MCL coexpression mm9:374

Phase1 CAGE Peaks

	Short description
Mm9::chr15:25914217..25914232,+	p3@Zfp622
Mm9::chr17:36005563..36005592,+	p@chr17:36005563..36005592 +
Mm9::chr19:36422775..36422803,+	p5@Pcgf5
Mm9::chr19:36422807..36422843,+	p2@Pcgf5
Mm9::chr19:36424066..36424074,+	p@chr19:36424066..36424074 +
Mm9::chr1:89516881..89516898,+	p2@Inpp5d
Mm9::chr4:102243160..102243173,+	p7@Pde4b
Mm9::chr4:102243191..102243223,+	p1@Pde4b
Mm9::chr4:102258666..102258669,+	p@chr4:102258666..102258669 +
Mm9::chr4:120689752..120689804,-	p2@Smap2
Mm9::chr4:140255901..140255913,+	p@chr4:140255901..140255913 +
Mm9::chr6:124679957..124679972,-	p@chr6:124679957..124679972 -
Mm9::chr6:128789641..128789666,-	p@chr6:128789641..128789666 -
Mm9::chr6:87800966..87800977,-	p2@Cnbp
Mm9::chr8:26311787..26311816,-	p4@Tacc1
Mm9::chr8:86773565..86773580,-	p2@D8Ertd738e
Mm9::chr9:64659258..64659283,+	p1@Dennd4a
Mm9::chr9:64659291..64659310,+	p2@Dennd4a
Mm9::chr9:64659311..64659314,+	p6@Dennd4a
Mm9::chr9:64659338..64659345,+	p5@Dennd4a
Mm9::chrX:12649180..12649195,+	p@chrX:12649180..12649195 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045659	negative regulation of neutrophil differentiation	0.0121075987508903
GO:0045658	regulation of neutrophil differentiation	0.0121075987508903
GO:0030852	regulation of granulocyte differentiation	0.0121075987508903
GO:0045656	negative regulation of monocyte differentiation	0.0121075987508903
GO:0045655	regulation of monocyte differentiation	0.0121075987508903
GO:0030853	negative regulation of granulocyte differentiation	0.0121075987508903
GO:0045409	negative regulation of interleukin-6 biosynthetic process	0.0121075987508903
GO:0030223	neutrophil differentiation	0.0211848151878558
GO:0030224	monocyte differentiation	0.0282417775969532
GO:0045779	negative regulation of bone resorption	0.0302242529538034
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	0.0302242529538034
GO:0045579	positive regulation of B cell differentiation	0.0302242529538034
GO:0045648	positive regulation of erythrocyte differentiation	0.0302242529538034
GO:0050777	negative regulation of immune response	0.0302242529538034
GO:0002683	negative regulation of immune system process	0.0302242529538034
GO:0045124	regulation of bone resorption	0.0302242529538034
GO:0030851	granulocyte differentiation	0.0302242529538034
GO:0008340	determination of adult life span	0.0302242529538034
GO:0008270	zinc ion binding	0.0302242529538034
GO:0030889	negative regulation of B cell proliferation	0.0302242529538034
GO:0045671	negative regulation of osteoclast differentiation	0.0302242529538034
GO:0002762	negative regulation of myeloid leukocyte differentiation	0.0302242529538034
GO:0045408	regulation of interleukin-6 biosynthetic process	0.0302242529538034
GO:0045577	regulation of B cell differentiation	0.0302242529538034
GO:0045646	regulation of erythrocyte differentiation	0.0302242529538034
GO:0010259	multicellular organismal aging	0.0302242529538034
GO:0042036	negative regulation of cytokine biosynthetic process	0.0302242529538034
GO:0042226	interleukin-6 biosynthetic process	0.0302242529538034
GO:0050869	negative regulation of B cell activation	0.032094965763412
GO:0042578	phosphoric ester hydrolase activity	0.0343631409171035
GO:0045639	positive regulation of myeloid cell differentiation	0.0343631409171035
GO:0046851	negative regulation of bone remodeling	0.0343631409171035
GO:0045621	positive regulation of lymphocyte differentiation	0.0358917949791537
GO:0045453	bone resorption	0.0358917949791537
GO:0045670	regulation of osteoclast differentiation	0.0358917949791537
GO:0042127	regulation of cell proliferation	0.0358917949791537
GO:0032635	interleukin-6 production	0.0358917949791537
GO:0046914	transition metal ion binding	0.0358917949791537
GO:0002761	regulation of myeloid leukocyte differentiation	0.0382274712110252
GO:0050672	negative regulation of lymphocyte proliferation	0.0382274712110252
GO:0032945	negative regulation of mononuclear cell proliferation	0.0382274712110252
GO:0045638	negative regulation of myeloid cell differentiation	0.0382274712110252
GO:0030316	osteoclast differentiation	0.0392971843375408
GO:0030888	regulation of B cell proliferation	0.0403176442248182
GO:0006695	cholesterol biosynthetic process	0.0406397771232482
GO:0045619	regulation of lymphocyte differentiation	0.0406397771232482
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	0.0406397771232482
GO:0017148	negative regulation of translation	0.0406397771232482
GO:0051250	negative regulation of lymphocyte activation	0.0406397771232482
GO:0001894	tissue homeostasis	0.0406397771232482
GO:0031327	negative regulation of cellular biosynthetic process	0.0406397771232482
GO:0048871	multicellular organismal homeostasis	0.0406397771232482
GO:0004112	cyclic-nucleotide phosphodiesterase activity	0.0406397771232482
GO:0050871	positive regulation of B cell activation	0.0406397771232482
GO:0042100	B cell proliferation	0.0414287135628179
GO:0007568	aging	0.0414670987599829
GO:0051241	negative regulation of multicellular organismal process	0.0414670987599829
GO:0046850	regulation of bone remodeling	0.0414670987599829
GO:0016126	sterol biosynthetic process	0.0414670987599829
GO:0004437	inositol or phosphatidylinositol phosphatase activity	0.0421751190266734
GO:0009890	negative regulation of biosynthetic process	0.0439822517988457
GO:0008283	cell proliferation	0.0439822517988457
GO:0045637	regulation of myeloid cell differentiation	0.0460911603436185
GO:0030183	B cell differentiation	0.0460911603436185
GO:0030218	erythrocyte differentiation	0.0472329066675493
GO:0050864	regulation of B cell activation	0.0472329066675493

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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