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|namespace=
|namespace=
|def="A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]. A highly vascular endocrine gland consisting of two lobes, one on either side of the trachea, joined by a narrow isthmus; it produces the thyroid hormones which are concerned in regulating the metabolic rate of the body[GAID]." [BTO:0001379, GAID:465, Wikipedia:Thyroid]
|def="A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]. A highly vascular endocrine gland consisting of two lobes, one on either side of the trachea, joined by a narrow isthmus; it produces the thyroid hormones which are concerned in regulating the metabolic rate of the body[GAID]." [BTO:0001379, GAID:465, Wikipedia:Thyroid]
|xref=AAO:0010544;;BTO:0001379;;EFO:0000861;;EHDAA:2148;;EHDAA:2975;;EHDAA2:0002028;;EMAPA:17068;;EMAPA:18698;;EMAPA:18827;;EV:0100133;;FMA:9603;;GAID:465;;galen:ThyroidGland;;http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Illu_endocrine_system.jpg/200px-Illu_endocrine_system.jpg;;MA:0000129;;MAT:0000081;;MESH:A.06.407.900;;MIAA:0000081;;ncithesaurus:Thyroid_Gland;;OpenCyc:Mx4rvVjLT5wpEbGdrcN5Y29ycA;;SCTID:181117000;;VHOG:0000418;;XAO:0000162
|xref=AAO:0010544;;BTO:0001379;;EFO:0000861;;EHDAA2:0002028;;EHDAA:2148;;EHDAA:2975;;EMAPA:17068;;EMAPA:18698;;EMAPA:18827;;EV:0100133;;FMA:9603;;GAID:465;;galen:ThyroidGland;;http://upload.wikimedia.org/wikipedia/commons/a/a3/Illu_thyroid_parathyroid.jpg;;http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Illu_endocrine_system.jpg/200px-Illu_endocrine_system.jpg;;MA:0000129;;MAT:0000081;;MESH:A.06.407.900;;MIAA:0000081;;ncithesaurus:Thyroid_Gland;;OpenCyc:Mx4rvVjLT5wpEbGdrcN5Y29ycA;;SCTID:181117000;;VHOG:0000418;;XAO:0000162
|is_a=UBERON:0002368;;UBERON:0002530;;UBERON:0004119
|is_a=UBERON:0002368;;UBERON:0004119;;UBERON:0010314
|synonym="thyroid" EXACT []
|synonym="glandula thyroidea" RELATED LATIN [Wikipedia:Thyroid];;"thyroid" EXACT []
|comment=
|comment=
|alt_id=UBERON:FMA_68805-FMA_9603-MA_0000129-MA_0000726-MIAA_0000081-XAO_0000162-ZFA_0001072
|alt_id=UBERON:FMA_68805-FMA_9603-MA_0000129-MA_0000726-MIAA_0000081-XAO_0000162-ZFA_0001072
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|obo_creation_date=
|obo_creation_date=
|subset=organ_slim;;uberon_slim
|subset=organ_slim;;uberon_slim
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=UBERON:0007689
|develops_from=
|has_quality=
|has_quality=
|located_in=
|located_in=
|part_of=UBERON:0000949
|part_of=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.obo.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "Either of paired structures located in the throat which develop from the ventral wall of the pharynx and excretes hormones involved in the morphological and functional changes during metamorphosis as well as influencing other tissues.[AAO]" xsd:string
|is_obsolete=
|is_obsolete=
|preceded_by=
|preceded_by=
}}
}}

Revision as of 17:00, 26 June 2012

Name:thyroid gland
Definition:"A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]. A highly vascular endocrine gland consisting of two lobes, one on either side of the trachea, joined by a narrow isthmus; it produces the thyroid hormones which are concerned in regulating the metabolic rate of the body[GAID]." [BTO:0001379, GAID:465, Wikipedia:Thyroid]
Xrefs:
links:

AAO:0010544
BTO:0001379
EFO:0000861
EHDAA2:0002028
EHDAA:2148
EHDAA:2975
EMAPA:17068
EMAPA:18698
EMAPA:18827
EV:0100133
FMA:9603
GAID:465
galen:ThyroidGland
[1]
[2]
MA:0000129
MAT:0000081
MESH:A.06.407.900
MIAA:0000081
ncithesaurus:Thyroid_Gland
OpenCyc:Mx4rvVjLT5wpEbGdrcN5Y29ycA
SCTID:181117000
VHOG:0000418

XAO:0000162
Synonyms: "glandula thyroidea" RELATED LATIN [Wikipedia:Thyroid]
"thyroid" EXACT []
Alt_id: UBERON:FMA_68805-FMA_9603-MA_0000129-MA_0000726-MIAA_0000081-XAO_0000162-ZFA_0001072
Subset: organ_slim
uberon_slim

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:UBERON:0002368(endocrine gland),UBERON:0004119(endoderm-derived structure),UBERON:0010314(structure with developmental contribution from neural crest)



Children

derives from:FF:0010028 (human thyroid - adult sample),FF:0010060 (human thyroid - fetal sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology


Human (Homo sapiens)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002046 (thyroid gland), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data


P-valueFFCPShort description
7.76e-118FFCP PHASE2:Hg19::chr8:11333461..11333472,-#_1987a6adcd9eb646d949d07d0bdca71bp@chr8:11333461..11333472, -
7.76e-118FFCP PHASE1:Hg19::chr8:11333461..11333472,-#_1987a6adcd9eb646d949d07d0bdca71bp@chr8:11333461..11333472, -
6.64e-89FFCP PHASE2:Hg19::chr8:11333445..11333459,-#_9ad73dfb8e3151378504da699925f2e7p@chr8:11333445..11333459, -
6.64e-89FFCP PHASE1:Hg19::chr8:11333445..11333459,-#_9ad73dfb8e3151378504da699925f2e7p@chr8:11333445..11333459, -
3.18e-79FFCP PHASE2:Hg19::chr14:36645825..36645840,-#_5eb7332b0d7e48332de68978eccad587p5@ENST00000556013
3.18e-79FFCP PHASE1:Hg19::chr14:36645825..36645840,-#_5eb7332b0d7e48332de68978eccad587p5@ENST00000556013
3.49e-79FFCP PHASE1:Hg19::chr8:134107312..134107315,+#_c3acdbdab95ff7e7ff9785f331e9ff61p46@TG
3.49e-79FFCP PHASE1:Hg19::chr8:133900431..133900436,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133900431..133900436, +
3.49e-79FFCP PHASE1:Hg19::chr8:133885307..133885312,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133885307..133885312, +
3.49e-79FFCP PHASE2:Hg19::chr2:1417430..1417444,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1417430..1417444, +
3.49e-79FFCP PHASE1:Hg19::chr8:133980132..133980143,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133980132..133980143, +
3.49e-79FFCP PHASE1:Hg19::chr7:107301406..107301418,+#_c3acdbdab95ff7e7ff9785f331e9ff61p5@SLC26A4
3.49e-79FFCP PHASE1:Hg19::chr21:39644214..39644219,+#_c3acdbdab95ff7e7ff9785f331e9ff61p21@KCNJ15
3.49e-79FFCP PHASE2:Hg19::chr14:21560489..21560506,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr14:21560489..21560506, -
3.49e-79FFCP PHASE2:Hg19::chr16:66420861..66420868,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr16:66420861..66420868, +
3.49e-79FFCP PHASE1:Hg19::chr2:1457477..1457487,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1457477..1457487, +
3.49e-79FFCP PHASE2:Hg19::chr8:133900431..133900436,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133900431..133900436, +
3.49e-79FFCP PHASE1:Hg19::chr8:133895057..133895065,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133895057..133895065, +
3.49e-79FFCP PHASE2:Hg19::chr14:67998625..67998628,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr14:67998625..67998628, -
3.49e-79FFCP PHASE1:Hg19::chr8:133899413..133899418,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133899413..133899418, +
3.49e-79FFCP PHASE1:Hg19::chr4:88047429..88047437,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr4:88047429..88047437, +
3.49e-79FFCP PHASE2:Hg19::chr8:133882027..133882038,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133882027..133882038, +
3.49e-79FFCP PHASE2:Hg19::chr21:39644214..39644219,+#_c3acdbdab95ff7e7ff9785f331e9ff61p21@KCNJ15
3.49e-79FFCP PHASE2:Hg19::chr8:133894780..133894789,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133894780..133894789, +
3.49e-79FFCP PHASE2:Hg19::chr15:64421903..64421920,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr15:64421903..64421920, +
3.49e-79FFCP PHASE1:Hg19::chr14:81421428..81421431,+#_c3acdbdab95ff7e7ff9785f331e9ff61p11@TSHR
3.49e-79FFCP PHASE2:Hg19::chr8:133980132..133980143,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133980132..133980143, +
3.49e-79FFCP PHASE2:Hg19::chr8:133961114..133961122,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133961114..133961122, +
3.49e-79FFCP PHASE1:Hg19::chr8:133981730..133981736,+#_c3acdbdab95ff7e7ff9785f331e9ff61p38@TG
3.49e-79FFCP PHASE1:Hg19::chr2:1417430..1417444,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1417430..1417444, +
3.49e-79FFCP PHASE2:Hg19::chr8:134107327..134107332,+#_c3acdbdab95ff7e7ff9785f331e9ff61p29@TG
3.49e-79FFCP PHASE2:Hg19::chr8:133899413..133899418,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133899413..133899418, +
3.49e-79FFCP PHASE2:Hg19::chr4:88047429..88047437,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr4:88047429..88047437, +
3.49e-79FFCP PHASE2:Hg19::chr2:134788853..134788858,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:134788853..134788858, -
3.49e-79FFCP PHASE2:Hg19::chr1:36771641..36771644,+#_c3acdbdab95ff7e7ff9785f331e9ff61p11@SH3D21
3.49e-79FFCP PHASE2:Hg19::chr8:133953595..133953600,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133953595..133953600, +
3.49e-79FFCP PHASE1:Hg19::chr16:66420861..66420868,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr16:66420861..66420868, +
3.49e-79FFCP PHASE1:Hg19::chr8:133894780..133894789,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133894780..133894789, +
3.49e-79FFCP PHASE2:Hg19::chr2:1457500..1457511,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1457500..1457511, +
3.49e-79FFCP PHASE1:Hg19::chr8:133899244..133899254,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133899244..133899254, -
3.49e-79FFCP PHASE1:Hg19::chr8:133882027..133882038,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133882027..133882038, +
3.49e-79FFCP PHASE2:Hg19::chr8:133981730..133981736,+#_c3acdbdab95ff7e7ff9785f331e9ff61p38@TG
3.49e-79FFCP PHASE1:Hg19::chr8:133961114..133961122,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133961114..133961122, +
3.49e-79FFCP PHASE1:Hg19::chr8:134107327..134107332,+#_c3acdbdab95ff7e7ff9785f331e9ff61p29@TG
3.49e-79FFCP PHASE1:Hg19::chr1:36771641..36771644,+#_c3acdbdab95ff7e7ff9785f331e9ff61p11@SH3D21
3.49e-79FFCP PHASE1:Hg19::chr8:133953595..133953600,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133953595..133953600, +
3.49e-79FFCP PHASE1:Hg19::chr2:134788853..134788858,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:134788853..134788858, -
3.49e-79FFCP PHASE2:Hg19::chr8:133899244..133899254,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133899244..133899254, -
3.49e-79FFCP PHASE1:Hg19::chr2:1457500..1457511,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1457500..1457511, +
3.49e-79FFCP PHASE2:Hg19::chr8:134145709..134145716,+#_c3acdbdab95ff7e7ff9785f331e9ff61p18@TG
3.49e-79FFCP PHASE2:Hg19::chr8:133895164..133895167,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133895164..133895167, +
3.49e-79FFCP PHASE1:Hg19::chr8:133898957..133898963,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133898957..133898963, -
3.49e-79FFCP PHASE2:Hg19::chr2:1426812..1426834,+#_c3acdbdab95ff7e7ff9785f331e9ff61p5@TPO
3.49e-79FFCP PHASE2:Hg19::chr6:43837226..43837237,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr6:43837226..43837237, -
3.49e-79FFCP PHASE2:Hg19::chr18:24321747..24321752,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr18:24321747..24321752, -
3.49e-79FFCP PHASE1:Hg19::chr8:133900307..133900325,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133900307..133900325, -
3.49e-79FFCP PHASE1:Hg19::chr8:133895164..133895167,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133895164..133895167, +
3.49e-79FFCP PHASE2:Hg19::chr8:133898734..133898737,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133898734..133898737, +
3.49e-79FFCP PHASE2:Hg19::chr8:133898957..133898963,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133898957..133898963, -
3.49e-79FFCP PHASE1:Hg19::chr8:134145709..134145716,+#_c3acdbdab95ff7e7ff9785f331e9ff61p18@TG
3.49e-79FFCP PHASE2:Hg19::chr8:133900307..133900325,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133900307..133900325, -
3.49e-79FFCP PHASE2:Hg19::chr2:1459933..1459941,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1459933..1459941, +
3.49e-79FFCP PHASE2:Hg19::chr2:1440068..1440076,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1440068..1440076, +
3.49e-79FFCP PHASE1:Hg19::chr6:43837226..43837237,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr6:43837226..43837237, -
3.49e-79FFCP PHASE1:Hg19::chr18:24321747..24321752,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr18:24321747..24321752, -
3.49e-79FFCP PHASE2:Hg19::chr14:81421428..81421431,+#_c3acdbdab95ff7e7ff9785f331e9ff61p11@TSHR
3.49e-79FFCP PHASE1:Hg19::chr2:1426812..1426834,+#_c3acdbdab95ff7e7ff9785f331e9ff61p5@TPO
3.49e-79FFCP PHASE2:Hg19::chr8:133885414..133885420,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133885414..133885420, -
3.49e-79FFCP PHASE1:Hg19::chr8:133898734..133898737,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133898734..133898737, +
3.49e-79FFCP PHASE1:Hg19::chr8:133981694..133981700,+#_c3acdbdab95ff7e7ff9785f331e9ff61p35@TG
3.49e-79FFCP PHASE1:Hg19::chr7:107301447..107301451,+#_c3acdbdab95ff7e7ff9785f331e9ff61p23@SLC26A4
3.49e-79FFCP PHASE1:Hg19::chr2:1459933..1459941,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1459933..1459941, +
3.49e-79FFCP PHASE2:Hg19::chr8:134145732..134145736,+#_c3acdbdab95ff7e7ff9785f331e9ff61p27@TG
3.49e-79FFCP PHASE2:Hg19::chr8:133895195..133895206,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133895195..133895206, +
3.49e-79FFCP PHASE2:Hg19::chr8:11333494..11333497,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:11333494..11333497, -
3.49e-79FFCP PHASE1:Hg19::chr2:1440068..1440076,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1440068..1440076, +
3.49e-79FFCP PHASE1:Hg19::chr8:133899004..133899013,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133899004..133899013, -
3.49e-79FFCP PHASE2:Hg19::chr8:133978809..133978829,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133978809..133978829, +
3.49e-79FFCP PHASE2:Hg19::chr8:133981694..133981700,+#_c3acdbdab95ff7e7ff9785f331e9ff61p35@TG
3.49e-79FFCP PHASE2:Hg19::chr7:107301447..107301451,+#_c3acdbdab95ff7e7ff9785f331e9ff61p23@SLC26A4
3.49e-79FFCP PHASE1:Hg19::chr8:133885414..133885420,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133885414..133885420, -
3.49e-79FFCP PHASE2:Hg19::chr2:1426850..1426859,+#_c3acdbdab95ff7e7ff9785f331e9ff61p10@TPO
3.49e-79FFCP PHASE2:Hg19::chr8:133898904..133898911,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133898904..133898911, +
3.49e-79FFCP PHASE1:Hg19::chr8:133900339..133900344,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133900339..133900344, -
3.49e-79FFCP PHASE2:Hg19::chr8:134108463..134108470,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:134108463..134108470, +
3.49e-79FFCP PHASE1:Hg19::chr15:64421903..64421920,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr15:64421903..64421920, +
3.49e-79FFCP PHASE1:Hg19::chr8:133895195..133895206,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133895195..133895206, +
3.49e-79FFCP PHASE2:Hg19::chr7:88388628..88388669,+#_c3acdbdab95ff7e7ff9785f331e9ff61p6@ZNF804B
3.49e-79FFCP PHASE1:Hg19::chr8:11333494..11333497,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:11333494..11333497, -
3.49e-79FFCP PHASE2:Hg19::chr8:133899004..133899013,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133899004..133899013, -
3.49e-79FFCP PHASE1:Hg19::chr8:134145732..134145736,+#_c3acdbdab95ff7e7ff9785f331e9ff61p27@TG
3.49e-79FFCP PHASE2:Hg19::chr8:133900339..133900344,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133900339..133900344, -
3.49e-79FFCP PHASE2:Hg19::chr2:1459978..1459990,-#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1459978..1459990, -
3.49e-79FFCP PHASE1:Hg19::chr8:133978809..133978829,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133978809..133978829, +
3.49e-79FFCP PHASE2:Hg19::chr8:133906083..133906088,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133906083..133906088, +
3.49e-79FFCP PHASE2:Hg19::chr2:1440089..1440096,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr2:1440089..1440096, +
3.49e-79FFCP PHASE1:Hg19::chr8:133898904..133898911,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:133898904..133898911, +
3.49e-79FFCP PHASE1:Hg19::chr8:134108463..134108470,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr8:134108463..134108470, +
3.49e-79FFCP PHASE2:Hg19::chr6:148533199..148533206,+#_c3acdbdab95ff7e7ff9785f331e9ff61p@chr6:148533199..148533206, +
3.49e-79FFCP PHASE1:Hg19::chr2:1426850..1426859,+#_c3acdbdab95ff7e7ff9785f331e9ff61p10@TPO










Property "Property value" (as page type) with input value "UBPROP:0000001 "Either of paired structures located in the throat which develop from the ventral wall of the pharynx and excretes hormones involved in the morphological and functional changes during metamorphosis as well as influencing other tissues.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.