377!protein myristoylation!0.00517959338214823!9397$GO:0043124!negative regulation of I-kappaB kinase/NF-kappaB cascade!0.00517959338214823!399$GO:0001948!glycoprotein binding!0.00517959338214823!3932$GO:0050857!positive regulation of antigen receptor-mediated signaling pathway!0.00517959338214823!3932$GO:0000242!pericentriolar material!0.00517959338214823!3932$GO:0019107!myristoyltransferase activity!0.00517959338214823!9397$GO:0050856!regulation of T cell receptor signaling pathway!0.00517959338214823!3932$GO:0006498!N-terminal protein lipidation!0.00584766978870286!9397$GO:0051283!negative regulation of sequestering of calcium ion!0.00609310113743239!3932$GO:0051282!regulation of sequestering of calcium ion!0.00609310113743239!3932$GO:0051209!release of sequestered calcium ion into cytosol!0.00609310113743239!3932$GO:0005095!GTPase inhibitor activity!0.00699821430729356!399$GO:0051208!sequestering of calcium ion!0.00699821430729356!3932$GO:0050854!regulation of antigen receptor-mediated signaling pathway!0.00699821430729356!3932$GO:0051238!sequestering of metal ion!0.00885709258062343!3932$GO:0018409!peptide or protein amino-terminal blocking!0.0092934224497359!9397$GO:0050852!T cell receptor signaling pathway!0.0110012908396699!3932$GO:0042169!SH2 domain binding!0.0110932487759747!3932$GO:0031365!N-terminal protein amino acid modification!0.0110932487759747!9397$GO:0044450!microtubule organizing center part!0.0138420057461097!3932$GO:0050851!antigen receptor-mediated signaling pathway!0.0158772036844918!3932$GO:0002429!immune response-activating cell surface receptor signaling pathway!0.0167375395149149!3932$GO:0043543!protein amino acid acylation!0.0167375395149149!9397$GO:0002768!immune response-regulating cell surface receptor signaling pathway!0.0167375395149149!3932$GO:0002757!immune response-activating signal transduction!0.0167375395149149!3932$GO:0017048!Rho GTPase binding!0.0167375395149149!399$GO:0007264!small GTPase mediated signal transduction!0.0167375395149149!3932;399$GO:0002764!immune response-regulating signal transduction!0.0167375395149149!3932$GO:0004715!non-membrane spanning protein tyrosine kinase activity!0.0196329023784135!3932$GO:0050870!positive regulation of T cell activation!0.0196329023784135!3932$GO:0051235!maintenance of localization!0.0196329023784135!3932$GO:0019210!kinase inhibitor activity!0.0197452133423667!399$GO:0006919!caspase activation!0.0208632269515984!3932$GO:0045121!lipid raft!0.0208632269515984!3932$GO:0043280!positive regulation of caspase activity!0.0222824936971152!3932$GO:0051251!positive regulation of lymphocyte activation!0.0223419340034754!3932$GO:0006497!protein amino acid lipidation!0.0228291034560098!9397$GO:0042158!lipoprotein biosynthetic process!0.0229369435690701!9397$GO:0048513!organ development!0.0229369435690701!3932;399$GO:0050863!regulation of T cell activation!0.0241969489110459!3932$GO:0043281!regulation of caspase activity!0.024221511413098!3932$GO:0042493!response to drug!0.0250379984664169!3932$GO:0004722!protein serine/threonine phosphatase activity!0.0254392012708153!3932$GO:0051480!cytosolic calcium ion homeostasis!0.0265722426642582!3932$GO:0007204!elevation of cytosolic calcium ion concentration!0.0265722426642582!3932$GO:0002253!activation of immune response!0.0265722426642582!3932$GO:0008022!protein C-terminus binding!0.0272315094563042!3932$GO:0051345!positive regulation of hydrolase activity!0.0272315094563042!3932$GO:0051249!regulation of lymphocyte activation!0.0272315094563042!3932$GO:0017016!Ras GTPase binding!0.0272315094563042!399$GO:0050865!regulation of cell activation!0.0277089471060443!3932$GO:0002376!immune system process!0.0277089471060443!3932;399$GO:0019901!protein kinase binding!0.0277421206030372!3932$GO:0042157!lipoprotein metabolic process!0.0277421206030372!9397$GO:0031267!small GTPase binding!0.0277421206030372!399$GO:0050778!positive regulation of immune response!0.0277421206030372!3932$GO:0002684!positive regulation of immune system process!0.0277421206030372!3932$GO:0008632!apoptotic program!0.0280059165722411!3932$GO:0016410!N-acyltransferase activity!0.0280059165722411!9397$GO:0051020!GTPase binding!0.0299891491571014!399$GO:0050776!regulation of immune response!0.0299891491571014!3932$GO:0019900!kinase binding!0.0299891491571014!3932$GO:0002682!regulation of immune system process!0.0299891491571014!3932$GO:0009968!negative regulation of signal transduction!0.0307661597671867!399$GO:0051240!positive regulation of multicellular organismal process!0.0307661597671867!3932$GO:0048731!system development!0.0309378657180192!3932;399$GO:0043122!regulation of I-kappaB kinase/NF-kappaB cascade!0.0309378657180192!399$GO:0006874!cellular calcium ion homeostasis!0.0324956904139546!3932$GO:0055074!calcium ion homeostasis!0.0324956904139546!3932$GO:0018193!peptidyl-amino acid modification!0.0330107331571969!9397$GO:0019207!kinase regulator activity!0.0330107331571969!399$GO:0006875!cellular metal ion homeostasis!0.0330107331571969!3932$GO:0055065!metal ion homeostasis!0.0330107331571969!3932$GO:0019904!protein domain specific binding!0.0337269077482176!3932$GO:0005813!centrosome!0.0339054720560488!3932$GO:0048869!cellular developmental process!0.034846178409539!3932;399$GO:0030154!cell differentiation!0.034846178409539!3932;399$GO:0007249!I-kappaB kinase/NF-kappaB cascade!0.0354329812943836!399$GO:0005815!microtubule organizing center!0.0370918001383408!3932$GO:0007242!intracellular signaling cascade!0.0396255033883722!3932;399$GO:0048856!anatomical structure development!0.0407925640331565!3932;399$GO:0030005!cellular di-, tri-valent inorganic cation homeostasis!0.0440565636089676!3932$GO:0055066!di-, tri-valent inorganic cation homeostasis!0.044362402403937!3932$GO:0030003!cellular cation homeostasis!0.047914710907547!3932$GO:0055080!cation homeostasis!0.047914710907547!3932$GO:0043687!post-translational protein modification!0.047914710907547!9397;3932$GO:0006917!induction of apoptosis!0.0492119839151446!3932$GO:0012502!induction of programmed cell death!0.0492119839151446!3932$GO:0007275!multicellular organismal development!0.0492119839151446!3932;399
|id=C580
|id=C580
}}
}}

Revision as of 17:40, 18 May 2012


Full id: C580_chronic_thymus_Hodgkin_acute_iPS_vein_Burkitt



Phase1 CAGE Peaks

Hg19::chr10:15183694..15183716,-p4@NMT2
Hg19::chr16:89165074..89165092,+p5@ACSF3
Hg19::chr1:198488823..198488834,-p@chr1:198488823..198488834
-
Hg19::chr1:198488915..198488926,-p@chr1:198488915..198488926
-
Hg19::chr1:32398355..32398370,-p@chr1:32398355..32398370
-
Hg19::chr1:32403130..32403147,-p@chr1:32403130..32403147
-
Hg19::chr1:32739715..32739730,+p3@LCK
Hg19::chr1:32739735..32739746,+p4@LCK
Hg19::chr2:136578012..136578026,+p3@LOC100507600
Hg19::chr4:109084747..109084756,-p@chr4:109084747..109084756
-
Hg19::chr4:109084760..109084771,-p@chr4:109084760..109084771
-
Hg19::chr4:145580820..145580831,+p@chr4:145580820..145580831
+
Hg19::chr4:40192723..40192736,+p10@RHOH
Hg19::chr7:2106220..2106240,-p@chr7:2106220..2106240
-
Hg19::chrX:123538949..123538959,-p@chrX:123538949..123538959
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0030217T cell differentiation0.00187293756729479
GO:0030098lymphocyte differentiation0.00230026342169233
GO:0002521leukocyte differentiation0.0027079740611187
GO:0042110T cell activation0.0027079740611187
GO:0042610CD8 receptor binding0.00374128978289831
GO:0046649lymphocyte activation0.00374128978289831
GO:0030097hemopoiesis0.00374128978289831
GO:0048534hemopoietic or lymphoid organ development0.00374128978289831
GO:0045321leukocyte activation0.00374128978289831
GO:0002520immune system development0.00374128978289831
GO:0001775cell activation0.00398500640042086
GO:0050862positive regulation of T cell receptor signaling pathway0.00398500640042086
GO:0042609CD4 receptor binding0.00398500640042086
GO:0051117ATPase binding0.00517959338214823
GO:0006882cellular zinc ion homeostasis0.00517959338214823
GO:0009249protein lipoylation0.00517959338214823
GO:0055069zinc ion homeostasis0.00517959338214823
GO:0019899enzyme binding0.00517959338214823
GO:0043548phosphoinositide 3-kinase binding0.00517959338214823
GO:0018065protein-cofactor linkage0.00517959338214823
GO:0006499N-terminal protein myristoylation0.00517959338214823
GO:0004379glycylpeptide N-tetradecanoyltransferase activity0.00517959338214823
GO:0018319protein amino acid myristoylation0.00517959338214823
GO:0018377protein myristoylation0.00517959338214823
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cascade0.00517959338214823
GO:0001948glycoprotein binding0.00517959338214823
GO:0050857positive regulation of antigen receptor-mediated signaling pathway0.00517959338214823
GO:0000242pericentriolar material0.00517959338214823
GO:0019107myristoyltransferase activity0.00517959338214823
GO:0050856regulation of T cell receptor signaling pathway0.00517959338214823
GO:0006498N-terminal protein lipidation0.00584766978870286
GO:0051283negative regulation of sequestering of calcium ion0.00609310113743239
GO:0051282regulation of sequestering of calcium ion0.00609310113743239
GO:0051209release of sequestered calcium ion into cytosol0.00609310113743239
GO:0005095GTPase inhibitor activity0.00699821430729356
GO:0051208sequestering of calcium ion0.00699821430729356
GO:0050854regulation of antigen receptor-mediated signaling pathway0.00699821430729356
GO:0051238sequestering of metal ion0.00885709258062343
GO:0018409peptide or protein amino-terminal blocking0.0092934224497359
GO:0050852T cell receptor signaling pathway0.0110012908396699
GO:0042169SH2 domain binding0.0110932487759747
GO:0031365N-terminal protein amino acid modification0.0110932487759747
GO:0044450microtubule organizing center part0.0138420057461097
GO:0050851antigen receptor-mediated signaling pathway0.0158772036844918
GO:0002429immune response-activating cell surface receptor signaling pathway0.0167375395149149
GO:0043543protein amino acid acylation0.0167375395149149
GO:0002768immune response-regulating cell surface receptor signaling pathway0.0167375395149149
GO:0002757immune response-activating signal transduction0.0167375395149149
GO:0017048Rho GTPase binding0.0167375395149149
GO:0007264small GTPase mediated signal transduction0.0167375395149149
GO:0002764immune response-regulating signal transduction0.0167375395149149
GO:0004715non-membrane spanning protein tyrosine kinase activity0.0196329023784135
GO:0050870positive regulation of T cell activation0.0196329023784135
GO:0051235maintenance of localization0.0196329023784135
GO:0019210kinase inhibitor activity0.0197452133423667
GO:0006919caspase activation0.0208632269515984
GO:0045121lipid raft0.0208632269515984
GO:0043280positive regulation of caspase activity0.0222824936971152
GO:0051251positive regulation of lymphocyte activation0.0223419340034754
GO:0006497protein amino acid lipidation0.0228291034560098
GO:0042158lipoprotein biosynthetic process0.0229369435690701
GO:0048513organ development0.0229369435690701
GO:0050863regulation of T cell activation0.0241969489110459
GO:0043281regulation of caspase activity0.024221511413098
GO:0042493response to drug0.0250379984664169
GO:0004722protein serine/threonine phosphatase activity0.0254392012708153
GO:0051480cytosolic calcium ion homeostasis0.0265722426642582
GO:0007204elevation of cytosolic calcium ion concentration0.0265722426642582
GO:0002253activation of immune response0.0265722426642582
GO:0008022protein C-terminus binding0.0272315094563042
GO:0051345positive regulation of hydrolase activity0.0272315094563042
GO:0051249regulation of lymphocyte activation0.0272315094563042
GO:0017016Ras GTPase binding0.0272315094563042
GO:0050865regulation of cell activation0.0277089471060443
GO:0002376immune system process0.0277089471060443
GO:0019901protein kinase binding0.0277421206030372
GO:0042157lipoprotein metabolic process0.0277421206030372
GO:0031267small GTPase binding0.0277421206030372
GO:0050778positive regulation of immune response0.0277421206030372
GO:0002684positive regulation of immune system process0.0277421206030372
GO:0008632apoptotic program0.0280059165722411
GO:0016410N-acyltransferase activity0.0280059165722411
GO:0051020GTPase binding0.0299891491571014
GO:0050776regulation of immune response0.0299891491571014
GO:0019900kinase binding0.0299891491571014
GO:0002682regulation of immune system process0.0299891491571014
GO:0009968negative regulation of signal transduction0.0307661597671867
GO:0051240positive regulation of multicellular organismal process0.0307661597671867
GO:0048731system development0.0309378657180192
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascade0.0309378657180192
GO:0006874cellular calcium ion homeostasis0.0324956904139546
GO:0055074calcium ion homeostasis0.0324956904139546
GO:0018193peptidyl-amino acid modification0.0330107331571969
GO:0019207kinase regulator activity0.0330107331571969
GO:0006875cellular metal ion homeostasis0.0330107331571969
GO:0055065metal ion homeostasis0.0330107331571969
GO:0019904protein domain specific binding0.0337269077482176
GO:0005813centrosome0.0339054720560488
GO:0048869cellular developmental process0.034846178409539
GO:0030154cell differentiation0.034846178409539
GO:0007249I-kappaB kinase/NF-kappaB cascade0.0354329812943836
GO:0005815microtubule organizing center0.0370918001383408
GO:0007242intracellular signaling cascade0.0396255033883722
GO:0048856anatomical structure development0.0407925640331565
GO:0030005cellular di-, tri-valent inorganic cation homeostasis0.0440565636089676
GO:0055066di-, tri-valent inorganic cation homeostasis0.044362402403937
GO:0030003cellular cation homeostasis0.047914710907547
GO:0055080cation homeostasis0.047914710907547
GO:0043687post-translational protein modification0.047914710907547
GO:0006917induction of apoptosis0.0492119839151446
GO:0012502induction of programmed cell death0.0492119839151446
GO:0007275multicellular organismal development0.0492119839151446



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.