MCL coexpression mm9:2163

Phase1 CAGE Peaks

	Short description
Mm9::chr15:91668686..91668696,+	p2@Smgc
Mm9::chr3:113267929..113267940,-	p@chr3:113267929..113267940 -
Mm9::chr5:118231026..118231084,+	p2@Nos1
Mm9::chr6:132391763..132391770,-	p1@uc009eje.1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042737	drug catabolic process	0.00243795540459103
GO:0042738	exogenous drug catabolic process	0.00243795540459103
GO:0051926	negative regulation of calcium ion transport	0.00243795540459103
GO:0004517	nitric-oxide synthase activity	0.00243795540459103
GO:0043267	negative regulation of potassium ion transport	0.00243795540459103
GO:0002028	regulation of sodium ion transport	0.00243795540459103
GO:0043271	negative regulation of ion transport	0.00243795540459103
GO:0043266	regulation of potassium ion transport	0.00243795540459103
GO:0051346	negative regulation of hydrolase activity	0.00243795540459103
GO:0017144	drug metabolic process	0.00243795540459103
GO:0051924	regulation of calcium ion transport	0.00310285233311585
GO:0010181	FMN binding	0.00406325900765171
GO:0050661	NADP binding	0.00412577068469251
GO:0043269	regulation of ion transport	0.00417935212215604
GO:0046209	nitric oxide metabolic process	0.00516272909207511
GO:0006809	nitric oxide biosynthetic process	0.00516272909207511
GO:0051051	negative regulation of transport	0.00516272909207511
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen	0.00595944654455584
GO:0042383	sarcolemma	0.00696558687026008
GO:0006941	striated muscle contraction	0.00696558687026008
GO:0042493	response to drug	0.00696558687026008
GO:0043086	negative regulation of catalytic activity	0.0104167185468889
GO:0050660	FAD binding	0.0125077712061627
GO:0044271	nitrogen compound biosynthetic process	0.0151695002952331
GO:0003012	muscle system process	0.0151695002952331
GO:0006936	muscle contraction	0.0151695002952331
GO:0051049	regulation of transport	0.0151695002952331
GO:0006816	calcium ion transport	0.0165485457766179
GO:0005516	calmodulin binding	0.0165485457766179
GO:0051336	regulation of hydrolase activity	0.0165485457766179
GO:0020037	heme binding	0.0165485457766179
GO:0046906	tetrapyrrole binding	0.0165485457766179
GO:0006814	sodium ion transport	0.0165485457766179
GO:0050662	coenzyme binding	0.0166354604077976
GO:0004497	monooxygenase activity	0.0169302458652155
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	0.0169302458652155
GO:0015674	di-, tri-valent inorganic cation transport	0.0174506281591779
GO:0009055	electron carrier activity	0.0174506281591779
GO:0006813	potassium ion transport	0.0191285731744834
GO:0048037	cofactor binding	0.0204788253985646
GO:0050790	regulation of catalytic activity	0.0317528825866246
GO:0015672	monovalent inorganic cation transport	0.0332026307482397
GO:0005506	iron ion binding	0.0333376227418494
GO:0065009	regulation of a molecular function	0.034023022090737
GO:0006118	electron transport	0.034023022090737
GO:0006807	nitrogen compound metabolic process	0.0374173155574188
GO:0042995	cell projection	0.0377623730753674
GO:0030001	metal ion transport	0.0395151938494129
GO:0044248	cellular catabolic process	0.0398849504191092
GO:0006091	generation of precursor metabolites and energy	0.0398849504191092
GO:0042221	response to chemical stimulus	0.0404413778879217
GO:0006812	cation transport	0.0430392896425877
GO:0009056	catabolic process	0.048391114823203

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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