MCL coexpression mm9:1009

Phase1 CAGE Peaks

	Short description
Mm9::chr10:120336020..120336044,-	p2@Msrb3
Mm9::chr10:120336045..120336067,-	p3@Msrb3
Mm9::chr10:120336082..120336093,-	p7@Msrb3
Mm9::chr10:120336107..120336118,-	p5@Msrb3
Mm9::chr10:126632296..126632354,+	p1@F420014N23Rik
Mm9::chr10:39332941..39332960,+	p2@Traf3ip2
Mm9::chr13:74946300..74946335,-	p9@Cast

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030161	calpain inhibitor activity	0.00813475747043468
GO:0001783	B cell apoptosis	0.00813475747043468
GO:0030091	protein repair	0.00813475747043468
GO:0000318	protein-methionine-R-oxide reductase activity	0.00813475747043468
GO:0016671	oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor	0.0173493954035186
GO:0048305	immunoglobulin secretion	0.0198762477607476
GO:0016667	oxidoreductase activity, acting on sulfur group of donors	0.0309606958326231
GO:0004869	cysteine protease inhibitor activity	0.036101018137574
GO:0009306	protein secretion	0.036101018137574
GO:0002377	immunoglobulin production	0.0393613436801453
GO:0002440	production of molecular mediator of immune response	0.0393613436801453

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
cardiovascular system	6.65e-10	23
circulatory system	6.65e-10	23
splanchnic layer of lateral plate mesoderm	1.20e-08	33
primary circulatory organ	7.45e-07	18
heart	7.45e-07	18
primitive heart tube	7.45e-07	18
primary heart field	7.45e-07	18
anterior lateral plate mesoderm	7.45e-07	18
heart tube	7.45e-07	18
heart primordium	7.45e-07	18
cardiac mesoderm	7.45e-07	18
cardiogenic plate	7.45e-07	18
heart rudiment	7.45e-07	18
reproductive structure	7.52e-07	26
reproductive system	7.52e-07	26

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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