Novel motif:18

name:	motif18_CATCAG

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0050896	response to stimulus	4.095376e-68
GO:0006950	response to stress	9.940090e-46
GO:0065008	regulation of biological quality	3.002687e-42
GO:0032501	multicellular organismal process	7.491159e-41
GO:0051716	cellular response to stimulus	2.862437e-40
GO:0007154	cell communication	2.010922e-38
GO:0065007	biological regulation	3.039710e-37
GO:0051179	localization	4.728476e-37
GO:0023052	signaling	3.776888e-36
GO:0002376	immune system process	1.250710e-34
GO:0007165	signal transduction	1.160417e-33
GO:0050789	regulation of biological process	1.368572e-32
GO:0006952	defense response	7.571770e-32
GO:0007166	cell surface receptor linked signaling pathway	3.705282e-30
GO:0042221	response to chemical stimulus	5.929788e-30
GO:0050794	regulation of cellular process	7.269950e-30
GO:0046903	secretion	1.639298e-29
GO:0003008	system process	2.082219e-29
GO:0065009	regulation of molecular function	3.860559e-29
GO:0048518	positive regulation of biological process	9.655301e-29
GO:0006810	transport	1.779388e-28
GO:0051234	establishment of localization	2.680245e-27
GO:0048856	anatomical structure development	7.591192e-27
GO:0009611	response to wounding	1.565783e-26
GO:0008217	regulation of blood pressure	1.048165e-25
GO:0048519	negative regulation of biological process	2.476568e-25
GO:0006928	cellular component movement	3.083663e-25
GO:0032502	developmental process	3.531879e-25
GO:0009888	tissue development	1.094203e-24
GO:0032940	secretion by cell	2.539484e-24
GO:0048522	positive regulation of cellular process	9.004054e-24
GO:0009987	cellular process	1.571935e-23
GO:0048731	system development	2.073669e-23
GO:0048583	regulation of response to stimulus	1.974831e-22
GO:0048523	negative regulation of cellular process	3.050503e-22
GO:0010035	response to inorganic substance	4.595452e-22
GO:0002576	platelet degranulation	8.372315e-22
GO:0007275	multicellular organismal development	2.658391e-21
GO:0010038	response to metal ion	6.715014e-21
GO:0050790	regulation of catalytic activity	1.042370e-20
GO:0042060	wound healing	2.779257e-20
GO:0048584	positive regulation of response to stimulus	3.964303e-20
GO:0006955	immune response	9.551314e-20
GO:0007155	cell adhesion	1.618374e-19
GO:0009653	anatomical structure morphogenesis	2.324581e-19
GO:2000191	regulation of fatty acid transport	2.992797e-19
GO:0050865	regulation of cell activation	3.698566e-19
GO:0002694	regulation of leukocyte activation	3.735675e-19
GO:0006954	inflammatory response	4.649577e-19
GO:0042127	regulation of cell proliferation	5.158333e-19
GO:0002544	chronic inflammatory response	5.559852e-19
GO:0002696	positive regulation of leukocyte activation	5.628318e-19
GO:0001775	cell activation	5.680911e-19
GO:0050867	positive regulation of cell activation	8.351065e-19
GO:0072358	cardiovascular system development	1.602823e-18
GO:0051050	positive regulation of transport	3.307149e-18
GO:0030168	platelet activation	3.880010e-18
GO:0002682	regulation of immune system process	7.001575e-18
GO:0051641	cellular localization	8.059941e-18
GO:0045214	sarcomere organization	1.058783e-17
GO:0071840	cellular component organization or biogenesis	1.170018e-17
GO:0016043	cellular component organization	1.309368e-17
GO:0048513	organ development	1.397061e-17
GO:0030048	actin filament-based movement	1.408312e-17
GO:0002684	positive regulation of immune system process	1.615124e-17
GO:0051246	regulation of protein metabolic process	1.734968e-17
GO:0032890	regulation of organic acid transport	2.038848e-17
GO:0050878	regulation of body fluid levels	6.208572e-17
GO:0045727	positive regulation of translation	9.813260e-17
GO:0030240	skeletal muscle thin filament assembly	9.883257e-17
GO:0016192	vesicle-mediated transport	1.047501e-16
GO:0007596	blood coagulation	1.342312e-16
GO:0006887	exocytosis	1.783591e-16
GO:0008219	cell death	2.112580e-16
GO:0007599	hemostasis	2.170556e-16
GO:0070252	actin-mediated cell contraction	2.219172e-16
GO:0030049	muscle filament sliding	2.432982e-16
GO:0032879	regulation of localization	2.866307e-16
GO:0010466	negative regulation of peptidase activity	2.929495e-16
GO:0007010	cytoskeleton organization	3.004127e-16
GO:0016265	death	5.259708e-16
GO:0048646	anatomical structure formation involved in morphogenesis	9.475891e-16
GO:0030595	leukocyte chemotaxis	1.240689e-15
GO:0009628	response to abiotic stimulus	1.567682e-15
GO:0050852	T cell receptor signaling pathway	1.798528e-15
GO:0003013	circulatory system process	1.896941e-15
GO:0009893	positive regulation of metabolic process	2.316554e-15
GO:0051049	regulation of transport	2.856704e-15
GO:0048870	cell motility	3.204079e-15
GO:0070887	cellular response to chemical stimulus	4.435064e-15
GO:0051649	establishment of localization in cell	6.548745e-15
GO:0006915	apoptosis	7.403970e-15
GO:0048644	muscle organ morphogenesis	8.557004e-15
GO:0016477	cell migration	1.159870e-14
GO:0051592	response to calcium ion	1.227853e-14
GO:0012501	programmed cell death	1.396029e-14
GO:0008015	blood circulation	1.631576e-14
GO:0050870	positive regulation of T cell activation	1.855837e-14
GO:0048747	muscle fiber development	2.353668e-14
GO:0048769	sarcomerogenesis	2.619489e-14
GO:0003012	muscle system process	2.675192e-14
GO:0032891	negative regulation of organic acid transport	3.796905e-14
GO:0006629	lipid metabolic process	3.924220e-14
GO:0006953	acute-phase response	5.529569e-14
GO:0051128	regulation of cellular component organization	6.262123e-14
GO:0048739	cardiac muscle fiber development	6.276528e-14
GO:0002437	inflammatory response to antigenic stimulus	6.529289e-14
GO:0050877	neurological system process	7.034468e-14
GO:0035556	intracellular signal transduction	7.705053e-14
GO:0010829	negative regulation of glucose transport	8.349203e-14
GO:0045076	regulation of interleukin-2 biosynthetic process	8.804134e-14
GO:0010033	response to organic substance	1.001077e-13
GO:0048468	cell development	1.221753e-13
GO:0044092	negative regulation of molecular function	1.243915e-13
GO:0008285	negative regulation of cell proliferation	1.421750e-13
GO:0032663	regulation of interleukin-2 production	1.485857e-13
GO:0031589	cell-substrate adhesion	1.487055e-13
GO:0009966	regulation of signal transduction	1.820986e-13
GO:0034605	cellular response to heat	1.872106e-13
GO:0051251	positive regulation of lymphocyte activation	1.897566e-13
GO:0060415	muscle tissue morphogenesis	2.171808e-13
GO:0040017	positive regulation of locomotion	2.221349e-13
GO:0032368	regulation of lipid transport	2.433063e-13
GO:0031622	positive regulation of fever generation	2.571219e-13
GO:0002526	acute inflammatory response	3.904659e-13
GO:0051249	regulation of lymphocyte activation	4.048405e-13
GO:0007160	cell-matrix adhesion	4.446147e-13
GO:0007267	cell-cell signaling	4.509839e-13
GO:0031325	positive regulation of cellular metabolic process	5.674857e-13
GO:0022603	regulation of anatomical structure morphogenesis	6.155212e-13
GO:0050863	regulation of T cell activation	6.395166e-13
GO:0071702	organic substance transport	6.423921e-13
GO:0032268	regulation of cellular protein metabolic process	9.289791e-13
GO:0048871	multicellular organismal homeostasis	1.170748e-12
GO:0030029	actin filament-based process	1.240580e-12
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport	1.264891e-12
GO:0031652	positive regulation of heat generation	1.303845e-12
GO:0010941	regulation of cell death	1.405516e-12
GO:0050793	regulation of developmental process	1.757058e-12
GO:0055013	cardiac muscle cell development	1.769895e-12
GO:0003007	heart morphogenesis	1.785169e-12
GO:0044093	positive regulation of molecular function	1.878854e-12
GO:0010604	positive regulation of macromolecule metabolic process	1.952125e-12
GO:0009791	post-embryonic development	2.121420e-12
GO:0040007	growth	2.135474e-12
GO:0010746	regulation of plasma membrane long-chain fatty acid transport	2.260866e-12
GO:0051346	negative regulation of hydrolase activity	2.304167e-12
GO:0002708	positive regulation of lymphocyte mediated immunity	2.975947e-12
GO:0050900	leukocyte migration	3.135721e-12
GO:0009887	organ morphogenesis	3.245870e-12
GO:0046709	IDP catabolic process	4.124320e-12
GO:0046032	ADP catabolic process	4.124320e-12
GO:0040011	locomotion	4.128956e-12
GO:0048729	tissue morphogenesis	4.411305e-12
GO:0014866	skeletal myofibril assembly	5.076813e-12
GO:0006936	muscle contraction	5.188917e-12
GO:0051336	regulation of hydrolase activity	5.408878e-12
GO:0071842	cellular component organization at cellular level	5.521542e-12
GO:0030036	actin cytoskeleton organization	5.788887e-12
GO:0032103	positive regulation of response to external stimulus	5.922323e-12
GO:0009582	detection of abiotic stimulus	6.211157e-12
GO:0043086	negative regulation of catalytic activity	6.443735e-12
GO:0051051	negative regulation of transport	7.713156e-12
GO:0050851	antigen receptor-mediated signaling pathway	8.098419e-12
GO:0040012	regulation of locomotion	8.847615e-12
GO:0002439	chronic inflammatory response to antigenic stimulus	9.389753e-12
GO:0014050	negative regulation of glutamate secretion	9.496416e-12
GO:0042981	regulation of apoptosis	1.018979e-11
GO:0030239	myofibril assembly	1.137033e-11
GO:2000147	positive regulation of cell motility	1.233505e-11
GO:0010827	regulation of glucose transport	1.388704e-11
GO:0055003	cardiac myofibril assembly	1.578871e-11
GO:0055001	muscle cell development	1.792539e-11
GO:0030335	positive regulation of cell migration	1.815422e-11
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	1.832027e-11
GO:0043067	regulation of programmed cell death	1.875913e-11
GO:0007162	negative regulation of cell adhesion	2.058665e-11
GO:0055008	cardiac muscle tissue morphogenesis	2.144854e-11
GO:0042592	homeostatic process	2.174586e-11
GO:0002768	immune response-regulating cell surface receptor signaling pathway	2.349832e-11
GO:0010757	negative regulation of plasminogen activation	2.379601e-11
GO:0023051	regulation of signaling	2.455535e-11
GO:0071675	regulation of mononuclear cell migration	2.673152e-11
GO:0002429	immune response-activating cell surface receptor signaling pathway	2.747106e-11
GO:0071622	regulation of granulocyte chemotaxis	3.206933e-11
GO:0032101	regulation of response to external stimulus	3.232888e-11
GO:0030154	cell differentiation	3.513273e-11
GO:0007015	actin filament organization	3.577296e-11
GO:0060537	muscle tissue development	3.641804e-11
GO:0010817	regulation of hormone levels	4.423652e-11
GO:0031399	regulation of protein modification process	4.615709e-11
GO:0008207	C21-steroid hormone metabolic process	4.710499e-11
GO:0045086	positive regulation of interleukin-2 biosynthetic process	5.194789e-11
GO:0043503	skeletal muscle fiber adaptation	5.623583e-11
GO:0071841	cellular component organization or biogenesis at cellular level	6.559294e-11
GO:0010876	lipid localization	7.154771e-11
GO:0043500	muscle adaptation	7.159446e-11
GO:0055002	striated muscle cell development	7.469980e-11
GO:0010759	positive regulation of macrophage chemotaxis	8.097327e-11
GO:0050778	positive regulation of immune response	8.100085e-11
GO:2000145	regulation of cell motility	8.572982e-11
GO:0042180	cellular ketone metabolic process	1.014123e-10
GO:0019222	regulation of metabolic process	1.015451e-10
GO:0051272	positive regulation of cellular component movement	1.062620e-10
GO:0030155	regulation of cell adhesion	1.222495e-10
GO:0032270	positive regulation of cellular protein metabolic process	1.349872e-10
GO:0016998	cell wall macromolecule catabolic process	1.367851e-10
GO:0051240	positive regulation of multicellular organismal process	1.386843e-10
GO:0010755	regulation of plasminogen activation	1.407854e-10
GO:0051606	detection of stimulus	1.466952e-10
GO:0023056	positive regulation of signaling	1.580241e-10
GO:0051247	positive regulation of protein metabolic process	1.588445e-10
GO:0014706	striated muscle tissue development	1.736902e-10
GO:0048869	cellular developmental process	1.749543e-10
GO:0009605	response to external stimulus	1.969681e-10
GO:0045766	positive regulation of angiogenesis	2.091235e-10
GO:0003018	vascular process in circulatory system	2.097651e-10
GO:0007507	heart development	2.137609e-10
GO:0006082	organic acid metabolic process	2.162755e-10
GO:0032914	positive regulation of transforming growth factor beta1 production	2.341640e-10
GO:0044036	cell wall macromolecule metabolic process	2.454885e-10
GO:0016049	cell growth	2.489593e-10
GO:0032880	regulation of protein localization	2.521423e-10
GO:0051239	regulation of multicellular organismal process	2.523482e-10
GO:0019752	carboxylic acid metabolic process	3.294481e-10
GO:0010758	regulation of macrophage chemotaxis	3.488300e-10
GO:0031032	actomyosin structure organization	3.512707e-10
GO:0009967	positive regulation of signal transduction	3.612346e-10
GO:0001568	blood vessel development	4.296314e-10
GO:0006448	regulation of translational elongation	4.464910e-10
GO:0050776	regulation of immune response	5.486567e-10
GO:0010647	positive regulation of cell communication	6.095493e-10
GO:0030334	regulation of cell migration	6.099541e-10
GO:0051967	negative regulation of synaptic transmission, glutamatergic	6.277876e-10
GO:0002673	regulation of acute inflammatory response	6.387715e-10
GO:0051270	regulation of cellular component movement	8.336014e-10
GO:0044255	cellular lipid metabolic process	8.375168e-10
GO:0007076	mitotic chromosome condensation	1.001072e-9
GO:0002675	positive regulation of acute inflammatory response	1.027351e-9
GO:0070201	regulation of establishment of protein localization	1.027551e-9
GO:0070613	regulation of protein processing	1.043495e-9
GO:0010646	regulation of cell communication	1.201086e-9
GO:0032370	positive regulation of lipid transport	1.208688e-9
GO:0008360	regulation of cell shape	1.395521e-9
GO:0003006	developmental process involved in reproduction	1.560670e-9
GO:0030593	neutrophil chemotaxis	1.611812e-9
GO:0052547	regulation of peptidase activity	1.639918e-9
GO:0001944	vasculature development	1.642851e-9
GO:0001894	tissue homeostasis	1.718687e-9
GO:0032989	cellular component morphogenesis	1.859908e-9
GO:0032733	positive regulation of interleukin-10 production	1.885174e-9
GO:0044281	small molecule metabolic process	1.981995e-9
GO:0060548	negative regulation of cell death	2.649495e-9
GO:0010648	negative regulation of cell communication	2.711614e-9
GO:0023057	negative regulation of signaling	2.718887e-9
GO:0050820	positive regulation of coagulation	3.017484e-9
GO:0006811	ion transport	3.303836e-9
GO:0070587	regulation of cell-cell adhesion involved in gastrulation	3.327533e-9
GO:0034114	regulation of heterotypic cell-cell adhesion	3.327533e-9
GO:0022607	cellular component assembly	3.334689e-9
GO:0071844	cellular component assembly at cellular level	3.410062e-9
GO:0010955	negative regulation of protein processing	3.426714e-9
GO:0009891	positive regulation of biosynthetic process	3.427350e-9
GO:0010557	positive regulation of macromolecule biosynthetic process	3.467679e-9
GO:0007517	muscle organ development	3.799203e-9
GO:0032846	positive regulation of homeostatic process	3.823785e-9
GO:0070163	regulation of adiponectin secretion	4.044192e-9
GO:0043652	engulfment of apoptotic cell	4.107654e-9
GO:0010754	negative regulation of cGMP-mediated signaling	4.107654e-9
GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	4.107654e-9
GO:0002605	negative regulation of dendritic cell antigen processing and presentation	4.107654e-9
GO:0010751	negative regulation of nitric oxide mediated signal transduction	4.107654e-9
GO:0080134	regulation of response to stress	4.474179e-9
GO:0032908	regulation of transforming growth factor beta1 production	4.602260e-9
GO:0006941	striated muscle contraction	4.835741e-9
GO:0019220	regulation of phosphate metabolic process	4.884026e-9
GO:0010951	negative regulation of endopeptidase activity	4.911171e-9
GO:0002764	immune response-regulating signaling pathway	5.623220e-9
GO:0000070	mitotic sister chromatid segregation	6.549925e-9
GO:0009581	detection of external stimulus	6.557548e-9
GO:0048878	chemical homeostasis	7.144930e-9
GO:0070164	negative regulation of adiponectin secretion	7.572237e-9
GO:0060355	positive regulation of cell adhesion molecule production	7.572237e-9
GO:0035505	positive regulation of myosin light chain kinase activity	7.572237e-9
GO:0035457	cellular response to interferon-alpha	7.590126e-9
GO:0010927	cellular component assembly involved in morphogenesis	8.136053e-9
GO:0014065	phosphatidylinositol 3-kinase cascade	8.432379e-9
GO:0046627	negative regulation of insulin receptor signaling pathway	8.618898e-9
GO:0032308	positive regulation of prostaglandin secretion	9.358928e-9
GO:0007608	sensory perception of smell	9.928791e-9
GO:0007399	nervous system development	1.076526e-8
GO:0042445	hormone metabolic process	1.087275e-8
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	1.093987e-8
GO:0046324	regulation of glucose import	1.183442e-8
GO:0006911	phagocytosis, engulfment	1.254743e-8
GO:0070482	response to oxygen levels	1.259120e-8
GO:0034754	cellular hormone metabolic process	1.352148e-8
GO:0001660	fever generation	1.398525e-8
GO:2000193	positive regulation of fatty acid transport	1.456360e-8
GO:0048520	positive regulation of behavior	1.502830e-8
GO:0009886	post-embryonic morphogenesis	1.507398e-8
GO:0010595	positive regulation of endothelial cell migration	1.519514e-8
GO:0033554	cellular response to stress	1.601813e-8
GO:0002757	immune response-activating signal transduction	1.678904e-8
GO:0048557	embryonic digestive tract morphogenesis	1.709398e-8
GO:0001819	positive regulation of cytokine production	1.711389e-8
GO:0032770	positive regulation of monooxygenase activity	1.764353e-8
GO:0008283	cell proliferation	1.817549e-8
GO:0030261	chromosome condensation	1.889210e-8
GO:0006916	anti-apoptosis	1.950786e-8
GO:0014829	vascular smooth muscle contraction	2.006628e-8
GO:0001525	angiogenesis	2.019965e-8
GO:0035455	response to interferon-alpha	2.028001e-8
GO:0051223	regulation of protein transport	2.041991e-8
GO:0042493	response to drug	2.063722e-8
GO:0001666	response to hypoxia	2.069372e-8
GO:0010193	response to ozone	2.092652e-8
GO:0048545	response to steroid hormone stimulus	2.096888e-8
GO:0048738	cardiac muscle tissue development	2.414242e-8
GO:0002053	positive regulation of mesenchymal cell proliferation	2.512327e-8
GO:0007600	sensory perception	2.562352e-8
GO:0007602	phototransduction	2.680142e-8
GO:0032026	response to magnesium ion	2.838886e-8
GO:0048585	negative regulation of response to stimulus	2.956139e-8
GO:0033129	positive regulation of histone phosphorylation	2.958797e-8
GO:0060326	cell chemotaxis	3.024019e-8
GO:0007566	embryo implantation	3.151632e-8
GO:0051896	regulation of protein kinase B signaling cascade	3.180691e-8
GO:0052548	regulation of endopeptidase activity	3.194544e-8
GO:0010627	regulation of intracellular protein kinase cascade	3.198744e-8
GO:0044106	cellular amine metabolic process	3.217621e-8
GO:0048485	sympathetic nervous system development	3.452634e-8
GO:0032456	endocytic recycling	3.665103e-8
GO:0042325	regulation of phosphorylation	3.683715e-8
GO:0046827	positive regulation of protein export from nucleus	3.697046e-8
GO:0000819	sister chromatid segregation	3.762310e-8
GO:0009309	amine biosynthetic process	3.769080e-8
GO:0010464	regulation of mesenchymal cell proliferation	3.804712e-8
GO:0009308	amine metabolic process	3.834563e-8
GO:0050708	regulation of protein secretion	4.099727e-8
GO:0019725	cellular homeostasis	4.100169e-8
GO:0030241	skeletal muscle myosin thick filament assembly	4.118602e-8
GO:0050727	regulation of inflammatory response	4.252952e-8
GO:0051897	positive regulation of protein kinase B signaling cascade	4.311267e-8
GO:0031058	positive regulation of histone modification	4.324246e-8
GO:0033044	regulation of chromosome organization	4.405623e-8
GO:0009968	negative regulation of signal transduction	4.493630e-8
GO:0051895	negative regulation of focal adhesion assembly	4.549849e-8
GO:0045765	regulation of angiogenesis	4.561304e-8
GO:0008152	metabolic process	4.563765e-8
GO:0007186	G-protein coupled receptor protein signaling pathway	4.570469e-8
GO:0031099	regeneration	4.704127e-8
GO:0032892	positive regulation of organic acid transport	4.915998e-8
GO:0050921	positive regulation of chemotaxis	5.073365e-8
GO:0006996	organelle organization	5.243895e-8
GO:0008211	glucocorticoid metabolic process	5.263211e-8
GO:0031223	auditory behavior	5.384192e-8
GO:0032729	positive regulation of interferon-gamma production	5.429288e-8
GO:0002839	positive regulation of immune response to tumor cell	5.556498e-8
GO:0050818	regulation of coagulation	6.159574e-8
GO:0009266	response to temperature stimulus	6.372355e-8
GO:2000026	regulation of multicellular organismal development	6.549221e-8
GO:0055085	transmembrane transport	6.685259e-8
GO:0051222	positive regulation of protein transport	7.218488e-8
GO:0030162	regulation of proteolysis	7.517482e-8
GO:0051047	positive regulation of secretion	7.990493e-8
GO:0046626	regulation of insulin receptor signaling pathway	8.016428e-8
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	8.260670e-8
GO:0051258	protein polymerization	8.701486e-8
GO:0060764	cell-cell signaling involved in mammary gland development	9.771268e-8
GO:0021544	subpallium development	9.995087e-8
GO:0043462	regulation of ATPase activity	1.018157e-7
GO:0050954	sensory perception of mechanical stimulus	1.052424e-7
GO:0050729	positive regulation of inflammatory response	1.067044e-7
GO:0045338	farnesyl diphosphate metabolic process	1.123947e-7
GO:0007050	cell cycle arrest	1.133057e-7
GO:0042310	vasoconstriction	1.137860e-7
GO:0061061	muscle structure development	1.141813e-7
GO:0019221	cytokine-mediated signaling pathway	1.159354e-7
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	1.204921e-7
GO:0009181	purine ribonucleoside diphosphate catabolic process	1.223788e-7
GO:0032653	regulation of interleukin-10 production	1.230326e-7
GO:0030730	sequestering of triglyceride	1.268434e-7
GO:0071310	cellular response to organic substance	1.332056e-7
GO:0042692	muscle cell differentiation	1.363778e-7
GO:0030194	positive regulation of blood coagulation	1.407363e-7
GO:0008037	cell recognition	1.486824e-7
GO:0043066	negative regulation of apoptosis	1.575548e-7
GO:0046825	regulation of protein export from nucleus	1.591938e-7
GO:0001932	regulation of protein phosphorylation	1.620771e-7
GO:0031328	positive regulation of cellular biosynthetic process	1.651510e-7
GO:0043085	positive regulation of catalytic activity	1.661827e-7
GO:0032787	monocarboxylic acid metabolic process	1.717401e-7
GO:0001501	skeletal system development	1.740326e-7
GO:0051146	striated muscle cell differentiation	1.793064e-7
GO:0048514	blood vessel morphogenesis	1.808548e-7
GO:0034284	response to monosaccharide stimulus	1.829996e-7
GO:0009191	ribonucleoside diphosphate catabolic process	1.838866e-7
GO:0051130	positive regulation of cellular component organization	1.885141e-7
GO:0001655	urogenital system development	1.916034e-7
GO:0055082	cellular chemical homeostasis	1.930829e-7
GO:0033036	macromolecule localization	2.028160e-7
GO:2000353	positive regulation of endothelial cell apoptosis	2.083114e-7
GO:0055007	cardiac muscle cell differentiation	2.125337e-7
GO:0051094	positive regulation of developmental process	2.142355e-7
GO:0050996	positive regulation of lipid catabolic process	2.143395e-7
GO:0007522	visceral muscle development	2.228355e-7
GO:0009746	response to hexose stimulus	2.330928e-7
GO:0045087	innate immune response	2.432417e-7
GO:0045070	positive regulation of viral genome replication	2.512393e-7
GO:0033043	regulation of organelle organization	2.564946e-7
GO:0090084	negative regulation of inclusion body assembly	2.700610e-7
GO:0032369	negative regulation of lipid transport	2.791171e-7
GO:0045685	regulation of glial cell differentiation	2.977041e-7
GO:0034763	negative regulation of transmembrane transport	3.067672e-7
GO:0014823	response to activity	3.101921e-7
GO:0032024	positive regulation of insulin secretion	3.111177e-7
GO:0006869	lipid transport	3.113766e-7
GO:0050795	regulation of behavior	3.164323e-7
GO:0031056	regulation of histone modification	3.236664e-7
GO:0044241	lipid digestion	3.304778e-7
GO:0002687	positive regulation of leukocyte migration	3.360973e-7
GO:0045905	positive regulation of translational termination	3.428731e-7
GO:0045901	positive regulation of translational elongation	3.428731e-7
GO:0006452	translational frameshifting	3.428731e-7
GO:0010763	positive regulation of fibroblast migration	3.502846e-7
GO:0043069	negative regulation of programmed cell death	3.504986e-7
GO:0043032	positive regulation of macrophage activation	3.517025e-7
GO:0048566	embryonic digestive tract development	3.538478e-7
GO:0050880	regulation of blood vessel size	3.625820e-7
GO:0035150	regulation of tube size	3.710463e-7
GO:0009749	response to glucose stimulus	3.833478e-7
GO:2000171	negative regulation of dendrite development	4.506361e-7
GO:0009607	response to biotic stimulus	4.567900e-7
GO:0050920	regulation of chemotaxis	4.662865e-7
GO:0007417	central nervous system development	4.810834e-7
GO:0051241	negative regulation of multicellular organismal process	4.886910e-7
GO:0019538	protein metabolic process	4.914700e-7
GO:0046942	carboxylic acid transport	4.960959e-7
GO:0043129	surfactant homeostasis	5.196462e-7
GO:0046887	positive regulation of hormone secretion	5.262843e-7
GO:0001546	preantral ovarian follicle growth	5.263824e-7
GO:0002253	activation of immune response	5.326299e-7
GO:0044085	cellular component biogenesis	5.344406e-7
GO:0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	5.463624e-7
GO:0007613	memory	5.554382e-7
GO:0051918	negative regulation of fibrinolysis	5.634471e-7
GO:0009448	gamma-aminobutyric acid metabolic process	5.654387e-7
GO:0022407	regulation of cell-cell adhesion	5.758958e-7
GO:0000165	MAPKKK cascade	6.197106e-7
GO:0015849	organic acid transport	6.261756e-7
GO:0010638	positive regulation of organelle organization	6.389834e-7
GO:0010226	response to lithium ion	6.423259e-7
GO:0042534	regulation of tumor necrosis factor biosynthetic process	6.492561e-7
GO:0010812	negative regulation of cell-substrate adhesion	6.603276e-7
GO:0002711	positive regulation of T cell mediated immunity	6.943877e-7
GO:0002699	positive regulation of immune effector process	7.020901e-7
GO:0008610	lipid biosynthetic process	7.038832e-7
GO:0048009	insulin-like growth factor receptor signaling pathway	7.593314e-7
GO:0051235	maintenance of location	7.732151e-7
GO:0070294	renal sodium ion absorption	8.482636e-7
GO:0034014	response to triglyceride	8.596200e-7
GO:0051707	response to other organism	9.404342e-7
GO:0006508	proteolysis	9.480879e-7
GO:0070383	DNA cytosine deamination	9.825030e-7
GO:0043163	cell envelope organization	9.825030e-7
GO:0051648	vesicle localization	9.843734e-7
GO:0002690	positive regulation of leukocyte chemotaxis	1.003564e-6
GO:0060341	regulation of cellular localization	1.021734e-6
GO:0018149	peptide cross-linking	1.040732e-6
GO:0002821	positive regulation of adaptive immune response	1.041099e-6
GO:0030003	cellular cation homeostasis	1.042962e-6
GO:0090277	positive regulation of peptide hormone secretion	1.061073e-6
GO:0060675	ureteric bud morphogenesis	1.068645e-6
GO:0051917	regulation of fibrinolysis	1.087150e-6
GO:0031529	ruffle organization	1.110732e-6
GO:0009617	response to bacterium	1.121533e-6
GO:0031214	biomineral tissue development	1.130186e-6
GO:0046394	carboxylic acid biosynthetic process	1.188431e-6
GO:0046325	negative regulation of glucose import	1.196126e-6
GO:0043507	positive regulation of JUN kinase activity	1.217478e-6
GO:0044238	primary metabolic process	1.235944e-6
GO:0051248	negative regulation of protein metabolic process	1.236045e-6
GO:0009296	flagellum assembly	1.238812e-6
GO:0032269	negative regulation of cellular protein metabolic process	1.250201e-6
GO:0007606	sensory perception of chemical stimulus	1.303136e-6
GO:0051893	regulation of focal adhesion assembly	1.307175e-6
GO:0045995	regulation of embryonic development	1.327003e-6
GO:2000758	positive regulation of peptidyl-lysine acetylation	1.343721e-6
GO:0055080	cation homeostasis	1.345162e-6
GO:0030193	regulation of blood coagulation	1.353699e-6
GO:0008202	steroid metabolic process	1.390489e-6
GO:0002793	positive regulation of peptide secretion	1.411656e-6
GO:0007638	mechanosensory behavior	1.435876e-6
GO:0071636	positive regulation of transforming growth factor beta production	1.442304e-6
GO:0032649	regulation of interferon-gamma production	1.494186e-6
GO:0021756	striatum development	1.514785e-6
GO:0010243	response to organic nitrogen	1.576603e-6
GO:0007420	brain development	1.591685e-6
GO:0060562	epithelial tube morphogenesis	1.633634e-6

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0050896	response to stimulus	9.206259e-27
GO:0051716	cellular response to stimulus	7.583972e-19
GO:0030300	regulation of intestinal cholesterol absorption	2.161604e-18
GO:0033344	cholesterol efflux	7.313653e-17
GO:0007165	signal transduction	5.557906e-16
GO:0033700	phospholipid efflux	8.909416e-16
GO:0032374	regulation of cholesterol transport	1.459261e-15
GO:0016125	sterol metabolic process	6.419602e-15
GO:0006581	acetylcholine catabolic process	2.872194e-14
GO:0008203	cholesterol metabolic process	5.328218e-14
GO:0034369	plasma lipoprotein particle remodeling	9.853623e-14
GO:0071827	plasma lipoprotein particle organization	2.647114e-13
GO:0032368	regulation of lipid transport	2.797874e-13
GO:0044281	small molecule metabolic process	3.541450e-13
GO:0042157	lipoprotein metabolic process	5.543136e-13
GO:0015914	phospholipid transport	6.556699e-13
GO:0010901	regulation of very-low-density lipoprotein particle remodeling	6.830533e-13
GO:0044241	lipid digestion	1.160442e-12
GO:0033058	directional locomotion	2.583917e-12
GO:0044058	regulation of digestive system process	3.818105e-12
GO:0023052	signaling	3.934495e-12
GO:0032375	negative regulation of cholesterol transport	3.976022e-12
GO:0042304	regulation of fatty acid biosynthetic process	4.165234e-12
GO:0007154	cell communication	4.460345e-12
GO:0042743	hydrogen peroxide metabolic process	4.636570e-12
GO:0043056	forward locomotion	5.297533e-12
GO:0006869	lipid transport	7.433890e-12
GO:0008291	acetylcholine metabolic process	1.386520e-11
GO:0007186	G-protein coupled receptor protein signaling pathway	1.457820e-11
GO:0097006	regulation of plasma lipoprotein particle levels	2.079366e-11
GO:0010876	lipid localization	3.270716e-11
GO:0006982	response to lipid hydroperoxide	3.279394e-11
GO:0009308	amine metabolic process	4.781917e-11
GO:0006629	lipid metabolic process	4.910964e-11
GO:0032369	negative regulation of lipid transport	5.520151e-11
GO:0010873	positive regulation of cholesterol esterification	6.645109e-11
GO:0002694	regulation of leukocyte activation	7.279580e-11
GO:0007166	cell surface receptor linked signaling pathway	7.436479e-11
GO:0030301	cholesterol transport	9.440087e-11
GO:0006278	RNA-dependent DNA replication	9.632619e-11
GO:0006950	response to stress	9.812779e-11
GO:0050746	regulation of lipoprotein metabolic process	1.306277e-10
GO:0071702	organic substance transport	1.386588e-10
GO:0010872	regulation of cholesterol esterification	2.078378e-10
GO:0006952	defense response	2.106956e-10
GO:0042439	ethanolamine-containing compound metabolic process	2.111330e-10
GO:2000351	regulation of endothelial cell apoptosis	2.667538e-10
GO:0043691	reverse cholesterol transport	2.676695e-10
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling	2.800281e-10
GO:0006955	immune response	2.838849e-10
GO:0007155	cell adhesion	4.463805e-10
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	6.862361e-10
GO:0022610	biological adhesion	7.496000e-10
GO:0050865	regulation of cell activation	8.291235e-10
GO:0034445	negative regulation of plasma lipoprotein particle oxidation	1.030866e-9
GO:0034442	regulation of lipoprotein oxidation	1.042049e-9
GO:0002521	leukocyte differentiation	1.133588e-9
GO:0090207	regulation of triglyceride metabolic process	1.215642e-9
GO:0044255	cellular lipid metabolic process	1.356886e-9
GO:0045940	positive regulation of steroid metabolic process	1.561760e-9
GO:0042135	neurotransmitter catabolic process	1.760974e-9
GO:0008202	steroid metabolic process	1.904831e-9
GO:0010896	regulation of triglyceride catabolic process	1.959478e-9
GO:0045212	neurotransmitter receptor biosynthetic process	2.403601e-9
GO:0007586	digestion	2.860672e-9
GO:0042744	hydrogen peroxide catabolic process	3.678457e-9
GO:0009628	response to abiotic stimulus	4.002755e-9
GO:0002227	innate immune response in mucosa	4.898509e-9
GO:0065005	protein-lipid complex assembly	6.579007e-9
GO:0002700	regulation of production of molecular mediator of immune response	7.793007e-9
GO:0033003	regulation of mast cell activation	1.269269e-8
GO:0006066	alcohol metabolic process	1.564530e-8
GO:0042402	cellular biogenic amine catabolic process	1.596278e-8
GO:0032800	receptor biosynthetic process	1.880452e-8
GO:0030183	B cell differentiation	1.916235e-8
GO:0043503	skeletal muscle fiber adaptation	2.031243e-8
GO:0030204	chondroitin sulfate metabolic process	2.304945e-8
GO:0051250	negative regulation of lymphocyte activation	2.325734e-8
GO:0010565	regulation of cellular ketone metabolic process	2.534344e-8
GO:0030299	intestinal cholesterol absorption	2.542514e-8
GO:0002695	negative regulation of leukocyte activation	3.645360e-8
GO:0046890	regulation of lipid biosynthetic process	4.212940e-8
GO:0050957	equilibrioception	4.811662e-8
GO:0002376	immune system process	5.020794e-8
GO:0030203	glycosaminoglycan metabolic process	5.682738e-8
GO:0046470	phosphatidylcholine metabolic process	6.447211e-8
GO:0048565	digestive tract development	6.628791e-8
GO:0006082	organic acid metabolic process	7.371967e-8
GO:0016042	lipid catabolic process	8.062413e-8
GO:0055003	cardiac myofibril assembly	8.288690e-8
GO:0090130	tissue migration	8.784081e-8
GO:0070301	cellular response to hydrogen peroxide	9.074959e-8
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	9.541543e-8
GO:0006664	glycolipid metabolic process	1.103427e-7
GO:0009611	response to wounding	1.133302e-7
GO:0002682	regulation of immune system process	1.146664e-7
GO:0006108	malate metabolic process	1.175440e-7
GO:0006022	aminoglycan metabolic process	1.330253e-7
GO:0035023	regulation of Rho protein signal transduction	1.369209e-7
GO:0050994	regulation of lipid catabolic process	1.424810e-7
GO:0050996	positive regulation of lipid catabolic process	1.505996e-7
GO:0050866	negative regulation of cell activation	1.588218e-7
GO:0042180	cellular ketone metabolic process	1.744474e-7
GO:0030098	lymphocyte differentiation	1.774884e-7
GO:0035556	intracellular signal transduction	1.804603e-7
GO:0019217	regulation of fatty acid metabolic process	2.001186e-7
GO:0010985	negative regulation of lipoprotein particle clearance	2.017536e-7
GO:0050748	negative regulation of lipoprotein metabolic process	2.316228e-7
GO:0044242	cellular lipid catabolic process	2.385498e-7
GO:0002076	osteoblast development	2.527162e-7
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	2.577592e-7
GO:0019752	carboxylic acid metabolic process	2.647862e-7
GO:0051048	negative regulation of secretion	2.752349e-7
GO:0010898	positive regulation of triglyceride catabolic process	2.797444e-7
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway	2.904175e-7
GO:0046889	positive regulation of lipid biosynthetic process	2.978740e-7
GO:0051249	regulation of lymphocyte activation	3.155611e-7
GO:0042113	B cell activation	3.573506e-7
GO:0010984	regulation of lipoprotein particle clearance	3.771215e-7
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	3.985387e-7
GO:0055090	acylglycerol homeostasis	4.293013e-7
GO:0001775	cell activation	4.310571e-7
GO:0045723	positive regulation of fatty acid biosynthetic process	4.381583e-7
GO:0033993	response to lipid	4.393522e-7
GO:0010949	negative regulation of intestinal phytosterol absorption	4.420296e-7
GO:0045796	negative regulation of intestinal cholesterol absorption	4.420296e-7
GO:0032501	multicellular organismal process	4.470857e-7
GO:0050776	regulation of immune response	4.609081e-7
GO:0002697	regulation of immune effector process	4.677326e-7
GO:0018924	mandelate metabolic process	4.932324e-7
GO:0055086	nucleobase-containing small molecule metabolic process	4.979059e-7
GO:0090208	positive regulation of triglyceride metabolic process	5.158733e-7
GO:0046649	lymphocyte activation	5.507577e-7
GO:0035590	purinergic nucleotide receptor signaling pathway	5.696581e-7
GO:0045834	positive regulation of lipid metabolic process	5.732280e-7
GO:0010033	response to organic substance	6.318395e-7
GO:0008283	cell proliferation	6.347169e-7
GO:0009056	catabolic process	6.366452e-7
GO:0042246	tissue regeneration	7.726599e-7
GO:0045321	leukocyte activation	7.730015e-7
GO:0044240	multicellular organismal lipid catabolic process	9.669314e-7
GO:0014823	response to activity	1.110662e-6
GO:0009117	nucleotide metabolic process	1.110693e-6
GO:0002819	regulation of adaptive immune response	1.157661e-6
GO:2000352	negative regulation of endothelial cell apoptosis	1.162840e-6
GO:0046503	glycerolipid catabolic process	1.196154e-6
GO:0060317	cardiac epithelial to mesenchymal transition	1.212112e-6
GO:0050869	negative regulation of B cell activation	1.396606e-6
GO:0020027	hemoglobin metabolic process	1.433438e-6
GO:0034699	response to luteinizing hormone stimulus	1.465867e-6
GO:0070328	triglyceride homeostasis	1.494376e-6
GO:0046642	negative regulation of alpha-beta T cell proliferation	1.607962e-6
GO:0050654	chondroitin sulfate proteoglycan metabolic process	1.725437e-6
GO:0006164	purine nucleotide biosynthetic process	1.809656e-6
GO:0032276	regulation of gonadotropin secretion	1.867401e-6
GO:0040007	growth	2.022960e-6
GO:0045471	response to ethanol	2.122727e-6
GO:0019376	galactolipid catabolic process	2.190491e-6
GO:0010035	response to inorganic substance	2.310087e-6
GO:0043933	macromolecular complex subunit organization	2.455071e-6
GO:0051006	positive regulation of lipoprotein lipase activity	2.522568e-6
GO:0045717	negative regulation of fatty acid biosynthetic process	2.648359e-6
GO:0019695	choline metabolic process	2.746811e-6
GO:0006641	triglyceride metabolic process	2.821469e-6
GO:0044243	multicellular organismal catabolic process	2.992549e-6
GO:0045923	positive regulation of fatty acid metabolic process	3.009890e-6
GO:0050864	regulation of B cell activation	3.120964e-6
GO:0006576	cellular biogenic amine metabolic process	3.192943e-6
GO:0008054	cyclin catabolic process	3.268910e-6
GO:0030154	cell differentiation	3.372127e-6
GO:0042632	cholesterol homeostasis	3.564099e-6
GO:0014866	skeletal myofibril assembly	3.754007e-6
GO:0030240	skeletal muscle thin filament assembly	3.886003e-6
GO:0006687	glycosphingolipid metabolic process	3.968471e-6
GO:0072593	reactive oxygen species metabolic process	3.997556e-6
GO:0000072	M phase specific microtubule process	4.056135e-6
GO:0019693	ribose phosphate metabolic process	4.297531e-6
GO:0019433	triglyceride catabolic process	4.377142e-6
GO:0018904	organic ether metabolic process	4.766111e-6
GO:0048566	embryonic digestive tract development	4.940505e-6
GO:0030097	hemopoiesis	4.989896e-6
GO:0002886	regulation of myeloid leukocyte mediated immunity	5.024901e-6
GO:0051234	establishment of localization	5.056655e-6
GO:0070848	response to growth factor stimulus	5.617311e-6
GO:0046464	acylglycerol catabolic process	5.648768e-6
GO:0046483	heterocycle metabolic process	5.791858e-6
GO:0046328	regulation of JNK cascade	5.942536e-6
GO:0070508	cholesterol import	5.951869e-6
GO:0070302	regulation of stress-activated protein kinase signaling cascade	6.323230e-6
GO:0002637	regulation of immunoglobulin production	6.333053e-6
GO:0031032	actomyosin structure organization	6.479886e-6
GO:0006810	transport	6.494498e-6
GO:0050863	regulation of T cell activation	6.519519e-6
GO:0035121	tail morphogenesis	6.760479e-6
GO:0000212	meiotic spindle organization	6.967233e-6
GO:0006639	acylglycerol metabolic process	7.072599e-6
GO:0019218	regulation of steroid metabolic process	7.515164e-6
GO:0072521	purine-containing compound metabolic process	7.636381e-6
GO:0006014	D-ribose metabolic process	8.004494e-6
GO:0009653	anatomical structure morphogenesis	8.038350e-6
GO:0035235	ionotropic glutamate receptor signaling pathway	8.336350e-6
GO:0019370	leukotriene biosynthetic process	8.338590e-6
GO:0006662	glycerol ether metabolic process	8.673025e-6
GO:0034605	cellular response to heat	8.762168e-6
GO:0072522	purine-containing compound biosynthetic process	8.870270e-6
GO:0030888	regulation of B cell proliferation	8.889738e-6
GO:0044106	cellular amine metabolic process	9.151045e-6
GO:0048856	anatomical structure development	9.250183e-6
GO:0045682	regulation of epidermis development	9.415027e-6
GO:0010954	positive regulation of protein processing	9.421093e-6
GO:0048869	cellular developmental process	9.458456e-6
GO:0050906	detection of stimulus involved in sensory perception	9.665210e-6
GO:0032185	septin cytoskeleton organization	1.013901e-5
GO:0044248	cellular catabolic process	1.093170e-5
GO:0045989	positive regulation of striated muscle contraction	1.112274e-5
GO:0046034	ATP metabolic process	1.128990e-5
GO:0042542	response to hydrogen peroxide	1.132429e-5
GO:0045599	negative regulation of fat cell differentiation	1.230161e-5
GO:0002703	regulation of leukocyte mediated immunity	1.256823e-5
GO:0015816	glycine transport	1.286237e-5
GO:0006691	leukotriene metabolic process	1.314803e-5
GO:0006643	membrane lipid metabolic process	1.319361e-5
GO:0006801	superoxide metabolic process	1.332507e-5
GO:0051051	negative regulation of transport	1.350346e-5
GO:0055013	cardiac muscle cell development	1.395811e-5
GO:0051023	regulation of immunoglobulin secretion	1.420997e-5
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	1.488412e-5
GO:0043506	regulation of JUN kinase activity	1.524588e-5
GO:0006163	purine nucleotide metabolic process	1.526367e-5
GO:0007021	tubulin complex assembly	1.563473e-5
GO:0019430	removal of superoxide radicals	1.588132e-5
GO:0006468	protein phosphorylation	1.652595e-5
GO:0006029	proteoglycan metabolic process	1.692648e-5
GO:0035588	G-protein coupled purinergic receptor signaling pathway	1.713630e-5
GO:0007159	leukocyte cell-cell adhesion	1.800616e-5
GO:0035330	regulation of hippo signaling cascade	1.824184e-5
GO:0035587	purinergic receptor signaling pathway	1.843234e-5
GO:0006638	neutral lipid metabolic process	1.898353e-5
GO:0008610	lipid biosynthetic process	1.906696e-5
GO:0009052	pentose-phosphate shunt, non-oxidative branch	2.057202e-5
GO:0006897	endocytosis	2.104309e-5
GO:0046466	membrane lipid catabolic process	2.131140e-5
GO:0008078	mesodermal cell migration	2.193411e-5
GO:0055006	cardiac cell development	2.202212e-5
GO:0065007	biological regulation	2.292647e-5
GO:0044283	small molecule biosynthetic process	2.315742e-5
GO:0060457	negative regulation of digestive system process	2.316457e-5
GO:0007181	transforming growth factor beta receptor complex assembly	2.316457e-5
GO:0010226	response to lithium ion	2.327744e-5
GO:0034382	chylomicron remnant clearance	2.378905e-5
GO:0048583	regulation of response to stimulus	2.410069e-5
GO:0007509	mesoderm migration involved in gastrulation	2.453236e-5
GO:2000353	positive regulation of endothelial cell apoptosis	2.459314e-5
GO:0030321	transepithelial chloride transport	2.459314e-5
GO:0001969	regulation of activation of membrane attack complex	2.558079e-5
GO:0042221	response to chemical stimulus	2.659819e-5
GO:0060191	regulation of lipase activity	2.836832e-5
GO:0033239	negative regulation of cellular amine metabolic process	2.994413e-5
GO:0009165	nucleotide biosynthetic process	2.997012e-5
GO:0048534	hemopoietic or lymphoid organ development	3.013446e-5
GO:0055123	digestive system development	3.019471e-5
GO:0002252	immune effector process	3.030730e-5
GO:0009310	amine catabolic process	3.067223e-5
GO:0043507	positive regulation of JUN kinase activity	3.147222e-5
GO:0007512	adult heart development	3.209908e-5
GO:0090234	regulation of kinetochore assembly	3.271176e-5
GO:0090169	regulation of spindle assembly	3.271176e-5
GO:0030036	actin cytoskeleton organization	3.289188e-5
GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	3.304378e-5
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	3.392931e-5
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	3.392931e-5
GO:0007442	hindgut morphogenesis	3.450639e-5
GO:0070349	positive regulation of brown fat cell proliferation	3.722637e-5
GO:0050747	positive regulation of lipoprotein metabolic process	3.722637e-5
GO:0010038	response to metal ion	3.881179e-5
GO:0048676	axon extension involved in development	3.970900e-5
GO:0051046	regulation of secretion	4.033024e-5
GO:0055088	lipid homeostasis	4.071437e-5
GO:0019216	regulation of lipid metabolic process	4.101779e-5
GO:0043252	sodium-independent organic anion transport	4.135056e-5
GO:0007271	synaptic transmission, cholinergic	4.246168e-5
GO:0042110	T cell activation	4.304781e-5
GO:0007010	cytoskeleton organization	4.305559e-5
GO:0032321	positive regulation of Rho GTPase activity	4.416348e-5
GO:0060461	right lung morphogenesis	4.484389e-5
GO:0060446	branching involved in open tracheal system development	4.484389e-5
GO:0090131	mesenchyme migration	4.484389e-5
GO:0048613	embryonic ectodermal digestive tract morphogenesis	4.484389e-5
GO:0014822	detection of wounding	4.484389e-5
GO:0048371	lateral mesodermal cell differentiation	4.484389e-5
GO:0002251	organ or tissue specific immune response	4.607403e-5
GO:0032471	reduction of endoplasmic reticulum calcium ion concentration	4.648053e-5
GO:0034370	triglyceride-rich lipoprotein particle remodeling	4.795587e-5
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	4.872134e-5
GO:0060754	positive regulation of mast cell chemotaxis	4.872134e-5
GO:0060696	regulation of phospholipid catabolic process	4.872134e-5
GO:0071363	cellular response to growth factor stimulus	4.893762e-5
GO:0034654	nucleobase-containing compound biosynthetic process	5.054103e-5
GO:0006814	sodium ion transport	5.092248e-5
GO:0048709	oligodendrocyte differentiation	5.092412e-5
GO:0031667	response to nutrient levels	5.094238e-5
GO:0072668	tubulin complex biogenesis	5.173197e-5
GO:0007257	activation of JUN kinase activity	5.284231e-5
GO:0055080	cation homeostasis	5.490992e-5
GO:0060193	positive regulation of lipase activity	5.574129e-5
GO:0061053	somite development	5.668103e-5
GO:0040018	positive regulation of multicellular organism growth	5.755486e-5
GO:0006467	protein thiol-disulfide exchange	5.767519e-5
GO:0048286	lung alveolus development	5.820323e-5
GO:0034381	plasma lipoprotein particle clearance	5.836124e-5
GO:0048731	system development	5.855433e-5
GO:0002718	regulation of cytokine production involved in immune response	5.933567e-5
GO:0050709	negative regulation of protein secretion	6.041145e-5
GO:0061029	eyelid development in camera-type eye	6.102473e-5
GO:0042756	drinking behavior	6.137590e-5
GO:0002683	negative regulation of immune system process	6.341386e-5
GO:0002740	negative regulation of cytokine secretion involved in immune response	6.567014e-5
GO:0035814	negative regulation of renal sodium excretion	6.699551e-5
GO:0002821	positive regulation of adaptive immune response	6.987018e-5
GO:0016126	sterol biosynthetic process	7.093455e-5
GO:0001570	vasculogenesis	7.106290e-5
GO:0009991	response to extracellular stimulus	7.115272e-5
GO:0031330	negative regulation of cellular catabolic process	7.274759e-5
GO:0006695	cholesterol biosynthetic process	7.583915e-5
GO:0009895	negative regulation of catabolic process	7.588623e-5
GO:0018149	peptide cross-linking	7.691296e-5
GO:0050892	intestinal absorption	7.715769e-5
GO:0010994	free ubiquitin chain polymerization	7.956221e-5
GO:0035112	genitalia morphogenesis	8.120874e-5
GO:0034372	very-low-density lipoprotein particle remodeling	8.288750e-5
GO:0045581	negative regulation of T cell differentiation	8.379134e-5
GO:0030003	cellular cation homeostasis	8.455912e-5
GO:0000303	response to superoxide	8.490835e-5
GO:0006665	sphingolipid metabolic process	8.775632e-5
GO:0022607	cellular component assembly	8.841709e-5
GO:0022600	digestive system process	8.862066e-5
GO:0009123	nucleoside monophosphate metabolic process	8.867272e-5
GO:0031099	regeneration	9.193774e-5
GO:0071474	cellular hyperosmotic response	9.311597e-5
GO:0010927	cellular component assembly involved in morphogenesis	9.410426e-5
GO:0034614	cellular response to reactive oxygen species	9.575473e-5
GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	9.820935e-5
GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification	9.820935e-5
GO:0070228	regulation of lymphocyte apoptosis	9.869265e-5
GO:0046880	regulation of follicle-stimulating hormone secretion	9.896149e-5
GO:0014013	regulation of gliogenesis	9.953724e-5
GO:0002520	immune system development	1.003222e-4
GO:0009260	ribonucleotide biosynthetic process	1.010280e-4
GO:0007215	glutamate signaling pathway	1.015692e-4
GO:0071840	cellular component organization or biogenesis	1.020805e-4
GO:0007020	microtubule nucleation	1.023140e-4
GO:0002066	columnar/cuboidal epithelial cell development	1.023140e-4
GO:0060576	intestinal epithelial cell development	1.026073e-4
GO:0043501	skeletal muscle adaptation	1.026566e-4
GO:0032502	developmental process	1.036370e-4
GO:0050708	regulation of protein secretion	1.038673e-4
GO:0002385	mucosal immune response	1.040016e-4
GO:0002739	regulation of cytokine secretion involved in immune response	1.056093e-4
GO:0051241	negative regulation of multicellular organismal process	1.061133e-4
GO:0045348	positive regulation of MHC class II biosynthetic process	1.066935e-4
GO:0000305	response to oxygen radical	1.077369e-4
GO:0055114	oxidation-reduction process	1.096940e-4
GO:0007584	response to nutrient	1.097821e-4
GO:0045604	regulation of epidermal cell differentiation	1.100162e-4
GO:0018130	heterocycle biosynthetic process	1.137035e-4
GO:0032319	regulation of Rho GTPase activity	1.142818e-4
GO:0042158	lipoprotein biosynthetic process	1.144461e-4
GO:0002065	columnar/cuboidal epithelial cell differentiation	1.146202e-4
GO:0051055	negative regulation of lipid biosynthetic process	1.170956e-4
GO:0009259	ribonucleotide metabolic process	1.177489e-4
GO:0060575	intestinal epithelial cell differentiation	1.177622e-4
GO:0065003	macromolecular complex assembly	1.196810e-4
GO:2000179	positive regulation of neural precursor cell proliferation	1.201308e-4
GO:0002335	mature B cell differentiation	1.219434e-4
GO:0048878	chemical homeostasis	1.234083e-4
GO:0001820	serotonin secretion	1.274707e-4
GO:0006650	glycerophospholipid metabolic process	1.286531e-4
GO:0048671	negative regulation of collateral sprouting	1.288253e-4
GO:0009612	response to mechanical stimulus	1.414743e-4
GO:0006725	cellular aromatic compound metabolic process	1.430695e-4
GO:0048589	developmental growth	1.433122e-4
GO:0045616	regulation of keratinocyte differentiation	1.446591e-4
GO:0030217	T cell differentiation	1.450150e-4
GO:0001970	positive regulation of activation of membrane attack complex	1.520432e-4
GO:0002883	regulation of hypersensitivity	1.537729e-4
GO:0002885	positive regulation of hypersensitivity	1.541239e-4
GO:0009150	purine ribonucleotide metabolic process	1.541262e-4
GO:0046486	glycerolipid metabolic process	1.566032e-4
GO:0000105	histidine biosynthetic process	1.571090e-4
GO:0045922	negative regulation of fatty acid metabolic process	1.573567e-4
GO:0032277	negative regulation of gonadotropin secretion	1.576015e-4
GO:0046636	negative regulation of alpha-beta T cell activation	1.576391e-4
GO:0030316	osteoclast differentiation	1.598327e-4
GO:0002684	positive regulation of immune system process	1.617773e-4
GO:0016043	cellular component organization	1.671658e-4
GO:0032944	regulation of mononuclear cell proliferation	1.679886e-4
GO:0051004	regulation of lipoprotein lipase activity	1.680360e-4
GO:0030382	sperm mitochondrion organization	1.701329e-4
GO:0043305	negative regulation of mast cell degranulation	1.701329e-4
GO:0009992	cellular water homeostasis	1.701329e-4
GO:0035092	sperm chromatin condensation	1.716415e-4
GO:0002903	negative regulation of B cell apoptosis	1.728593e-4
GO:0046640	regulation of alpha-beta T cell proliferation	1.731400e-4
GO:0045580	regulation of T cell differentiation	1.734789e-4
GO:0002690	positive regulation of leukocyte chemotaxis	1.742129e-4
GO:0050670	regulation of lymphocyte proliferation	1.749477e-4
GO:0003008	system process	1.767390e-4
GO:0032890	regulation of organic acid transport	1.815614e-4
GO:0045213	neurotransmitter receptor metabolic process	1.820298e-4
GO:0043304	regulation of mast cell degranulation	1.822717e-4
GO:0010507	negative regulation of autophagy	1.822717e-4
GO:0002699	positive regulation of immune effector process	1.877808e-4
GO:0002360	T cell lineage commitment	1.892672e-4
GO:0070663	regulation of leukocyte proliferation	1.917694e-4
GO:0070542	response to fatty acid	1.947086e-4
GO:0006970	response to osmotic stress	1.988175e-4
GO:0050868	negative regulation of T cell activation	2.008946e-4
GO:0014003	oligodendrocyte development	2.122838e-4
GO:0010900	negative regulation of phosphatidylcholine catabolic process	2.134286e-4
GO:0007264	small GTPase mediated signal transduction	2.156372e-4
GO:0009152	purine ribonucleotide biosynthetic process	2.175578e-4
GO:0014074	response to purine-containing compound	2.191616e-4
GO:0006915	apoptosis	2.242394e-4
GO:0001878	response to yeast	2.271072e-4
GO:0045598	regulation of fat cell differentiation	2.273383e-4
GO:2000348	regulation of CD40 signaling pathway	2.285275e-4
GO:0030029	actin filament-based process	2.389409e-4
GO:0030890	positive regulation of B cell proliferation	2.408342e-4
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	2.457718e-4
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	2.457718e-4
GO:0065009	regulation of molecular function	2.530820e-4
GO:0060513	prostatic bud formation	2.546154e-4
GO:0050713	negative regulation of interleukin-1 beta secretion	2.546154e-4
GO:0001798	positive regulation of type IIa hypersensitivity	2.557635e-4
GO:0051179	localization	2.560610e-4
GO:0030168	platelet activation	2.570858e-4
GO:0048261	negative regulation of receptor-mediated endocytosis	2.591700e-4
GO:0043408	regulation of MAPKKK cascade	2.611136e-4
GO:0046514	ceramide catabolic process	2.638138e-4
GO:0006875	cellular metal ion homeostasis	2.654997e-4
GO:0030239	myofibril assembly	2.670791e-4
GO:0051707	response to other organism	2.680016e-4
GO:0006144	purine base metabolic process	2.699005e-4
GO:0050789	regulation of biological process	2.709077e-4
GO:0033194	response to hydroperoxide	2.726771e-4
GO:0048513	organ development	2.740235e-4
GO:0071375	cellular response to peptide hormone stimulus	2.794032e-4
GO:0002675	positive regulation of acute inflammatory response	2.834004e-4
GO:0072358	cardiovascular system development	2.862020e-4
GO:0070887	cellular response to chemical stimulus	2.867793e-4
GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity	2.955309e-4
GO:0070367	negative regulation of hepatocyte differentiation	2.955309e-4
GO:0051272	positive regulation of cellular component movement	3.004985e-4
GO:0042178	xenobiotic catabolic process	3.016279e-4
GO:0048646	anatomical structure formation involved in morphogenesis	3.026540e-4
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	3.062216e-4
GO:0051258	protein polymerization	3.064398e-4
GO:2000147	positive regulation of cell motility	3.091446e-4
GO:0019374	galactolipid metabolic process	3.115173e-4
GO:0032469	endoplasmic reticulum calcium ion homeostasis	3.143112e-4
GO:0032879	regulation of localization	3.190150e-4
GO:0002720	positive regulation of cytokine production involved in immune response	3.211275e-4
GO:0090209	negative regulation of triglyceride metabolic process	3.215163e-4
GO:0002922	positive regulation of humoral immune response	3.234685e-4
GO:0016310	phosphorylation	3.249399e-4
GO:0045620	negative regulation of lymphocyte differentiation	3.290065e-4
GO:2000347	positive regulation of hepatocyte proliferation	3.308333e-4
GO:0006636	unsaturated fatty acid biosynthetic process	3.313104e-4
GO:0048010	vascular endothelial growth factor receptor signaling pathway	3.318403e-4
GO:0045445	myoblast differentiation	3.330755e-4
GO:0070059	apoptosis in response to endoplasmic reticulum stress	3.331128e-4
GO:0044085	cellular component biogenesis	3.391209e-4
GO:0009888	tissue development	3.391603e-4
GO:0048305	immunoglobulin secretion	3.434735e-4
GO:0006954	inflammatory response	3.436778e-4
GO:0033006	regulation of mast cell activation involved in immune response	3.454009e-4
GO:0003012	muscle system process	3.466170e-4
GO:0042424	catecholamine catabolic process	3.533372e-4
GO:0050911	detection of chemical stimulus involved in sensory perception of smell	3.716585e-4
GO:0080135	regulation of cellular response to stress	3.757955e-4
GO:0048598	embryonic morphogenesis	3.759058e-4
GO:0050918	positive chemotaxis	3.815003e-4
GO:0002313	mature B cell differentiation involved in immune response	3.890799e-4
GO:0035089	establishment of apical/basal cell polarity	3.945266e-4
GO:0072573	tolerance induction to lipopolysaccharide	3.974057e-4
GO:2000349	negative regulation of CD40 signaling pathway	3.974057e-4
GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	3.974057e-4
GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	3.974057e-4
GO:0007099	centriole replication	3.974057e-4
GO:0034148	negative regulation of toll-like receptor 5 signaling pathway	3.974057e-4
GO:0002632	negative regulation of granuloma formation	3.974057e-4
GO:0032691	negative regulation of interleukin-1 beta production	4.057940e-4
GO:0019377	glycolipid catabolic process	4.181565e-4
GO:0006707	cholesterol catabolic process	4.186457e-4
GO:0060742	epithelial cell differentiation involved in prostate gland development	4.390970e-4
GO:0006694	steroid biosynthetic process	4.414329e-4
GO:0051098	regulation of binding	4.448210e-4
GO:0051049	regulation of transport	4.478589e-4
GO:0002687	positive regulation of leukocyte migration	4.483975e-4
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	4.560387e-4