MCL coexpression mm9:1838

Phase1 CAGE Peaks

	Short description
Mm9::chr7:125740809..125740856,+	p5@Tmc5
Mm9::chr7:86058795..86058804,+	p9@Isg20
Mm9::chr7:86058812..86058835,+	p4@Isg20
Mm9::chr7:86061540..86061574,+	p@chr7:86061540..86061574 +
Mm9::chrX:48499591..48499593,-	p3@Mbnl3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008859	exoribonuclease II activity	0.00953267955952446
GO:0045662	negative regulation of myoblast differentiation	0.0142974525237943
GO:0045661	regulation of myoblast differentiation	0.0238134233910549
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	0.0238134233910549
GO:0004532	exoribonuclease activity	0.0238134233910549
GO:0008408	3'-5' exonuclease activity	0.0238134233910549
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.0244897800963701
GO:0045445	myoblast differentiation	0.0428148497827463
GO:0004527	exonuclease activity	0.0467683106069337
GO:0004540	ribonuclease activity	0.0467683106069337
GO:0042692	muscle cell differentiation	0.0467683106069337
GO:0048741	skeletal muscle fiber development	0.0467683106069337
GO:0048747	muscle fiber development	0.0467683106069337

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
mixed endoderm/mesoderm-derived structure	6.74e-12	35
respiratory system	6.78e-11	42
respiratory tract	2.54e-10	41
hemopoietic organ	1.11e-08	29
immune organ	1.11e-08	29
foregut	2.33e-08	80
segment of respiratory tract	5.12e-08	27
pharynx	6.50e-07	24
upper respiratory tract	6.50e-07	24
chordate pharynx	6.50e-07	24
pharyngeal arch system	6.50e-07	24
pharyngeal region of foregut	6.50e-07	24
gland of gut	8.40e-07	24

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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