MCL coexpression mm9:1583

Phase1 CAGE Peaks

	Short description
Mm9::chr11:72823222..72823239,+	p5@P2rx1
Mm9::chr6:108778502..108778511,+	p6@Edem1
Mm9::chr6:108778599..108778610,+	p4@Edem1
Mm9::chr6:108794661..108794664,+	p@chr6:108794661..108794664 +
Mm9::chr7:134422075..134422089,+	p@chr7:134422075..134422089 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007320	insemination	0.0150817990477646
GO:0030433	ER-associated protein catabolic process	0.0150817990477646
GO:0007620	copulation	0.0150817990477646
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	0.0150817990477646
GO:0006515	misfolded or incompletely synthesized protein catabolic process	0.0150817990477646
GO:0015924	mannosyl-oligosaccharide mannosidase activity	0.0150817990477646
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	0.0201052086526011
GO:0007618	mating	0.0201052086526011
GO:0015923	mannosidase activity	0.0201052086526011
GO:0006940	regulation of smooth muscle contraction	0.0219703145114774
GO:0030176	integral to endoplasmic reticulum membrane	0.023495730629226
GO:0031227	intrinsic to endoplasmic reticulum membrane	0.024766379441129
GO:0006939	smooth muscle contraction	0.0258339695861031
GO:0006986	response to unfolded protein	0.0258339695861031
GO:0051789	response to protein stimulus	0.0258339695861031
GO:0006937	regulation of muscle contraction	0.0258339695861031
GO:0016502	nucleotide receptor activity	0.0258339695861031
GO:0001614	purinergic nucleotide receptor activity	0.0258339695861031
GO:0031301	integral to organelle membrane	0.0339790161096225
GO:0031300	intrinsic to organelle membrane	0.035503201710864
GO:0005789	endoplasmic reticulum membrane	0.0392493008543478
GO:0048609	reproductive process in a multicellular organism	0.0392493008543478
GO:0032504	multicellular organism reproduction	0.0392493008543478
GO:0042175	nuclear envelope-endoplasmic reticulum network	0.0392493008543478
GO:0044432	endoplasmic reticulum part	0.0396565940540057
GO:0003012	muscle system process	0.0396565940540057
GO:0006936	muscle contraction	0.0396565940540057
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	0.0400787904412177
GO:0016798	hydrolase activity, acting on glycosyl bonds	0.0454545468189168
GO:0045211	postsynaptic membrane	0.0454545468189168
GO:0006511	ubiquitin-dependent protein catabolic process	0.0454545468189168
GO:0044456	synapse part	0.0454545468189168
GO:0043632	modification-dependent macromolecule catabolic process	0.0454545468189168
GO:0019941	modification-dependent protein catabolic process	0.0454545468189168
GO:0051603	proteolysis involved in cellular protein catabolic process	0.0454545468189168
GO:0044257	cellular protein catabolic process	0.0454545468189168

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
endocrine system	3.26e-14	72
pancreas	3.51e-12	12
thymus	1.01e-11	23
neck	1.01e-11	23
respiratory system epithelium	1.01e-11	23
hemolymphoid system gland	1.01e-11	23
pharyngeal epithelium	1.01e-11	23
thymic region	1.01e-11	23
pharyngeal gland	1.01e-11	23
entire pharyngeal arch endoderm	1.01e-11	23
thymus primordium	1.01e-11	23
early pharyngeal endoderm	1.01e-11	23
pharynx	5.22e-11	24
gland of gut	5.22e-11	24
upper respiratory tract	5.22e-11	24
chordate pharynx	5.22e-11	24
pharyngeal arch system	5.22e-11	24
pharyngeal region of foregut	5.22e-11	24
hemopoietic organ	2.17e-10	29
immune organ	2.17e-10	29
mixed endoderm/mesoderm-derived structure	7.48e-10	35
segment of respiratory tract	3.34e-09	27
viscus	8.22e-09	19
gland	6.17e-08	65
gut epithelium	1.39e-07	55
endocrine gland	8.86e-07	60

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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