MCL coexpression mm9:89: Difference between revisions
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Latest revision as of 14:40, 17 September 2013
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0043492 | ATPase activity, coupled to movement of substances | 0.000261983846171992 |
GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | 0.000261983846171992 |
GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | 0.000261983846171992 |
GO:0015399 | primary active transmembrane transporter activity | 0.000261983846171992 |
GO:0015405 | P-P-bond-hydrolysis-driven transmembrane transporter activity | 0.000261983846171992 |
GO:0022890 | inorganic cation transmembrane transporter activity | 0.000261983846171992 |
GO:0042623 | ATPase activity, coupled | 0.00113551783422043 |
GO:0016887 | ATPase activity | 0.00143225804776179 |
GO:0022857 | transmembrane transporter activity | 0.00143225804776179 |
GO:0019829 | cation-transporting ATPase activity | 0.00196826326539344 |
GO:0022804 | active transmembrane transporter activity | 0.00196826326539344 |
GO:0017111 | nucleoside-triphosphatase activity | 0.00382345223712324 |
GO:0042625 | ATPase activity, coupled to transmembrane movement of ions | 0.00382345223712324 |
GO:0008324 | cation transmembrane transporter activity | 0.00382345223712324 |
GO:0006812 | cation transport | 0.00382345223712324 |
GO:0016462 | pyrophosphatase activity | 0.00382345223712324 |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.00382345223712324 |
GO:0016817 | hydrolase activity, acting on acid anhydrides | 0.00382345223712324 |
GO:0008281 | sulfonylurea receptor activity | 0.00382345223712324 |
GO:0015078 | hydrogen ion transmembrane transporter activity | 0.00402197291278715 |
GO:0015077 | monovalent inorganic cation transmembrane transporter activity | 0.00426228829950633 |
GO:0044444 | cytoplasmic part | 0.00682722862485371 |
GO:0015075 | ion transmembrane transporter activity | 0.00694111304843444 |
GO:0006811 | ion transport | 0.00916983564024917 |
GO:0022891 | substrate-specific transmembrane transporter activity | 0.00964404751801714 |
GO:0016787 | hydrolase activity | 0.015556254694115 |
GO:0045261 | proton-transporting ATP synthase complex, catalytic core F(1) | 0.015556254694115 |
GO:0045822 | negative regulation of heart contraction | 0.015556254694115 |
GO:0022892 | substrate-specific transporter activity | 0.0158781682819606 |
GO:0005743 | mitochondrial inner membrane | 0.0158781682819606 |
GO:0005739 | mitochondrion | 0.0158781682819606 |
GO:0033178 | proton-transporting two-sector ATPase complex, catalytic domain | 0.0158781682819606 |
GO:0019866 | organelle inner membrane | 0.0163316586477871 |
GO:0005388 | calcium-transporting ATPase activity | 0.0163316586477871 |
GO:0015085 | calcium ion transmembrane transporter activity | 0.0163316586477871 |
GO:0031966 | mitochondrial membrane | 0.0163316586477871 |
GO:0006810 | transport | 0.0170374105095469 |
GO:0051607 | defense response to virus | 0.0171866913912484 |
GO:0005740 | mitochondrial envelope | 0.0174298880022101 |
GO:0051234 | establishment of localization | 0.0174298880022101 |
GO:0015672 | monovalent inorganic cation transport | 0.0181365385753757 |
GO:0016681 | oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor | 0.0181365385753757 |
GO:0008121 | ubiquinol-cytochrome-c reductase activity | 0.0181365385753757 |
GO:0016679 | oxidoreductase activity, acting on diphenols and related substances as donors | 0.0181365385753757 |
GO:0002026 | regulation of the force of heart contraction | 0.0205627534392368 |
GO:0044429 | mitochondrial part | 0.0205627534392368 |
GO:0051179 | localization | 0.0234035705418116 |
GO:0005524 | ATP binding | 0.0241959533458616 |
GO:0032559 | adenyl ribonucleotide binding | 0.0245317249527846 |
GO:0006984 | ER-nuclear signaling pathway | 0.0249284428697 |
GO:0045259 | proton-transporting ATP synthase complex | 0.0249284428697 |
GO:0031975 | envelope | 0.0249284428697 |
GO:0031967 | organelle envelope | 0.0249284428697 |
GO:0030554 | adenyl nucleotide binding | 0.0255460380134302 |
GO:0030001 | metal ion transport | 0.025798276506608 |
GO:0006091 | generation of precursor metabolites and energy | 0.0279310251649472 |
GO:0016529 | sarcoplasmic reticulum | 0.0304914112504821 |
GO:0005746 | mitochondrial respiratory chain | 0.034348616802724 |
GO:0016528 | sarcoplasm | 0.034348616802724 |
GO:0005737 | cytoplasm | 0.034404236229464 |
GO:0051241 | negative regulation of multicellular organismal process | 0.034404236229464 |
GO:0032553 | ribonucleotide binding | 0.0345042940770394 |
GO:0032555 | purine ribonucleotide binding | 0.0345042940770394 |
GO:0015985 | energy coupled proton transport, down electrochemical gradient | 0.0345042940770394 |
GO:0015986 | ATP synthesis coupled proton transport | 0.0345042940770394 |
GO:0015082 | di-, tri-valent inorganic cation transmembrane transporter activity | 0.0350728759100535 |
GO:0006937 | regulation of muscle contraction | 0.0356241901384143 |
GO:0017076 | purine nucleotide binding | 0.0356539037701388 |
GO:0031090 | organelle membrane | 0.0356539037701388 |
GO:0006754 | ATP biosynthetic process | 0.0356539037701388 |
GO:0008016 | regulation of heart contraction | 0.0356539037701388 |
GO:0006753 | nucleoside phosphate metabolic process | 0.0356539037701388 |
GO:0046933 | hydrogen ion transporting ATP synthase activity, rotational mechanism | 0.0356539037701388 |
GO:0016469 | proton-transporting two-sector ATPase complex | 0.0356622251257868 |
GO:0046961 | hydrogen ion transporting ATPase activity, rotational mechanism | 0.0356622251257868 |
GO:0046034 | ATP metabolic process | 0.0380308442694986 |
GO:0046872 | metal ion binding | 0.0386396994300299 |
GO:0003015 | heart process | 0.0386834730076833 |
GO:0044455 | mitochondrial membrane part | 0.0386834730076833 |
GO:0060047 | heart contraction | 0.0386834730076833 |
GO:0043167 | ion binding | 0.0386834730076833 |
GO:0009145 | purine nucleoside triphosphate biosynthetic process | 0.0386834730076833 |
GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | 0.0386834730076833 |
GO:0009201 | ribonucleoside triphosphate biosynthetic process | 0.0386834730076833 |
GO:0009142 | nucleoside triphosphate biosynthetic process | 0.0397338313523514 |
GO:0031072 | heat shock protein binding | 0.0397338313523514 |
GO:0000166 | nucleotide binding | 0.0397338313523514 |
GO:0009615 | response to virus | 0.0397338313523514 |
GO:0009205 | purine ribonucleoside triphosphate metabolic process | 0.0397338313523514 |
GO:0009199 | ribonucleoside triphosphate metabolic process | 0.0399961135745742 |
GO:0006119 | oxidative phosphorylation | 0.0399961135745742 |
GO:0009144 | purine nucleoside triphosphate metabolic process | 0.0399961135745742 |
GO:0015992 | proton transport | 0.0411063997127163 |
GO:0006752 | group transfer coenzyme metabolic process | 0.0414307661811456 |
GO:0009141 | nucleoside triphosphate metabolic process | 0.042501333781138 |
GO:0009152 | purine ribonucleotide biosynthetic process | 0.042660028059148 |
GO:0006818 | hydrogen transport | 0.042660028059148 |
GO:0051082 | unfolded protein binding | 0.042660028059148 |
GO:0006874 | cellular calcium ion homeostasis | 0.0429513261419073 |
GO:0015662 | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | 0.0430894060987638 |
GO:0009260 | ribonucleotide biosynthetic process | 0.0430894060987638 |
GO:0055074 | calcium ion homeostasis | 0.0430894060987638 |
GO:0009150 | purine ribonucleotide metabolic process | 0.0447512556476065 |
GO:0006164 | purine nucleotide biosynthetic process | 0.0448313313920833 |
GO:0006875 | cellular metal ion homeostasis | 0.0448313313920833 |
GO:0030017 | sarcomere | 0.0448313313920833 |
GO:0055065 | metal ion homeostasis | 0.0457456490522219 |
GO:0044449 | contractile fiber part | 0.0459822841835844 |
GO:0009259 | ribonucleotide metabolic process | 0.0462143975165351 |
GO:0006163 | purine nucleotide metabolic process | 0.0483845809800927 |
GO:0030016 | myofibril | 0.0485899872175221 |
GO:0043292 | contractile fiber | 0.0494267785038611 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
tube | 4.48e-10 | 114 |
multi-cellular organism | 1.69e-09 | 333 |
multi-tissue structure | 2.33e-09 | 230 |
anatomical conduit | 5.86e-09 | 122 |
epithelial tube | 6.89e-09 | 47 |
structure with developmental contribution from neural crest | 2.13e-08 | 92 |
compound organ | 3.29e-08 | 43 |
primary circulatory organ | 5.69e-08 | 18 |
heart | 5.69e-08 | 18 |
primitive heart tube | 5.69e-08 | 18 |
primary heart field | 5.69e-08 | 18 |
anterior lateral plate mesoderm | 5.69e-08 | 18 |
heart tube | 5.69e-08 | 18 |
heart primordium | 5.69e-08 | 18 |
cardiac mesoderm | 5.69e-08 | 18 |
cardiogenic plate | 5.69e-08 | 18 |
heart rudiment | 5.69e-08 | 18 |
anatomical cluster | 6.49e-07 | 244 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0 |
MA0004.1 | 0.000113815 |
MA0006.1 | 4.50139e-07 |
MA0007.1 | 7.91436e-05 |
MA0009.1 | 0.0332518 |
MA0014.1 | 0 |
MA0017.1 | 1.38882e-06 |
MA0019.1 | 0.0070307 |
MA0024.1 | 0.0243869 |
MA0025.1 | 0.112484 |
MA0027.1 | 1.27344 |
MA0028.1 | 7.10733e-07 |
MA0029.1 | 0.0206395 |
MA0030.1 | 0.0217275 |
MA0031.1 | 0.0162748 |
MA0038.1 | 0.00172518 |
MA0040.1 | 0.948421 |
MA0041.1 | 0.237592 |
MA0042.1 | 0.202258 |
MA0043.1 | 0.0594714 |
MA0046.1 | 0.369888 |
MA0048.1 | 8.10402e-12 |
MA0050.1 | 0.00225801 |
MA0051.1 | 0.0127417 |
MA0052.1 | 0.0380511 |
MA0055.1 | 4.82164e-17 |
MA0056.1 | 0 |
MA0057.1 | 1.95382e-12 |
MA0058.1 | 7.71782e-06 |
MA0059.1 | 1.15233e-05 |
MA0060.1 | 5.93165e-09 |
MA0061.1 | 6.23503e-07 |
MA0063.1 | 0 |
MA0066.1 | 0.00146164 |
MA0067.1 | 0.168725 |
MA0068.1 | 3.67647e-09 |
MA0069.1 | 0.0381337 |
MA0070.1 | 0.601714 |
MA0071.1 | 0.00955853 |
MA0072.1 | 0.0338673 |
MA0073.1 | 0 |
MA0074.1 | 0.00597934 |
MA0076.1 | 2.90458e-06 |
MA0077.1 | 0.0291972 |
MA0078.1 | 0.00309721 |
MA0081.1 | 2.33209e-05 |
MA0083.1 | 0.0592182 |
MA0084.1 | 0.389496 |
MA0087.1 | 0.176117 |
MA0088.1 | 9.03575e-14 |
MA0089.1 | 0 |
MA0090.1 | 4.8236e-05 |
MA0091.1 | 0.00628658 |
MA0092.1 | 0.000491385 |
MA0093.1 | 1.00787e-06 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.000667479 |
MA0101.1 | 0.000171657 |
MA0103.1 | 2.12132e-06 |
MA0105.1 | 4.25942e-10 |
MA0106.1 | 0.0204187 |
MA0107.1 | 0.000152329 |
MA0108.2 | 0.0089207 |
MA0109.1 | 0 |
MA0111.1 | 0.000678687 |
MA0113.1 | 0.00235077 |
MA0114.1 | 5.50748e-07 |
MA0115.1 | 0.0603699 |
MA0116.1 | 4.45992e-07 |
MA0117.1 | 0.0504915 |
MA0119.1 | 0.000174506 |
MA0122.1 | 0.0564431 |
MA0124.1 | 0.140394 |
MA0125.1 | 0.10523 |
MA0130.1 | 0 |
MA0131.1 | 0.00669352 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.0717833 |
MA0136.1 | 0.0011368 |
MA0139.1 | 1.4073e-08 |
MA0140.1 | 0.000666116 |
MA0141.1 | 5.4901e-05 |
MA0142.1 | 0.0674733 |
MA0143.1 | 0.0179177 |
MA0144.1 | 3.25461e-05 |
MA0145.1 | 2.65582e-10 |
MA0146.1 | 0 |
MA0147.1 | 7.31385e-08 |
MA0148.1 | 0.00663778 |
MA0149.1 | 1.80341e-05 |
MA0062.2 | 2.81582e-11 |
MA0035.2 | 0.00538304 |
MA0039.2 | 0 |
MA0138.2 | 0.00613288 |
MA0002.2 | 1.83165e-07 |
MA0137.2 | 3.95936e-06 |
MA0104.2 | 2.3022e-09 |
MA0047.2 | 0.00170565 |
MA0112.2 | 4.24661e-12 |
MA0065.2 | 3.83079e-13 |
MA0150.1 | 7.8922e-05 |
MA0151.1 | 0 |
MA0152.1 | 0.0112967 |
MA0153.1 | 0.268164 |
MA0154.1 | 9.14241e-11 |
MA0155.1 | 3.01357e-12 |
MA0156.1 | 2.81239e-06 |
MA0157.1 | 0.0106833 |
MA0158.1 | 0 |
MA0159.1 | 1.23225e-07 |
MA0160.1 | 0.00017664 |
MA0161.1 | 0 |
MA0162.1 | 0 |
MA0163.1 | 0 |
MA0164.1 | 0.00114344 |
MA0080.2 | 1.72907e-06 |
MA0018.2 | 0.00133342 |
MA0099.2 | 0.00571341 |
MA0079.2 | 0 |
MA0102.2 | 0.430603 |
MA0258.1 | 2.61195e-07 |
MA0259.1 | 7.04293e-07 |
MA0442.1 | 0 |