Coexpression cluster:C1848

Full id: C1848_Corneal_Keratinocyte_Small_Urothelial_Esophageal_Tracheal_Sebocyte

Phase1 CAGE Peaks

Hg19::chr1:209600864..209600901,+	p@chr1:209600864..209600901 +
Hg19::chr1:209601463..209601482,+	p@chr1:209601463..209601482 +
Hg19::chr1:209601486..209601506,+	p@chr1:209601486..209601506 +
Hg19::chr1:209601525..209601530,+	p@chr1:209601525..209601530 +
Hg19::chr1:209601594..209601611,+	p@chr1:209601594..209601611 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
endo-epithelial cell	3.48e-23	43
epithelial cell	9.54e-17	254
endodermal cell	4.53e-16	59
general ecto-epithelial cell	3.34e-14	13
epithelial cell of alimentary canal	5.27e-14	21
respiratory epithelial cell	5.66e-14	13
ecto-epithelial cell	1.15e-09	33
acinar cell	2.06e-09	5
transitional epithelial cell	6.64e-09	4
urothelial cell	6.64e-09	4
squamous epithelial cell	7.98e-08	62
protein secreting cell	9.52e-08	6
epithelial cell of tracheobronchial tree	9.79e-08	9
epithelial cell of lower respiratory tract	9.79e-08	9
duct epithelial cell	5.83e-07	3
branched duct epithelial cell	5.83e-07	3
tracheal epithelial cell	5.83e-07	3
tracheoblast	5.83e-07	3
bronchial epithelial cell	7.75e-07	3

Uber Anatomy

Ontology term	p-value	n
respiratory system	5.00e-19	72
oral opening	1.37e-15	21
orifice	4.92e-15	35
mouth	1.57e-12	28
stomodeum	1.57e-12	28
endoderm-derived structure	1.91e-12	169
endoderm	1.91e-12	169
presumptive endoderm	1.91e-12	169
respiratory tract	1.71e-11	53
male reproductive organ	8.85e-11	11
surface structure	9.96e-11	95
urothelium	2.19e-10	5
mouth mucosa	1.82e-09	5
male organism	1.27e-08	22
male reproductive system	1.27e-08	22
transitional epithelium	1.53e-08	6
pharynx	1.60e-08	11
mucosa	1.96e-08	12
digestive system	3.07e-08	155
digestive tract	3.07e-08	155
primitive gut	3.07e-08	155
subdivision of head	1.05e-07	48
mucosa of oral region	1.36e-07	4
respiratory system mucosa	1.36e-07	4
neck	1.50e-07	10
mixed ectoderm/mesoderm/endoderm-derived structure	1.88e-07	18
anatomical space	2.40e-07	104
chordate pharynx	3.38e-07	10
pharyngeal region of foregut	3.38e-07	10
thoracic cavity element	3.47e-07	34
thoracic cavity	3.47e-07	34
gland of gut	4.09e-07	10
testis	6.00e-07	8
saliva-secreting gland	6.79e-07	6
gland of oral region	6.79e-07	6
gland of foregut	6.79e-07	6
oral gland	6.79e-07	6
oral cavity	6.79e-07	6
thoracic segment organ	6.96e-07	35
segment of respiratory tract	7.36e-07	46
lower respiratory tract epithelium	7.75e-07	3
epithelium of bronchus	7.75e-07	3

Disease

Ontology term	p-value	n
squamous cell carcinoma	1.92e-16	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
EP300#2033	4	5.41915338097856	0.0020938692794389	0.0121193534513035
FOXA1#3169	4	8.86513579950836	0.000307546859137271	0.00316795408042583
GATA3#2625	4	21.7892130857648	8.81158303710445e-06	0.000237673791532064
STAT3#6774	4	8.41557199772339	0.000377152721159863	0.00374317714009455

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.