MCL coexpression mm9:857

Phase1 CAGE Peaks

	Short description
Mm9::chr10:126913630..126913649,+	p@chr10:126913630..126913649 +
Mm9::chr16:21650184..21650196,-	p@chr16:21650184..21650196 -
Mm9::chr18:36447764..36447777,+	p@chr18:36447764..36447777 +
Mm9::chr19:23239717..23239730,+	p@chr19:23239717..23239730 +
Mm9::chr1:130090307..130090310,+	p@chr1:130090307..130090310 +
Mm9::chr2:166937189..166937194,-	p@chr2:166937189..166937194 -
Mm9::chr3:30708739..30708782,+	p@chr3:30708739..30708782 +
Mm9::chr9:47641021..47641027,+	p@chr9:47641021..47641027 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0031575	G1/S transition checkpoint	0.0206307894664708
GO:0005662	DNA replication factor A complex	0.0206307894664708
GO:0046332	SMAD binding	0.0206307894664708
GO:0030894	replisome	0.0206307894664708
GO:0043601	nuclear replisome	0.0206307894664708
GO:0043596	nuclear replication fork	0.0206307894664708
GO:0007093	mitotic cell cycle checkpoint	0.0229867042445797
GO:0003697	single-stranded DNA binding	0.0278385920403671
GO:0003690	double-stranded DNA binding	0.0278385920403671
GO:0005657	replication fork	0.0278385920403671
GO:0000075	cell cycle checkpoint	0.0278385920403671
GO:0007088	regulation of mitosis	0.0278385920403671
GO:0043566	structure-specific DNA binding	0.0456575436413394
GO:0065002	intracellular protein transport across a membrane	0.0476879771821804

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
structure with developmental contribution from neural crest	1.20e-10	92
neurectoderm	1.35e-09	64
neural plate	1.35e-09	64
presumptive neural plate	1.35e-09	64
tube	1.23e-08	114
occipital lobe	1.78e-08	10
visual cortex	1.78e-08	10
neocortex	1.78e-08	10
regional part of nervous system	2.08e-08	54
developing anatomical structure	2.30e-08	304
pre-chordal neural plate	4.10e-08	49
central nervous system	4.58e-08	73
neural tube	4.66e-08	52
neural rod	4.66e-08	52
future spinal cord	4.66e-08	52
neural keel	4.66e-08	52
ectoderm-derived structure	5.84e-08	95
ectoderm	5.84e-08	95
presumptive ectoderm	5.84e-08	95
ecto-epithelium	8.82e-08	73
brain	1.01e-07	47
future brain	1.01e-07	47
anatomical conduit	1.05e-07	122
nervous system	1.16e-07	75
regional part of brain	2.60e-07	46
anatomical cluster	3.08e-07	244
gray matter	3.37e-07	34
embryo	5.39e-07	320
brain grey matter	6.38e-07	29
regional part of telencephalon	6.38e-07	29
telencephalon	6.38e-07	29
anatomical system	6.85e-07	308
anatomical group	6.85e-07	308
anterior neural tube	7.41e-07	40

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}