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{{UBERON
{{UBERON
|id=UBERON:0003220
|alt_id=
|name=metanephric mesenchyme
|namespace=
|def="one of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO]" [GO:0072075, Wikipedia:Metanephric_blastema]
|xref=EHDAA2:0004062;;EHDAA:4041;;EHDAA:5021;;EHDAA:5915;;EMAPA:17208;;EMAPA:17375;;EMAPA:29990;;SCTID:361529008;;VHOG:0000540
|is_a=UBERON:0003918;;UBERON:0004120;;UBERON:0005291
|synonym="metanephric blastema" EXACT [Wikipedia:Metanephric_blastema];;"metanephric mesoderm" EXACT [Wikipedia:Metanephric_blastema];;"metanephrogenic mesenchyme" EXACT [EHDAA:5021];;"metanephros associated mesenchyme" EXACT [RETIRED_EHDAA2:0001139]
|comment=Genes: The positional specification of the metanephrogenic mesenchyme is negatively regulated by Foxc1 and Foxc2. Next the permanent kidney forming metanephrogenic mesenchyme is specified by Hox11 genes. The competence to respond to ureteric bud inducers is regulated by WT1. GDNF secretion restricted to posterior region by Robo2 and Sprouty1. The receptors for GDNF are synthesized in the nephric ducts and later in ureteric buds [ISBN:9780878932504 "Developmental Biology"]
|comment=Genes: The positional specification of the metanephrogenic mesenchyme is negatively regulated by Foxc1 and Foxc2. Next the permanent kidney forming metanephrogenic mesenchyme is specified by Hox11 genes. The competence to respond to ureteric bud inducers is regulated by WT1. GDNF secretion restricted to posterior region by Robo2 and Sprouty1. The receptors for GDNF are synthesized in the nephric ducts and later in ureteric buds [ISBN:9780878932504 "Developmental Biology"]
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="one of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO]" [GO:0072075, Wikipedia:Metanephric_blastema]
|subset=
|derives_from=
|derives_from=
|develops_from=UBERON:0003074
|develops_from=UBERON:0003074
|disjoint_from=
|has_quality=
|has_quality=
|id=UBERON:0003220
|is_a=UBERON:0003918 ;;UBERON:0004120 ;;UBERON:0005291
|is_obsolete=
|located_in=
|located_in=
|name=metanephric mesenchyme
|namespace=
|obo_creation_date=
|part_of=UBERON:0000922
|part_of=UBERON:0000922
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="metanephric blastema" EXACT [Wikipedia:Metanephric_blastema];;"metanephric mesoderm" EXACT [Wikipedia:Metanephric_blastema];;"metanephrogenic mesenchyme" EXACT [EHDAA:5021];;"metanephros associated mesenchyme" EXACT [RETIRED_EHDAA2:0001139]
|union_of=
|xref=EHDAA2:0004062;;EHDAA:4041;;EHDAA:5021;;EHDAA:5915;;EMAPA:17208;;EMAPA:17375;;EMAPA:29990;;SCTID:361529008;;VHOG:0000540
}}
}}

Revision as of 11:23, 12 September 2014

Name:metanephric mesenchyme
Definition:"one of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO]" [GO:0072075, Wikipedia:Metanephric_blastema]
Xrefs:
links:

EHDAA2:0004062
EHDAA:4041
EHDAA:5021
EHDAA:5915
EMAPA:17208
EMAPA:17375
EMAPA:29990
SCTID:361529008

VHOG:0000540
Synonyms: "metanephric blastema" EXACT [Wikipedia:Metanephric_blastema]
"metanephric mesoderm" EXACT [Wikipedia:Metanephric_blastema]
"metanephrogenic mesenchyme" EXACT [EHDAA:5021]
"metanephros associated mesenchyme" EXACT [RETIRED_EHDAA2:0001139]
Comments:Genes: The positional specification of the metanephrogenic mesenchyme is negatively regulated by Foxc1 and Foxc2. Next the permanent kidney forming metanephrogenic mesenchyme is specified by Hox11 genes. The competence to respond to ureteric bud inducers is regulated by WT1. GDNF secretion restricted to posterior region by Robo2 and Sprouty1. The receptors for GDNF are synthesized in the nephric ducts and later in ureteric buds [ISBN:9780878932504 "Developmental Biology"]

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0003918(kidney mesenchyme),UBERON:0004120(mesoderm-derived structure),UBERON:0005291(embryonic tissue)
develops_from:UBERON:0003074(mesonephric duct)
part_of:UBERON:0000922(embryo)



Children

develops from:UBERON:0005749 (glomerular tuft)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology



Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0003220 (metanephric mesenchyme), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
6.87e-64FFCP PHASE2:Hg19::chr2:120409486..120409492,+#_83fbdd50aa28246c64943a7b73e741a4p@chr2:120409486..120409492, +
6.87e-64FFCP PHASE1:Hg19::chr2:120409486..120409492,+#_83fbdd50aa28246c64943a7b73e741a4p@chr2:120409486..120409492, +
9.62e-40FFCP PHASE1:Hg19::chr1:94713418..94713436,+#_f61dd9deb140c86304b798a1ed8590f2p1@ENST00000413103
9.62e-40FFCP PHASE2:Hg19::chr1:94713418..94713436,+#_f61dd9deb140c86304b798a1ed8590f2p1@ENST00000413103
1.16e-36FFCP PHASE1:Hg19::chr17:79426453..79426462,+#_242007d7dd089e48953b9498d685e272p@chr17:79426453..79426462, +
1.16e-36FFCP PHASE2:Hg19::chr17:79426453..79426462,+#_242007d7dd089e48953b9498d685e272p@chr17:79426453..79426462, +
1.31e-36FFCP PHASE2:Hg19::chr8:77557753..77557755,-#_9b8421b059f5cc9f547ac1779bb595f3p@chr8:77557753..77557755, -
1.31e-36FFCP PHASE1:Hg19::chr8:77557753..77557755,-#_9b8421b059f5cc9f547ac1779bb595f3p@chr8:77557753..77557755, -
5.58e-32FFCP PHASE1:Hg19::chr1:32042764..32042776,+#_a9d6d658b2610bc9acc95798d2540120p6@TINAGL1
5.58e-32FFCP PHASE2:Hg19::chr1:32042764..32042776,+#_a9d6d658b2610bc9acc95798d2540120p6@TINAGL1
1.53e-30FFCP PHASE2:Hg19::chr15:91416076..91416089,+#_b0b380dd4acffeded930fd2c4705dc5ap9@FURIN
1.53e-30FFCP PHASE1:Hg19::chr15:91416076..91416089,+#_b0b380dd4acffeded930fd2c4705dc5ap9@FURIN
3.83e-30FFCP PHASE2:Hg19::chr20:6034598..6034603,-#_0cea42b886dafd88d2d03dbbc5d7bc3fp7@LRRN4
3.83e-30FFCP PHASE1:Hg19::chr20:6034598..6034603,-#_0cea42b886dafd88d2d03dbbc5d7bc3fp7@LRRN4
1.78e-29FFCP PHASE2:Hg19::chr2:26700331..26700340,-#_61d080117ee6d846ad35c8f7305bdab0p@chr2:26700331..26700340, -
1.78e-29FFCP PHASE1:Hg19::chr1:42777312..42777314,+#_61d080117ee6d846ad35c8f7305bdab0p@chr1:42777312..42777314, +
1.78e-29FFCP PHASE1:Hg19::chr2:26700984..26700993,-#_61d080117ee6d846ad35c8f7305bdab0p7@OTOF
1.78e-29FFCP PHASE1:Hg19::chr6:18225523..18225534,-#_61d080117ee6d846ad35c8f7305bdab0p@chr6:18225523..18225534, -
1.78e-29FFCP PHASE1:Hg19::chr2:26700331..26700340,-#_61d080117ee6d846ad35c8f7305bdab0p@chr2:26700331..26700340, -
1.78e-29FFCP PHASE2:Hg19::chr22:47030082..47030087,+#_61d080117ee6d846ad35c8f7305bdab0p@chr22:47030082..47030087, +
1.78e-29FFCP PHASE2:Hg19::chr1:42777312..42777314,+#_61d080117ee6d846ad35c8f7305bdab0p@chr1:42777312..42777314, +
1.78e-29FFCP PHASE1:Hg19::chr22:47030082..47030087,+#_61d080117ee6d846ad35c8f7305bdab0p@chr22:47030082..47030087, +
1.78e-29FFCP PHASE2:Hg19::chr2:26700984..26700993,-#_61d080117ee6d846ad35c8f7305bdab0p7@OTOF
1.78e-29FFCP PHASE2:Hg19::chr6:18225523..18225534,-#_61d080117ee6d846ad35c8f7305bdab0p@chr6:18225523..18225534, -
7.96e-27FFCP PHASE2:Hg19::chr10:3477893..3477912,-#_d65391cd0b34520e30a59f1b535dfdc7p@chr10:3477893..3477912, -
7.96e-27FFCP PHASE1:Hg19::chr10:3477893..3477912,-#_d65391cd0b34520e30a59f1b535dfdc7p@chr10:3477893..3477912, -
6.29e-26FFCP PHASE2:Hg19::chr1:172926077..172926120,-#_c4a052724237ae191817d48dab549295p@chr1:172926077..172926120, -
6.29e-26FFCP PHASE1:Hg19::chr1:172926077..172926120,-#_c4a052724237ae191817d48dab549295p@chr1:172926077..172926120, -
6.32e-26FFCP PHASE1:Hg19::chrX:128782722..128782738,-#_9d28d90b5d2d18211db240b600309ca3p5@APLN
6.32e-26FFCP PHASE2:Hg19::chrX:128782722..128782738,-#_9d28d90b5d2d18211db240b600309ca3p5@APLN
9.89e-26FFCP PHASE1:Hg19::chr2:693380..693398,+#_99035b83d5ef3fbb9f0b4873286697cap@chr2:693380..693398, +
9.89e-26FFCP PHASE2:Hg19::chr2:693380..693398,+#_99035b83d5ef3fbb9f0b4873286697cap@chr2:693380..693398, +
1.28e-23FFCP PHASE2:Hg19::chr6:84849252..84849259,+#_cb1d7883b6785364ac75793d54260e34p@chr6:84849252..84849259, +
1.28e-23FFCP PHASE2:Hg19::chr2:133426030..133426041,-#_cb1d7883b6785364ac75793d54260e34p@chr2:133426030..133426041, -
1.28e-23FFCP PHASE1:Hg19::chr6:84849252..84849259,+#_cb1d7883b6785364ac75793d54260e34p@chr6:84849252..84849259, +
1.28e-23FFCP PHASE1:Hg19::chr2:133426030..133426041,-#_cb1d7883b6785364ac75793d54260e34p@chr2:133426030..133426041, -
1.44e-23FFCP PHASE1:Hg19::chr1:51791596..51791607,-#_b1c0a3dea8de09f944818ab03c813d5bp23@TTC39A
1.44e-23FFCP PHASE1:Hg19::chr7:28998254..28998261,-#_b1c0a3dea8de09f944818ab03c813d5bp10@TRIL
1.44e-23FFCP PHASE2:Hg19::chr1:51791596..51791607,-#_b1c0a3dea8de09f944818ab03c813d5bp23@TTC39A
1.44e-23FFCP PHASE2:Hg19::chr7:28998254..28998261,-#_b1c0a3dea8de09f944818ab03c813d5bp10@TRIL
1.61e-23FFCP PHASE1:Hg19::chr7:4051097..4051112,+#_1097f8da36fd4b36e3fe0eafba66e28bp@chr7:4051097..4051112, +
1.61e-23FFCP PHASE2:Hg19::chr7:4051097..4051112,+#_1097f8da36fd4b36e3fe0eafba66e28bp@chr7:4051097..4051112, +
1.61e-23FFCP PHASE2:Hg19::chr15:85403302..85403304,+#_1097f8da36fd4b36e3fe0eafba66e28bp@chr15:85403302..85403304, +
1.61e-23FFCP PHASE1:Hg19::chr15:85403302..85403304,+#_1097f8da36fd4b36e3fe0eafba66e28bp@chr15:85403302..85403304, +
1.8e-23FFCP PHASE2:Hg19::chr16:2141529..2141537,+#_f765763d12619d34cac7b13b2eefd615p@chr16:2141529..2141537, +
1.8e-23FFCP PHASE1:Hg19::chr16:2141529..2141537,+#_f765763d12619d34cac7b13b2eefd615p@chr16:2141529..2141537, +
2.92e-22FFCP PHASE2:Hg19::chr5:74244100..74244117,+#_1e7be0377b507e255ae825f176576a61p@chr5:74244100..74244117, +
2.92e-22FFCP PHASE1:Hg19::chr5:74244100..74244117,+#_1e7be0377b507e255ae825f176576a61p@chr5:74244100..74244117, +
5.69e-22FFCP PHASE1:Hg19::chr5:148651758..148651769,-#_33e13c431f0984d1bac4d3fef37a0932p@chr5:148651758..148651769, -
5.69e-22FFCP PHASE2:Hg19::chr5:148651758..148651769,-#_33e13c431f0984d1bac4d3fef37a0932p@chr5:148651758..148651769, -
2.9e-21FFCP PHASE2:Hg19::chr16:86768403..86768437,+#_7579a79a0657d3da8f7fad7dd7db47a7p@chr16:86768403..86768437, +
2.9e-21FFCP PHASE1:Hg19::chr16:86768403..86768437,+#_7579a79a0657d3da8f7fad7dd7db47a7p@chr16:86768403..86768437, +
4.78e-21FFCP PHASE1:Hg19::chr17:2076002..2076026,-#_8ea946546a3dafdb6c52b3fdf4c1d5aap@chr17:2076002..2076026, -
4.78e-21FFCP PHASE2:Hg19::chr17:2076002..2076026,-#_8ea946546a3dafdb6c52b3fdf4c1d5aap@chr17:2076002..2076026, -
1.26e-20FFCP PHASE1:Hg19::chr1:32712897..32712909,+#_061cfa58210f9d27f27c8a2eb285cc27p3@FAM167B
1.26e-20FFCP PHASE2:Hg19::chr1:32712897..32712909,+#_061cfa58210f9d27f27c8a2eb285cc27p3@FAM167B
2.32e-20FFCP PHASE2:Hg19::chr11:124628392..124628427,-#_ef77d6a63eec4d6e8a69c4989ff3d74ep@chr11:124628392..124628427, -
2.32e-20FFCP PHASE1:Hg19::chr11:124628392..124628427,-#_ef77d6a63eec4d6e8a69c4989ff3d74ep@chr11:124628392..124628427, -
3.42e-20FFCP PHASE2:Hg19::chr3:98591021..98591026,-#_d5a174b9a8ee15113d09b51a0705cce1p1@ENST00000487339
3.42e-20FFCP PHASE1:Hg19::chr3:98591021..98591026,-#_d5a174b9a8ee15113d09b51a0705cce1p1@ENST00000487339
3.44e-20FFCP PHASE1:Hg19::chr19:47231340..47231383,-#_ea8a6372a3b45c769139fda13d8b11dfp@chr19:47231340..47231383, -
3.44e-20FFCP PHASE2:Hg19::chr19:47231340..47231383,-#_ea8a6372a3b45c769139fda13d8b11dfp@chr19:47231340..47231383, -
3.58e-20FFCP PHASE1:Hg19::chr19:1826957..1826984,-#_6bee355fcfa6fb9f81055f3de720bc43p@chr19:1826957..1826984, -
3.58e-20FFCP PHASE2:Hg19::chr19:1826957..1826984,-#_6bee355fcfa6fb9f81055f3de720bc43p@chr19:1826957..1826984, -
4.39e-20FFCP PHASE1:Hg19::chr4:38057595..38057624,-#_8a3d967c4ebe7f8fb843186be157e412p@chr4:38057595..38057624, -
4.39e-20FFCP PHASE2:Hg19::chr4:38057595..38057624,-#_8a3d967c4ebe7f8fb843186be157e412p@chr4:38057595..38057624, -
7.13e-20FFCP PHASE1:Hg19::chr2:133426106..133426117,-#_3dd84c408042616daab393f71bd230c0p@chr2:133426106..133426117, -
7.13e-20FFCP PHASE2:Hg19::chr2:133426106..133426117,-#_3dd84c408042616daab393f71bd230c0p@chr2:133426106..133426117, -
7.84e-20FFCP PHASE2:Hg19::chr9:35753821..35753835,-#_34495f8c314905b90e8f6a3c427d547ap@chr9:35753821..35753835, -
7.84e-20FFCP PHASE2:Hg19::chr15:36653709..36653720,-#_34495f8c314905b90e8f6a3c427d547ap@chr15:36653709..36653720, -
7.84e-20FFCP PHASE1:Hg19::chr15:36653709..36653720,-#_34495f8c314905b90e8f6a3c427d547ap@chr15:36653709..36653720, -
7.84e-20FFCP PHASE1:Hg19::chr9:35753821..35753835,-#_34495f8c314905b90e8f6a3c427d547ap@chr9:35753821..35753835, -
8.62e-20FFCP PHASE1:Hg19::chr4:145568170..145568180,-#_b0fe8ff306090608f34b2a25fa37b182p@chr4:145568170..145568180, -
8.62e-20FFCP PHASE2:Hg19::chr4:145568170..145568180,-#_b0fe8ff306090608f34b2a25fa37b182p@chr4:145568170..145568180, -
1.04e-19FFCP PHASE2:Hg19::chr19:38397228..38397266,-#_7e7926b1882e8e13d34947dd1ab9ce0cp1@WDR87
1.04e-19FFCP PHASE1:Hg19::chr19:38397228..38397266,-#_7e7926b1882e8e13d34947dd1ab9ce0cp1@WDR87
1.15e-19FFCP PHASE2:Hg19::chr14:91270270..91270281,-#_860289b8eeae157ffa3d34f17d73443bp@chr14:91270270..91270281, -
1.15e-19FFCP PHASE1:Hg19::chr14:91270270..91270281,-#_860289b8eeae157ffa3d34f17d73443bp@chr14:91270270..91270281, -
2.44e-19FFCP PHASE2:Hg19::chr12:52306196..52306215,+#_373facf1a6ce48b6e5c4d1acb157fbf3p6@ACVRL1
2.44e-19FFCP PHASE1:Hg19::chr12:52306196..52306215,+#_373facf1a6ce48b6e5c4d1acb157fbf3p6@ACVRL1
3.27e-19FFCP PHASE2:Hg19::chr3:43538305..43538325,-#_051a2e5a8ab09c3e0e613d0b51398d19p@chr3:43538305..43538325, -
3.27e-19FFCP PHASE1:Hg19::chr3:43538305..43538325,-#_051a2e5a8ab09c3e0e613d0b51398d19p@chr3:43538305..43538325, -
4.64e-19FFCP PHASE2:Hg19::chr17:171147..171161,+#_de9bd875f915a6529f82614196b0c762p@chr17:171147..171161, +
4.64e-19FFCP PHASE1:Hg19::chr17:171147..171161,+#_de9bd875f915a6529f82614196b0c762p@chr17:171147..171161, +
5.39e-19FFCP PHASE1:Hg19::chr1:22211913..22211920,+#_39bc24fa0b10d6721ce0f026fb9a9f1ap@chr1:22211913..22211920, +
5.39e-19FFCP PHASE2:Hg19::chr1:22211913..22211920,+#_39bc24fa0b10d6721ce0f026fb9a9f1ap@chr1:22211913..22211920, +
1.99e-18FFCP PHASE1:Hg19::chr7:27219833..27219845,-#_22edc03dbd9df99edd658866653dabf8p7@HOXA10
1.99e-18FFCP PHASE2:Hg19::chr7:27219833..27219845,-#_22edc03dbd9df99edd658866653dabf8p7@HOXA10
2.69e-18FFCP PHASE2:Hg19::chr1:32041957..32041990,+#_b0317e690e1e1f690dcb8665fc489840p3@TINAGL1
2.69e-18FFCP PHASE1:Hg19::chr1:32041957..32041990,+#_b0317e690e1e1f690dcb8665fc489840p3@TINAGL1
4.1e-18FFCP PHASE2:Hg19::chr6:132270228..132270243,-#_f096c64b8a07c169fcc5f8e9783b1d59p17@CTGF
4.1e-18FFCP PHASE1:Hg19::chr6:132270228..132270243,-#_f096c64b8a07c169fcc5f8e9783b1d59p17@CTGF
5.7e-18FFCP PHASE1:Hg19::chr11:940729..940745,+#_253aa156180f1f6fcc09117941102095p5@AP2A2
5.7e-18FFCP PHASE2:Hg19::chr11:940729..940745,+#_253aa156180f1f6fcc09117941102095p5@AP2A2
6.5e-18FFCP PHASE2:Hg19::chr19:42007093..42007107,-#_7fb83aa92c4c2eb54544e5fe8d5faf6dp@chr19:42007093..42007107, -
6.5e-18FFCP PHASE1:Hg19::chr19:42007093..42007107,-#_7fb83aa92c4c2eb54544e5fe8d5faf6dp@chr19:42007093..42007107, -
6.99e-18FFCP PHASE2:Hg19::chrX:128781853..128781866,-#_d327f6b4c642c13def5477aae2f9bca5p@chrX:128781853..128781866, -
6.99e-18FFCP PHASE1:Hg19::chrX:128781853..128781866,-#_d327f6b4c642c13def5477aae2f9bca5p@chrX:128781853..128781866, -
1.24e-17FFCP PHASE1:Hg19::chr16:86604624..86604648,+#_ade0482471a0b266b3d32a5232d5b6e4p@chr16:86604624..86604648, +
1.24e-17FFCP PHASE2:Hg19::chr16:86604624..86604648,+#_ade0482471a0b266b3d32a5232d5b6e4p@chr16:86604624..86604648, +

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