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Coexpression cluster:C1119

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Full id: C1119_nonsmall_smallcell_argyrophil_small_duodenum_esophagus_cerebellum



Phase1 CAGE Peaks

Hg19::chr10:5406920..5406934,+p2@UCN3
Hg19::chr10:5406935..5406962,+p1@UCN3
Hg19::chr10:5407062..5407072,+p3@UCN3
Hg19::chr10:5407085..5407093,+p5@UCN3
Hg19::chr2:241836244..241836276,-p2@C2orf54
Hg19::chr6:18208375..18208387,+p@chr6:18208375..18208387
+
Hg19::chr8:141018677..141018706,-p5@TRAPPC9


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0007189G-protein signaling, adenylate cyclase activating pathway0.0100553396915107
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messenger0.0100553396915107
GO:0019933cAMP-mediated signaling0.0100553396915107
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messenger0.0100553396915107
GO:0019935cyclic-nucleotide-mediated signaling0.0100553396915107
GO:0005179hormone activity0.0149044311001217
GO:0019932second-messenger-mediated signaling0.0157776992817614



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
small intestine4.76e-224
intestine1.87e-1617
maxillary sinus6.06e-131
paranasal sinus6.06e-131
gastrointestinal system2.24e-1125
uterine epithelium2.43e-072
cervix epithelium2.43e-072
open tracheal system trachea4.98e-072
subdivision of digestive tract6.12e-07118
Disease
Ontology termp-valuen
somatostatinoma4.77e-131
paranasal sinus cancer6.06e-131
maxillary sinus cancer6.06e-131
respiratory system cancer3.28e-0716


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.