MCL coexpression mm9:963

Phase1 CAGE Peaks

	Short description
Mm9::chr15:75760163..75760202,-	p1@Tsta3
Mm9::chr17:57201683..57201738,+	p1@Crb3
Mm9::chr4:135519657..135519675,+	p1@Gale
Mm9::chr5:135461886..135461903,+	p3@Cldn3
Mm9::chr5:135462061..135462140,+	p1@Cldn3
Mm9::chr5:135462146..135462162,+	p4@Cldn3
Mm9::chr5:135462172..135462193,+	p2@Cldn3
Mm9::chr7:4741143..4741216,-	p1@2210411K11Rik

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005923	tight junction	0.00246194977465085
GO:0043296	apical junction complex	0.00246194977465085
GO:0016327	apicolateral plasma membrane	0.00246194977465085
GO:0050577	GDP-L-fucose synthase activity	0.00246194977465085
GO:0003978	UDP-glucose 4-epimerase activity	0.00246194977465085
GO:0050662	coenzyme binding	0.00246194977465085
GO:0005911	intercellular junction	0.00316853207102322
GO:0016853	isomerase activity	0.00316853207102322
GO:0048037	cofactor binding	0.00343874979263409
GO:0045198	establishment of epithelial cell polarity	0.00543338323525149
GO:0006012	galactose metabolic process	0.00565930905470452
GO:0030859	polarized epithelial cell differentiation	0.00565930905470452
GO:0035089	establishment of apical/basal cell polarity	0.00582052519543573
GO:0016338	calcium-independent cell-cell adhesion	0.00582052519543573
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	0.00594129780225743
GO:0045197	establishment and/or maintenance of epithelial cell polarity	0.00594129780225743
GO:0045216	intercellular junction assembly and maintenance	0.00639011442359807
GO:0009225	nucleotide-sugar metabolic process	0.00740428882746588
GO:0001738	morphogenesis of a polarized epithelium	0.00740428882746588
GO:0035088	establishment and/or maintenance of apical/basal cell polarity	0.00740428882746588
GO:0030054	cell junction	0.00740428882746588
GO:0016854	racemase and epimerase activity	0.00740428882746588
GO:0030010	establishment of cell polarity	0.00767192954625124
GO:0007028	cytoplasm organization and biogenesis	0.00961134086558938
GO:0007163	establishment and/or maintenance of cell polarity	0.0130187005868609
GO:0030855	epithelial cell differentiation	0.0187584578422186
GO:0016324	apical plasma membrane	0.0245604382893872
GO:0045177	apical part of cell	0.0371309899944031

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
epithelial cell	1.93e-09	25
endodermal cell	3.84e-07	20
intestinal epithelial cell	4.71e-07	9
epithelial cell of alimentary canal	4.71e-07	9

Uber Anatomy

Ontology term	p-value	n
intestine	1.80e-16	31
endoderm-derived structure	3.06e-15	118
endoderm	3.06e-15	118
presumptive endoderm	3.06e-15	118
digestive system	8.68e-15	116
digestive tract	8.68e-15	116
primitive gut	8.68e-15	116
subdivision of digestive tract	1.06e-13	114
gastrointestinal system	5.66e-13	47
mucosa	5.78e-11	15
trunk region element	2.04e-10	79
intestinal mucosa	1.14e-09	13
anatomical wall	1.14e-09	13
wall of intestine	1.14e-09	13
gastrointestinal system mucosa	1.14e-09	13
immaterial anatomical entity	1.27e-09	79
trunk	4.86e-08	90
simple columnar epithelium	2.32e-07	11
epithelium of mucosa	4.71e-07	9
gastrointestinal system epithelium	4.71e-07	9
intestinal epithelium	4.71e-07	9

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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