MCL coexpression mm9:1221

Phase1 CAGE Peaks

	Short description
Mm9::chr10:12268528..12268573,-	p@chr10:12268528..12268573 -
Mm9::chr18:62483479..62483498,+	p2@Htr4
Mm9::chr2:24950600..24950612,-	p3@Noxa1
Mm9::chr2:24950615..24950630,-	p4@Noxa1
Mm9::chr2:24950645..24950658,-	p2@Noxa1
Mm9::chr2:24950672..24950689,-	p1@Noxa1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016176	superoxide-generating NADPH oxidase activator activity	0.00569753744574322
GO:0004993	serotonin receptor activity	0.00712133649185093
GO:0004935	adrenoceptor activity	0.0104429099297523
GO:0006801	superoxide metabolic process	0.0106790781611359
GO:0006800	oxygen and reactive oxygen species metabolic process	0.0165106372086046
GO:0008227	amine receptor activity	0.0203932444933924

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
gastrointestinal system	5.58e-25	47
intestine	4.51e-23	31
digestive system	1.58e-13	116
digestive tract	1.58e-13	116
primitive gut	1.58e-13	116
endoderm-derived structure	5.09e-13	118
endoderm	5.09e-13	118
presumptive endoderm	5.09e-13	118
subdivision of digestive tract	3.08e-12	114
mucosa	2.01e-11	15
intestinal mucosa	1.43e-09	13
anatomical wall	1.43e-09	13
wall of intestine	1.43e-09	13
gastrointestinal system mucosa	1.43e-09	13
simple columnar epithelium	2.77e-07	11

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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