MCL coexpression mm9:695

Phase1 CAGE Peaks

	Short description
Mm9::chr10:99950207..99950267,+	p@chr10:99950207..99950267 +
Mm9::chr12:117501419..117501519,-	p1@Wdr60
Mm9::chr14:57287079..57287186,+	p1@Mphosph8
Mm9::chr15:8119067..8119105,+	p2@2410089E03Rik
Mm9::chr16:37868651..37868819,+	p@chr16:37868651..37868819 +
Mm9::chr17:49754429..49754476,+	p1@Kif6
Mm9::chr18:24629345..24629423,+	p1@2700062C07Rik
Mm9::chr1:93391208..93391275,+	p1@Traf3ip1
Mm9::chr8:126042743..126042828,+	p1@Gas8
Mm9::chr8:49075889..49075931,-	p3@Wwc2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015630	microtubule cytoskeleton	0.010513171268616
GO:0042527	negative regulation of tyrosine phosphorylation of Stat6 protein	0.0117498832881236
GO:0042505	tyrosine phosphorylation of Stat6 protein	0.0117498832881236
GO:0042525	regulation of tyrosine phosphorylation of Stat6 protein	0.0117498832881236
GO:0043232	intracellular non-membrane-bound organelle	0.0117498832881236
GO:0043228	non-membrane-bound organelle	0.0117498832881236
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	0.0117498832881236
GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	0.0117498832881236
GO:0046426	negative regulation of JAK-STAT cascade	0.0128162988067131
GO:0042326	negative regulation of phosphorylation	0.0128162988067131
GO:0045936	negative regulation of phosphate metabolic process	0.0128162988067131
GO:0005874	microtubule	0.0189395092156769
GO:0005856	cytoskeleton	0.0205308899203803
GO:0033239	negative regulation of amine metabolic process	0.0205482177766548
GO:0001933	negative regulation of protein amino acid phosphorylation	0.0205482177766548
GO:0045763	negative regulation of amino acid metabolic process	0.0205482177766548
GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.024858259520906
GO:0051101	regulation of DNA binding	0.0260822551445187
GO:0007260	tyrosine phosphorylation of STAT protein	0.029643284328871
GO:0046425	regulation of JAK-STAT cascade	0.0305037018392697
GO:0051098	regulation of binding	0.0446512394951314
GO:0030317	sperm motility	0.0447465908164342
GO:0009434	microtubule-based flagellum	0.0468645424416261

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
ecto-epithelium	2.03e-13	73
neurectoderm	2.79e-13	64
neural plate	2.79e-13	64
presumptive neural plate	2.79e-13	64
ectoderm-derived structure	2.23e-12	95
ectoderm	2.23e-12	95
presumptive ectoderm	2.23e-12	95
pre-chordal neural plate	5.24e-12	49
regional part of nervous system	2.37e-11	54
neural tube	7.73e-11	52
neural rod	7.73e-11	52
future spinal cord	7.73e-11	52
neural keel	7.73e-11	52
central nervous system	8.90e-11	73
brain	2.30e-10	47
future brain	2.30e-10	47
nervous system	2.43e-10	75
regional part of brain	7.75e-10	46
anterior neural tube	1.48e-09	40
regional part of forebrain	4.51e-09	39
forebrain	4.51e-09	39
future forebrain	4.51e-09	39
structure with developmental contribution from neural crest	2.08e-08	92
multi-cellular organism	2.25e-07	333

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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