MCL coexpression mm9:3448

Phase1 CAGE Peaks

	Short description
Mm9::chr4:109339333..109339370,-	p3@Cdkn2c
Mm9::chr8:86479566..86479575,+	p3@Asf1b
Mm9::chr8:86479576..86479587,+	p2@Asf1b

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004861	cyclin-dependent protein kinase inhibitor activity	0.0276066045612885
GO:0042393	histone binding	0.0276066045612885
GO:0004860	protein kinase inhibitor activity	0.0379445204273789
GO:0019210	kinase inhibitor activity	0.0379445204273789
GO:0019887	protein kinase regulator activity	0.0464516653986035
GO:0019207	kinase regulator activity	0.0464516653986035
GO:0006355	regulation of transcription, DNA-dependent	0.0464516653986035
GO:0006351	transcription, DNA-dependent	0.0464516653986035
GO:0032774	RNA biosynthetic process	0.0464516653986035
GO:0006334	nucleosome assembly	0.0464516653986035
GO:0045449	regulation of transcription	0.0464516653986035
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0464516653986035
GO:0006350	transcription	0.0464516653986035
GO:0031497	chromatin assembly	0.0464516653986035
GO:0010468	regulation of gene expression	0.0464516653986035
GO:0031323	regulation of cellular metabolic process	0.0464516653986035
GO:0065004	protein-DNA complex assembly	0.0464516653986035
GO:0019222	regulation of metabolic process	0.0464516653986035
GO:0006333	chromatin assembly or disassembly	0.0464516653986035
GO:0016070	RNA metabolic process	0.0464516653986035

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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