MCL coexpression mm9:351

Phase1 CAGE Peaks

	Short description
Mm9::chr11:102007554..102007574,-	p1@ENSMUST00000123060
Mm9::chr11:53236625..53236637,-	p1@Leap2
Mm9::chr11:98448507..98448567,-	p1@Ormdl3
Mm9::chr13:96661836..96661857,-	p2@Iqgap2
Mm9::chr14:56178830..56178841,+	p4@Dcaf11
Mm9::chr15:85565338..85565355,+	p7@Ppara
Mm9::chr15:85566051..85566080,+	p4@Ppara
Mm9::chr16:21826090..21826118,+	p@chr16:21826090..21826118 +
Mm9::chr17:85082272..85082284,-	p2@Abcg5
Mm9::chr17:85082473..85082481,+	p4@Abcg8
Mm9::chr17:85082530..85082533,+	p8@Abcg8
Mm9::chr1:159456258..159456284,+	p2@Sec16b
Mm9::chr2:27282009..27282055,-	p3@Vav2
Mm9::chr2:27282056..27282083,-	p2@Vav2
Mm9::chr3:104621398..104621422,-	p3@Mov10
Mm9::chr3:40753703..40753736,+	p@chr3:40753703..40753736 +
Mm9::chr3:40753740..40753774,+	p@chr3:40753740..40753774 +
Mm9::chr4:149594810..149594830,-	p@chr4:149594810..149594830 -
Mm9::chr5:89022703..89022738,+	p@chr5:89022703..89022738 +
Mm9::chr7:97591412..97591431,+	p2@Crebzf
Mm9::chr8:124900800..124900829,+	p@chr8:124900800..124900829 +
Mm9::chr9:44205228..44205237,+	p8@Slc37a4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042632	cholesterol homeostasis	0.00142028186206366
GO:0055088	lipid homeostasis	0.00142028186206366
GO:0055092	sterol homeostasis	0.00142028186206366
GO:0032642	regulation of chemokine production	0.0163918260012053
GO:0032682	negative regulation of chemokine production	0.0163918260012053
GO:0035166	post-embryonic hemopoiesis	0.018209647453125
GO:0002318	myeloid progenitor cell differentiation	0.018209647453125
GO:0045730	respiratory burst	0.018209647453125
GO:0006089	lactate metabolic process	0.018209647453125
GO:0015760	glucose-6-phosphate transport	0.0245783101549847
GO:0001780	neutrophil homeostasis	0.0297861785229007
GO:0002244	hemopoietic progenitor cell differentiation	0.0338786606807993
GO:0019217	regulation of fatty acid metabolic process	0.0338786606807993
GO:0048569	post-embryonic organ development	0.0338786606807993
GO:0046983	protein dimerization activity	0.0338786606807993
GO:0048878	chemical homeostasis	0.0338786606807993
GO:0032602	chemokine production	0.0338786606807993
GO:0002262	myeloid cell homeostasis	0.0338786606807993
GO:0001818	negative regulation of cytokine production	0.0338786606807993
GO:0032787	monocarboxylic acid metabolic process	0.0338786606807993
GO:0044262	cellular carbohydrate metabolic process	0.0419816813137615
GO:0015914	phospholipid transport	0.0419816813137615
GO:0030593	neutrophil chemotaxis	0.0419816813137615
GO:0016887	ATPase activity	0.0419816813137615
GO:0015918	sterol transport	0.0490436475972099

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
intestinal epithelial cell	1.89e-07	9
epithelial cell of alimentary canal	1.89e-07	9
epithelial cell	7.85e-07	25

Uber Anatomy

Ontology term	p-value	n
intestine	4.42e-18	31
gastrointestinal system	3.07e-14	47
digestive tract diverticulum	1.14e-13	23
sac	1.14e-13	23
liver	3.25e-13	22
epithelial sac	3.25e-13	22
digestive gland	3.25e-13	22
epithelium of foregut-midgut junction	3.25e-13	22
anatomical boundary	3.25e-13	22
hepatobiliary system	3.25e-13	22
foregut-midgut junction	3.25e-13	22
hepatic diverticulum	3.25e-13	22
liver primordium	3.25e-13	22
septum transversum	3.25e-13	22
liver bud	3.25e-13	22
exocrine gland	3.64e-12	25
exocrine system	3.64e-12	25
mucosa	1.61e-11	15
abdomen element	2.18e-10	49
abdominal segment element	2.18e-10	49
abdominal segment of trunk	2.18e-10	49
abdomen	2.18e-10	49
intestinal mucosa	3.04e-10	13
anatomical wall	3.04e-10	13
wall of intestine	3.04e-10	13
gastrointestinal system mucosa	3.04e-10	13
digestive system	1.19e-09	116
digestive tract	1.19e-09	116
primitive gut	1.19e-09	116
endoderm-derived structure	2.57e-09	118
endoderm	2.57e-09	118
presumptive endoderm	2.57e-09	118
subdivision of digestive tract	8.72e-09	114
trunk mesenchyme	1.38e-08	45
mesenchyme	1.58e-07	61
entire embryonic mesenchyme	1.58e-07	61
epithelium of mucosa	1.89e-07	9
gastrointestinal system epithelium	1.89e-07	9
intestinal epithelium	1.89e-07	9
organ component layer	6.84e-07	24

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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