MCL coexpression mm9:30
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005216 | ion channel activity | 1.63774054743321e-09 |
| GO:0022838 | substrate specific channel activity | 1.63774054743321e-09 |
| GO:0022803 | passive transmembrane transporter activity | 1.86923100814581e-09 |
| GO:0015267 | channel activity | 1.86923100814581e-09 |
| GO:0022892 | substrate-specific transporter activity | 4.70974134581281e-09 |
| GO:0022836 | gated channel activity | 6.21590362878898e-09 |
| GO:0015075 | ion transmembrane transporter activity | 1.28031085804656e-08 |
| GO:0022857 | transmembrane transporter activity | 6.17442837630027e-08 |
| GO:0022891 | substrate-specific transmembrane transporter activity | 1.29331922835659e-07 |
| GO:0006811 | ion transport | 4.11433623995841e-07 |
| GO:0051179 | localization | 9.38420198635919e-07 |
| GO:0046873 | metal ion transmembrane transporter activity | 1.11501881861437e-06 |
| GO:0005261 | cation channel activity | 1.65259073179895e-06 |
| GO:0022832 | voltage-gated channel activity | 3.88665630831102e-06 |
| GO:0005244 | voltage-gated ion channel activity | 3.88665630831102e-06 |
| GO:0051234 | establishment of localization | 4.47507893605575e-06 |
| GO:0006810 | transport | 8.31090052839595e-06 |
| GO:0030054 | cell junction | 2.49627488802123e-05 |
| GO:0008324 | cation transmembrane transporter activity | 2.78171798657946e-05 |
| GO:0044456 | synapse part | 3.04880083778431e-05 |
| GO:0044459 | plasma membrane part | 4.87302170916916e-05 |
| GO:0005886 | plasma membrane | 6.99852829746216e-05 |
| GO:0043167 | ion binding | 6.99852829746216e-05 |
| GO:0006812 | cation transport | 0.000132563764960938 |
| GO:0030001 | metal ion transport | 0.000132563764960938 |
| GO:0005509 | calcium ion binding | 0.000132563764960938 |
| GO:0046872 | metal ion binding | 0.000321186068935908 |
| GO:0043169 | cation binding | 0.0007975472545692 |
| GO:0014051 | gamma-aminobutyric acid secretion | 0.00115752704513594 |
| GO:0016020 | membrane | 0.00128676240087821 |
| GO:0007242 | intracellular signaling cascade | 0.00132507572060849 |
| GO:0045211 | postsynaptic membrane | 0.00144143804496103 |
| GO:0030955 | potassium ion binding | 0.0014712886710819 |
| GO:0042995 | cell projection | 0.00178097047682171 |
| GO:0030695 | GTPase regulator activity | 0.00178097047682171 |
| GO:0022843 | voltage-gated cation channel activity | 0.00181513801051948 |
| GO:0005891 | voltage-gated calcium channel complex | 0.00184542344627076 |
| GO:0005267 | potassium channel activity | 0.00226284093603648 |
| GO:0031420 | alkali metal ion binding | 0.00226284093603648 |
| GO:0003779 | actin binding | 0.00242554453585042 |
| GO:0005234 | extracellular-glutamate-gated ion channel activity | 0.00299773570106501 |
| GO:0008066 | glutamate receptor activity | 0.00299773570106501 |
| GO:0022834 | ligand-gated channel activity | 0.00299773570106501 |
| GO:0015276 | ligand-gated ion channel activity | 0.00299773570106501 |
| GO:0004970 | ionotropic glutamate receptor activity | 0.00334282620711643 |
| GO:0005515 | protein binding | 0.00357575201637856 |
| GO:0008092 | cytoskeletal protein binding | 0.00357575201637856 |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | 0.00370535511664569 |
| GO:0007216 | metabotropic glutamate receptor signaling pathway | 0.00407834144526985 |
| GO:0046058 | cAMP metabolic process | 0.00416671473348487 |
| GO:0005245 | voltage-gated calcium channel activity | 0.00474517782371481 |
| GO:0005096 | GTPase activator activity | 0.00532798463033904 |
| GO:0006813 | potassium ion transport | 0.00561022880187941 |
| GO:0050881 | musculoskeletal movement | 0.00603207185723325 |
| GO:0050879 | multicellular organismal movement | 0.00603207185723325 |
| GO:0006816 | calcium ion transport | 0.00616124866551924 |
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | 0.00616124866551924 |
| GO:0007270 | nerve-nerve synaptic transmission | 0.00616124866551924 |
| GO:0051015 | actin filament binding | 0.00616124866551924 |
| GO:0004112 | cyclic-nucleotide phosphodiesterase activity | 0.00771544358280764 |
| GO:0008331 | high voltage-gated calcium channel activity | 0.00812628727241511 |
| GO:0008081 | phosphoric diester hydrolase activity | 0.00928275007838412 |
| GO:0005230 | extracellular ligand-gated ion channel activity | 0.00928275007838412 |
| GO:0043005 | neuron projection | 0.00974371848507528 |
| GO:0005262 | calcium channel activity | 0.0100930192112849 |
| GO:0019932 | second-messenger-mediated signaling | 0.0123160850868702 |
| GO:0044464 | cell part | 0.0141804090146408 |
| GO:0005623 | cell | 0.0141804090146408 |
| GO:0015674 | di-, tri-valent inorganic cation transport | 0.016718454095615 |
| GO:0035249 | synaptic transmission, glutamatergic | 0.016797493205983 |
| GO:0008047 | enzyme activator activity | 0.0179647894081325 |
| GO:0009187 | cyclic nucleotide metabolic process | 0.0183197382585951 |
| GO:0007215 | glutamate signaling pathway | 0.0200555370586092 |
| GO:0015672 | monovalent inorganic cation transport | 0.0211450117671988 |
| GO:0003001 | generation of a signal involved in cell-cell signaling | 0.0231876464974608 |
| GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 0.0247678782734796 |
| GO:0042391 | regulation of membrane potential | 0.0247678782734796 |
| GO:0014069 | postsynaptic density | 0.0272654741047312 |
| GO:0050808 | synapse organization and biogenesis | 0.0272654741047312 |
| GO:0048015 | phosphoinositide-mediated signaling | 0.0272654741047312 |
| GO:0019992 | diacylglycerol binding | 0.0287279809683155 |
| GO:0050905 | neuromuscular process | 0.0321484501795127 |
| GO:0030425 | dendrite | 0.0337326049120814 |
| GO:0030029 | actin filament-based process | 0.0349359976435137 |
| GO:0017016 | Ras GTPase binding | 0.0349359976435137 |
| GO:0031267 | small GTPase binding | 0.0382496195692279 |
| GO:0007269 | neurotransmitter secretion | 0.0382496195692279 |
| GO:0019717 | synaptosome | 0.0399575013426778 |
| GO:0005516 | calmodulin binding | 0.0407824515600866 |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.0407824515600866 |
| GO:0051020 | GTPase binding | 0.0444367707127684 |
| GO:0051899 | membrane depolarization | 0.0444367707127684 |
| GO:0043025 | cell soma | 0.0444367707127684 |
| GO:0007416 | synaptogenesis | 0.0444367707127684 |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 0.0444367707127684 |
| GO:0004089 | carbonate dehydratase activity | 0.0444367707127684 |
| GO:0017137 | Rab GTPase binding | 0.0444367707127684 |
| GO:0007268 | synaptic transmission | 0.0444367707127684 |
| GO:0021548 | pons development | 0.0444367707127684 |
| GO:0032353 | negative regulation of hormone biosynthetic process | 0.0444367707127684 |
| GO:0002860 | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | 0.0444367707127684 |
| GO:0002717 | positive regulation of natural killer cell mediated immunity | 0.0444367707127684 |
| GO:0021626 | central nervous system maturation | 0.0444367707127684 |
| GO:0005845 | mRNA cap complex | 0.0444367707127684 |
| GO:0016921 | pyroglutamyl-peptidase II activity | 0.0444367707127684 |
| GO:0002420 | natural killer cell mediated cytotoxicity directed against tumor cell target | 0.0444367707127684 |
| GO:0002858 | regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | 0.0444367707127684 |
| GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity | 0.0444367707127684 |
| GO:0032351 | negative regulation of hormone metabolic process | 0.0444367707127684 |
| GO:0002715 | regulation of natural killer cell mediated immunity | 0.0444367707127684 |
| GO:0021679 | cerebellar molecular layer development | 0.0444367707127684 |
| GO:0006551 | leucine metabolic process | 0.0444367707127684 |
| GO:0050882 | voluntary musculoskeletal movement | 0.0444367707127684 |
| GO:0021590 | cerebellum maturation | 0.0444367707127684 |
| GO:0021750 | vestibular nucleus development | 0.0444367707127684 |
| GO:0002355 | detection of tumor cell | 0.0444367707127684 |
| GO:0021578 | hindbrain maturation | 0.0444367707127684 |
| GO:0048541 | Peyer's patch development | 0.0444367707127684 |
| GO:0004671 | protein-S-isoprenylcysteine O-methyltransferase activity | 0.0444367707127684 |
| GO:0048791 | calcium ion-dependent exocytosis of neurotransmitter | 0.0444367707127684 |
| GO:0006198 | cAMP catabolic process | 0.0444367707127684 |
| GO:0017026 | procollagen C-endopeptidase activity | 0.0444367707127684 |
| GO:0004482 | mRNA (guanine-N7-)-methyltransferase activity | 0.0444367707127684 |
| GO:0002423 | natural killer cell mediated immune response to tumor cell | 0.0444367707127684 |
| GO:0002855 | regulation of natural killer cell mediated immune response to tumor cell | 0.0444367707127684 |
| GO:0002857 | positive regulation of natural killer cell mediated immune response to tumor cell | 0.0444367707127684 |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 0.0444367707127684 |
| GO:0051969 | regulation of transmission of nerve impulse | 0.0453853625805822 |
| GO:0017156 | calcium ion-dependent exocytosis | 0.0453853625805822 |
| GO:0050804 | regulation of synaptic transmission | 0.0453853625805822 |
| GO:0045055 | regulated secretory pathway | 0.0476917705886419 |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 0.0479115883147536 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
