MCL coexpression mm9:1034

Phase1 CAGE Peaks

	Short description
Mm9::chr10:62523378..62523405,+	p2@Pbld1
Mm9::chr12:33987111..33987131,+	p10@Atxn7l1
Mm9::chr12:74968671..74968675,+	p@chr12:74968671..74968675 +
Mm9::chr17:43804437..43804461,+	p2@Cyp39a1
Mm9::chr6:139535719..139535751,+	p1@Pik3c2g
Mm9::chr6:139845232..139845235,+	p@chr6:139845232..139845235 +
Mm9::chr8:108659441..108659470,+	p2@ENSMUST00000140509

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0033782	24-hydroxycholesterol 7alpha-hydroxylase activity	0.00442654832323127
GO:0008387	steroid 7-alpha-hydroxylase activity	0.00442654832323127
GO:0030573	bile acid catabolic process	0.00442654832323127
GO:0008396	oxysterol 7-alpha-hydroxylase activity	0.00442654832323127
GO:0035005	phosphatidylinositol-4-phosphate 3-kinase activity	0.00442654832323127
GO:0006707	cholesterol catabolic process	0.00553197275074394
GO:0016127	sterol catabolic process	0.00553197275074394
GO:0006699	bile acid biosynthetic process	0.00553197275074394
GO:0046395	carboxylic acid catabolic process	0.00553197275074394
GO:0006706	steroid catabolic process	0.00553197275074394
GO:0016054	organic acid catabolic process	0.00553197275074394
GO:0044255	cellular lipid metabolic process	0.00553197275074394
GO:0046854	phosphoinositide phosphorylation	0.00553197275074394
GO:0035004	phosphoinositide 3-kinase activity	0.00553197275074394
GO:0016303	1-phosphatidylinositol-3-kinase activity	0.00553197275074394
GO:0006629	lipid metabolic process	0.00553197275074394
GO:0005942	phosphoinositide 3-kinase complex	0.00553197275074394
GO:0016307	phosphatidylinositol phosphate kinase activity	0.00553197275074394
GO:0046834	lipid phosphorylation	0.00553197275074394
GO:0008395	steroid hydroxylase activity	0.00553197275074394
GO:0008206	bile acid metabolic process	0.00579524122475263
GO:0001727	lipid kinase activity	0.0105578556728842
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen	0.0105794246050111
GO:0030258	lipid modification	0.0105991708625171
GO:0044242	cellular lipid catabolic process	0.0119091415279413
GO:0004428	inositol or phosphatidylinositol kinase activity	0.0119091415279413
GO:0007586	digestion	0.0163775564470731
GO:0048015	phosphoinositide-mediated signaling	0.0167710368873478
GO:0030384	phosphoinositide metabolic process	0.0167710368873478
GO:0006650	glycerophospholipid metabolic process	0.0213621610797628
GO:0008203	cholesterol metabolic process	0.0228078961176848
GO:0006694	steroid biosynthetic process	0.0230363935280724
GO:0016125	sterol metabolic process	0.0230363935280724
GO:0016053	organic acid biosynthetic process	0.0230363935280724
GO:0046394	carboxylic acid biosynthetic process	0.0230363935280724
GO:0016042	lipid catabolic process	0.0280437053928451
GO:0044445	cytosolic part	0.0280437053928451
GO:0020037	heme binding	0.0314025432472364
GO:0046906	tetrapyrrole binding	0.0314025432472364
GO:0006644	phospholipid metabolic process	0.0319922495485837
GO:0019932	second-messenger-mediated signaling	0.0320612840675953
GO:0004497	monooxygenase activity	0.0320612840675953
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	0.0320612840675953
GO:0008202	steroid metabolic process	0.0350780635844419
GO:0006643	membrane lipid metabolic process	0.0366554511166649
GO:0005792	microsome	0.0366554511166649
GO:0042598	vesicular fraction	0.0368094199443403
GO:0035091	phosphoinositide binding	0.0376422993612194
GO:0005543	phospholipid binding	0.0449238549794652
GO:0032787	monocarboxylic acid metabolic process	0.0468702382571968

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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